HRP970671A2 - Novel heterocyclically substituted benzamides and their use - Google Patents
Novel heterocyclically substituted benzamides and their useInfo
- Publication number
- HRP970671A2 HRP970671A2 HR19650975.0A HRP970671A HRP970671A2 HR P970671 A2 HRP970671 A2 HR P970671A2 HR P970671 A HRP970671 A HR P970671A HR P970671 A2 HRP970671 A2 HR P970671A2
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- formula
- phenyl
- hydrogen
- heterocyclic substituted
- Prior art date
Links
- 150000003936 benzamides Chemical class 0.000 title claims description 25
- 229940054066 benzamide antipsychotics Drugs 0.000 title claims description 20
- 108010032088 Calpain Proteins 0.000 claims description 28
- 102000007590 Calpain Human genes 0.000 claims description 28
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 27
- 239000001257 hydrogen Substances 0.000 claims description 25
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 125000000623 heterocyclic group Chemical group 0.000 claims description 24
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 24
- 239000003814 drug Substances 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 15
- 239000000460 chlorine Substances 0.000 claims description 14
- 229910052794 bromium Inorganic materials 0.000 claims description 12
- 229910052801 chlorine Inorganic materials 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 229910052731 fluorine Inorganic materials 0.000 claims description 12
- 238000002360 preparation method Methods 0.000 claims description 12
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 11
- 201000010099 disease Diseases 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 10
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 9
- 208000014674 injury Diseases 0.000 claims description 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 9
- 230000000694 effects Effects 0.000 claims description 7
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- 150000003839 salts Chemical class 0.000 claims description 4
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- 206010061218 Inflammation Diseases 0.000 claims description 3
- 230000004054 inflammatory process Effects 0.000 claims description 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- 208000003890 Coronary Vasospasm Diseases 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
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- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
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- 125000001041 indolyl group Chemical group 0.000 claims description 2
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- 125000001624 naphthyl group Chemical group 0.000 claims description 2
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- 125000004076 pyridyl group Chemical group 0.000 claims description 2
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 52
- 239000000543 intermediate Substances 0.000 description 31
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- 239000003112 inhibitor Substances 0.000 description 23
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 21
- 238000000034 method Methods 0.000 description 20
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 18
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 8
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- 125000005605 benzo group Chemical group 0.000 description 8
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- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 description 8
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/66—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19650975A DE19650975A1 (de) | 1996-12-09 | 1996-12-09 | Neue heterocyclisch substituierte Benzamide und deren Anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP970671A2 true HRP970671A2 (en) | 1998-10-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR19650975.0A HRP970671A2 (en) | 1996-12-09 | 1997-12-08 | Novel heterocyclically substituted benzamides and their use |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6172072B1 (xx) |
| EP (1) | EP0946509A1 (xx) |
| JP (1) | JP2001505889A (xx) |
| KR (1) | KR20000057445A (xx) |
| CN (1) | CN1239949A (xx) |
| AR (1) | AR010339A1 (xx) |
| AU (1) | AU742732B2 (xx) |
| BG (1) | BG63388B1 (xx) |
| BR (1) | BR9713884A (xx) |
| CA (1) | CA2273988A1 (xx) |
| CO (1) | CO4910161A1 (xx) |
| CZ (1) | CZ292391B6 (xx) |
| DE (1) | DE19650975A1 (xx) |
| HR (1) | HRP970671A2 (xx) |
| HU (1) | HUP0000496A3 (xx) |
| ID (1) | ID22490A (xx) |
| IL (1) | IL129358A0 (xx) |
| NO (1) | NO992770D0 (xx) |
| NZ (1) | NZ335066A (xx) |
| SK (1) | SK56699A3 (xx) |
| TR (1) | TR199901282T2 (xx) |
| TW (1) | TW420666B (xx) |
| WO (1) | WO1998025899A1 (xx) |
| ZA (1) | ZA9710979B (xx) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR200003071T2 (tr) * | 1998-04-20 | 2001-04-20 | Basf Aktiengesellschaft | Sistein-proteazı önleyici etkiye sahip yeni heterosiklik ikame edilmiş amidler |
| NZ518420A (en) * | 1999-11-05 | 2004-02-27 | Sod Conseils Rech Applic | Heterocyclic compounds having an inhibitory activity on calpains or a trapping activity on reactive oxygen species (ROS's) and their use as medicines |
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| GB8524663D0 (en) * | 1985-10-07 | 1985-11-13 | Fujisawa Pharmaceutical Co | Quinazoline derivatives |
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| EP0473551A1 (de) * | 1990-08-31 | 1992-03-04 | Ciba-Geigy Ag | 3-Aryluracil-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Unkrautbekämpfungsmittel |
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| US5541290A (en) | 1993-06-24 | 1996-07-30 | Harbeson; Scott L. | Optically pure calpain inhibitor compounds |
-
1996
- 1996-12-09 DE DE19650975A patent/DE19650975A1/de not_active Withdrawn
-
1997
- 1997-11-28 KR KR1019990705071A patent/KR20000057445A/ko not_active Application Discontinuation
- 1997-11-28 HU HU0000496A patent/HUP0000496A3/hu unknown
- 1997-11-28 CN CN97180437A patent/CN1239949A/zh active Pending
- 1997-11-28 CA CA002273988A patent/CA2273988A1/en not_active Abandoned
- 1997-11-28 AU AU55580/98A patent/AU742732B2/en not_active Ceased
- 1997-11-28 NZ NZ335066A patent/NZ335066A/xx unknown
- 1997-11-28 TR TR1999/01282T patent/TR199901282T2/xx unknown
- 1997-11-28 BR BR9713884-3A patent/BR9713884A/pt not_active IP Right Cessation
- 1997-11-28 JP JP52615598A patent/JP2001505889A/ja active Pending
- 1997-11-28 EP EP97952007A patent/EP0946509A1/de not_active Withdrawn
- 1997-11-28 IL IL12935897A patent/IL129358A0/xx unknown
- 1997-11-28 SK SK566-99A patent/SK56699A3/sk unknown
- 1997-11-28 CZ CZ19991743A patent/CZ292391B6/cs not_active IP Right Cessation
- 1997-11-28 US US09/308,350 patent/US6172072B1/en not_active Expired - Fee Related
- 1997-11-28 WO PCT/EP1997/006653 patent/WO1998025899A1/de active IP Right Grant
- 1997-11-28 ID IDW990486D patent/ID22490A/id unknown
- 1997-12-08 HR HR19650975.0A patent/HRP970671A2/hr not_active Application Discontinuation
- 1997-12-08 ZA ZA9710979A patent/ZA9710979B/xx unknown
- 1997-12-08 TW TW086118462A patent/TW420666B/zh active
- 1997-12-09 CO CO97071820A patent/CO4910161A1/es unknown
- 1997-12-09 AR ARP970105766A patent/AR010339A1/es not_active Application Discontinuation
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1999
- 1999-05-12 BG BG103399A patent/BG63388B1/bg unknown
- 1999-06-08 NO NO992770A patent/NO992770D0/no unknown
-
2000
- 2000-09-21 US US09/666,304 patent/US6436949B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ335066A (en) | 2000-03-27 |
| NO992770L (no) | 1999-06-08 |
| CO4910161A1 (es) | 2000-04-24 |
| EP0946509A1 (de) | 1999-10-06 |
| NO992770D0 (no) | 1999-06-08 |
| ZA9710979B (en) | 1999-06-18 |
| HUP0000496A2 (hu) | 2000-09-28 |
| JP2001505889A (ja) | 2001-05-08 |
| KR20000057445A (ko) | 2000-09-15 |
| CN1239949A (zh) | 1999-12-29 |
| CA2273988A1 (en) | 1998-06-18 |
| US6436949B1 (en) | 2002-08-20 |
| SK56699A3 (en) | 1999-10-08 |
| AU742732B2 (en) | 2002-01-10 |
| AU5558098A (en) | 1998-07-03 |
| HUP0000496A3 (en) | 2002-11-28 |
| IL129358A0 (en) | 2000-02-17 |
| CZ292391B6 (cs) | 2003-09-17 |
| BR9713884A (pt) | 2000-02-29 |
| AR010339A1 (es) | 2000-06-07 |
| TR199901282T2 (xx) | 1999-10-21 |
| US6172072B1 (en) | 2001-01-09 |
| CZ174399A3 (cs) | 1999-08-11 |
| WO1998025899A1 (de) | 1998-06-18 |
| DE19650975A1 (de) | 1998-06-10 |
| TW420666B (en) | 2001-02-01 |
| ID22490A (id) | 1999-10-21 |
| BG63388B1 (bg) | 2001-12-29 |
| BG103399A (en) | 2000-01-31 |
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