HRP980511A2 - New imidazoline derivatives, their preparation and use, and pharmaceutical compositions containing them - Google Patents
New imidazoline derivatives, their preparation and use, and pharmaceutical compositions containing themInfo
- Publication number
- HRP980511A2 HRP980511A2 HR19741235.1A HRP980511A HRP980511A2 HR P980511 A2 HRP980511 A2 HR P980511A2 HR P980511 A HRP980511 A HR P980511A HR P980511 A2 HRP980511 A2 HR P980511A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- residue
- cycloalkyl
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title description 16
- 150000002462 imidazolines Chemical class 0.000 title 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- -1 heteroaryl radical Chemical class 0.000 claims description 254
- 150000001875 compounds Chemical class 0.000 claims description 165
- 125000004178 (C1-C4) alkyl group Chemical class 0.000 claims description 109
- 125000003118 aryl group Chemical group 0.000 claims description 81
- 125000001072 heteroaryl group Chemical group 0.000 claims description 77
- 239000001257 hydrogen Substances 0.000 claims description 66
- 229910052739 hydrogen Inorganic materials 0.000 claims description 66
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 61
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 60
- 239000000203 mixture Substances 0.000 claims description 59
- 150000003839 salts Chemical class 0.000 claims description 56
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 53
- 125000001424 substituent group Chemical group 0.000 claims description 53
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 50
- 108010008212 Integrin alpha4beta1 Proteins 0.000 claims description 48
- 229910052757 nitrogen Inorganic materials 0.000 claims description 45
- 125000005842 heteroatom Chemical group 0.000 claims description 43
- 229910052760 oxygen Inorganic materials 0.000 claims description 42
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 41
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 41
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- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 34
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 34
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 31
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- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19741235A DE19741235A1 (de) | 1997-09-18 | 1997-09-18 | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP980511A2 true HRP980511A2 (en) | 1999-06-30 |
Family
ID=7842856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR19741235.1A HRP980511A2 (en) | 1997-09-18 | 1998-09-17 | New imidazoline derivatives, their preparation and use, and pharmaceutical compositions containing them |
Country Status (26)
Country | Link |
---|---|
US (2) | US6423712B1 (xx) |
EP (1) | EP0903353B1 (xx) |
JP (1) | JP4537505B2 (xx) |
KR (1) | KR19990029915A (xx) |
CN (1) | CN1125054C (xx) |
AR (1) | AR015444A1 (xx) |
AT (1) | ATE449786T1 (xx) |
AU (1) | AU748599B2 (xx) |
BR (1) | BR9803486A (xx) |
CA (1) | CA2247551A1 (xx) |
CZ (1) | CZ298898A3 (xx) |
DE (2) | DE19741235A1 (xx) |
HK (1) | HK1019606A1 (xx) |
HR (1) | HRP980511A2 (xx) |
HU (1) | HUP9802121A3 (xx) |
ID (1) | ID20855A (xx) |
IL (1) | IL126247A0 (xx) |
MY (1) | MY121745A (xx) |
NO (1) | NO984309L (xx) |
NZ (1) | NZ331924A (xx) |
PL (1) | PL328686A1 (xx) |
RU (1) | RU2213737C2 (xx) |
SK (1) | SK124798A3 (xx) |
TR (1) | TR199801840A3 (xx) |
TW (1) | TW553937B (xx) |
ZA (1) | ZA988496B (xx) |
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IL146312A0 (en) * | 1999-05-07 | 2002-07-25 | Texas Biotechnology Corp | Propanoic acid derivatives that inhibit the binding of integrins to their receptors |
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KR101492351B1 (ko) * | 2010-09-22 | 2015-02-10 | 미쓰이가가쿠 아그로 가부시키가이샤 | 함불소 카바메이트기를 가지는 아미노산 아미드 유도체의 제조방법, 그 제조 중간체, 및 에틸렌디아민 유도체의 제조방법 |
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-
1997
- 1997-09-18 DE DE19741235A patent/DE19741235A1/de not_active Withdrawn
-
1998
- 1998-09-10 TR TR1998/01840A patent/TR199801840A3/tr unknown
- 1998-09-11 SK SK1247-98A patent/SK124798A3/sk unknown
- 1998-09-11 EP EP98117231A patent/EP0903353B1/de not_active Expired - Lifetime
- 1998-09-11 AT AT98117231T patent/ATE449786T1/de not_active IP Right Cessation
- 1998-09-11 DE DE59814412T patent/DE59814412D1/de not_active Expired - Lifetime
- 1998-09-16 IL IL12624798A patent/IL126247A0/xx unknown
- 1998-09-16 MY MYPI98004246A patent/MY121745A/en unknown
- 1998-09-16 AR ARP980104601A patent/AR015444A1/es unknown
- 1998-09-16 ID IDP981241A patent/ID20855A/id unknown
- 1998-09-16 NZ NZ331924A patent/NZ331924A/en unknown
- 1998-09-16 CA CA002247551A patent/CA2247551A1/en not_active Abandoned
- 1998-09-17 RU RU98117230/04A patent/RU2213737C2/ru not_active IP Right Cessation
- 1998-09-17 BR BR9803486-3A patent/BR9803486A/pt not_active Application Discontinuation
- 1998-09-17 JP JP26316498A patent/JP4537505B2/ja not_active Expired - Fee Related
- 1998-09-17 NO NO984309A patent/NO984309L/no not_active Application Discontinuation
- 1998-09-17 AU AU85231/98A patent/AU748599B2/en not_active Ceased
- 1998-09-17 CZ CZ982988A patent/CZ298898A3/cs unknown
- 1998-09-17 ZA ZA988496A patent/ZA988496B/xx unknown
- 1998-09-17 HR HR19741235.1A patent/HRP980511A2/hr not_active Application Discontinuation
- 1998-09-18 CN CN98119629A patent/CN1125054C/zh not_active Expired - Fee Related
- 1998-09-18 PL PL98328686A patent/PL328686A1/xx not_active Application Discontinuation
- 1998-09-18 HU HU9802121A patent/HUP9802121A3/hu unknown
- 1998-09-18 US US09/157,241 patent/US6423712B1/en not_active Expired - Lifetime
- 1998-09-18 KR KR1019980038607A patent/KR19990029915A/ko not_active Application Discontinuation
- 1998-09-25 TW TW087115382A patent/TW553937B/zh not_active IP Right Cessation
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1999
- 1999-10-27 HK HK99104805A patent/HK1019606A1/xx not_active IP Right Cessation
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2002
- 2002-05-20 US US10/147,921 patent/US6759424B2/en not_active Expired - Lifetime
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