PL128599B1 - Insulin obtaining method - Google Patents

Insulin obtaining method Download PDF

Info

Publication number
PL128599B1
PL128599B1 PL1981230295A PL23029581A PL128599B1 PL 128599 B1 PL128599 B1 PL 128599B1 PL 1981230295 A PL1981230295 A PL 1981230295A PL 23029581 A PL23029581 A PL 23029581A PL 128599 B1 PL128599 B1 PL 128599B1
Authority
PL
Poland
Prior art keywords
insulin
chain
solution
yield
sulfonate
Prior art date
Application number
PL1981230295A
Other languages
English (en)
Polish (pl)
Other versions
PL230295A1 (en, 2012
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PL230295A1 publication Critical patent/PL230295A1/xx
Publication of PL128599B1 publication Critical patent/PL128599B1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/067General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for sulfur-containing functions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL1981230295A 1980-03-27 1981-03-24 Insulin obtaining method PL128599B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13439080A 1980-03-27 1980-03-27

Publications (2)

Publication Number Publication Date
PL230295A1 PL230295A1 (en, 2012) 1981-11-13
PL128599B1 true PL128599B1 (en) 1984-02-29

Family

ID=22463156

Family Applications (1)

Application Number Title Priority Date Filing Date
PL1981230295A PL128599B1 (en) 1980-03-27 1981-03-24 Insulin obtaining method

Country Status (28)

Country Link
EP (1) EP0037256B1 (en, 2012)
JP (1) JPS56154443A (en, 2012)
KR (1) KR840000947B1 (en, 2012)
AR (1) AR227305A1 (en, 2012)
AT (1) ATE4638T1 (en, 2012)
AU (1) AU540645B2 (en, 2012)
CA (1) CA1155109A (en, 2012)
CS (1) CS236463B2 (en, 2012)
DD (1) DD157613A5 (en, 2012)
DE (1) DE3160862D1 (en, 2012)
DK (1) DK149756C (en, 2012)
EG (1) EG15248A (en, 2012)
ES (1) ES500750A0 (en, 2012)
FI (1) FI810918L (en, 2012)
GB (1) GB2072680B (en, 2012)
GR (1) GR73619B (en, 2012)
HU (1) HU185416B (en, 2012)
IE (1) IE51608B1 (en, 2012)
IL (1) IL62483A (en, 2012)
NO (1) NO151897C (en, 2012)
NZ (1) NZ196610A (en, 2012)
PH (1) PH16153A (en, 2012)
PL (1) PL128599B1 (en, 2012)
PT (1) PT72733B (en, 2012)
RO (1) RO81640B (en, 2012)
SU (1) SU1327790A3 (en, 2012)
YU (1) YU76981A (en, 2012)
ZA (1) ZA811970B (en, 2012)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4451396A (en) * 1983-08-01 1984-05-29 Eli Lilly And Company Process for inhibiting undesired thiol reactions during cyanogen bromide cleavage of peptides
DE3501641A1 (de) * 1985-01-19 1986-07-24 Hoechst Ag, 6230 Frankfurt Verfahren zur gewinnung von insulin-vorlaeufern aus reaktionsgemischen, die bei der faltung von insulin-vorlaeufern aus den entsprechenden s-sulfonaten anfallen
US4835251A (en) * 1986-06-23 1989-05-30 Genetech, Inc. Method of chain combination
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
JP3406244B2 (ja) 1999-04-30 2003-05-12 伊藤ハム株式会社 新規な融合蛋白質からの組み換えインスリンの製造方法

Also Published As

Publication number Publication date
GR73619B (en, 2012) 1984-03-26
NO151897C (no) 1985-06-26
GB2072680B (en) 1983-09-21
PT72733A (en) 1981-04-01
RO81640B (ro) 1983-04-30
ZA811970B (en) 1982-11-24
NZ196610A (en) 1984-03-16
KR830004855A (ko) 1983-07-20
NO811038L (no) 1981-09-28
AU6884481A (en) 1981-10-01
DE3160862D1 (en) 1983-10-20
IE51608B1 (en) 1987-01-21
CA1155109A (en) 1983-10-11
KR840000947B1 (ko) 1984-07-01
FI810918A7 (fi) 1981-09-28
DD157613A5 (de) 1982-11-24
IL62483A0 (en) 1981-05-20
JPS6318960B2 (en, 2012) 1988-04-20
DK136581A (da) 1981-09-28
PH16153A (en) 1983-07-12
EP0037256B1 (en) 1983-09-14
ES8207551A1 (es) 1982-09-16
AR227305A1 (es) 1982-10-15
EP0037256A1 (en) 1981-10-07
CS236463B2 (en) 1985-05-15
IL62483A (en) 1984-05-31
SU1327790A3 (ru) 1987-07-30
ATE4638T1 (de) 1983-09-15
GB2072680A (en) 1981-10-07
JPS56154443A (en) 1981-11-30
DK149756C (da) 1987-06-15
RO81640A (ro) 1983-04-29
FI810918L (fi) 1981-09-28
NO151897B (no) 1985-03-18
YU76981A (en) 1983-09-30
EG15248A (en) 1985-12-31
AU540645B2 (en) 1984-11-29
ES500750A0 (es) 1982-09-16
IE810680L (en) 1981-09-27
PL230295A1 (en, 2012) 1981-11-13
DK149756B (da) 1986-09-22
PT72733B (en) 1982-03-22
HU185416B (en) 1985-02-28

Similar Documents

Publication Publication Date Title
US4421685A (en) Process for producing an insulin
Akaji et al. Total synthesis of human insulin by regioselective disulfide formation using the silyl chloride-sulfoxide method
Lindahl et al. Interaction of the cysteine proteinase inhibitor chicken cystatin with papain
EP0497368B1 (en) CNP analog peptides and their use
EP0251615B1 (en) Method of chain combination
US6414114B2 (en) Disulfides and thiol compounds
IE841890L (en) Treatment of diabetes mellitus
Klostermeyer et al. The chemistry and biochemistry of insulin
Chang et al. Chemical modification of the tryptophan residue in cobratoxin
Sieber et al. Synthesis and biological activity of two disulphide bond isomers of human insulin:[A7-A11, A6-B7-cystine]-and [A6-A7, A11-B7-cystine] insulin (human)
PL128599B1 (en) Insulin obtaining method
Jones et al. Peptide map analysis of recombinant human granulocyte colony stimulating factor: elimination of methionine modification and nonspecific cleavages
Seidah et al. Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity
EP0037255B1 (en) Process for producing an insulin precursor
RODEWALD et al. Homeothermic fish and hemoglobin: primary structure of the hemoglobin from bluefin tuna (Thunnus thynnus, Scromboidei)
Fairwell et al. Total solid-phase synthesis, purification and characterization of human parathyroid hormone-(1-84)
Chino et al. Generation of two isomers with the same disulfide connectivity during disulfide bond formation of human uroguanylin
Glass et al. Bidirectional solid-phase peptide synthesis. Extension of the dinitrophenylene-bridging method to cysteine-containing peptides
McClelland et al. The refolding of hen egg white riboflavin-binding protein: effect of protein disulphide isomerase on the reoxidation of the reduced protein
Stroh et al. Tissue‐specific and species‐specific distribution of–SH groups in cytochrome c oxidase subunits
Ruoppolo et al. Protein-SS-glutathione mixed disulfides as models of unfolded proteins
KONDO et al. Importance of methionine residues in the enzymatic carboxylation of biotin‐containing peptides representing the local biotinyl site of E. coli acetyl‐CoA carboxylase
ES2527693T3 (es) Procedimiento para la obtención de insulinas mediante una mejor aireación del plegado
Erickson et al. Stability of Side‐Chain Protecting Groups in Solid‐Phase Peptide Synthesis
Joshi et al. Structural features involved in the biological activity of insulin and the insulin-like growth factors: A27insulinBIGF-I