HRP980502B1 - Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments - Google Patents

Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments

Info

Publication number
HRP980502B1
HRP980502B1 HR980502A HRP980502A HRP980502B1 HR P980502 B1 HRP980502 B1 HR P980502B1 HR 980502 A HR980502 A HR 980502A HR P980502 A HRP980502 A HR P980502A HR P980502 B1 HRP980502 B1 HR P980502B1
Authority
HR
Croatia
Prior art keywords
benzazocin
oles
methano
hexahydro
medicaments
Prior art date
Application number
HR980502A
Other languages
English (en)
Inventor
Grauert Matthias
Carter Adrian
Bechtel Wolf-Dietrich
Weiser Thomas
Palluk Rainer
Paschorn Uwe
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg. filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg.
Publication of HRP980502A2 publication Critical patent/HRP980502A2/hr
Publication of HRP980502B1 publication Critical patent/HRP980502B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HR980502A 1997-09-12 1998-09-11 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments HRP980502B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19740110A DE19740110A1 (de) 1997-09-12 1997-09-12 Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Publications (2)

Publication Number Publication Date
HRP980502A2 HRP980502A2 (en) 1999-06-30
HRP980502B1 true HRP980502B1 (en) 2005-02-28

Family

ID=7842134

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980502A HRP980502B1 (en) 1997-09-12 1998-09-11 Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles, processes for their preparation and their use as medicaments

Country Status (38)

Country Link
US (1) US6455538B1 (no)
EP (1) EP1015433B1 (no)
JP (1) JP3827528B2 (no)
KR (1) KR100601008B1 (no)
CN (1) CN1166640C (no)
AR (1) AR017095A1 (no)
AT (1) ATE267811T1 (no)
AU (1) AU751036B2 (no)
BG (1) BG64418B1 (no)
BR (1) BR9812443A (no)
CA (1) CA2302347C (no)
CO (1) CO5011117A1 (no)
CZ (1) CZ296909B6 (no)
DE (2) DE19740110A1 (no)
DK (1) DK1015433T3 (no)
EE (1) EE04398B1 (no)
ES (1) ES2222612T3 (no)
HR (1) HRP980502B1 (no)
HU (1) HUP0004588A3 (no)
ID (1) ID24173A (no)
IL (1) IL134572A (no)
MY (1) MY120550A (no)
NO (1) NO315650B1 (no)
NZ (1) NZ503710A (no)
PE (1) PE122899A1 (no)
PL (1) PL198486B1 (no)
PT (1) PT1015433E (no)
RS (1) RS49888B (no)
RU (1) RU2218334C2 (no)
SA (1) SA98190765B1 (no)
SK (1) SK284670B6 (no)
TR (1) TR200000697T2 (no)
TW (1) TW505645B (no)
UA (1) UA61973C2 (no)
UY (2) UY25175A1 (no)
WO (1) WO1999014199A1 (no)
YU (1) YU12000A (no)
ZA (1) ZA988285B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
DE19957156A1 (de) * 1999-11-27 2001-05-31 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6355652B1 (en) 1999-11-27 2002-03-12 Boehringer Ingelheim Pharma Kg Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines and their use as pharmaceutical compositions
DE10204276A1 (de) * 2002-02-02 2003-08-07 Boehringer Ingelheim Pharma N-Allyloxyethyl-1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocine und ihre Verwendung als Arzneimittel
US6683089B2 (en) 2002-02-02 2004-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg N-allyoxyethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocine-10-ols
US20040019075A1 (en) * 2002-05-29 2004-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg New formulation for the parenteral application of crobenetine
US6828311B2 (en) 2002-05-29 2004-12-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Formulation for the parenteral application of a sodium channel blocker
DE10223783A1 (de) * 2002-05-29 2003-12-11 Boehringer Ingelheim Pharma Neue Formulierung zur parenteralen Applikation eines Na-Kanal-Blockers
DE10226814A1 (de) * 2002-06-15 2004-01-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung ischämischer Zustände
US20030235576A1 (en) * 2002-06-15 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg New drug combinations for the treatment of ischaemic conditions
PT1963280E (pt) 2005-12-22 2016-02-02 Newron Pharm Spa Derivados de 2-feniletilamino como cálcio e/ou moduladores do canal de sódio
NZ581288A (en) 2007-06-15 2011-08-26 Newron Pharm Spa Substituted 2- [2- (phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators
RS55240B1 (sr) 2011-06-27 2017-02-28 Newron Pharm Spa Fluorisani derivati arilalkilaminokarboksamida

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2828039A1 (de) 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
DE4121821A1 (de) 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
SK3342000A3 (en) 2000-09-12
HUP0004588A2 (hu) 2001-07-30
NO20001288L (no) 2000-03-13
DE59811477D1 (de) 2004-07-01
CN1166640C (zh) 2004-09-15
NO315650B1 (no) 2003-10-06
AR017095A1 (es) 2001-08-22
WO1999014199A1 (de) 1999-03-25
RU2218334C2 (ru) 2003-12-10
CA2302347A1 (en) 1999-03-25
CA2302347C (en) 2008-06-17
PE122899A1 (es) 1999-12-06
BR9812443A (pt) 2000-09-26
SK284670B6 (sk) 2005-08-04
TW505645B (en) 2002-10-11
EP1015433B1 (de) 2004-05-26
IL134572A0 (en) 2001-04-30
SA98190765B1 (ar) 2006-06-10
ZA988285B (en) 1999-03-12
ES2222612T3 (es) 2005-02-01
NO20001288D0 (no) 2000-03-10
HUP0004588A3 (en) 2002-10-28
NZ503710A (en) 2002-04-26
DK1015433T3 (da) 2004-09-27
KR20010023879A (ko) 2001-03-26
PL198486B1 (pl) 2008-06-30
YU12000A (sh) 2002-11-15
EE04398B1 (et) 2004-12-15
KR100601008B1 (ko) 2006-07-19
CO5011117A1 (es) 2001-02-28
HRP980502A2 (en) 1999-06-30
PL339061A1 (en) 2000-12-04
TR200000697T2 (tr) 2001-01-22
MY120550A (en) 2005-11-30
IL134572A (en) 2005-05-17
JP3827528B2 (ja) 2006-09-27
EP1015433A1 (de) 2000-07-05
UY25175A1 (es) 2000-12-29
UY25439A1 (es) 1999-11-17
CZ2000894A3 (cs) 2000-09-13
JP2001516747A (ja) 2001-10-02
EE200000129A (et) 2001-02-15
DE19740110A1 (de) 1999-03-18
UA61973C2 (en) 2003-12-15
CN1269790A (zh) 2000-10-11
CZ296909B6 (cs) 2006-07-12
AU751036B2 (en) 2002-08-08
US6455538B1 (en) 2002-09-24
AU9624298A (en) 1999-04-05
PT1015433E (pt) 2004-08-31
BG104232A (en) 2000-10-31
ATE267811T1 (de) 2004-06-15
RS49888B (sr) 2008-08-07
BG64418B1 (bg) 2005-01-31
ID24173A (id) 2000-07-13

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
PNAN Change of the applicant name, address/residence

Owner name: BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG., DE

B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20080911

Year of fee payment: 11

PBON Lapse due to non-payment of renewal fee

Effective date: 20090912