HRP921157A2 - Transdermal system of applying acetilsalicilyc acid in antithrombosys therapy - Google Patents
Transdermal system of applying acetilsalicilyc acid in antithrombosys therapy Download PDFInfo
- Publication number
- HRP921157A2 HRP921157A2 HR921157A HRP921157A HRP921157A2 HR P921157 A2 HRP921157 A2 HR P921157A2 HR 921157 A HR921157 A HR 921157A HR P921157 A HRP921157 A HR P921157A HR P921157 A2 HRP921157 A2 HR P921157A2
- Authority
- HR
- Croatia
- Prior art keywords
- delivery system
- asa
- transdermal delivery
- acetylsalicylic acid
- active substance
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 229940100640 transdermal system Drugs 0.000 title description 4
- 239000002253 acid Substances 0.000 title description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims abstract description 57
- 229960001138 acetylsalicylic acid Drugs 0.000 claims abstract description 53
- 230000002785 anti-thrombosis Effects 0.000 claims abstract description 11
- 239000003146 anticoagulant agent Substances 0.000 claims abstract description 10
- 239000011159 matrix material Substances 0.000 claims abstract description 8
- 239000013543 active substance Substances 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000012528 membrane Substances 0.000 claims description 10
- 230000037317 transdermal delivery Effects 0.000 claims description 8
- 230000035515 penetration Effects 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 238000004026 adhesive bonding Methods 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 230000007246 mechanism Effects 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000006185 dispersion Substances 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract description 15
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229920001600 hydrophobic polymer Polymers 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 13
- 239000004793 Polystyrene Substances 0.000 description 10
- 229920006267 polyester film Polymers 0.000 description 7
- 239000011241 protective layer Substances 0.000 description 7
- 206010061218 Inflammation Diseases 0.000 description 6
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 6
- 230000004054 inflammatory process Effects 0.000 description 6
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 239000012790 adhesive layer Substances 0.000 description 5
- BODMYPYTCKYRSP-UHFFFAOYSA-N 1,1-dioctylcyclohexane Chemical compound CCCCCCCCC1(CCCCCCCC)CCCCC1 BODMYPYTCKYRSP-UHFFFAOYSA-N 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 230000001754 anti-pyretic effect Effects 0.000 description 4
- 239000002221 antipyretic Substances 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 208000002193 Pain Diseases 0.000 description 3
- 230000001760 anti-analgesic effect Effects 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000007062 hydrolysis Effects 0.000 description 3
- 238000006460 hydrolysis reaction Methods 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 239000003094 microcapsule Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 3
- 229920001195 polyisoprene Polymers 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 230000002265 prevention Effects 0.000 description 3
- 229960004889 salicylic acid Drugs 0.000 description 3
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000011888 foil Substances 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- -1 glycerine ester Chemical class 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 2
- 229940117958 vinyl acetate Drugs 0.000 description 2
- 239000004475 Arginine Substances 0.000 description 1
- 229920004939 Cariflex™ Polymers 0.000 description 1
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010048620 Intracardiac thrombus Diseases 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000007814 Unstable Angina Diseases 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000036765 blood level Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 229960000800 cetrimonium bromide Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 239000003246 corticosteroid Substances 0.000 description 1
- 229960001334 corticosteroids Drugs 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005370 electroosmosis Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000007903 penetration ability Effects 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4142483 | 1991-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP921157A2 true HRP921157A2 (en) | 1994-10-31 |
Family
ID=6447817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR921157A HRP921157A2 (en) | 1991-12-20 | 1992-10-30 | Transdermal system of applying acetilsalicilyc acid in antithrombosys therapy |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US6264978B1 (no) |
| EP (1) | EP0617623B1 (no) |
| JP (1) | JP3748270B2 (no) |
| KR (2) | KR100267442B1 (no) |
| AT (1) | ATE217528T1 (no) |
| AU (1) | AU667067B2 (no) |
| CA (1) | CA2125662C (no) |
| CZ (1) | CZ285190B6 (no) |
| DE (2) | DE4241128C2 (no) |
| DK (1) | DK0617623T3 (no) |
| ES (1) | ES2176197T3 (no) |
| FI (1) | FI113838B (no) |
| HR (1) | HRP921157A2 (no) |
| HU (1) | HU221679B1 (no) |
| IL (1) | IL103917A (no) |
| NO (1) | NO306599B1 (no) |
| NZ (1) | NZ246158A (no) |
| PT (1) | PT617623E (no) |
| SI (1) | SI9200312A (no) |
| SK (1) | SK67094A3 (no) |
| WO (1) | WO1993012799A1 (no) |
| YU (1) | YU75093A (no) |
| ZA (1) | ZA922814B (no) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5240917A (en) * | 1991-04-03 | 1993-08-31 | Keimowitz Rudolph M | Suppression of thromboxane levels by percutaneous administration of aspirin |
| WO1994013302A1 (de) * | 1991-12-20 | 1994-06-23 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Ein acetylsalicylsäure enthaltendes transdermales verabreichungssystem für die antithrombotische therapie und die krebsprophylaxe |
| US6071896A (en) * | 1992-06-16 | 2000-06-06 | Gundersen Clinic, Ltd. | Suppression of thromboxane levels by percutaneous administration of aspirin |
| EP0671916A1 (de) * | 1992-12-07 | 1995-09-20 | LTS Lohmann Therapie-Systeme GmbH & Co. KG | Ein acetylsalicylsäure enthaltendes transdermales verabreichungssystem für die antithrombotische therapie und die krebsprophylaxe |
| DE4332093C2 (de) * | 1993-09-22 | 1995-07-13 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Acetylsalicylsäure und Verfahren zu seiner Herstellung |
| DE4429663C2 (de) * | 1994-08-20 | 1997-09-11 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit Hydrolyseschutz |
| WO1997004757A1 (en) * | 1995-07-27 | 1997-02-13 | Cal International Limited | Transdermal nitrate formulation |
| AU6709096A (en) * | 1995-07-27 | 1997-02-26 | Cal International Limited | Pharmaceutical preparation for percutaneous absorbtion |
| GB2319473A (en) * | 1995-07-27 | 1998-05-27 | Cal Int Ltd | Transdemal patch containing aspirin |
| ES2250983T3 (es) * | 1995-12-26 | 2006-04-16 | Teikoku Seiyaku Kabushiki Kaisha | Utilizacion del acido acetilsalicilico en la fabricacion de un medicamento para el tratamiento de las lesiones de la piel. |
| DE19601487C2 (de) * | 1996-01-17 | 2001-09-13 | Micronas Gmbh | Vorrichtung zum Behandeln von malignen Gewebsveränderungen |
| JPH1112177A (ja) * | 1997-06-25 | 1999-01-19 | Teikoku Seiyaku Co Ltd | 安定なアスピリン含有外用製剤 |
| DE19949252B4 (de) * | 1999-10-13 | 2004-02-12 | Lts Lohmann Therapie-Systeme Ag | Verwendung eines superfiziellen therapeutischen Systems zur topischen Applikation von Acetylsalicylsäure zur Behandlung von Akne-Erkrankungen und Verfahren zu seiner Herstellung |
| JP2001187739A (ja) * | 1999-12-28 | 2001-07-10 | Teikoku Seiyaku Co Ltd | アレルギー性皮膚疾患治療用外用剤 |
| WO2003018023A1 (en) * | 2001-08-23 | 2003-03-06 | Bruce Frome | Compositions and methods for targeting cerebral circulation and treatment of headache |
| US20040248858A1 (en) * | 2003-06-09 | 2004-12-09 | Parghi Kaumil H. | Cure for cancer |
| US20060127463A1 (en) * | 2004-12-15 | 2006-06-15 | Nugara Peter N | Composite structure including a low vinyl acetate layer |
| US20060188558A1 (en) * | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
| EP2610242A1 (en) | 2006-07-09 | 2013-07-03 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of aspirin |
| US20090238763A1 (en) * | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| CN101688370A (zh) * | 2007-05-09 | 2010-03-31 | 巴科曼实验室国际公司 | 用于纸或纸板的烯基琥珀酸酐施胶乳液 |
| CN101687792B (zh) * | 2007-06-04 | 2016-03-02 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其医药用途 |
| RU2630577C2 (ru) | 2008-12-04 | 2017-09-11 | Чунси ЮЙ | Композиции интенсивного проникновения и их применение |
| WO2011076401A1 (de) | 2009-12-23 | 2011-06-30 | Holger Schankin | Acetylsalicylsäure-haltige, im wesentlichen wasserfreie pharmazeutische zusammensetzungen |
| AU2013262320B2 (en) | 2012-05-16 | 2018-02-22 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions and pharmaceutical composition thereof for treatment of pulmonary conditions |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3996934A (en) * | 1971-08-09 | 1976-12-14 | Alza Corporation | Medical bandage |
| US3742951A (en) * | 1971-08-09 | 1973-07-03 | Alza Corp | Bandage for controlled release of vasodilators |
| FR2297612A1 (fr) | 1975-01-20 | 1976-08-13 | Moorleghem Guy Van | Procede de fabrication d'un produit analgesique a usage externe |
| US4012508A (en) | 1975-02-03 | 1977-03-15 | Burton Verna M | Topical composition and method |
| US4219548A (en) | 1978-09-01 | 1980-08-26 | The Procter & Gamble Company | Topical anti-inflammatory composition |
| FR2496459A1 (fr) | 1980-12-19 | 1982-06-25 | Astier Laboratoires Docteur P | Composition pharmaceutique sous forme d'un gel contenant de l'acide acetylsalicylique |
| US4460368A (en) * | 1981-10-29 | 1984-07-17 | Almedco, Inc. | Trans-dermal medication system |
| IL68965A (en) | 1983-06-13 | 1987-02-27 | Rafa Labor Ltd | Topical pharmaceutical preparation comprising acetylsalicylic acid for the treatment of dermatological disorders |
| US4640689A (en) * | 1983-08-18 | 1987-02-03 | Drug Delivery Systems Inc. | Transdermal drug applicator and electrodes therefor |
| EP0162239B1 (en) | 1984-04-23 | 1991-08-07 | Kao Corporation | Percutaneous absorption accelerator and preparation containing same |
| JPS61167615A (ja) | 1985-01-18 | 1986-07-29 | Teisan Seiyaku Kk | 薬剤投与方法 |
| US4810699A (en) | 1987-02-20 | 1989-03-07 | American Home Products Corporation | Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them |
| JPH01203336A (ja) | 1988-02-09 | 1989-08-16 | Teikoku Seiyaku Kk | 経皮・口腔粘膜適用製剤 |
| JPH01242521A (ja) | 1988-03-23 | 1989-09-27 | Nikko Kemikaruzu Kk | 経皮吸収性を高めた消炎鎮痛薬組成物 |
| US4975269A (en) | 1989-07-31 | 1990-12-04 | Leonard Chavkin | Shelf stable aspirin solutions |
| WO1992020343A1 (en) | 1991-04-03 | 1992-11-26 | Gunderson Medical Foundation, Ltd. | Suppression of thromboxane levels by percutaneous administration of aspirin |
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1992
- 1992-10-30 HR HR921157A patent/HRP921157A2/hr not_active Application Discontinuation
- 1992-11-10 SI SI19929200312A patent/SI9200312A/sl unknown
- 1992-11-29 IL IL10391792A patent/IL103917A/en not_active IP Right Cessation
- 1992-12-07 DE DE4241128A patent/DE4241128C2/de not_active Expired - Fee Related
- 1992-12-16 CA CA002125662A patent/CA2125662C/en not_active Expired - Fee Related
- 1992-12-16 DE DE59209956T patent/DE59209956D1/de not_active Expired - Fee Related
- 1992-12-16 ES ES93900057T patent/ES2176197T3/es not_active Expired - Lifetime
- 1992-12-16 PT PT93900057T patent/PT617623E/pt unknown
- 1992-12-16 AU AU31589/93A patent/AU667067B2/en not_active Ceased
- 1992-12-16 WO PCT/EP1992/002914 patent/WO1993012799A1/de active IP Right Grant
- 1992-12-16 JP JP51140593A patent/JP3748270B2/ja not_active Expired - Fee Related
- 1992-12-16 EP EP93900057A patent/EP0617623B1/de not_active Expired - Lifetime
- 1992-12-16 SK SK670-94A patent/SK67094A3/sk unknown
- 1992-12-16 CZ CZ941456A patent/CZ285190B6/cs not_active IP Right Cessation
- 1992-12-16 KR KR1019940702176A patent/KR100267442B1/ko not_active IP Right Cessation
- 1992-12-16 HU HU9401849A patent/HU221679B1/hu not_active IP Right Cessation
- 1992-12-16 NZ NZ246158A patent/NZ246158A/en unknown
- 1992-12-16 AT AT93900057T patent/ATE217528T1/de not_active IP Right Cessation
- 1992-12-16 US US08/256,065 patent/US6264978B1/en not_active Expired - Fee Related
- 1992-12-16 DK DK93900057T patent/DK0617623T3/da active
- 1992-12-18 ZA ZA922814A patent/ZA922814B/xx unknown
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1993
- 1993-11-18 KR KR1019950702301A patent/KR100267359B1/ko not_active IP Right Cessation
- 1993-12-02 YU YU75093A patent/YU75093A/sh unknown
-
1994
- 1994-03-22 US US08/216,089 patent/US5861170A/en not_active Expired - Lifetime
- 1994-06-17 FI FI942922A patent/FI113838B/fi active
- 1994-06-17 NO NO942325A patent/NO306599B1/no not_active IP Right Cessation
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