HU185416B - Process for preparing insuline - Google Patents

Process for preparing insuline Download PDF

Info

Publication number
HU185416B
HU185416B HU81771A HU77181A HU185416B HU 185416 B HU185416 B HU 185416B HU 81771 A HU81771 A HU 81771A HU 77181 A HU77181 A HU 77181A HU 185416 B HU185416 B HU 185416B
Authority
HU
Hungary
Prior art keywords
chain
insulin
sulfonate
solution
derivative
Prior art date
Application number
HU81771A
Other languages
German (de)
English (en)
Hungarian (hu)
Inventor
Ronald E Chance
James A Hoffmann
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HU185416B publication Critical patent/HU185416B/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HU81771A 1980-03-27 1981-03-26 Process for preparing insuline HU185416B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13439080A 1980-03-27 1980-03-27

Publications (1)

Publication Number Publication Date
HU185416B true HU185416B (en) 1985-02-28

Family

ID=22463156

Family Applications (1)

Application Number Title Priority Date Filing Date
HU81771A HU185416B (en) 1980-03-27 1981-03-26 Process for preparing insuline

Country Status (28)

Country Link
EP (1) EP0037256B1 (en, 2012)
JP (1) JPS56154443A (en, 2012)
KR (1) KR840000947B1 (en, 2012)
AR (1) AR227305A1 (en, 2012)
AT (1) ATE4638T1 (en, 2012)
AU (1) AU540645B2 (en, 2012)
CA (1) CA1155109A (en, 2012)
CS (1) CS236463B2 (en, 2012)
DD (1) DD157613A5 (en, 2012)
DE (1) DE3160862D1 (en, 2012)
DK (1) DK149756C (en, 2012)
EG (1) EG15248A (en, 2012)
ES (1) ES500750A0 (en, 2012)
FI (1) FI810918L (en, 2012)
GB (1) GB2072680B (en, 2012)
GR (1) GR73619B (en, 2012)
HU (1) HU185416B (en, 2012)
IE (1) IE51608B1 (en, 2012)
IL (1) IL62483A (en, 2012)
NO (1) NO151897C (en, 2012)
NZ (1) NZ196610A (en, 2012)
PH (1) PH16153A (en, 2012)
PL (1) PL128599B1 (en, 2012)
PT (1) PT72733B (en, 2012)
RO (1) RO81640B (en, 2012)
SU (1) SU1327790A3 (en, 2012)
YU (1) YU76981A (en, 2012)
ZA (1) ZA811970B (en, 2012)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451396A (en) * 1983-08-01 1984-05-29 Eli Lilly And Company Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法

Also Published As

Publication number Publication date
GR73619B (en, 2012) 1984-03-26
NO151897C (no) 1985-06-26
GB2072680B (en) 1983-09-21
PT72733A (en) 1981-04-01
RO81640B (ro) 1983-04-30
ZA811970B (en) 1982-11-24
NZ196610A (en) 1984-03-16
KR830004855A (ko) 1983-07-20
NO811038L (no) 1981-09-28
AU6884481A (en) 1981-10-01
DE3160862D1 (en) 1983-10-20
IE51608B1 (en) 1987-01-21
CA1155109A (en) 1983-10-11
KR840000947B1 (ko) 1984-07-01
FI810918A7 (fi) 1981-09-28
DD157613A5 (de) 1982-11-24
IL62483A0 (en) 1981-05-20
JPS6318960B2 (en, 2012) 1988-04-20
DK136581A (da) 1981-09-28
PH16153A (en) 1983-07-12
EP0037256B1 (en) 1983-09-14
PL128599B1 (en) 1984-02-29
ES8207551A1 (es) 1982-09-16
AR227305A1 (es) 1982-10-15
EP0037256A1 (en) 1981-10-07
CS236463B2 (en) 1985-05-15
IL62483A (en) 1984-05-31
SU1327790A3 (ru) 1987-07-30
ATE4638T1 (de) 1983-09-15
GB2072680A (en) 1981-10-07
JPS56154443A (en) 1981-11-30
DK149756C (da) 1987-06-15
RO81640A (ro) 1983-04-29
FI810918L (fi) 1981-09-28
NO151897B (no) 1985-03-18
YU76981A (en) 1983-09-30
EG15248A (en) 1985-12-31
AU540645B2 (en) 1984-11-29
ES500750A0 (es) 1982-09-16
IE810680L (en) 1981-09-27
PL230295A1 (en, 2012) 1981-11-13
DK149756B (da) 1986-09-22
PT72733B (en) 1982-03-22

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Legal Events

Date Code Title Description
HU90 Patent valid on 900628
HMM4 Cancellation of final prot. due to non-payment of fee