HU178015B - Process for preparing new 5-methyl-isoxazola-4-carboxylic acid-/4-trifluoromethyl/-anilide - Google Patents

Process for preparing new 5-methyl-isoxazola-4-carboxylic acid-/4-trifluoromethyl/-anilide Download PDF

Info

Publication number
HU178015B
HU178015B HU79HO2201A HUHO002201A HU178015B HU 178015 B HU178015 B HU 178015B HU 79HO2201 A HU79HO2201 A HU 79HO2201A HU HO002201 A HUHO002201 A HU HO002201A HU 178015 B HU178015 B HU 178015B
Authority
HU
Hungary
Prior art keywords
formula
trifluoromethyl
anilide
compound
carboxylic acid
Prior art date
Application number
HU79HO2201A
Other languages
English (en)
Hungarian (hu)
Inventor
Friedrich-Jochannes Kaemmerer
Rudolf Schleyerbach
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of HU178015B publication Critical patent/HU178015B/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Lubricants (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HU79HO2201A 1978-12-16 1979-12-14 Process for preparing new 5-methyl-isoxazola-4-carboxylic acid-/4-trifluoromethyl/-anilide HU178015B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19782854439 DE2854439A1 (de) 1978-12-16 1978-12-16 Ein isoxazolderivat, verfahren zu seiner herstellung, diese verbindung enthaltende mittel und verwendung

Publications (1)

Publication Number Publication Date
HU178015B true HU178015B (en) 1982-02-28

Family

ID=6057414

Family Applications (1)

Application Number Title Priority Date Filing Date
HU79HO2201A HU178015B (en) 1978-12-16 1979-12-14 Process for preparing new 5-methyl-isoxazola-4-carboxylic acid-/4-trifluoromethyl/-anilide

Country Status (25)

Country Link
US (2) US4284786A (en, 2012)
EP (1) EP0013376B1 (en, 2012)
JP (1) JPS5583767A (en, 2012)
AR (2) AR222680A1 (en, 2012)
AT (1) ATE1067T1 (en, 2012)
AU (1) AU529341B2 (en, 2012)
BG (1) BG60764B2 (en, 2012)
CA (1) CA1129867A (en, 2012)
DE (2) DE2854439A1 (en, 2012)
DK (1) DK149886C (en, 2012)
EG (1) EG13926A (en, 2012)
ES (2) ES486750A1 (en, 2012)
FI (1) FI64154C (en, 2012)
GR (1) GR72731B (en, 2012)
HU (1) HU178015B (en, 2012)
IE (1) IE49126B1 (en, 2012)
IL (1) IL58951A (en, 2012)
LU (1) LU90466I2 (en, 2012)
MX (2) MX6174E (en, 2012)
NL (1) NL990037I2 (en, 2012)
NO (1) NO148925C (en, 2012)
NZ (1) NZ192400A (en, 2012)
PH (1) PH16627A (en, 2012)
PT (1) PT70596A (en, 2012)
ZA (1) ZA796793B (en, 2012)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3247454A1 (de) * 1982-12-22 1984-06-28 Laboratorios Bago S.A., Buenos Aires Substituierte 3-phenyl-5-methyl-isoxazol-4-carboxy-anilide, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
FR2538806B1 (fr) * 1982-12-30 1986-02-21 Bago Sa Labor Composes phenyl-3 methyl isoxazole-5 carboxy-4 anilides substitues, actifs therapeutiquement contre l'inflammation et la douleur
DE3534440A1 (de) * 1985-09-27 1987-04-02 Hoechst Ag Arzneimittel gegen chronische graft-versus-host-krankheiten sowie gegen autoimmunerkrankungen, insbesondere systemischen lupus erythematodes
US5268382A (en) * 1985-09-27 1993-12-07 Hoechst Aktiengesellschaft Medicaments to combat autoimmune diseases, in particular systemic lupus erythematosus
US4935434A (en) * 1988-01-26 1990-06-19 Bristol-Myers Company Antiarthritic isoxazole-4-carboxamides
US5258397A (en) * 1988-11-30 1993-11-02 Novapharme 3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions
FR2662692B1 (fr) * 1990-05-30 1995-04-28 Novapharme Derives heterocycliques doues d'activite anticonvulsivante, procede de preparation et composition pharmaceutique.
US5583150A (en) * 1989-08-18 1996-12-10 Alcon Laboratories, Inc. 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic anilides for the treatment of ocular diseases
DD297328A5 (de) 1989-08-18 1992-01-09 �������@���������k���Kk�� 5-methyl-isoxalol-4-carbonsaeureanilide und 2 hydroxyethyliden-cyanoessigsaeureanilide zur behandlung von augenerkrankungen
US5001124A (en) * 1990-02-02 1991-03-19 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
US5108999A (en) * 1990-02-02 1992-04-28 Syntex (U.S.A.) Inc. 4-isoxazolecarboxamide derivatives
DE59010701D1 (de) * 1990-05-18 1997-05-22 Hoechst Ag Isoxazol-4-carbonsäureamide und hydroxyalkyliden-cyanessigsäureamide, diese verbindungen enthaltende arzneimittel und deren verwendung
DE4127737A1 (de) 1991-08-22 1993-02-25 Hoechst Ag Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
US6133301A (en) * 1991-08-22 2000-10-17 Aventis Pharma Deutschland Gmbh Pharmaceuticals for the treatment of rejection reactions in organ transplantations
ES2124800T3 (es) * 1993-01-08 1999-02-16 Hoechst Ag Empleo de leflunomida para la inhibicion de interleuquina 1 beta.
DK0607774T3 (da) * 1993-01-08 1999-08-16 Hoechst Ag Anvendelse af leflunomid til inhibering af interleukin 1 alfa
ES2124801T3 (es) * 1993-01-08 1999-02-16 Hoechst Ag Empleo de leflunomida para la inhibicion del factor de necrosis de tumores alfa.
DE59407415D1 (de) * 1993-01-08 1999-01-21 Hoechst Ag Verwendung von Leflunomid zur Hemmung von Interleukin 8
TW314467B (en, 2012) * 1993-03-31 1997-09-01 Hoechst Ag
DE4323636A1 (de) * 1993-07-15 1995-01-19 Hoechst Ag Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung
LT3589B (en) 1993-11-30 1995-12-27 Hoechst Ag Using of known combination for treatment of rejection reaction by transplantation of organs
US6335356B1 (en) 1994-01-07 2002-01-01 Sugen, Inc. Method of treating a patient by parenteral administration of a lipophilic compound
US5610173A (en) * 1994-01-07 1997-03-11 Sugen, Inc. Formulations for lipophilic compounds
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5519042A (en) * 1994-01-13 1996-05-21 Hoechst Aktiengesellschaft Method of treating hyperproliferative vascular disease
US5624946A (en) * 1994-07-05 1997-04-29 Williams; James Use of leflunomide to control and reverse chronic allograft rejection
HU222888B1 (hu) * 1994-10-17 2003-12-29 Hoechst Pharmaceuticals & Chemicals K.K. Anilid vegyületek alkalmazása I típusú allergiás betegségek megelőzésére és kezelésére alkalmas gyógyszerkészítmények előállítására
US5721277A (en) * 1995-04-21 1998-02-24 Sugen, Inc. Compounds and methods for inhibiting hyper-proliferative cell growth
US6331555B1 (en) 1995-06-01 2001-12-18 University Of California Treatment of platelet derived growth factor related disorders such as cancers
DE19539638A1 (de) * 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
DE19702988A1 (de) * 1997-01-28 1998-07-30 Hoechst Ag Isoxazol- und Crotonsäureamidderivate und deren Verwendung als Arzneimittel und Diagnostika
US6316479B1 (en) 1997-05-19 2001-11-13 Sugen, Inc. Isoxazole-4-carboxamide compounds active against protein tryosine kinase related disorders
PT903345E (pt) * 1997-08-08 2001-01-31 Aventis Pharma Gmbh Forma cristalina de n-(4-trifluorometilfenil)-5-metil-isoxazolo-4-carboxamida
US7691890B2 (en) 1998-03-11 2010-04-06 James W. Williams Anti-viral uses of leflunomide products
US20050255071A1 (en) * 1998-12-10 2005-11-17 Aventis Pharma Deutschland Gmbh Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
DE19908527C2 (de) 1999-02-26 2001-08-30 Aventis Pharma Gmbh Verfahren zur Kristallisation von N-(4-Trifluormethylphenyl)-5-methyl-isoxazol-4-carboxamid
US6566395B1 (en) 1999-05-25 2003-05-20 Biomedicines, Inc. Methods of treating proliferative disorders
DE19960443C2 (de) * 1999-12-15 2002-05-08 Aventis Pharma Gmbh Verfahren zur Auffindung von Nukleotidsyntheseinhibitoren mit weniger Nebenwirkungen
AU779931B2 (en) * 1999-12-16 2005-02-17 Teva Pharmaceutical Industries Ltd. Novel processes for making- and a new crystalline form of- leflunomide
KR20020072312A (ko) * 2000-02-15 2002-09-14 테바 파마슈티컬 인더스트리즈 리미티드 레플루노미드를 합성하는 방법
EP1473035A1 (en) * 2000-02-15 2004-11-03 Teva Pharmaceutical Industries Ltd. Leflunomide of high purity
WO2002013822A1 (en) * 2000-08-14 2002-02-21 Teva Pharmaceutical Industries Ltd. Micronized leflunomide
GB0123571D0 (en) 2001-04-05 2001-11-21 Aventis Pharm Prod Inc Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
ATE396719T1 (de) 2001-04-05 2008-06-15 Aventis Pharma Inc Verwendung von (z)-2-cyano-3-hydroxy-but-2- ensäure-(4'-trifluoromethylphenyl)-amid zur behandlung der multiplen sklerose
WO2003042193A1 (en) * 2001-11-09 2003-05-22 Geneva Pharmaceuticals, Inc. Process for preparing 5-methylisoxazole-4-carboxylic-(4'-trifluoromethyl)-anilide
US20050158371A1 (en) * 2002-02-12 2005-07-21 Sumitomo Pharmaceuticals Co., Ltd. Novel external agent
WO2006115509A2 (en) 2004-06-24 2006-11-02 Novartis Vaccines And Diagnostics Inc. Small molecule immunopotentiators and assays for their detection
US20060024376A1 (en) * 2004-07-30 2006-02-02 The University Of Chicago Methods and compositions for reducing toxicity associated with leflunomide treatment
EP1920772A4 (en) * 2005-08-31 2010-11-17 Kowa Co PROPHYLACTIC AND / OR THERAPEUTIC METHOD FOR COMBATING RHEUMATOID ARTHRITIS
EP2125895B1 (en) 2007-02-02 2015-04-08 Vegenics Pty Ltd Vegf receptor antagonists for treating organ transplant alloimmunity and arteriosclerosis
CN101817797B (zh) * 2009-02-26 2013-04-10 江苏亚邦爱普森药业有限公司 高纯度3-甲基-n-[4-(三氟甲基)苯基]-4-异噁唑甲酰胺的合成方法
US9138309B2 (en) 2010-02-05 2015-09-22 Allergan, Inc. Porous materials, methods of making and uses
US9205577B2 (en) * 2010-02-05 2015-12-08 Allergan, Inc. Porogen compositions, methods of making and uses
US11202853B2 (en) * 2010-05-11 2021-12-21 Allergan, Inc. Porogen compositions, methods of making and uses
JOP20190207A1 (ar) 2017-03-14 2019-09-10 Actelion Pharmaceuticals Ltd تركيبة صيدلانية تشتمل على بونيسيمود
US10889548B2 (en) 2018-03-26 2021-01-12 Clear Creek Bio, Inc. Compositions and methods for inhibiting dihydroorotate dehydrogenase
CA3170688A1 (en) 2020-03-06 2021-09-10 Actelion Pharmaceuticals Ltd Methods of slowing brain volume loss
US20210308117A1 (en) 2020-03-20 2021-10-07 Clear Creek Bio, Inc. Methods of treating viral infections using inhibitors of nucleotide synthesis pathways
CA3221343A1 (en) 2021-10-11 2023-04-20 Allitia DIBERNARDO Methods of treating multiple sclerosis
WO2023061935A1 (en) 2021-10-11 2023-04-20 Actelion Pharmaceuticals Ltd Methods of treating multiple sclerosis
US20240261268A1 (en) 2022-02-11 2024-08-08 Vanda Pharmaceuticals Inc. Methods of slowing an increase in brain ventricular volume

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087534A (en) * 1974-05-22 1978-05-02 David Ovadia N-haloalkylmio urazole pesticides
ES448386A1 (es) * 1975-06-05 1978-04-16 Hoechst Ag Procedimiento para la preparacion de anilidas de acido 5-me-til-isoxazol-4-carboxilico.
DE2524959C2 (de) * 1975-06-05 1983-02-10 Hoechst Ag, 6000 Frankfurt 5-Methyl-isoxazol-4-carbonsäureanilide, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Mittel
DE2654797A1 (de) * 1976-12-03 1978-06-08 Hoechst Ag Verfahren zur herstellung von isoxazolderivaten

Also Published As

Publication number Publication date
EP0013376A3 (en) 1980-09-17
AR222680A1 (es) 1981-06-15
DE2854439A1 (de) 1980-07-03
NO794094L (no) 1980-06-17
GR72731B (en, 2012) 1983-12-01
FI793899A7 (fi) 1980-06-17
US4284786A (en) 1981-08-18
DK149886C (da) 1987-04-21
PH16627A (en) 1983-12-05
ATE1067T1 (de) 1982-06-15
IL58951A (en) 1984-01-31
NL990037I1 (nl) 2000-01-03
NO148925C (no) 1984-01-11
FI64154C (fi) 1983-10-10
JPH0133470B2 (en, 2012) 1989-07-13
IL58951A0 (en) 1980-03-31
IE792426L (en) 1980-06-16
CA1129867A (en) 1982-08-17
ZA796793B (en) 1980-11-26
EG13926A (en) 1982-09-30
DK534279A (da) 1980-06-17
US4351841A (en) 1982-09-28
FI64154B (fi) 1983-06-30
AU529341B2 (en) 1983-06-02
EP0013376B1 (de) 1982-05-19
NO148925B (no) 1983-10-03
ES486750A1 (es) 1980-06-16
PT70596A (de) 1980-01-01
LU90466I2 (fr) 2000-01-03
BG60764B2 (bg) 1996-02-29
IE49126B1 (en) 1985-08-07
NZ192400A (en) 1982-02-23
ES486758A1 (es) 1980-05-16
DE2962929D1 (en) 1982-07-08
AU5385379A (en) 1980-06-19
JPS5583767A (en) 1980-06-24
NL990037I2 (nl) 2000-01-03
MX8403A (es) 1994-03-31
MX6174E (es) 1984-12-04
AR226894A1 (es) 1982-08-31
EP0013376A2 (de) 1980-07-23
DK149886B (da) 1986-10-20

Similar Documents

Publication Publication Date Title
HU178015B (en) Process for preparing new 5-methyl-isoxazola-4-carboxylic acid-/4-trifluoromethyl/-anilide
Daidone et al. Synthesis and Pharmacological Activities of Novel 3‐(Isoxazol‐3‐yl)‐quinazolin‐4 (3H)‐one Derivatives
EP0091468B1 (en) (1-(2-benzoxazolyl)hydrazino)alkyl nitrile derivatives
US4032644A (en) Isoxazolyl benzoic acids
EP0273369B1 (en) New alkanesulfonanilide derivatives, processes for preparation thereof and pharmaceutical composition comprising the same
SU1080745A3 (ru) Способ получени производных тетразола
CS267551B1 (en) Pharmaceutical agents for asthma treatment and method of effective substance production
CA2133140C (en) Isoxazole derivatives
JPH03215456A (ja) アシルフェノール誘導体
US4636513A (en) Isoxazole derivatives and medicaments containing these compounds
US4766138A (en) Use of 4-(isoxazolyl)-thiazole-2-oxamic acid derivatives
EP0080010B1 (en) Novel compounds with antiinflammatory and analgesic activity, process for the preparation thereof and pharmaceutical compositions therefrom
JPH033658B2 (en, 2012)
DE3012124C2 (de) 1,1,3,5-substituierte Biuretverbindungen, Verfahren zur Herstellung dieser Verbindungen und sie enthaltende analgetische, antipyretische und/oder entzündungshemmende Mittel
KR920000374B1 (ko) 소염작용 및 점액 용해작용을 갖는 n-아세틸 시스테인 및 s-카르복시메틸시스테인의 2',4'-디플루오로-4-히드록시-(1,1'-디페닐)-3-카르복실산 유도체의 제조방법
EP0012435A2 (de) Isoxazolderivate, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und bei dem Verfahren benötigte Zwischenprodukte
CS216206B2 (en) Method of making the derivatives of the diphenylpyrazole
US3676463A (en) Oxobenzofuran carboxamides
US4128550A (en) 1-Methyl-4-piperidyl 5-phenyl-2-furoates
JPS6223751B2 (en, 2012)
KR820002229B1 (ko) 이속사졸 유도체의 제조방법
JPS5833870B2 (ja) チアゾリン誘導体
EP0440324A2 (en) Substituted beta-diketones and their use
JPS6352621B2 (en, 2012)
US4435591A (en) Compound with analgesic, antiinflammatory and antipyretic activity, and pharmaceutical compositions therefrom

Legal Events

Date Code Title Description
HU90 Patent valid on 900628