HRP921322B1 - Organic salts of n,n'-diacetyl cystine - Google Patents

Organic salts of n,n'-diacetyl cystine

Info

Publication number
HRP921322B1
HRP921322B1 HR9103572-5A HRP921322A HRP921322B1 HR P921322 B1 HRP921322 B1 HR P921322B1 HR P921322 A HRP921322 A HR P921322A HR P921322 B1 HRP921322 B1 HR P921322B1
Authority
HR
Croatia
Prior art keywords
organic salts
diacetyl cystine
cystine
diacetyl
salts
Prior art date
Application number
HR9103572-5A
Other languages
English (en)
Inventor
Eric Teneberg
Original Assignee
Eric Teneberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eric Teneberg filed Critical Eric Teneberg
Publication of HRP921322A2 publication Critical patent/HRP921322A2/xx
Publication of HRP921322B1 publication Critical patent/HRP921322B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HR9103572-5A 1991-11-29 1992-11-23 Organic salts of n,n'-diacetyl cystine HRP921322B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103572A SE9103572D0 (sv) 1991-11-29 1991-11-29 Organic salts of n,n'-diacetyl cystine

Publications (2)

Publication Number Publication Date
HRP921322A2 HRP921322A2 (en) 1996-10-31
HRP921322B1 true HRP921322B1 (en) 1998-12-31

Family

ID=20384494

Family Applications (1)

Application Number Title Priority Date Filing Date
HR9103572-5A HRP921322B1 (en) 1991-11-29 1992-11-23 Organic salts of n,n'-diacetyl cystine

Country Status (38)

Country Link
US (5) US5385904A (et)
EP (1) EP0621862B1 (et)
JP (1) JP3302018B2 (et)
KR (1) KR100256185B1 (et)
CN (1) CN1039586C (et)
AP (1) AP350A (et)
AT (1) ATE141913T1 (et)
AU (1) AU657827B2 (et)
CA (1) CA2123516A1 (et)
CZ (1) CZ282085B6 (et)
DE (1) DE69213256T2 (et)
DK (1) DK0621862T3 (et)
DZ (1) DZ1637A1 (et)
EE (1) EE03025B1 (et)
ES (1) ES2090713T3 (et)
FI (1) FI942504A0 (et)
GR (1) GR3021546T3 (et)
HK (1) HK62297A (et)
HR (1) HRP921322B1 (et)
HU (1) HU215390B (et)
IL (1) IL103778A (et)
IS (1) IS1645B (et)
LV (1) LV11949B (et)
MA (1) MA22716A1 (et)
MX (1) MX9206851A (et)
MY (1) MY110523A (et)
NO (1) NO301325B1 (et)
NZ (1) NZ245077A (et)
PL (2) PL171336B1 (et)
RU (1) RU2135468C1 (et)
SE (1) SE9103572D0 (et)
SG (1) SG73962A1 (et)
SI (1) SI9200351A (et)
SK (1) SK281697B6 (et)
TN (1) TNSN92108A1 (et)
WO (1) WO1993011104A1 (et)
YU (1) YU48594B (et)
ZA (1) ZA928739B (et)

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SE9602416D0 (sv) * 1996-06-18 1996-06-18 Astra Ab New forms of an organic salt of N'N-diacetylcystine
US6017959A (en) * 1996-06-18 2000-01-25 Astra Aktiebolag Forms of organic salts of N,N'-diacetylcystine
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US6197749B1 (en) * 1997-10-29 2001-03-06 Ajinomoto Co., Inc. Method of suppressing immune responses by reducing intracellular content of glutathione in macrophages and monocytes
US20030203006A1 (en) * 1997-10-29 2003-10-30 Ajinomoto Co. Inc. Immunomodulator
SE9800932D0 (sv) * 1998-03-20 1998-03-20 Astra Ab New compunds
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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
SE518784C2 (sv) * 2000-12-27 2002-11-19 Nactilus Ab "N-Acetyl-L-cystein med kompositioner för behandling av neoplasier"
KR20040021589A (ko) * 2001-03-13 2004-03-10 아지노모토 가부시키가이샤 화장품 또는 피부 외용제
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DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
CN104436170B (zh) 2004-08-23 2018-02-23 曼金德公司 用于药物输送的二酮哌嗪盐
HUE028623T2 (en) 2005-09-14 2016-12-28 Mannkind Corp Active substance formulation method based on increasing the affinity of the active ingredient for binding to the surface of crystalline microparticles
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US8438729B2 (en) * 2006-03-09 2013-05-14 Canon Kabushiki Kaisha Method of producing liquid discharge head
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
ES2570400T3 (es) 2008-06-13 2016-05-18 Mannkind Corp Un inhalador de polvo seco y un sistema para el suministro de fármacos
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2405963B1 (en) 2009-03-11 2013-11-06 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
JP5784622B2 (ja) 2009-11-03 2015-09-24 マンカインド コーポレ−ション 吸入活動をシミュレートするための装置及び方法
MX359281B (es) 2010-06-21 2018-09-21 Mannkind Corp Sistema y metodos para suministrar un farmaco en polvo seco.
MX353285B (es) 2011-04-01 2018-01-05 Mannkind Corp Paquete de blister para cartuchos farmaceuticos.
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
CN103945859A (zh) 2011-10-24 2014-07-23 曼金德公司 用于治疗疼痛的方法和组合物
CN102491926B (zh) * 2011-12-15 2013-09-25 青岛市药品检验所 一种硫普罗宁二硫化物的制备和纯化方法
WO2014012069A2 (en) 2012-07-12 2014-01-16 Mannkind Corporation Dry powder drug delivery systems and methods
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
KR102321339B1 (ko) 2013-07-18 2021-11-02 맨카인드 코포레이션 열-안정성 건조 분말 약제학적 조성물 및 방법
US11446127B2 (en) 2013-08-05 2022-09-20 Mannkind Corporation Insufflation apparatus and methods
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
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Also Published As

Publication number Publication date
YU48594B (sh) 1998-12-23
ZA928739B (en) 1993-06-09
IS3949A (is) 1993-05-30
US5824681A (en) 1998-10-20
SE9103572D0 (sv) 1991-11-29
JPH07501539A (ja) 1995-02-16
US5385904A (en) 1995-01-31
AP350A (en) 1994-08-09
FI942504A (fi) 1994-05-27
AU3099692A (en) 1993-06-28
US5804582A (en) 1998-09-08
MX9206851A (es) 1993-05-01
NO941968D0 (no) 1994-05-26
TNSN92108A1 (fr) 1993-06-08
FI942504A0 (fi) 1994-05-27
RU2135468C1 (ru) 1999-08-27
CN1039586C (zh) 1998-08-26
AP9200448A0 (en) 1993-01-31
JP3302018B2 (ja) 2002-07-15
NZ245077A (en) 1995-04-27
CA2123516A1 (en) 1993-06-10
YU99092A (sh) 1995-12-04
HK62297A (en) 1997-05-16
NO941968L (no) 1994-05-26
AU657827B2 (en) 1995-03-23
MY110523A (en) 1998-07-31
EP0621862A1 (en) 1994-11-02
HUT70851A (en) 1995-11-28
HRP921322A2 (en) 1996-10-31
CZ282085B6 (cs) 1997-05-14
CZ129794A3 (en) 1995-01-18
SK281697B6 (sk) 2001-06-11
PL171336B1 (en) 1997-04-30
US5650538A (en) 1997-07-22
DE69213256T2 (de) 1997-01-23
HU9401473D0 (en) 1994-08-29
SK63294A3 (en) 1995-02-08
CN1073683A (zh) 1993-06-30
GR3021546T3 (en) 1997-02-28
HU215390B (hu) 1998-12-28
NO301325B1 (no) 1997-10-13
IL103778A0 (en) 1993-04-04
IL103778A (en) 1997-08-14
US5693858A (en) 1997-12-02
LV11949B (en) 1998-07-20
PL170787B1 (en) 1997-01-31
DE69213256D1 (de) 1996-10-02
IS1645B (is) 1997-03-25
KR100256185B1 (ko) 2000-05-15
DK0621862T3 (da) 1996-09-16
WO1993011104A1 (en) 1993-06-10
SG73962A1 (en) 2000-07-18
ATE141913T1 (de) 1996-09-15
ES2090713T3 (es) 1996-10-16
EE03025B1 (et) 1997-08-15
SI9200351A (en) 1993-06-30
EP0621862B1 (en) 1996-08-28
DZ1637A1 (fr) 2002-02-17
LV11949A (lv) 1998-01-20
MA22716A1 (fr) 1993-07-01

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