HRP980511A2 - New imidazoline derivatives, their preparation and use, and pharmaceutical compositions containing them - Google Patents

Info

Publication number

HRP980511A2

HRP980511A2 HR19741235.1A HRP980511A HRP980511A2 HR P980511 A2 HRP980511 A2 HR P980511A2 HR P980511 A HRP980511 A HR P980511A HR P980511 A2 HRP980511 A2 HR P980511A2

Authority

HR

Croatia

Prior art keywords

alkyl

optionally substituted

aryl

residue

cycloalkyl

Prior art date

1997-09-18

Links

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• 238000002360 preparation method Methods 0.000 title description 16
• 150000002462 imidazolines Chemical class 0.000 title 1
• 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title 1
• 239000008194 pharmaceutical composition Substances 0.000 title 1
• -1 heteroaryl radical Chemical class 0.000 claims description 254
• 150000001875 compounds Chemical class 0.000 claims description 165
• 125000004178 (C1-C4) alkyl group Chemical class 0.000 claims description 109
• 125000003118 aryl group Chemical group 0.000 claims description 81
• 125000001072 heteroaryl group Chemical group 0.000 claims description 77
• 239000001257 hydrogen Substances 0.000 claims description 66
• 229910052739 hydrogen Inorganic materials 0.000 claims description 66
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 61
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 60
• 239000000203 mixture Substances 0.000 claims description 59
• 150000003839 salts Chemical class 0.000 claims description 56
• 125000005915 C6-C14 aryl group Chemical group 0.000 claims description 53
• 125000001424 substituent group Chemical group 0.000 claims description 53
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 50
• 108010008212 Integrin alpha4beta1 Proteins 0.000 claims description 48
• 229910052757 nitrogen Inorganic materials 0.000 claims description 45
• 125000005842 heteroatom Chemical group 0.000 claims description 43
• 229910052760 oxygen Inorganic materials 0.000 claims description 42
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 41
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 41
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• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 34
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 34
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 31
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 31
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