ES8707549A1 - Substituted peptide compounds - Google Patents

Substituted peptide compounds

Info

Publication number
ES8707549A1
ES8707549A1 ES539083A ES539083A ES8707549A1 ES 8707549 A1 ES8707549 A1 ES 8707549A1 ES 539083 A ES539083 A ES 539083A ES 539083 A ES539083 A ES 539083A ES 8707549 A1 ES8707549 A1 ES 8707549A1
Authority
ES
Spain
Prior art keywords
peptide compounds
substituted peptide
useful
compounds
inhibition activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539083A
Other languages
Spanish (es)
Other versions
ES539083A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of ES8707549A1 publication Critical patent/ES8707549A1/en
Publication of ES539083A0 publication Critical patent/ES539083A0/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Substituted peptide compounds of the formula < IMAGE > are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.
ES539083A 1982-07-19 1984-12-27 Substituted peptide compounds Expired ES8707549A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (2)

Publication Number Publication Date
ES8707549A1 true ES8707549A1 (en) 1986-04-01
ES539083A0 ES539083A0 (en) 1986-04-01

Family

ID=23580391

Family Applications (4)

Application Number Title Priority Date Filing Date
ES524200A Granted ES524200A0 (en) 1982-07-19 1983-07-18 A PROCEDURE FOR PREPARING REPLACED PEPTIDE COMPOUNDS
ES539082A Expired ES8707548A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds
ES539083A Expired ES8707549A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds
ES539084A Expired ES8707550A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES524200A Granted ES524200A0 (en) 1982-07-19 1983-07-18 A PROCEDURE FOR PREPARING REPLACED PEPTIDE COMPOUNDS
ES539082A Expired ES8707548A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES539084A Expired ES8707550A1 (en) 1982-07-19 1984-12-27 Substituted peptide compounds

Country Status (21)

Country Link
JP (3) JPS5951246A (en)
KR (1) KR840005709A (en)
AU (1) AU1643283A (en)
BE (1) BE897327A (en)
CA (1) CA1244006A (en)
CH (1) CH659475A5 (en)
DE (1) DE3325850A1 (en)
DK (1) DK330683A (en)
ES (4) ES524200A0 (en)
FI (1) FI832620A (en)
FR (3) FR2530238B1 (en)
GB (1) GB2123834B (en)
GR (1) GR79602B (en)
HU (1) HU187090B (en)
IE (1) IE55818B1 (en)
IL (1) IL69136A0 (en)
IT (1) IT1163800B (en)
NL (1) NL8302562A (en)
PT (1) PT77045B (en)
SE (1) SE8304031L (en)
ZA (1) ZA834980B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
DE3588094T2 (en) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive derivatives
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (en) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Process for the Preparation of Remin Inhibitors Using 2- (L-Alayl-L-Histidylamino) -butanol Derivatives
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3414099A1 (en) 2017-01-10 2018-12-19 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (en) * 1980-04-17 1981-10-23 Roques Bernard AMINO ACID DERIVATIVES AND THEIR THERAPEUTIC APPLICATION
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
GR75019B (en) * 1980-09-17 1984-07-12 Univ Miami
DE19575012I2 (en) * 1980-10-23 2002-01-24 Schering Corp Carboxyalkyl dipeptides Process for their preparation and medicaments containing them
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
HUT34040A (en) 1985-01-28
GB2123834A (en) 1984-02-08
AU1643283A (en) 1984-01-26
BE897327A (en) 1984-01-19
FR2540866A1 (en) 1984-08-17
FR2530238B1 (en) 1989-06-30
JPH0526775B2 (en) 1993-04-19
ZA834980B (en) 1984-03-28
SE8304031D0 (en) 1983-07-18
GB2123834B (en) 1986-10-22
GB8318492D0 (en) 1983-08-10
JPH0532601A (en) 1993-02-09
IT8322114A0 (en) 1983-07-18
ES539084A0 (en) 1986-04-01
ES8504675A1 (en) 1985-04-16
PT77045A (en) 1983-08-01
GR79602B (en) 1984-10-31
FR2540867A1 (en) 1984-08-17
FI832620A (en) 1984-01-20
DK330683A (en) 1984-01-20
FI832620A0 (en) 1983-07-19
HU187090B (en) 1985-11-28
PT77045B (en) 1986-02-12
DK330683D0 (en) 1983-07-18
IT1163800B (en) 1987-04-08
ES8707550A1 (en) 1986-04-01
DE3325850A1 (en) 1984-01-19
IE831655L (en) 1984-01-19
ES539082A0 (en) 1986-05-16
SE8304031L (en) 1984-03-30
IL69136A0 (en) 1983-10-31
IE55818B1 (en) 1991-01-30
ES539083A0 (en) 1986-04-01
ES524200A0 (en) 1985-04-16
ES8707548A1 (en) 1986-05-16
JPH0645582B2 (en) 1994-06-15
CA1244006A (en) 1988-11-01
JPH0653713B2 (en) 1994-07-20
CH659475A5 (en) 1987-01-30
JPS5951246A (en) 1984-03-24
KR840005709A (en) 1984-11-16
NL8302562A (en) 1984-02-16
FR2540867B1 (en) 1987-07-31
JPH0517420A (en) 1993-01-26
FR2530238A1 (en) 1984-01-20

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