DE3325850A1 - Substituierte peptide - Google Patents

Substituierte peptide

Info

Publication number
DE3325850A1
DE3325850A1 DE19833325850 DE3325850A DE3325850A1 DE 3325850 A1 DE3325850 A1 DE 3325850A1 DE 19833325850 DE19833325850 DE 19833325850 DE 3325850 A DE3325850 A DE 3325850A DE 3325850 A1 DE3325850 A1 DE 3325850A1
Authority
DE
Germany
Prior art keywords
hydrogen atom
group
lower alkyl
general formula
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19833325850
Other languages
German (de)
English (en)
Inventor
Eric Michael Pennington N.J. Gordon
Sesha Iyer Neshanic Station N.J. Natarajan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of DE3325850A1 publication Critical patent/DE3325850A1/de
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19833325850 1982-07-19 1983-07-18 Substituierte peptide Ceased DE3325850A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (1)

Publication Number Publication Date
DE3325850A1 true DE3325850A1 (de) 1984-01-19

Family

ID=23580391

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19833325850 Ceased DE3325850A1 (de) 1982-07-19 1983-07-18 Substituierte peptide

Country Status (21)

Country Link
JP (3) JPS5951246A (it)
KR (1) KR840005709A (it)
AU (1) AU1643283A (it)
BE (1) BE897327A (it)
CA (1) CA1244006A (it)
CH (1) CH659475A5 (it)
DE (1) DE3325850A1 (it)
DK (1) DK330683A (it)
ES (4) ES8504675A1 (it)
FI (1) FI832620A (it)
FR (3) FR2530238B1 (it)
GB (1) GB2123834B (it)
GR (1) GR79602B (it)
HU (1) HU187090B (it)
IE (1) IE55818B1 (it)
IL (1) IL69136A0 (it)
IT (1) IT1163800B (it)
NL (1) NL8302562A (it)
PT (1) PT77045B (it)
SE (1) SE8304031L (it)
ZA (1) ZA834980B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
DE3588094T2 (de) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive Derivate
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3414099A1 (en) 2017-01-10 2018-12-19 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052991A1 (en) * 1980-11-24 1982-06-02 E.R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
ATE20469T1 (de) * 1980-10-23 1986-07-15 Schering Corp Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0052991A1 (en) * 1980-11-24 1982-06-02 E.R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines

Also Published As

Publication number Publication date
NL8302562A (nl) 1984-02-16
FR2540867B1 (fr) 1987-07-31
ES524200A0 (es) 1985-04-16
GB2123834A (en) 1984-02-08
KR840005709A (ko) 1984-11-16
AU1643283A (en) 1984-01-26
BE897327A (fr) 1984-01-19
ES8707550A1 (es) 1986-04-01
SE8304031D0 (sv) 1983-07-18
JPH0532601A (ja) 1993-02-09
CA1244006A (en) 1988-11-01
ES8504675A1 (es) 1985-04-16
FI832620A0 (fi) 1983-07-19
PT77045B (en) 1986-02-12
FR2540867A1 (fr) 1984-08-17
FR2530238B1 (it) 1989-06-30
JPH0645582B2 (ja) 1994-06-15
IE55818B1 (en) 1991-01-30
HUT34040A (en) 1985-01-28
DK330683D0 (da) 1983-07-18
GB2123834B (en) 1986-10-22
JPH0517420A (ja) 1993-01-26
IE831655L (en) 1984-01-19
ES539082A0 (es) 1986-05-16
JPH0653713B2 (ja) 1994-07-20
ES539084A0 (es) 1986-04-01
SE8304031L (sv) 1984-03-30
DK330683A (da) 1984-01-20
IT8322114A0 (it) 1983-07-18
FI832620A (fi) 1984-01-20
ZA834980B (en) 1984-03-28
PT77045A (en) 1983-08-01
ES8707548A1 (es) 1986-05-16
GR79602B (it) 1984-10-31
IL69136A0 (en) 1983-10-31
FR2540866A1 (fr) 1984-08-17
JPS5951246A (ja) 1984-03-24
JPH0526775B2 (it) 1993-04-19
GB8318492D0 (en) 1983-08-10
CH659475A5 (fr) 1987-01-30
ES539083A0 (es) 1986-04-01
FR2530238A1 (it) 1984-01-20
HU187090B (en) 1985-11-28
ES8707549A1 (es) 1986-04-01
IT1163800B (it) 1987-04-08

Similar Documents

Publication Publication Date Title
EP0119955B1 (de) Gewisse 3-(5-Aminopentyl)-amino-1-benzazepin-2-on-1-alkansäuren, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
EP0046953B1 (de) Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung
EP0608759B1 (de) Piperazinderivate
DE69919397T2 (de) Thrombin-inhibitoren
DE3643977A1 (de) Harnstoff-derivate mit renin inhibierender wirkung
EP0119161B1 (de) Gewisse Benzazocinon- und Benzazoninon-Derivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
DD243932A5 (de) Verfahren zur herstellung von n,n'-dialkylguanidino-dipeptiden
EP0161588B1 (de) Diaminosäurederivate
DD148770A5 (de) Verfahren zur herstellung von carboxyalkyldipeptiden und ihrer derivate
DE3508251A1 (de) Dipeptide
DE3542567A1 (de) Aminosaeure-ester und amide
DD239407A5 (de) Verfahren zur herstellung von statin oder derivate hiervon enthaltenden renin-inhibitoren
EP0796271B1 (de) Dipeptidische p-amidinobenzylamide mit n-terminalen sulfonyl- bzw. aminosulfonylresten
DD236522A5 (de) Verfahren zur herstellung medizinisch wertvoller verbindungen und zwischenverbindungen
DE3341610A1 (de) Carboxy- und substituierte carboxyalkanoyl- und cycloalkanoylpeptide
EP0374097A2 (de) Verwendung von Peptidisosteren als retrovirale Proteasehemmer
DE69738601T2 (de) Stabile, nicht-hygroskopische, kristalline form von n-än-n(4-(piperidin-4-yl)butanoyl)-n-ethylglycyl verbindungen
DE3024256A1 (de) Peptidamide, verfahren zur herstellung derselben und diese enthaltende arzneimittel
EP0374098A2 (de) Retrovirale Proteasehemmer
DE3606448A1 (de) Aminoalkanoylureidoamino- und -iminosaeure-verbindungen
DE3325850A1 (de) Substituierte peptide
CH676003A5 (it)
JPS60231643A (ja) ヒドロキシ置換ウレイドアミノおよびイミノ酸類
DD228547A5 (de) Verfahren zur herstellung von neuen amid-verbindungen
US4602002A (en) N-carboxymethyl substituted lysyl and α-(ε-aminoalkyl) glycyl amino acid antihypertensive agents

Legal Events

Date Code Title Description
8128 New person/name/address of the agent

Representative=s name: VOSSIUS, V., DIPL.-CHEM. DR.RER.NAT. TAUCHNER, P.,

8110 Request for examination paragraph 44
8131 Rejection