IE831655L - Pharmaceutically active n-acyl peptides - Google Patents

Pharmaceutically active n-acyl peptides

Info

Publication number
IE831655L
IE831655L IE831655A IE165583A IE831655L IE 831655 L IE831655 L IE 831655L IE 831655 A IE831655 A IE 831655A IE 165583 A IE165583 A IE 165583A IE 831655 L IE831655 L IE 831655L
Authority
IE
Ireland
Prior art keywords
pharmaceutically active
acyl peptides
useful
inhibition activity
compounds
Prior art date
Application number
IE831655A
Other versions
IE55818B1 (en
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Priority to IE110/87A priority Critical patent/IE55820B1/en
Priority to IE109/87A priority patent/IE55819B1/en
Publication of IE831655L publication Critical patent/IE831655L/en
Publication of IE55818B1 publication Critical patent/IE55818B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Substituted peptide compounds of the formula <IMAGE> are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity. [GB2123834A]
IE1655/83A 1982-07-19 1983-07-15 Pharmaceuticaly active n-acyl dipeptides IE55818B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IE110/87A IE55820B1 (en) 1982-07-19 1983-07-15 Substituted peptide compounds
IE109/87A IE55819B1 (en) 1982-07-19 1983-07-15 Substituted peptide compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (2)

Publication Number Publication Date
IE831655L true IE831655L (en) 1984-01-19
IE55818B1 IE55818B1 (en) 1991-01-30

Family

ID=23580391

Family Applications (1)

Application Number Title Priority Date Filing Date
IE1655/83A IE55818B1 (en) 1982-07-19 1983-07-15 Pharmaceuticaly active n-acyl dipeptides

Country Status (21)

Country Link
JP (3) JPS5951246A (en)
KR (1) KR840005709A (en)
AU (1) AU1643283A (en)
BE (1) BE897327A (en)
CA (1) CA1244006A (en)
CH (1) CH659475A5 (en)
DE (1) DE3325850A1 (en)
DK (1) DK330683A (en)
ES (4) ES524200A0 (en)
FI (1) FI832620A (en)
FR (3) FR2530238B1 (en)
GB (1) GB2123834B (en)
GR (1) GR79602B (en)
HU (1) HU187090B (en)
IE (1) IE55818B1 (en)
IL (1) IL69136A0 (en)
IT (1) IT1163800B (en)
NL (1) NL8302562A (en)
PT (1) PT77045B (en)
SE (1) SE8304031L (en)
ZA (1) ZA834980B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
DE3588094T2 (en) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive derivatives
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (en) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Process for the Preparation of Remin Inhibitors Using 2- (L-Alayl-L-Histidylamino) -butanol Derivatives
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3414099A1 (en) 2017-01-10 2018-12-19 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (en) * 1980-04-17 1981-10-23 Roques Bernard AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
GR75019B (en) * 1980-09-17 1984-07-12 Univ Miami
DE19575012I2 (en) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl dipeptides Process for their preparation and medicaments containing them
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
HUT34040A (en) 1985-01-28
GB2123834A (en) 1984-02-08
AU1643283A (en) 1984-01-26
BE897327A (en) 1984-01-19
FR2540866A1 (en) 1984-08-17
FR2530238B1 (en) 1989-06-30
JPH0526775B2 (en) 1993-04-19
ZA834980B (en) 1984-03-28
SE8304031D0 (en) 1983-07-18
ES8707549A1 (en) 1986-04-01
GB2123834B (en) 1986-10-22
GB8318492D0 (en) 1983-08-10
JPH0532601A (en) 1993-02-09
IT8322114A0 (en) 1983-07-18
ES539084A0 (en) 1986-04-01
ES8504675A1 (en) 1985-04-16
PT77045A (en) 1983-08-01
GR79602B (en) 1984-10-31
FR2540867A1 (en) 1984-08-17
FI832620A (en) 1984-01-20
DK330683A (en) 1984-01-20
FI832620A0 (en) 1983-07-19
HU187090B (en) 1985-11-28
PT77045B (en) 1986-02-12
DK330683D0 (en) 1983-07-18
IT1163800B (en) 1987-04-08
ES8707550A1 (en) 1986-04-01
DE3325850A1 (en) 1984-01-19
ES539082A0 (en) 1986-05-16
SE8304031L (en) 1984-03-30
IL69136A0 (en) 1983-10-31
IE55818B1 (en) 1991-01-30
ES539083A0 (en) 1986-04-01
ES524200A0 (en) 1985-04-16
ES8707548A1 (en) 1986-05-16
JPH0645582B2 (en) 1994-06-15
CA1244006A (en) 1988-11-01
JPH0653713B2 (en) 1994-07-20
CH659475A5 (en) 1987-01-30
JPS5951246A (en) 1984-03-24
KR840005709A (en) 1984-11-16
NL8302562A (en) 1984-02-16
FR2540867B1 (en) 1987-07-31
JPH0517420A (en) 1993-01-26
FR2530238A1 (en) 1984-01-20

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Legal Events

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MM4A Patent lapsed