FR2540867B1 - Halo-aminocetones utilisables comme intermediaires pour la preparation de peptides substitues - Google Patents

Halo-aminocetones utilisables comme intermediaires pour la preparation de peptides substitues

Info

Publication number
FR2540867B1
FR2540867B1 FR8400115A FR8400115A FR2540867B1 FR 2540867 B1 FR2540867 B1 FR 2540867B1 FR 8400115 A FR8400115 A FR 8400115A FR 8400115 A FR8400115 A FR 8400115A FR 2540867 B1 FR2540867 B1 FR 2540867B1
Authority
FR
France
Prior art keywords
aminocetones
intermediates
halo
preparation
substituted peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8400115A
Other languages
English (en)
Other versions
FR2540867A1 (fr
Inventor
Sesha I Natarajan
Eric M Gordon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2540867A1 publication Critical patent/FR2540867A1/fr
Application granted granted Critical
Publication of FR2540867B1 publication Critical patent/FR2540867B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
FR8400115A 1982-07-19 1984-01-05 Halo-aminocetones utilisables comme intermediaires pour la preparation de peptides substitues Expired FR2540867B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (2)

Publication Number Publication Date
FR2540867A1 FR2540867A1 (fr) 1984-08-17
FR2540867B1 true FR2540867B1 (fr) 1987-07-31

Family

ID=23580391

Family Applications (3)

Application Number Title Priority Date Filing Date
FR838311764A Expired FR2530238B1 (fr) 1982-07-19 1983-07-13
FR8400114A Pending FR2540866A1 (fr) 1982-07-19 1984-01-05 Acides aminocetone carboxyliques utilisables comme intermediaires pour la preparation de peptides substitues
FR8400115A Expired FR2540867B1 (fr) 1982-07-19 1984-01-05 Halo-aminocetones utilisables comme intermediaires pour la preparation de peptides substitues

Family Applications Before (2)

Application Number Title Priority Date Filing Date
FR838311764A Expired FR2530238B1 (fr) 1982-07-19 1983-07-13
FR8400114A Pending FR2540866A1 (fr) 1982-07-19 1984-01-05 Acides aminocetone carboxyliques utilisables comme intermediaires pour la preparation de peptides substitues

Country Status (21)

Country Link
JP (3) JPS5951246A (fr)
KR (1) KR840005709A (fr)
AU (1) AU1643283A (fr)
BE (1) BE897327A (fr)
CA (1) CA1244006A (fr)
CH (1) CH659475A5 (fr)
DE (1) DE3325850A1 (fr)
DK (1) DK330683A (fr)
ES (4) ES524200A0 (fr)
FI (1) FI832620A (fr)
FR (3) FR2530238B1 (fr)
GB (1) GB2123834B (fr)
GR (1) GR79602B (fr)
HU (1) HU187090B (fr)
IE (1) IE55818B1 (fr)
IL (1) IL69136A0 (fr)
IT (1) IT1163800B (fr)
NL (1) NL8302562A (fr)
PT (1) PT77045B (fr)
SE (1) SE8304031L (fr)
ZA (1) ZA834980B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
DE3588094T2 (de) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive Derivate
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
EP1264707A3 (fr) 2001-05-14 2004-05-19 Oji Paper Co., Ltd. Matériau d'enregistrement sensible à la chaleur et composés développeur de couleur
DE202018107306U1 (de) 2017-01-10 2019-01-28 Mitsubishi Hitec Paper Europe Gmbh Neuartiger Farbentwickler für ein wärmeempfindliches Aufzeichnungsmedium und ein wärmeempfindliches Aufzeichnungsmaterial auf der Basis PLA

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
EP0048159A3 (fr) * 1980-09-17 1982-05-12 University Of Miami Peptides carboxyalcoyliques, thioéthers et éthers de peptides comme agents antihypertensifs
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
EP0054862B1 (fr) * 1980-12-18 1985-11-27 Schering Corporation Dipeptides substitués, leur procédé de préparation, compositions pharmaceutiques les contenant et leur emploi comme inhibiteurs de l'enképhalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
ES8504675A1 (es) 1985-04-16
AU1643283A (en) 1984-01-26
BE897327A (fr) 1984-01-19
HUT34040A (en) 1985-01-28
SE8304031D0 (sv) 1983-07-18
GB8318492D0 (en) 1983-08-10
JPH0645582B2 (ja) 1994-06-15
IE831655L (en) 1984-01-19
FI832620A (fi) 1984-01-20
PT77045A (en) 1983-08-01
JPH0517420A (ja) 1993-01-26
IT1163800B (it) 1987-04-08
GB2123834B (en) 1986-10-22
SE8304031L (sv) 1984-03-30
JPH0532601A (ja) 1993-02-09
FR2540867A1 (fr) 1984-08-17
KR840005709A (ko) 1984-11-16
DK330683D0 (da) 1983-07-18
IL69136A0 (en) 1983-10-31
ES539083A0 (es) 1986-04-01
ES524200A0 (es) 1985-04-16
FR2530238B1 (fr) 1989-06-30
JPS5951246A (ja) 1984-03-24
PT77045B (en) 1986-02-12
ES8707549A1 (es) 1986-04-01
IT8322114A0 (it) 1983-07-18
ES8707548A1 (es) 1986-05-16
ZA834980B (en) 1984-03-28
JPH0526775B2 (fr) 1993-04-19
JPH0653713B2 (ja) 1994-07-20
FI832620A0 (fi) 1983-07-19
DE3325850A1 (de) 1984-01-19
CH659475A5 (fr) 1987-01-30
ES8707550A1 (es) 1986-04-01
ES539084A0 (es) 1986-04-01
NL8302562A (nl) 1984-02-16
DK330683A (da) 1984-01-20
IE55818B1 (en) 1991-01-30
FR2540866A1 (fr) 1984-08-17
ES539082A0 (es) 1986-05-16
HU187090B (en) 1985-11-28
GB2123834A (en) 1984-02-08
GR79602B (fr) 1984-10-31
FR2530238A1 (fr) 1984-01-20
CA1244006A (fr) 1988-11-01

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Legal Events

Date Code Title Description
ST Notification of lapse