HRP990246A2 - Succinoylamino benzodiazepines as inhibitors of a beta protein production - Google Patents

Info

Publication number

HRP990246A2

HRP990246A2 HR990246A HRP990246A HRP990246A2 HR P990246 A2 HRP990246 A2 HR P990246A2 HR 990246 A HR990246 A HR 990246A HR P990246 A HRP990246 A HR P990246A HR P990246 A2 HRP990246 A2 HR P990246A2

Authority

HR

Croatia

Prior art keywords

butanediamide

oxo

phenyl

benzyl

azepin

Prior art date

1998-08-07

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• 238000004519 manufacturing process Methods 0.000 title claims description 36
• 229940049706 benzodiazepine Drugs 0.000 title description 9
• 239000003112 inhibitor Substances 0.000 title description 5
• 230000006269 (delayed) early viral mRNA transcription Effects 0.000 title 1
• 150000001557 benzodiazepines Chemical class 0.000 title 1
• -1 phenoxy, benzyloxy Chemical group 0.000 claims description 252
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 244
• 229910052731 fluorine Inorganic materials 0.000 claims description 227
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 208
• 229910052801 chlorine Inorganic materials 0.000 claims description 207
• 150000001875 compounds Chemical class 0.000 claims description 187
• 125000000623 heterocyclic group Chemical group 0.000 claims description 171
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 163
• 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 145
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 138
• 229910052794 bromium Inorganic materials 0.000 claims description 136
• 229910052740 iodine Inorganic materials 0.000 claims description 135
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 123
• 125000000041 C6-C10 aryl group Chemical group 0.000 claims description 109
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 105
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 100
• 238000000034 method Methods 0.000 claims description 98
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 92
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 92
• 101100054666 Streptomyces halstedii sch3 gene Proteins 0.000 claims description 85
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 84
• 229910052739 hydrogen Inorganic materials 0.000 claims description 84
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 68
• 125000001188 haloalkyl group Chemical group 0.000 claims description 61
• 150000003951 lactams Chemical class 0.000 claims description 61
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 60
• 229910052799 carbon Inorganic materials 0.000 claims description 60
• JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 58
• 125000004438 haloalkoxy group Chemical group 0.000 claims description 56
• 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 54
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 54
• 229910052760 oxygen Inorganic materials 0.000 claims description 44
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims description 40
• 150000003839 salts Chemical class 0.000 claims description 35
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 33
• 229920006395 saturated elastomer Polymers 0.000 claims description 33
• 125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 32
• 239000002253 acid Substances 0.000 claims description 30
• 125000003118 aryl group Chemical group 0.000 claims description 29
• 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 29
• 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims description 28
• 125000004432 carbon atom Chemical group C* 0.000 claims description 28
• 239000000651 prodrug Substances 0.000 claims description 28
• 229940002612 prodrug Drugs 0.000 claims description 28
• 125000001424 substituent group Chemical group 0.000 claims description 28
• 208000024827 Alzheimer disease Diseases 0.000 claims description 26
• 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims description 25
• 125000000217 alkyl group Chemical group 0.000 claims description 21
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims description 20
• 230000000694 effects Effects 0.000 claims description 20
• 125000005842 heteroatom Chemical group 0.000 claims description 20
• 108010090849 Amyloid beta-Peptides Proteins 0.000 claims description 19
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 17
• 102000013455 Amyloid beta-Peptides Human genes 0.000 claims description 17
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 17
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 17
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 17
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 17
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 17
• 150000003254 radicals Chemical class 0.000 claims description 17
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
• 125000005605 benzo group Chemical group 0.000 claims description 16
• 238000012360 testing method Methods 0.000 claims description 16
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 14
• 125000004180 3-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(F)=C1[H] 0.000 claims description 14
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 12
• 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 12
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 12
• 125000004076 pyridyl group Chemical group 0.000 claims description 12
• 208000012902 Nervous system disease Diseases 0.000 claims description 11
• 125000001544 thienyl group Chemical group 0.000 claims description 11
• 125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 10
• 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims description 10
• 125000002541 furyl group Chemical group 0.000 claims description 10
• 208000025966 Neurological disease Diseases 0.000 claims description 9
• 125000000842 isoxazolyl group Chemical group 0.000 claims description 9
• 125000002971 oxazolyl group Chemical group 0.000 claims description 9
• 230000002401 inhibitory effect Effects 0.000 claims description 8
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 8
• 238000001114 immunoprecipitation Methods 0.000 claims description 7
• 239000003475 metalloproteinase inhibitor Substances 0.000 claims description 7
• NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical group C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 claims description 6
• 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 claims description 6
• 125000004106 butoxy group Chemical group [*]OC([H])([H])C([H])([H])C(C([H])([H])[H])([H])[H] 0.000 claims description 6
• 125000005448 ethoxyethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims description 6
• 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims description 6
• 125000002883 imidazolyl group Chemical group 0.000 claims description 6
• 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 claims description 6
• 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 6
• 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims description 6
• 125000003342 alkenyl group Chemical group 0.000 claims description 5
• 125000000304 alkynyl group Chemical group 0.000 claims description 5
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 5
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 5
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 5
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 5
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 4
• 125000004173 1-benzimidazolyl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N1* 0.000 claims description 4
• ZQDLBYQRPAVQKO-RCSZBHJWSA-N 3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(OC=2C=CC=CC=2)=C1 ZQDLBYQRPAVQKO-RCSZBHJWSA-N 0.000 claims description 4
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 4
• 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 claims description 4
• OSFBJERFMQCEQY-UHFFFAOYSA-N propylidene Chemical compound [CH]CC OSFBJERFMQCEQY-UHFFFAOYSA-N 0.000 claims description 4
• WKOVQMBIGQHIFN-RCSZBHJWSA-N 2-(2-methylpropyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]-3-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(C(CC(C)C)C(N)=O)CCC)CCCCN1CC1=CC=CC(OC=2C=CC=CC=2)=C1 WKOVQMBIGQHIFN-RCSZBHJWSA-N 0.000 claims description 3
• TYIKDNXILKREJN-FHZUCYEKSA-N 2-(2-methylpropyl)-n-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(N)=O)CC(C)C)CCCCN1CC1=CC=CC(OC=2C=CC=CC=2)=C1 TYIKDNXILKREJN-FHZUCYEKSA-N 0.000 claims description 3
• 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 claims description 3
• WOHDRVIYZQAFNT-NXCFDTQHSA-N (2s,3r)-3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-[[5-[4-(trifluoromethyl)phenyl]pyridin-3-yl]methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)[C@H](CC(C)C)[C@H](CCC)C(N)=O)CCCCN1CC1=CN=CC(C=2C=CC(=CC=2)C(F)(F)F)=C1 WOHDRVIYZQAFNT-NXCFDTQHSA-N 0.000 claims description 2
• NPPDLXRHPIHQTR-VJGNERBWSA-N (2s,3r)-n'-[(3s)-1-[[5-(4-methoxyphenyl)pyridin-3-yl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)[C@H](CC(C)C)[C@H](CCC)C(N)=O)CCCCN1CC1=CN=CC(C=2C=CC(OC)=CC=2)=C1 NPPDLXRHPIHQTR-VJGNERBWSA-N 0.000 claims description 2
• FOMISRCNJZNGTG-ONHAVXAHSA-N 2-(2-methylpropyl)-n-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]-n'-(3-phenylprop-2-enyl)-3-propylbutanediamide Chemical compound C([C@@H](C1=O)NC(=O)C(CC(C)C)C(CCC)C(=O)NCC=CC=2C=CC=CC=2)CCCN1CC(C=1)=CC=CC=1OC1=CC=CC=C1 FOMISRCNJZNGTG-ONHAVXAHSA-N 0.000 claims description 2
• GTUTWYAKNHAAJZ-PDZHLSQESA-N 2-butyl-3-(2-methylpropyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=C3C=CC=CC3=CC=2)=C1 GTUTWYAKNHAAJZ-PDZHLSQESA-N 0.000 claims description 2
• NXQOMXPDZQZOFF-VNXZQDSDSA-N 2-butyl-3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-(2-phenylethyl)azepan-3-yl]butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CCC1=CC=CC=C1 NXQOMXPDZQZOFF-VNXZQDSDSA-N 0.000 claims description 2
• AGHFNSOZVBICLL-LADMEODRSA-N 2-butyl-3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC(OC=2C=CC=CC=2)=C1 AGHFNSOZVBICLL-LADMEODRSA-N 0.000 claims description 2
• ZVPRXYMUVSCSGP-LADMEODRSA-N 2-butyl-3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=CC(=CC=2)C(F)(F)F)=C1 ZVPRXYMUVSCSGP-LADMEODRSA-N 0.000 claims description 2
• GAFDXRLHTNUGFQ-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 GAFDXRLHTNUGFQ-UHFFFAOYSA-N 0.000 claims description 2
• LKIOGYJIRMYYHA-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[2-oxo-1-[(3-phenoxyphenyl)methyl]-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 LKIOGYJIRMYYHA-UHFFFAOYSA-N 0.000 claims description 2
• JAPNXBGCOXIDQL-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[2-oxo-5-phenyl-1-(2-phenylethyl)-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CCC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 JAPNXBGCOXIDQL-UHFFFAOYSA-N 0.000 claims description 2
• DEIUHFYFANTAIQ-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 DEIUHFYFANTAIQ-UHFFFAOYSA-N 0.000 claims description 2
• MZGWJMRHOQOLTM-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[4-oxo-1-phenyl-5-(2-phenylethyl)-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CCC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 MZGWJMRHOQOLTM-UHFFFAOYSA-N 0.000 claims description 2
• JNNKGXBKTSFZEA-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 JNNKGXBKTSFZEA-UHFFFAOYSA-N 0.000 claims description 2
• PLKCURMAARKLCU-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 PLKCURMAARKLCU-UHFFFAOYSA-N 0.000 claims description 2
• AWQUUUHVQUXWSG-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 AWQUUUHVQUXWSG-UHFFFAOYSA-N 0.000 claims description 2
• SYISGWHRMKOJAQ-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1=CC=CC(C=2C=C3C=CC=CC3=CC=2)=C1 SYISGWHRMKOJAQ-UHFFFAOYSA-N 0.000 claims description 2
• DNRIBMVNRFZYTQ-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[6-oxo-5-(2-phenylethyl)-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1=CC=CC=C1 DNRIBMVNRFZYTQ-UHFFFAOYSA-N 0.000 claims description 2
• UCVQESXCBQCSIS-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[6-oxo-5-[(3-phenoxyphenyl)methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1OC1=CC=CC=C1 UCVQESXCBQCSIS-UHFFFAOYSA-N 0.000 claims description 2
• IMMUOILNTLRIHE-UHFFFAOYSA-N 2-butyl-3-(2-methylpropyl)-n'-[6-oxo-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=C(C(F)(F)F)C=C1 IMMUOILNTLRIHE-UHFFFAOYSA-N 0.000 claims description 2
• PDIKDHFTCYMOCI-PJUZOBRJSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCC1 PDIKDHFTCYMOCI-PJUZOBRJSA-N 0.000 claims description 2
• LFWMVEZBALBRKP-DMVZSUBZSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCC1 LFWMVEZBALBRKP-DMVZSUBZSA-N 0.000 claims description 2
• UMJQLNXLASXOJC-DSNFFHCTSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCC1 UMJQLNXLASXOJC-DSNFFHCTSA-N 0.000 claims description 2
• CTZUJIHOOBTPOY-PPUMFKDSSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCC1 CTZUJIHOOBTPOY-PPUMFKDSSA-N 0.000 claims description 2
• RVFYQMQXSSEKRK-PPUMFKDSSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCC1 RVFYQMQXSSEKRK-PPUMFKDSSA-N 0.000 claims description 2
• XSGSWVJRIOXTQX-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 XSGSWVJRIOXTQX-UHFFFAOYSA-N 0.000 claims description 2
• KQJGKUWRAANYEX-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 KQJGKUWRAANYEX-UHFFFAOYSA-N 0.000 claims description 2
• SRWWBWZMYFZCNS-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 SRWWBWZMYFZCNS-UHFFFAOYSA-N 0.000 claims description 2
• HSXPOZNAXRXMTL-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 HSXPOZNAXRXMTL-UHFFFAOYSA-N 0.000 claims description 2
• KUEBFZCVWBWYLM-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[2-oxo-1-[(3-phenoxyphenyl)methyl]-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 KUEBFZCVWBWYLM-UHFFFAOYSA-N 0.000 claims description 2
• FDGGTRCOUMMBQY-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 FDGGTRCOUMMBQY-UHFFFAOYSA-N 0.000 claims description 2
• XJYBUWUMFFWRLT-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 XJYBUWUMFFWRLT-UHFFFAOYSA-N 0.000 claims description 2
• QBAJESMOJCSZLA-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 QBAJESMOJCSZLA-UHFFFAOYSA-N 0.000 claims description 2
• YLIGJCYYTYZASR-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 YLIGJCYYTYZASR-UHFFFAOYSA-N 0.000 claims description 2
• OVUNVQGZMNUEJS-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 OVUNVQGZMNUEJS-UHFFFAOYSA-N 0.000 claims description 2
• RPSTVQMENBDQAX-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 RPSTVQMENBDQAX-UHFFFAOYSA-N 0.000 claims description 2
• AFRKEQPPZNCNPY-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 AFRKEQPPZNCNPY-UHFFFAOYSA-N 0.000 claims description 2
• GPQGOODWGVYUOL-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 GPQGOODWGVYUOL-UHFFFAOYSA-N 0.000 claims description 2
• NCQAAQCIDIFRIE-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 NCQAAQCIDIFRIE-UHFFFAOYSA-N 0.000 claims description 2
• VTDLXCMHVIQFKJ-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 VTDLXCMHVIQFKJ-UHFFFAOYSA-N 0.000 claims description 2
• AMQLYPJSELWZCJ-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 AMQLYPJSELWZCJ-UHFFFAOYSA-N 0.000 claims description 2
• FALALMCOKUBWNM-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[6-oxo-5-[(3-phenoxyphenyl)methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 FALALMCOKUBWNM-UHFFFAOYSA-N 0.000 claims description 2
• RLGIZKMATOEFCF-UHFFFAOYSA-N 2-butyl-3-(cyclobutylmethyl)-n'-[6-oxo-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 RLGIZKMATOEFCF-UHFFFAOYSA-N 0.000 claims description 2
• UZSCJBPGHFTFHT-PZIMRNDGSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCCC1 UZSCJBPGHFTFHT-PZIMRNDGSA-N 0.000 claims description 2
• YTYXFVVNBZWIDZ-UEYYRQBOSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCCC1 YTYXFVVNBZWIDZ-UEYYRQBOSA-N 0.000 claims description 2
• CEEHXVTWVANKAA-VCBVRPFLSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[(3s)-1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCCC1 CEEHXVTWVANKAA-VCBVRPFLSA-N 0.000 claims description 2
• KBGBQRRBJVXLCB-VCBVRPFLSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCCC1 KBGBQRRBJVXLCB-VCBVRPFLSA-N 0.000 claims description 2
• HHRLXVJGLORWHX-DSNFFHCTSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCCC1 HHRLXVJGLORWHX-DSNFFHCTSA-N 0.000 claims description 2
• YRNFCALLWMZHCT-DSNFFHCTSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCCC1 YRNFCALLWMZHCT-DSNFFHCTSA-N 0.000 claims description 2
• ZVVWSBPHQVLQTA-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 ZVVWSBPHQVLQTA-UHFFFAOYSA-N 0.000 claims description 2
• GCAZKDSPQRIJFJ-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 GCAZKDSPQRIJFJ-UHFFFAOYSA-N 0.000 claims description 2
• BZSREFJMNUQVHX-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 BZSREFJMNUQVHX-UHFFFAOYSA-N 0.000 claims description 2
• CHOKMQARSYARNA-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[2-oxo-1-[(3-phenoxyphenyl)methyl]-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 CHOKMQARSYARNA-UHFFFAOYSA-N 0.000 claims description 2
• ZSMQWNBULGQYIT-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 ZSMQWNBULGQYIT-UHFFFAOYSA-N 0.000 claims description 2
• CEDJVLWEWHWSRQ-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 CEDJVLWEWHWSRQ-UHFFFAOYSA-N 0.000 claims description 2
• BRWFYQGSZIPKAR-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 BRWFYQGSZIPKAR-UHFFFAOYSA-N 0.000 claims description 2
• HJVUXHMPNNEUMW-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 HJVUXHMPNNEUMW-UHFFFAOYSA-N 0.000 claims description 2
• IPWWZPXKZPQNPK-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 IPWWZPXKZPQNPK-UHFFFAOYSA-N 0.000 claims description 2
• NESQSCGQZSELJH-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 NESQSCGQZSELJH-UHFFFAOYSA-N 0.000 claims description 2
• VVQMTHNFOPMZMD-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 VVQMTHNFOPMZMD-UHFFFAOYSA-N 0.000 claims description 2
• SOFHPAARSPCLKG-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 SOFHPAARSPCLKG-UHFFFAOYSA-N 0.000 claims description 2
• ZXAQQPFKYVVFHN-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 ZXAQQPFKYVVFHN-UHFFFAOYSA-N 0.000 claims description 2
• HXWLOIUNMJXGJP-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 HXWLOIUNMJXGJP-UHFFFAOYSA-N 0.000 claims description 2
• OJJPEQJSLKEBMY-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 OJJPEQJSLKEBMY-UHFFFAOYSA-N 0.000 claims description 2
• KNBIMTBWICOKLW-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[6-oxo-5-[(3-phenoxyphenyl)methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 KNBIMTBWICOKLW-UHFFFAOYSA-N 0.000 claims description 2
• OTFLUWASUZJHTK-UHFFFAOYSA-N 2-butyl-3-(cyclopentylmethyl)-n'-[6-oxo-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 OTFLUWASUZJHTK-UHFFFAOYSA-N 0.000 claims description 2
• BYJUXNMJEZXZJY-PDZHLSQESA-N 2-butyl-3-(cyclopropylmethyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CC1 BYJUXNMJEZXZJY-PDZHLSQESA-N 0.000 claims description 2
• SJDRDNZZFSRDAB-ZRZZZMTFSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CC1 SJDRDNZZFSRDAB-ZRZZZMTFSA-N 0.000 claims description 2
• WRPXLXXDWJSLQC-PPUMFKDSSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[(3s)-1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CC1 WRPXLXXDWJSLQC-PPUMFKDSSA-N 0.000 claims description 2
• VSRKFSLCLZGCIE-PPUMFKDSSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CC1 VSRKFSLCLZGCIE-PPUMFKDSSA-N 0.000 claims description 2
• WVOVICZOBDCHCW-LADMEODRSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CC1 WVOVICZOBDCHCW-LADMEODRSA-N 0.000 claims description 2
• PIQZLKFXLPKGBQ-LADMEODRSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CC1 PIQZLKFXLPKGBQ-LADMEODRSA-N 0.000 claims description 2
• VVRUDIKOFWLGKE-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 VVRUDIKOFWLGKE-UHFFFAOYSA-N 0.000 claims description 2
• SMNJBKFESMKMNK-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 SMNJBKFESMKMNK-UHFFFAOYSA-N 0.000 claims description 2
• BQJRFXDZZBFLET-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 BQJRFXDZZBFLET-UHFFFAOYSA-N 0.000 claims description 2
• TVTOHKVMQFFEAC-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 TVTOHKVMQFFEAC-UHFFFAOYSA-N 0.000 claims description 2
• XNHHRSUPNUMGMM-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[2-oxo-1-[(3-phenoxyphenyl)methyl]-5-phenyl-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 XNHHRSUPNUMGMM-UHFFFAOYSA-N 0.000 claims description 2
• QVLAKDLUSTXMNU-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 QVLAKDLUSTXMNU-UHFFFAOYSA-N 0.000 claims description 2
• DPMCSHZAOOUDDI-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 DPMCSHZAOOUDDI-UHFFFAOYSA-N 0.000 claims description 2
• CVKUQIQEYKULCY-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 CVKUQIQEYKULCY-UHFFFAOYSA-N 0.000 claims description 2
• BDOYFSRMMWBSOM-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 BDOYFSRMMWBSOM-UHFFFAOYSA-N 0.000 claims description 2
• PNCLOSAEGBYVMA-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 PNCLOSAEGBYVMA-UHFFFAOYSA-N 0.000 claims description 2
• ORXKKXAEOJXCIK-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 ORXKKXAEOJXCIK-UHFFFAOYSA-N 0.000 claims description 2
• LEQKYDIGMMGNBP-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 LEQKYDIGMMGNBP-UHFFFAOYSA-N 0.000 claims description 2
• OUVBYIAYRYLXEE-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 OUVBYIAYRYLXEE-UHFFFAOYSA-N 0.000 claims description 2
• HLVMBIISRJVGSJ-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 HLVMBIISRJVGSJ-UHFFFAOYSA-N 0.000 claims description 2
• KFYAFFBONWPJKR-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 KFYAFFBONWPJKR-UHFFFAOYSA-N 0.000 claims description 2
• PLAXRHXCWILAHI-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 PLAXRHXCWILAHI-UHFFFAOYSA-N 0.000 claims description 2
• WPOTVUOFRPZJJK-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[6-oxo-5-[(3-phenoxyphenyl)methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 WPOTVUOFRPZJJK-UHFFFAOYSA-N 0.000 claims description 2
• QADQEUKQUBVDQR-UHFFFAOYSA-N 2-butyl-3-(cyclopropylmethyl)-n'-[6-oxo-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-7h-benzo[d][1]benzazepin-7-yl]butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 QADQEUKQUBVDQR-UHFFFAOYSA-N 0.000 claims description 2
• UAMMIPBSZHJOLN-CBNMVNINSA-N 2-butyl-n'-[(3s)-1-(2-cyclobutylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CCC1CCC1 UAMMIPBSZHJOLN-CBNMVNINSA-N 0.000 claims description 2
• RWXWOSMZVFUDHX-VNXZQDSDSA-N 2-butyl-n'-[(3s)-1-(2-cyclohexylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CCC1CCCCC1 RWXWOSMZVFUDHX-VNXZQDSDSA-N 0.000 claims description 2
• IKCDZTSNNTVKPR-HRTMPFAESA-N 2-butyl-n'-[(3s)-1-(2-cyclopentylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CCC1CCCC1 IKCDZTSNNTVKPR-HRTMPFAESA-N 0.000 claims description 2
• CHVSIBROCBPLOR-MHJFOBGBSA-N 2-butyl-n'-[(3s)-1-(2-cyclopropylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CCC1CC1 CHVSIBROCBPLOR-MHJFOBGBSA-N 0.000 claims description 2
• VJRQKUNLXDCNRS-MHJFOBGBSA-N 2-butyl-n'-[(3s)-1-(cyclobutylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1CCC1 VJRQKUNLXDCNRS-MHJFOBGBSA-N 0.000 claims description 2
• YYTAMSBQWVJYIG-HRTMPFAESA-N 2-butyl-n'-[(3s)-1-(cyclohexylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1CCCCC1 YYTAMSBQWVJYIG-HRTMPFAESA-N 0.000 claims description 2
• IXBRRGYLKDBTCR-CBNMVNINSA-N 2-butyl-n'-[(3s)-1-(cyclopentylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1CCCC1 IXBRRGYLKDBTCR-CBNMVNINSA-N 0.000 claims description 2
• AKPJCLOMWPCDCI-ACBHZAAOSA-N 2-butyl-n'-[(3s)-1-(cyclopropylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1CC1 AKPJCLOMWPCDCI-ACBHZAAOSA-N 0.000 claims description 2
• QFGBLDDFCSBKNJ-HRTMPFAESA-N 2-butyl-n'-[(3s)-1-[(4-fluorophenyl)methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=C(F)C=C1 QFGBLDDFCSBKNJ-HRTMPFAESA-N 0.000 claims description 2
• LTFKQWMYFBXAEP-ZRZZZMTFSA-N 2-butyl-n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C(=CC(Cl)=CC=2)Cl)=C1 LTFKQWMYFBXAEP-ZRZZZMTFSA-N 0.000 claims description 2
• MDPMGHZTMRKZKI-KBMIILLGSA-N 2-butyl-n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=C(Cl)C(F)=CC=2)=C1 MDPMGHZTMRKZKI-KBMIILLGSA-N 0.000 claims description 2
• JZVHTIUDIDIXQD-XSLSENLXSA-N 2-butyl-n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(cyclobutylmethyl)butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCC1 JZVHTIUDIDIXQD-XSLSENLXSA-N 0.000 claims description 2
• SICWMAHRFMZUQJ-VSBJFVJKSA-N 2-butyl-n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(cyclopentylmethyl)butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CCCC1 SICWMAHRFMZUQJ-VSBJFVJKSA-N 0.000 claims description 2
• BEVDDRQMAJZFRW-KBMIILLGSA-N 2-butyl-n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(cyclopropylmethyl)butanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)CCCC1)=O)C(=O)C(C(CCCC)C(N)=O)CC1CC1 BEVDDRQMAJZFRW-KBMIILLGSA-N 0.000 claims description 2
• QMZGRRVWQIUEOX-PPUMFKDSSA-N 2-butyl-n'-[(3s)-1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=CC(OC)=CC=2)=C1 QMZGRRVWQIUEOX-PPUMFKDSSA-N 0.000 claims description 2
• QVYKPHMYGAYJMU-PPUMFKDSSA-N 2-butyl-n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=CC(C)=CC=2)=C1 QVYKPHMYGAYJMU-PPUMFKDSSA-N 0.000 claims description 2
• CVKYVZHNONJXKQ-UHFFFAOYSA-N 2-butyl-n'-[1-(2-cyclobutylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CCC2CCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 CVKYVZHNONJXKQ-UHFFFAOYSA-N 0.000 claims description 2
• WFLAYEILNLGCJV-UHFFFAOYSA-N 2-butyl-n'-[1-(2-cyclohexylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 WFLAYEILNLGCJV-UHFFFAOYSA-N 0.000 claims description 2
• VRDXYGKKXQRMSY-UHFFFAOYSA-N 2-butyl-n'-[1-(2-cyclopentylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 VRDXYGKKXQRMSY-UHFFFAOYSA-N 0.000 claims description 2
• CNNVSFSSTWEGOD-UHFFFAOYSA-N 2-butyl-n'-[1-(2-cyclopropylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CCC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 CNNVSFSSTWEGOD-UHFFFAOYSA-N 0.000 claims description 2
• LWPSAGBYTKRUNF-UHFFFAOYSA-N 2-butyl-n'-[1-(cyclobutylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 LWPSAGBYTKRUNF-UHFFFAOYSA-N 0.000 claims description 2
• DOICTBIALLNLPI-UHFFFAOYSA-N 2-butyl-n'-[1-(cyclohexylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 DOICTBIALLNLPI-UHFFFAOYSA-N 0.000 claims description 2
• YFBIKQMZBBWVAL-UHFFFAOYSA-N 2-butyl-n'-[1-(cyclopentylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 YFBIKQMZBBWVAL-UHFFFAOYSA-N 0.000 claims description 2
• OCNGSNZUWVWZCV-UHFFFAOYSA-N 2-butyl-n'-[1-(cyclopropylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 OCNGSNZUWVWZCV-UHFFFAOYSA-N 0.000 claims description 2
• SSCMGYJHJNEMFW-UHFFFAOYSA-N 2-butyl-n'-[1-[(4-fluorophenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC(F)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 SSCMGYJHJNEMFW-UHFFFAOYSA-N 0.000 claims description 2
• NGRXOXRMPDMVFT-UHFFFAOYSA-N 2-butyl-n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 NGRXOXRMPDMVFT-UHFFFAOYSA-N 0.000 claims description 2
• DRUSPBYGSPOJKK-UHFFFAOYSA-N 2-butyl-n'-[1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 DRUSPBYGSPOJKK-UHFFFAOYSA-N 0.000 claims description 2
• KASQRBJOTNOATD-UHFFFAOYSA-N 2-butyl-n'-[1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(cyclobutylmethyl)butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 KASQRBJOTNOATD-UHFFFAOYSA-N 0.000 claims description 2
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• IWCZMEJAICSEMQ-UHFFFAOYSA-N 2-butyl-n'-[1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(cyclopropylmethyl)butanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 IWCZMEJAICSEMQ-UHFFFAOYSA-N 0.000 claims description 2
• FZHPEODLFLJJPN-UHFFFAOYSA-N 2-butyl-n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 FZHPEODLFLJJPN-UHFFFAOYSA-N 0.000 claims description 2
• YFDCSIFIWMLVLW-UHFFFAOYSA-N 2-butyl-n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 YFDCSIFIWMLVLW-UHFFFAOYSA-N 0.000 claims description 2
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• AWTYUAWKVYDRMW-UHFFFAOYSA-N 2-butyl-n'-[5-(2-cyclobutylethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1CCC1 AWTYUAWKVYDRMW-UHFFFAOYSA-N 0.000 claims description 2
• HWVKQDJPZGEBPV-UHFFFAOYSA-N 2-butyl-n'-[5-(2-cyclohexylethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 HWVKQDJPZGEBPV-UHFFFAOYSA-N 0.000 claims description 2
• KEJKBAFGGPPXHO-UHFFFAOYSA-N 2-butyl-n'-[5-(2-cyclopentylethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 KEJKBAFGGPPXHO-UHFFFAOYSA-N 0.000 claims description 2
• ZIFIQVFEVZEQBX-UHFFFAOYSA-N 2-butyl-n'-[5-(2-cyclopentylethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1CCCC1 ZIFIQVFEVZEQBX-UHFFFAOYSA-N 0.000 claims description 2
• KKTCNCLRLBIORP-UHFFFAOYSA-N 2-butyl-n'-[5-(2-cyclopropylethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CCC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 KKTCNCLRLBIORP-UHFFFAOYSA-N 0.000 claims description 2
• HIBXYJAWFFSTGW-UHFFFAOYSA-N 2-butyl-n'-[5-(2-cyclopropylethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1CC1 HIBXYJAWFFSTGW-UHFFFAOYSA-N 0.000 claims description 2
• XQBYTUQLCQITSX-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclobutylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 XQBYTUQLCQITSX-UHFFFAOYSA-N 0.000 claims description 2
• UNWOUUFFFCFFPJ-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclobutylmethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1CCC1 UNWOUUFFFCFFPJ-UHFFFAOYSA-N 0.000 claims description 2
• HZXGYTQKLHQTOO-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclohexylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 HZXGYTQKLHQTOO-UHFFFAOYSA-N 0.000 claims description 2
• PGLGQFMZPGRKLR-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclohexylmethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1CCCCC1 PGLGQFMZPGRKLR-UHFFFAOYSA-N 0.000 claims description 2
• LEXYPQMLUNVKLL-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclopentylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 LEXYPQMLUNVKLL-UHFFFAOYSA-N 0.000 claims description 2
• MGVJYQKTMLLGBD-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclopentylmethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1CCCC1 MGVJYQKTMLLGBD-UHFFFAOYSA-N 0.000 claims description 2
• KJLACDUBIXIUJB-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclopropylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 KJLACDUBIXIUJB-UHFFFAOYSA-N 0.000 claims description 2
• LFMYDSGWUJDQHF-UHFFFAOYSA-N 2-butyl-n'-[5-(cyclopropylmethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1CC1 LFMYDSGWUJDQHF-UHFFFAOYSA-N 0.000 claims description 2
• BHXWLYKSWHEHGX-UHFFFAOYSA-N 2-butyl-n'-[5-[(4-fluorophenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC(F)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 BHXWLYKSWHEHGX-UHFFFAOYSA-N 0.000 claims description 2
• AMCZPPRIZIXPON-UHFFFAOYSA-N 2-butyl-n'-[5-[(4-fluorophenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1=CC=C(F)C=C1 AMCZPPRIZIXPON-UHFFFAOYSA-N 0.000 claims description 2
• AKVYVAXVDXEXSU-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 AKVYVAXVDXEXSU-UHFFFAOYSA-N 0.000 claims description 2
• WZVVHGXRUVQTMM-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=C(Cl)C=C1Cl WZVVHGXRUVQTMM-UHFFFAOYSA-N 0.000 claims description 2
• BKJXKRVGIBBVLU-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 BKJXKRVGIBBVLU-UHFFFAOYSA-N 0.000 claims description 2
• JDULNEVFZZHWLX-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(cyclobutylmethyl)butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 JDULNEVFZZHWLX-UHFFFAOYSA-N 0.000 claims description 2
• PBTKAZBHJIIZQH-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(cyclopentylmethyl)butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 PBTKAZBHJIIZQH-UHFFFAOYSA-N 0.000 claims description 2
• LPQIDNQAJYGXEN-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(cyclopropylmethyl)butanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 LPQIDNQAJYGXEN-UHFFFAOYSA-N 0.000 claims description 2
• MULWJKZDLHPVTN-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=C(F)C(Cl)=C1 MULWJKZDLHPVTN-UHFFFAOYSA-N 0.000 claims description 2
• YHYAGWXKVQCSGJ-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(cyclobutylmethyl)butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCC1 YHYAGWXKVQCSGJ-UHFFFAOYSA-N 0.000 claims description 2
• LXNIBYZGVSRIBO-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(cyclopentylmethyl)butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CCCC1 LXNIBYZGVSRIBO-UHFFFAOYSA-N 0.000 claims description 2
• ZMGISKAEUBUOIK-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(cyclopropylmethyl)butanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCCC)C(N)=O)CC1CC1 ZMGISKAEUBUOIK-UHFFFAOYSA-N 0.000 claims description 2
• KIHMYZWHHDHNSO-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 KIHMYZWHHDHNSO-UHFFFAOYSA-N 0.000 claims description 2
• JXUZRSDUPZKFJI-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=C(OC)C=C1 JXUZRSDUPZKFJI-UHFFFAOYSA-N 0.000 claims description 2
• XQZLKKUJRGDANN-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 XQZLKKUJRGDANN-UHFFFAOYSA-N 0.000 claims description 2
• UUSSJTQILLYBKX-UHFFFAOYSA-N 2-butyl-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=C(C)C=C1 UUSSJTQILLYBKX-UHFFFAOYSA-N 0.000 claims description 2
• UTJBXGWVFIBXDO-VCBVRPFLSA-N 3-(2-methylpropyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=C3C=CC=CC3=CC=2)=C1 UTJBXGWVFIBXDO-VCBVRPFLSA-N 0.000 claims description 2
• RNQUVBIEGIMHSP-HRTMPFAESA-N 3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-(2-phenylethyl)azepan-3-yl]-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CCC1=CC=CC=C1 RNQUVBIEGIMHSP-HRTMPFAESA-N 0.000 claims description 2
• FCIHODRGNYCXCG-RCSZBHJWSA-N 3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=CC(=CC=2)C(F)(F)F)=C1 FCIHODRGNYCXCG-RCSZBHJWSA-N 0.000 claims description 2
• GZLIYOGWLHBOAT-RCSZBHJWSA-N 3-(2-methylpropyl)-n'-[(3s)-2-oxo-1-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=C(C=2C=CC(=CC=2)C(F)(F)F)C=C1 GZLIYOGWLHBOAT-RCSZBHJWSA-N 0.000 claims description 2
• UNVGOUUEIYHPGD-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 UNVGOUUEIYHPGD-UHFFFAOYSA-N 0.000 claims description 2
• YHWSPDXEHVKXGR-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[2-oxo-1-[(3-phenoxyphenyl)methyl]-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 YHWSPDXEHVKXGR-UHFFFAOYSA-N 0.000 claims description 2
• LDHANDKKSAYIRP-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[2-oxo-5-phenyl-1-(2-phenylethyl)-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 LDHANDKKSAYIRP-UHFFFAOYSA-N 0.000 claims description 2
• JPZBXAMHIOFAFH-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 JPZBXAMHIOFAFH-UHFFFAOYSA-N 0.000 claims description 2
• UKAXPOFTWWMIFA-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[4-oxo-1-phenyl-5-(2-phenylethyl)-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 UKAXPOFTWWMIFA-UHFFFAOYSA-N 0.000 claims description 2
• JWZNGHBOOWXXFI-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 JWZNGHBOOWXXFI-UHFFFAOYSA-N 0.000 claims description 2
• YDMSTRKXBRIRFU-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 YDMSTRKXBRIRFU-UHFFFAOYSA-N 0.000 claims description 2
• AHSMVLDBNIQNCL-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 AHSMVLDBNIQNCL-UHFFFAOYSA-N 0.000 claims description 2
• MCTBMGWXRISMMB-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1=CC=CC(C=2C=C3C=CC=CC3=CC=2)=C1 MCTBMGWXRISMMB-UHFFFAOYSA-N 0.000 claims description 2
• XQFQKKJNPLMECP-UHFFFAOYSA-N 3-(2-methylpropyl)-n'-[6-oxo-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=C(C(F)(F)F)C=C1 XQFQKKJNPLMECP-UHFFFAOYSA-N 0.000 claims description 2
• VYEJNVSFKCBPMB-PDZHLSQESA-N 3-(cyclobutylmethyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCC1 VYEJNVSFKCBPMB-PDZHLSQESA-N 0.000 claims description 2
• MLSVJWNVPWMGOO-ZRZZZMTFSA-N 3-(cyclobutylmethyl)-n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCC1 MLSVJWNVPWMGOO-ZRZZZMTFSA-N 0.000 claims description 2
• MJPXRILYKNQHOO-PPUMFKDSSA-N 3-(cyclobutylmethyl)-n'-[(3s)-1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCC1 MJPXRILYKNQHOO-PPUMFKDSSA-N 0.000 claims description 2
• AHZRLYPQUUTSLT-PPUMFKDSSA-N 3-(cyclobutylmethyl)-n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCC1 AHZRLYPQUUTSLT-PPUMFKDSSA-N 0.000 claims description 2
• UCKCEGBORVUAHP-LADMEODRSA-N 3-(cyclobutylmethyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCC1 UCKCEGBORVUAHP-LADMEODRSA-N 0.000 claims description 2
• XCHWQANYEJKBEH-LADMEODRSA-N 3-(cyclobutylmethyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCC1 XCHWQANYEJKBEH-LADMEODRSA-N 0.000 claims description 2
• NQHLRROXJRQAIL-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 NQHLRROXJRQAIL-UHFFFAOYSA-N 0.000 claims description 2
• OKTATARGUFZNHX-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 OKTATARGUFZNHX-UHFFFAOYSA-N 0.000 claims description 2
• RBYQQYUFTCGXRD-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 RBYQQYUFTCGXRD-UHFFFAOYSA-N 0.000 claims description 2
• SMFAIGBKZKVGSU-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 SMFAIGBKZKVGSU-UHFFFAOYSA-N 0.000 claims description 2
• FHFLTXAJYHJDAI-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[2-oxo-1-[(3-phenoxyphenyl)methyl]-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 FHFLTXAJYHJDAI-UHFFFAOYSA-N 0.000 claims description 2
• MHYSHLCNTUKTFM-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 MHYSHLCNTUKTFM-UHFFFAOYSA-N 0.000 claims description 2
• IRERAEZBEXBGPQ-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 IRERAEZBEXBGPQ-UHFFFAOYSA-N 0.000 claims description 2
• COWPRBVDCQEZAZ-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 COWPRBVDCQEZAZ-UHFFFAOYSA-N 0.000 claims description 2
• WDQSJPRRMVVKPP-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 WDQSJPRRMVVKPP-UHFFFAOYSA-N 0.000 claims description 2
• ZOLVUOKRDQBFIL-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 ZOLVUOKRDQBFIL-UHFFFAOYSA-N 0.000 claims description 2
• ZNHNDKXKSSXBKM-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 ZNHNDKXKSSXBKM-UHFFFAOYSA-N 0.000 claims description 2
• VSMHQCBUZBKDIN-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 VSMHQCBUZBKDIN-UHFFFAOYSA-N 0.000 claims description 2
• DTFNAWIXBUNQPX-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 DTFNAWIXBUNQPX-UHFFFAOYSA-N 0.000 claims description 2
• YKACCFBGOUUKRG-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 YKACCFBGOUUKRG-UHFFFAOYSA-N 0.000 claims description 2
• PZUYUEAVEGTYJT-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 PZUYUEAVEGTYJT-UHFFFAOYSA-N 0.000 claims description 2
• MWOGTYJPDRZOHE-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[6-oxo-5-[(3-phenoxyphenyl)methyl]-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 MWOGTYJPDRZOHE-UHFFFAOYSA-N 0.000 claims description 2
• DCRMBIYGZDRVSD-UHFFFAOYSA-N 3-(cyclobutylmethyl)-n'-[6-oxo-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 DCRMBIYGZDRVSD-UHFFFAOYSA-N 0.000 claims description 2
• WWTVPXYHJAGKGW-PJUZOBRJSA-N 3-(cyclopentylmethyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCCC1 WWTVPXYHJAGKGW-PJUZOBRJSA-N 0.000 claims description 2
• BPZJAMGUPGJKPI-DMVZSUBZSA-N 3-(cyclopentylmethyl)-n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCCC1 BPZJAMGUPGJKPI-DMVZSUBZSA-N 0.000 claims description 2
• BOGZKFJEYZCRJX-DSNFFHCTSA-N 3-(cyclopentylmethyl)-n'-[(3s)-1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCCC1 BOGZKFJEYZCRJX-DSNFFHCTSA-N 0.000 claims description 2
• DXJYUUCCMLIXSC-DSNFFHCTSA-N 3-(cyclopentylmethyl)-n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCCC1 DXJYUUCCMLIXSC-DSNFFHCTSA-N 0.000 claims description 2
• DJIHYPQSQWGMDT-PPUMFKDSSA-N 3-(cyclopentylmethyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCCC1 DJIHYPQSQWGMDT-PPUMFKDSSA-N 0.000 claims description 2
• DZTASLYVTUEYKO-PPUMFKDSSA-N 3-(cyclopentylmethyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCCC1 DZTASLYVTUEYKO-PPUMFKDSSA-N 0.000 claims description 2
• DOALUSKAQUWLCC-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 DOALUSKAQUWLCC-UHFFFAOYSA-N 0.000 claims description 2
• LFCCESCUDVVLKR-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 LFCCESCUDVVLKR-UHFFFAOYSA-N 0.000 claims description 2
• KUEVNGDBTXEPNS-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 KUEVNGDBTXEPNS-UHFFFAOYSA-N 0.000 claims description 2
• AKIWKBSOFWUQII-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 AKIWKBSOFWUQII-UHFFFAOYSA-N 0.000 claims description 2
• DXEQFAKUXFHQDJ-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[2-oxo-1-[(3-phenoxyphenyl)methyl]-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 DXEQFAKUXFHQDJ-UHFFFAOYSA-N 0.000 claims description 2
• RKHBCFHXGRNIAT-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 RKHBCFHXGRNIAT-UHFFFAOYSA-N 0.000 claims description 2
• PQZYHFBMXQCLEG-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 PQZYHFBMXQCLEG-UHFFFAOYSA-N 0.000 claims description 2
• QUZDWRUOBMEKPW-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 QUZDWRUOBMEKPW-UHFFFAOYSA-N 0.000 claims description 2
• SMYKYDIUXHVFRX-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 SMYKYDIUXHVFRX-UHFFFAOYSA-N 0.000 claims description 2
• ZSQGUPUUQZEWNA-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 ZSQGUPUUQZEWNA-UHFFFAOYSA-N 0.000 claims description 2
• MEFOEUUZSADQNZ-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 MEFOEUUZSADQNZ-UHFFFAOYSA-N 0.000 claims description 2
• QJSHZBBSVZGREL-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 QJSHZBBSVZGREL-UHFFFAOYSA-N 0.000 claims description 2
• BKDCCOJEZMJFIP-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 BKDCCOJEZMJFIP-UHFFFAOYSA-N 0.000 claims description 2
• PYFSKMKQFQGOJW-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 PYFSKMKQFQGOJW-UHFFFAOYSA-N 0.000 claims description 2
• PRPHVOUBXXFQRB-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 PRPHVOUBXXFQRB-UHFFFAOYSA-N 0.000 claims description 2
• YDAHVULSSDCBCX-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 YDAHVULSSDCBCX-UHFFFAOYSA-N 0.000 claims description 2
• ZLTSSJNNNGSVEG-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[6-oxo-5-[(3-phenoxyphenyl)methyl]-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 ZLTSSJNNNGSVEG-UHFFFAOYSA-N 0.000 claims description 2
• HPDHWXPHPVVQOU-UHFFFAOYSA-N 3-(cyclopentylmethyl)-n'-[6-oxo-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 HPDHWXPHPVVQOU-UHFFFAOYSA-N 0.000 claims description 2
• JQRTUEZHBOUKSW-VCBVRPFLSA-N 3-(cyclopropylmethyl)-n'-[(3s)-1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CC1 JQRTUEZHBOUKSW-VCBVRPFLSA-N 0.000 claims description 2
• SQUNXFNIVNMURG-ONJSCSTBSA-N 3-(cyclopropylmethyl)-n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CC1 SQUNXFNIVNMURG-ONJSCSTBSA-N 0.000 claims description 2
• OVHGTOQRNPXKIY-LADMEODRSA-N 3-(cyclopropylmethyl)-n'-[(3s)-1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CC1 OVHGTOQRNPXKIY-LADMEODRSA-N 0.000 claims description 2
• KQVMKFAMNMWSND-LADMEODRSA-N 3-(cyclopropylmethyl)-n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CC1 KQVMKFAMNMWSND-LADMEODRSA-N 0.000 claims description 2
• XXZYPIOGLIRGJI-RCSZBHJWSA-N 3-(cyclopropylmethyl)-n'-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CC1 XXZYPIOGLIRGJI-RCSZBHJWSA-N 0.000 claims description 2
• LHGBXAULISYURX-RCSZBHJWSA-N 3-(cyclopropylmethyl)-n'-[(3s)-2-oxo-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]azepan-3-yl]-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CC1 LHGBXAULISYURX-RCSZBHJWSA-N 0.000 claims description 2
• ZYBQKXDLDISIMW-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[1-[(3-naphthalen-2-ylphenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 ZYBQKXDLDISIMW-UHFFFAOYSA-N 0.000 claims description 2
• YGRPUIOHNVOGCO-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 YGRPUIOHNVOGCO-UHFFFAOYSA-N 0.000 claims description 2
• SVCPWBNOVAYCAR-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 SVCPWBNOVAYCAR-UHFFFAOYSA-N 0.000 claims description 2
• RCLDXEWVAUGOQV-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 RCLDXEWVAUGOQV-UHFFFAOYSA-N 0.000 claims description 2
• JOKYPICLHVYNCR-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[2-oxo-5-phenyl-1-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-3h-1,4-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 JOKYPICLHVYNCR-UHFFFAOYSA-N 0.000 claims description 2
• JAGPUWQIIKSFSW-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[4-oxo-1-phenyl-5-[[3-[4-(trifluoromethyl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(=CC=2)C(F)(F)F)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 JAGPUWQIIKSFSW-UHFFFAOYSA-N 0.000 claims description 2
• AHNUQLZNUKGVLF-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[4-oxo-5-[(3-phenoxyphenyl)methyl]-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 AHNUQLZNUKGVLF-UHFFFAOYSA-N 0.000 claims description 2
• ZXXHWGXQVVUWKM-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 ZXXHWGXQVVUWKM-UHFFFAOYSA-N 0.000 claims description 2
• AVCNKUCIKDRTPD-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[(3-naphthalen-2-ylphenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C3C=CC=CC3=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 AVCNKUCIKDRTPD-UHFFFAOYSA-N 0.000 claims description 2
• RNGVDHULFALRQK-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 RNGVDHULFALRQK-UHFFFAOYSA-N 0.000 claims description 2
• DTDQRFHIRTYBCN-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 DTDQRFHIRTYBCN-UHFFFAOYSA-N 0.000 claims description 2
• RGECEKUASINHHY-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 RGECEKUASINHHY-UHFFFAOYSA-N 0.000 claims description 2
• LRLPXSKCQBCYIM-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[[3-(4-methoxyphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 LRLPXSKCQBCYIM-UHFFFAOYSA-N 0.000 claims description 2
• LSBTXOBBGQJZBZ-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 LSBTXOBBGQJZBZ-UHFFFAOYSA-N 0.000 claims description 2
• MYAPAROBIYXYRS-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[5-[[3-(4-methylphenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 MYAPAROBIYXYRS-UHFFFAOYSA-N 0.000 claims description 2
• FVDAQSDWGMWOTM-UHFFFAOYSA-N 3-(cyclopropylmethyl)-n'-[6-oxo-5-[(3-phenoxyphenyl)methyl]-7h-benzo[d][1]benzazepin-7-yl]-2-propylbutanediamide Chemical compound C12=CC=CC=C2C2=CC=CC=C2N(CC=2C=C(OC=3C=CC=CC=3)C=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 FVDAQSDWGMWOTM-UHFFFAOYSA-N 0.000 claims description 2
• NAYNUYGVZDONJN-RCSZBHJWSA-N 3-(hydrazinecarbonyl)-2-(2-methylpropyl)-n-[(3s)-2-oxo-1-[(3-phenoxyphenyl)methyl]azepan-3-yl]hexanamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(=O)NN)CCCCN1CC1=CC=CC(OC=2C=CC=CC=2)=C1 NAYNUYGVZDONJN-RCSZBHJWSA-N 0.000 claims description 2
• XPEAZODSRZLGPH-RCSZBHJWSA-N O=C1[C@@H](NC(=O)C(C(CC(C)C)C(N)=O)CCC)CCCCN1CC1=CC=CC(C=2C(=CC=CC=2)C=2NN=NN=2)=C1 Chemical compound O=C1[C@@H](NC(=O)C(C(CC(C)C)C(N)=O)CCC)CCCCN1CC1=CC=CC(C=2C(=CC=CC=2)C=2NN=NN=2)=C1 XPEAZODSRZLGPH-RCSZBHJWSA-N 0.000 claims description 2
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 2
• 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 claims description 2
• ZMKLWAOBPDAMOD-UHFFFAOYSA-N n'-(1-benzyl-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl)-2-butyl-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)N=C1C1=CC=CC=C1 ZMKLWAOBPDAMOD-UHFFFAOYSA-N 0.000 claims description 2
• IAPHSBLMPQNTNX-UHFFFAOYSA-N n'-(1-benzyl-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl)-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 IAPHSBLMPQNTNX-UHFFFAOYSA-N 0.000 claims description 2
• ITDKULHAHZZKLF-UHFFFAOYSA-N n'-(5-benzyl-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl)-2-butyl-3-(2-methylpropyl)butanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CN1C1=CC=CC=C1 ITDKULHAHZZKLF-UHFFFAOYSA-N 0.000 claims description 2
• QHQUAWXVPJFSFD-UHFFFAOYSA-N n'-(5-benzyl-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl)-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 QHQUAWXVPJFSFD-UHFFFAOYSA-N 0.000 claims description 2
• GDHDEVVQDKZAFM-UHFFFAOYSA-N n'-(5-benzyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)-2-butyl-3-(2-methylpropyl)butanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1=CC=CC=C1 GDHDEVVQDKZAFM-UHFFFAOYSA-N 0.000 claims description 2
• WNNSYZLSNLLUMG-UHFFFAOYSA-N n'-(5-benzyl-6-oxo-7h-benzo[d][1]benzazepin-7-yl)-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1=CC=CC=C1 WNNSYZLSNLLUMG-UHFFFAOYSA-N 0.000 claims description 2
• QKIMXQFBBCYOBX-MHJFOBGBSA-N n'-[(3s)-1-(2-cyclobutylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CCC1CCC1 QKIMXQFBBCYOBX-MHJFOBGBSA-N 0.000 claims description 2
• PQEGJWSNZKKSPV-HRTMPFAESA-N n'-[(3s)-1-(2-cyclohexylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CCC1CCCCC1 PQEGJWSNZKKSPV-HRTMPFAESA-N 0.000 claims description 2
• SSVLPVQUQMIUNC-CBNMVNINSA-N n'-[(3s)-1-(2-cyclopentylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CCC1CCCC1 SSVLPVQUQMIUNC-CBNMVNINSA-N 0.000 claims description 2
• UMKXKCLTTNTRMS-ACBHZAAOSA-N n'-[(3s)-1-(2-cyclopropylethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CCC1CC1 UMKXKCLTTNTRMS-ACBHZAAOSA-N 0.000 claims description 2
• GGKBQLMRFLTIMR-ACBHZAAOSA-N n'-[(3s)-1-(cyclobutylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1CCC1 GGKBQLMRFLTIMR-ACBHZAAOSA-N 0.000 claims description 2
• IFEZKTOIAAWTHF-CBNMVNINSA-N n'-[(3s)-1-(cyclohexylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1CCCCC1 IFEZKTOIAAWTHF-CBNMVNINSA-N 0.000 claims description 2
• TYZNYOBMQDERHY-MHJFOBGBSA-N n'-[(3s)-1-(cyclopentylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1CCCC1 TYZNYOBMQDERHY-MHJFOBGBSA-N 0.000 claims description 2
• CDPUHORNHIKXJG-ABHNRTSZSA-N n'-[(3s)-1-(cyclopropylmethyl)-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1CC1 CDPUHORNHIKXJG-ABHNRTSZSA-N 0.000 claims description 2
• XBYIVRJPDBMEOU-CBNMVNINSA-N n'-[(3s)-1-[(4-fluorophenyl)methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=C(F)C=C1 XBYIVRJPDBMEOU-CBNMVNINSA-N 0.000 claims description 2
• CDCFVXRICMQMEG-ONJSCSTBSA-N n'-[(3s)-1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C(=CC(Cl)=CC=2)Cl)=C1 CDCFVXRICMQMEG-ONJSCSTBSA-N 0.000 claims description 2
• ZXAPQTSHGJKYIE-RCSZBHJWSA-N n'-[(3s)-1-[[3-(2-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C(=CC=CC=2)OC)=C1 ZXAPQTSHGJKYIE-RCSZBHJWSA-N 0.000 claims description 2
• GCJHRGSBHDJDMS-CXTIUDGFSA-N n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=C(Cl)C(F)=CC=2)=C1 GCJHRGSBHDJDMS-CXTIUDGFSA-N 0.000 claims description 2
• RVJURKMHVXNMKQ-KBMIILLGSA-N n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(cyclobutylmethyl)-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCC1 RVJURKMHVXNMKQ-KBMIILLGSA-N 0.000 claims description 2
• QYUGNEUHFPDWNU-XSLSENLXSA-N n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(cyclopentylmethyl)-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CCCC1 QYUGNEUHFPDWNU-XSLSENLXSA-N 0.000 claims description 2
• RKGXPCPVWHCLPG-CXTIUDGFSA-N n'-[(3s)-1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(cyclopropylmethyl)-2-propylbutanediamide Chemical compound N([C@@H]1C(N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)CCCC1)=O)C(=O)C(C(CCC)C(N)=O)CC1CC1 RKGXPCPVWHCLPG-CXTIUDGFSA-N 0.000 claims description 2
• DXAMIGRAGGVLFS-RCSZBHJWSA-N n'-[(3s)-1-[[3-(3-fluorophenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=C(F)C=CC=2)=C1 DXAMIGRAGGVLFS-RCSZBHJWSA-N 0.000 claims description 2
• SHXZNEHEOWWDFY-LADMEODRSA-N n'-[(3s)-1-[[3-(3-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=C(OC)C=CC=2)=C1 SHXZNEHEOWWDFY-LADMEODRSA-N 0.000 claims description 2
• MLEDNDFUKNFMCW-LADMEODRSA-N n'-[(3s)-1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=CC(OC)=CC=2)=C1 MLEDNDFUKNFMCW-LADMEODRSA-N 0.000 claims description 2
• MVUCGZSBMJTQTB-LADMEODRSA-N n'-[(3s)-1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC(C=2C=CC(C)=CC=2)=C1 MVUCGZSBMJTQTB-LADMEODRSA-N 0.000 claims description 2
• MUVFESNOIMFTNV-JGZAQREWSA-N n'-[(3s)-1-[[5-(3-chloro-4-fluorophenyl)pyridin-3-yl]methyl]-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CN=CC(C=2C=C(Cl)C(F)=CC=2)=C1 MUVFESNOIMFTNV-JGZAQREWSA-N 0.000 claims description 2
• VKCQXBOLMHZLGK-HRTMPFAESA-N n'-[(3s)-1-benzyl-2-oxoazepan-3-yl]-2-butyl-3-(2-methylpropyl)butanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCCC)C(N)=O)CCCCN1CC1=CC=CC=C1 VKCQXBOLMHZLGK-HRTMPFAESA-N 0.000 claims description 2
• NXBONQZFUUZVNE-CBNMVNINSA-N n'-[(3s)-1-benzyl-2-oxoazepan-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1[C@@H](NC(=O)C(CC(C)C)C(CCC)C(N)=O)CCCCN1CC1=CC=CC=C1 NXBONQZFUUZVNE-CBNMVNINSA-N 0.000 claims description 2
• QFMBUGLDMHFIFQ-UHFFFAOYSA-N n'-[1-(2-cyclobutylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 QFMBUGLDMHFIFQ-UHFFFAOYSA-N 0.000 claims description 2
• UDYJKNKBGJHGQD-UHFFFAOYSA-N n'-[1-(2-cyclohexylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 UDYJKNKBGJHGQD-UHFFFAOYSA-N 0.000 claims description 2
• JPKIXVFBHUOJIJ-UHFFFAOYSA-N n'-[1-(2-cyclopentylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 JPKIXVFBHUOJIJ-UHFFFAOYSA-N 0.000 claims description 2
• OUHMIDMVHSYXSG-UHFFFAOYSA-N n'-[1-(2-cyclopropylethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 OUHMIDMVHSYXSG-UHFFFAOYSA-N 0.000 claims description 2
• FDVOJRXZKPBXMT-UHFFFAOYSA-N n'-[1-(cyclobutylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 FDVOJRXZKPBXMT-UHFFFAOYSA-N 0.000 claims description 2
• VCKWIMURNOYHTD-UHFFFAOYSA-N n'-[1-(cyclohexylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 VCKWIMURNOYHTD-UHFFFAOYSA-N 0.000 claims description 2
• ILRQNSYAWNPZSA-UHFFFAOYSA-N n'-[1-(cyclopentylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 ILRQNSYAWNPZSA-UHFFFAOYSA-N 0.000 claims description 2
• UNVSQRWFRAQTDO-UHFFFAOYSA-N n'-[1-(cyclopropylmethyl)-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 UNVSQRWFRAQTDO-UHFFFAOYSA-N 0.000 claims description 2
• QWRLAKWGKOEEGM-UHFFFAOYSA-N n'-[1-[(4-fluorophenyl)methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC(F)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 QWRLAKWGKOEEGM-UHFFFAOYSA-N 0.000 claims description 2
• BIEOYPJUXXRXNB-UHFFFAOYSA-N n'-[1-[[3-(2,4-dichlorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 BIEOYPJUXXRXNB-UHFFFAOYSA-N 0.000 claims description 2
• YQYGYVCNPXQTBK-UHFFFAOYSA-N n'-[1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 YQYGYVCNPXQTBK-UHFFFAOYSA-N 0.000 claims description 2
• VAZAQPICIQUCEY-UHFFFAOYSA-N n'-[1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(cyclobutylmethyl)-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 VAZAQPICIQUCEY-UHFFFAOYSA-N 0.000 claims description 2
• CKUCKPMIQSCQGU-UHFFFAOYSA-N n'-[1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(cyclopentylmethyl)-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCCC1 CKUCKPMIQSCQGU-UHFFFAOYSA-N 0.000 claims description 2
• JCWLJRRHVMNGIW-UHFFFAOYSA-N n'-[1-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(cyclopropylmethyl)-2-propylbutanediamide Chemical compound N1=C(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CC1 JCWLJRRHVMNGIW-UHFFFAOYSA-N 0.000 claims description 2
• MXORDLMDOMUPLK-UHFFFAOYSA-N n'-[1-[[3-(4-methoxyphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(OC)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 MXORDLMDOMUPLK-UHFFFAOYSA-N 0.000 claims description 2
• XTYPVNFCPMCCIW-UHFFFAOYSA-N n'-[1-[[3-(4-methylphenyl)phenyl]methyl]-2-oxo-5-phenyl-3h-1,4-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=CC(C)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)N=C1C1=CC=CC=C1 XTYPVNFCPMCCIW-UHFFFAOYSA-N 0.000 claims description 2
• DTQZERRQLLZKIB-UHFFFAOYSA-N n'-[5-(2-cyclobutylethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 DTQZERRQLLZKIB-UHFFFAOYSA-N 0.000 claims description 2
• GVTFFFVXKRFJFF-UHFFFAOYSA-N n'-[5-(2-cyclobutylethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1CCC1 GVTFFFVXKRFJFF-UHFFFAOYSA-N 0.000 claims description 2
• CSZTZWYKQDKESZ-UHFFFAOYSA-N n'-[5-(2-cyclohexylethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 CSZTZWYKQDKESZ-UHFFFAOYSA-N 0.000 claims description 2
• KUCGICYZYVGOGB-UHFFFAOYSA-N n'-[5-(2-cyclohexylethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1CCCCC1 KUCGICYZYVGOGB-UHFFFAOYSA-N 0.000 claims description 2
• BUJRWSLVSGABDD-UHFFFAOYSA-N n'-[5-(2-cyclopentylethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 BUJRWSLVSGABDD-UHFFFAOYSA-N 0.000 claims description 2
• FUELFQVQWJGRLJ-UHFFFAOYSA-N n'-[5-(2-cyclopentylethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1CCCC1 FUELFQVQWJGRLJ-UHFFFAOYSA-N 0.000 claims description 2
• CCELIJKTDPWYPZ-UHFFFAOYSA-N n'-[5-(2-cyclopropylethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CCC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 CCELIJKTDPWYPZ-UHFFFAOYSA-N 0.000 claims description 2
• NGIMOOHZPCOCEF-UHFFFAOYSA-N n'-[5-(2-cyclopropylethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CCC1CC1 NGIMOOHZPCOCEF-UHFFFAOYSA-N 0.000 claims description 2
• WASXQKCUMRKBIM-UHFFFAOYSA-N n'-[5-(cyclobutylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 WASXQKCUMRKBIM-UHFFFAOYSA-N 0.000 claims description 2
• NFZJICUENBVCDM-UHFFFAOYSA-N n'-[5-(cyclobutylmethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1CCC1 NFZJICUENBVCDM-UHFFFAOYSA-N 0.000 claims description 2
• CRMABYMZBMBNRD-UHFFFAOYSA-N n'-[5-(cyclohexylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CCCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 CRMABYMZBMBNRD-UHFFFAOYSA-N 0.000 claims description 2
• ZLIGJQQOPKUWHY-UHFFFAOYSA-N n'-[5-(cyclopentylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CCCC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 ZLIGJQQOPKUWHY-UHFFFAOYSA-N 0.000 claims description 2
• PXWQCNCDHZNWLN-UHFFFAOYSA-N n'-[5-(cyclopentylmethyl)-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1CCCC1 PXWQCNCDHZNWLN-UHFFFAOYSA-N 0.000 claims description 2
• OVGNKBZRSGHVOV-UHFFFAOYSA-N n'-[5-(cyclopropylmethyl)-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC2CC2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 OVGNKBZRSGHVOV-UHFFFAOYSA-N 0.000 claims description 2
• CCFSASPURMSALN-UHFFFAOYSA-N n'-[5-[(4-fluorophenyl)methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=CC(F)=CC=2)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 CCFSASPURMSALN-UHFFFAOYSA-N 0.000 claims description 2
• UKDLRZBPBQQTEZ-UHFFFAOYSA-N n'-[5-[(4-fluorophenyl)methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC1=CC=C(F)C=C1 UKDLRZBPBQQTEZ-UHFFFAOYSA-N 0.000 claims description 2
• BAPUHUCINJWSMI-UHFFFAOYSA-N n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound C12=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C(=CC(Cl)=CC=2)Cl)C(=O)C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)CN1C1=CC=CC=C1 BAPUHUCINJWSMI-UHFFFAOYSA-N 0.000 claims description 2
• XRMVNGSTPAACND-UHFFFAOYSA-N n'-[5-[[3-(2,4-dichlorophenyl)phenyl]methyl]-6-oxo-7h-benzo[d][1]benzazepin-7-yl]-3-(2-methylpropyl)-2-propylbutanediamide Chemical compound O=C1C(NC(=O)C(CC(C)C)C(CCC)C(N)=O)C2=CC=CC=C2C2=CC=CC=C2N1CC(C=1)=CC=CC=1C1=CC=C(Cl)C=C1Cl XRMVNGSTPAACND-UHFFFAOYSA-N 0.000 claims description 2
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• QBEWFNWOZAEGAD-UHFFFAOYSA-N n'-[5-[[3-(3-chloro-4-fluorophenyl)phenyl]methyl]-4-oxo-1-phenyl-2,3-dihydro-1,5-benzodiazepin-3-yl]-3-(cyclobutylmethyl)-2-propylbutanediamide Chemical compound C1N(C=2C=CC=CC=2)C2=CC=CC=C2N(CC=2C=C(C=CC=2)C=2C=C(Cl)C(F)=CC=2)C(=O)C1NC(=O)C(C(CCC)C(N)=O)CC1CCC1 QBEWFNWOZAEGAD-UHFFFAOYSA-N 0.000 claims description 2
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