CH659475A5 - Composes peptidiques substitues et compositions pharmaceutiques les contenant. - Google Patents

Composes peptidiques substitues et compositions pharmaceutiques les contenant. Download PDF

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Publication number
CH659475A5
CH659475A5 CH3950/83A CH395083A CH659475A5 CH 659475 A5 CH659475 A5 CH 659475A5 CH 3950/83 A CH3950/83 A CH 3950/83A CH 395083 A CH395083 A CH 395083A CH 659475 A5 CH659475 A5 CH 659475A5
Authority
CH
Switzerland
Prior art keywords
lower alkyl
hydrogen
proline
mmol
oxo
Prior art date
Application number
CH3950/83A
Other languages
English (en)
French (fr)
Inventor
Sesha Iyer Natarajan
Eric Michael Gordon
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of CH659475A5 publication Critical patent/CH659475A5/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CH3950/83A 1982-07-19 1983-07-19 Composes peptidiques substitues et compositions pharmaceutiques les contenant. CH659475A5 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39965082A 1982-07-19 1982-07-19

Publications (1)

Publication Number Publication Date
CH659475A5 true CH659475A5 (fr) 1987-01-30

Family

ID=23580391

Family Applications (1)

Application Number Title Priority Date Filing Date
CH3950/83A CH659475A5 (fr) 1982-07-19 1983-07-19 Composes peptidiques substitues et compositions pharmaceutiques les contenant.

Country Status (21)

Country Link
JP (3) JPS5951246A (it)
KR (1) KR840005709A (it)
AU (1) AU1643283A (it)
BE (1) BE897327A (it)
CA (1) CA1244006A (it)
CH (1) CH659475A5 (it)
DE (1) DE3325850A1 (it)
DK (1) DK330683A (it)
ES (4) ES8504675A1 (it)
FI (1) FI832620A (it)
FR (3) FR2530238B1 (it)
GB (1) GB2123834B (it)
GR (1) GR79602B (it)
HU (1) HU187090B (it)
IE (1) IE55818B1 (it)
IL (1) IL69136A0 (it)
IT (1) IT1163800B (it)
NL (1) NL8302562A (it)
PT (1) PT77045B (it)
SE (1) SE8304031L (it)
ZA (1) ZA834980B (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55159749A (en) * 1979-05-31 1980-12-12 Takeda Chem Ind Ltd Preparation of dried fish flesh
US4500518A (en) * 1984-04-19 1985-02-19 E. R. Squibb & Sons, Inc. Amino thiol dipeptides
DE3588094T2 (de) * 1984-09-12 1996-08-22 Rhone Poulenc Rorer Pharma Antihypertensive Derivate
US4629724A (en) * 1984-12-03 1986-12-16 E. R. Squibb & Sons, Inc. Amino acid ester and amide renin inhibitors
FR2578544A1 (en) * 1985-03-11 1986-09-12 Usv Pharma Corp Antihypertension spirocyclic compounds
FI89058C (fi) * 1987-02-27 1993-08-10 Yamanouchi Pharma Co Ltd Foerfarande foer framstaellning av som remin-inhibitorer anvaenda 2-(l-alanyl-l-histidylamino)-butanol-derivat
US6858565B2 (en) 2001-05-14 2005-02-22 Oji Paper Co., Ltd. Thermosensitive recording material and novel color developer compounds
EP3414099A1 (en) 2017-01-10 2018-12-19 Mitsubishi HiTec Paper Europe GmbH Novel colour developer for a thermo-sensitive recording medium, and a heat-sensitive recording material based on pla

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3751239A (en) * 1969-05-29 1973-08-07 Rohm & Haas Herbicidal compositions containing n-(1,1-dialkyl-3-chloroacetonyl) benzamides
JPS5430167A (en) * 1977-08-11 1979-03-06 Mitsubishi Chem Ind Ltd 4-aminomethyl-2-phenyloxazoles and their pharmaceutically acceptable acid salts
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
FR2480747A1 (fr) * 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
IE51409B1 (en) * 1980-07-24 1986-12-24 Ici Ltd Amide derivatives
EP0048159A3 (en) * 1980-09-17 1982-05-12 University Of Miami Novel carboxyalkyl peptides and thioethers and ethers of peptides as antihypertensive agents
ATE20469T1 (de) * 1980-10-23 1986-07-15 Schering Corp Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel.
US4462943A (en) * 1980-11-24 1984-07-31 E. R. Squibb & Sons, Inc. Carboxyalkyl amino acid derivatives of various substituted prolines
CY1406A (en) * 1980-12-18 1988-04-22 Schering Corp Substituted dipeptides, processes for their preparation and pharmaceutical compositions containing them and their use in the inhibition of enkephalinase
US4514391A (en) * 1983-07-21 1985-04-30 E. R. Squibb & Sons, Inc. Hydroxy substituted peptide compounds

Also Published As

Publication number Publication date
NL8302562A (nl) 1984-02-16
FR2540867B1 (fr) 1987-07-31
ES524200A0 (es) 1985-04-16
GB2123834A (en) 1984-02-08
KR840005709A (ko) 1984-11-16
AU1643283A (en) 1984-01-26
BE897327A (fr) 1984-01-19
ES8707550A1 (es) 1986-04-01
SE8304031D0 (sv) 1983-07-18
JPH0532601A (ja) 1993-02-09
CA1244006A (en) 1988-11-01
ES8504675A1 (es) 1985-04-16
FI832620A0 (fi) 1983-07-19
PT77045B (en) 1986-02-12
FR2540867A1 (fr) 1984-08-17
FR2530238B1 (it) 1989-06-30
JPH0645582B2 (ja) 1994-06-15
IE55818B1 (en) 1991-01-30
HUT34040A (en) 1985-01-28
DK330683D0 (da) 1983-07-18
GB2123834B (en) 1986-10-22
JPH0517420A (ja) 1993-01-26
IE831655L (en) 1984-01-19
ES539082A0 (es) 1986-05-16
JPH0653713B2 (ja) 1994-07-20
ES539084A0 (es) 1986-04-01
SE8304031L (sv) 1984-03-30
DK330683A (da) 1984-01-20
IT8322114A0 (it) 1983-07-18
FI832620A (fi) 1984-01-20
ZA834980B (en) 1984-03-28
PT77045A (en) 1983-08-01
ES8707548A1 (es) 1986-05-16
GR79602B (it) 1984-10-31
IL69136A0 (en) 1983-10-31
FR2540866A1 (fr) 1984-08-17
JPS5951246A (ja) 1984-03-24
JPH0526775B2 (it) 1993-04-19
GB8318492D0 (en) 1983-08-10
DE3325850A1 (de) 1984-01-19
ES539083A0 (es) 1986-04-01
FR2530238A1 (it) 1984-01-20
HU187090B (en) 1985-11-28
ES8707549A1 (es) 1986-04-01
IT1163800B (it) 1987-04-08

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PL Patent ceased