HRP980399B1 - Process for the production of heparin - Google Patents

Process for the production of heparin

Info

Publication number
HRP980399B1
HRP980399B1 HR980399A HRP980399A HRP980399B1 HR P980399 B1 HRP980399 B1 HR P980399B1 HR 980399 A HR980399 A HR 980399A HR P980399 A HRP980399 A HR P980399A HR P980399 B1 HRP980399 B1 HR P980399B1
Authority
HR
Croatia
Prior art keywords
heparin
production
Prior art date
Application number
HR980399A
Other languages
English (en)
Inventor
Francois Egbert Ab Houdenhoven
Adrianus Lambertus Sanders
Petrus Johannes Joseph Zutphen
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of HRP980399A2 publication Critical patent/HRP980399A2/hr
Publication of HRP980399B1 publication Critical patent/HRP980399B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
HR980399A 1997-07-16 1998-07-16 Process for the production of heparin HRP980399B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202213 1997-07-16

Publications (2)

Publication Number Publication Date
HRP980399A2 HRP980399A2 (en) 1999-04-30
HRP980399B1 true HRP980399B1 (en) 2003-04-30

Family

ID=8228564

Family Applications (1)

Application Number Title Priority Date Filing Date
HR980399A HRP980399B1 (en) 1997-07-16 1998-07-16 Process for the production of heparin

Country Status (24)

Country Link
US (1) US6232093B1 (zh)
EP (1) EP0996642B1 (zh)
JP (1) JP4455680B2 (zh)
KR (1) KR100515706B1 (zh)
CN (1) CN1109048C (zh)
AR (1) AR013223A1 (zh)
AT (1) ATE315588T1 (zh)
AU (1) AU739225B2 (zh)
BR (1) BR9810881B1 (zh)
CA (1) CA2294780C (zh)
CZ (1) CZ299281B6 (zh)
DE (1) DE69833205T2 (zh)
DK (1) DK0996642T3 (zh)
ES (1) ES2256954T3 (zh)
HR (1) HRP980399B1 (zh)
HU (1) HU225240B1 (zh)
IL (1) IL133363A (zh)
NO (1) NO320786B1 (zh)
PL (1) PL195526B1 (zh)
TR (1) TR200000086T2 (zh)
TW (1) TW581814B (zh)
UY (1) UY25097A1 (zh)
WO (1) WO1999003893A1 (zh)
ZA (1) ZA986289B (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4828795B2 (ja) * 2002-03-11 2011-11-30 モメンタ ファーマシューティカルズ インコーポレイテッド 硫酸化多糖類の分析
WO2004000035A1 (en) 2002-06-19 2003-12-31 Can Technologies, Inc. Animal feed composition_comprising mucosa byproduct
US6933372B2 (en) * 2003-03-07 2005-08-23 Warner-Lambert Company Method to produce a solid form of heparin
CN100425624C (zh) * 2006-05-11 2008-10-15 中国农业大学 一种同步提取肝素钠和猪肠粘膜抗菌肽的方法
CN100439402C (zh) * 2006-10-12 2008-12-03 孙红 采用卵磷脂液膜分离法提取肝素的方法
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
WO2010110654A1 (en) * 2009-03-24 2010-09-30 Van Hessen Bv Method for preparation of heparin from mucosa
CN102791742B (zh) * 2010-01-19 2014-12-24 动量制药公司 评价肝素制剂
WO2012115952A1 (en) 2011-02-21 2012-08-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
KR101447123B1 (ko) 2014-02-27 2014-10-06 박상협 헤파린의 추출 방법
CN104086672A (zh) * 2014-06-10 2014-10-08 安徽申奥生物科技有限公司 一种粗品肝素钠的生产方法
HRP20231510T1 (hr) 2018-07-11 2024-03-01 Ajinomoto Co., Inc. Postupak enzimskog sulfuriliranja alkohola i amina uz pomoć bakterije iz porodice enterobacteriaceae
KR102180261B1 (ko) * 2019-03-19 2020-11-18 중앙대학교 산학협력단 돈육 부산물 유래 헤파린의 추출 방법
KR102104367B1 (ko) 2019-09-02 2020-04-24 팜앤바이오 주식회사 헤파린나트륨의 제조장치 및 제조방법
CN115028757A (zh) * 2022-06-29 2022-09-09 江苏麦德森制药有限公司 一种肝素钠的脱色方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH617963A5 (zh) * 1973-10-05 1980-06-30 Derivati Organici Lab
HU177887B (en) * 1979-03-21 1982-01-28 Richter Gedeon Vegyeszet Process for preparing a raw material containing heparin
ES2062307T3 (es) * 1989-10-04 1994-12-16 Akzo Nv Un proceso para la fabricacion de glicosaminoglicuronano sulfatado con actividad antitrombotica.
WO1994012524A1 (en) * 1992-11-30 1994-06-09 Celsus, Inc. Protein hydrolysate derived from mucosal tissue

Also Published As

Publication number Publication date
DK0996642T3 (da) 2006-05-08
HUP0003064A2 (hu) 2000-12-28
EP0996642A1 (en) 2000-05-03
CN1109048C (zh) 2003-05-21
KR100515706B1 (ko) 2005-09-15
JP4455680B2 (ja) 2010-04-21
ZA986289B (en) 1999-05-04
AU739225B2 (en) 2001-10-04
AR013223A1 (es) 2000-12-13
CN1264391A (zh) 2000-08-23
TW581814B (en) 2004-04-01
CZ2000138A3 (cs) 2000-07-12
DE69833205T2 (de) 2006-07-20
NO20000189L (no) 2000-03-14
HUP0003064A3 (en) 2003-01-28
CA2294780A1 (en) 1999-01-28
IL133363A (en) 2005-08-31
EP0996642B1 (en) 2006-01-11
DE69833205D1 (de) 2006-04-06
NO20000189D0 (no) 2000-01-14
TR200000086T2 (tr) 2000-08-21
KR20010014387A (ko) 2001-02-26
AU9071598A (en) 1999-02-10
HRP980399A2 (en) 1999-04-30
HU225240B1 (en) 2006-08-28
UY25097A1 (es) 1999-01-11
IL133363A0 (en) 2001-04-30
CA2294780C (en) 2008-03-04
PL338007A1 (en) 2000-09-25
WO1999003893A1 (en) 1999-01-28
NO320786B1 (no) 2006-01-30
ES2256954T3 (es) 2006-07-16
BR9810881B1 (pt) 2009-01-13
CZ299281B6 (cs) 2008-06-04
PL195526B1 (pl) 2007-09-28
BR9810881A (pt) 2000-09-26
JP2002508805A (ja) 2002-03-19
ATE315588T1 (de) 2006-02-15
US6232093B1 (en) 2001-05-15

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Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
PPPP Transfer of rights

Owner name: N.V. ORGANON, NL

PPPP Transfer of rights

Owner name: MSD OSS B.V., NL

PPPP Transfer of rights

Owner name: ORGANON BIOSCIENCES NEDERLAND B.V., NL

Owner name: MERCK SHARP & DOHME B.V., NL

ODRP Renewal fee for the maintenance of a patent

Payment date: 20170711

Year of fee payment: 20

PB20 Patent expired after termination of 20 years

Effective date: 20180716