HRP20251302T1 - Spojevi antagonisti pcsk9 - Google Patents
Spojevi antagonisti pcsk9Info
- Publication number
- HRP20251302T1 HRP20251302T1 HRP20251302TT HRP20251302T HRP20251302T1 HR P20251302 T1 HRP20251302 T1 HR P20251302T1 HR P20251302T T HRP20251302T T HR P20251302TT HR P20251302 T HRP20251302 T HR P20251302T HR P20251302 T1 HRP20251302 T1 HR P20251302T1
- Authority
- HR
- Croatia
- Prior art keywords
- formula
- residue
- pharmaceutically acceptable
- compound according
- acceptable salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6454—Dibasic site splicing serine proteases, e.g. kexin (3.4.21.61); furin (3.4.21.75) and other proprotein convertases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21061—Kexin (3.4.21.61), i.e. proprotein convertase subtilisin/kexin type 9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862687913P | 2018-06-21 | 2018-06-21 | |
| EP19739801.9A EP3810626B1 (en) | 2018-06-21 | 2019-06-20 | Pcsk9 antagonist compounds |
| PCT/US2019/038155 WO2019246349A1 (en) | 2018-06-21 | 2019-06-20 | Pcsk9 antagonist compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20251302T1 true HRP20251302T1 (hr) | 2025-12-19 |
Family
ID=67263083
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20251302TT HRP20251302T1 (hr) | 2018-06-21 | 2019-06-20 | Spojevi antagonisti pcsk9 |
Country Status (38)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100558932B1 (ko) * | 2005-04-21 | 2006-03-10 | 주식회사 엠제이스마트 테크놀러지 | 다공성 세라믹 분리막 제조방법과, 이에 의해 제조되어진 다공성 세라믹 분리막 |
| EP4091624A1 (en) | 2013-03-15 | 2022-11-23 | Protagonist Therapeutics, Inc. | Hepcidin analogues and uses thereof |
| CA2949215C (en) | 2014-05-16 | 2023-03-14 | Protagonist Therapeutics, Inc. | .alpha.4.beta.7 integrin thioether peptide antagonists |
| SG10201810154WA (en) | 2014-07-17 | 2018-12-28 | Protagonist Therapeutics Inc | Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases |
| WO2018022937A1 (en) | 2016-07-27 | 2018-02-01 | Protagonist Therapeutics, Inc. | Peptide inhibitors of interleukin-23 and their use to treat inflammatory diseases |
| WO2019157268A1 (en) | 2018-02-08 | 2019-08-15 | Protagonist Therapeutics, Inc. | Conjugated hepcidin mimetics |
| US11814444B2 (en) | 2018-06-21 | 2023-11-14 | Ra Pharmaceuticals, Inc. | Cyclic polypeptides for PCSK9 inhibition |
| KR20250161677A (ko) | 2018-06-21 | 2025-11-17 | 머크 샤프 앤드 돔 엘엘씨 | Pcsk9 길항제 화합물 |
| EP3810129B1 (en) | 2018-06-21 | 2023-08-16 | Merck Sharp & Dohme LLC | Pcsk9 antagonist bicyclo-compounds |
| EP3810178A4 (en) | 2018-06-21 | 2022-05-04 | Merck Sharp & Dohme Corp. | CYCLIC POLYPEPTIDES TO INHIBIT PCSK9 |
| WO2019246405A1 (en) | 2018-06-21 | 2019-12-26 | Merck Sharp & Dohme Corp. | Cyclic polypeptides for pcsk9 inhibition |
| ES3015132T3 (en) | 2018-06-21 | 2025-04-29 | Ucb Holdings Inc | Cyclic polypeptides for pcsk9 inhibition |
| EP4021919A1 (en) | 2019-08-30 | 2022-07-06 | Merck Sharp & Dohme Corp. | Pcsk9 antagonist compounds |
| US12577259B2 (en) | 2019-12-20 | 2026-03-17 | Merck Sharp & Dohme Llc | PCSK9 antagonist compounds |
| SMT202500254T1 (it) | 2020-01-15 | 2025-09-12 | Janssen Biotech Inc | Inibitori peptidici del recettore dell'interleuchina-23 e loro uso per trattare malattie infiammatorie |
| MX2022008740A (es) | 2020-01-15 | 2022-09-23 | Janssen Biotech Inc | Peptidos inhibidores del receptor de interleucina-23 y su uso para tratar enfermedades inflamatorias. |
| AU2021383828A1 (en) | 2020-11-20 | 2023-07-06 | Janssen Pharmaceutica Nv | Compositions of peptide inhibitors of interleukin-23 receptor |
| US11932705B2 (en) | 2020-12-18 | 2024-03-19 | Merck Sharp & Dohme Llc | Cyclic polypeptides for PCSK9 inhibition |
| KR20240034224A (ko) | 2021-07-14 | 2024-03-13 | 얀센 바이오테크 인코포레이티드 | 인터류킨-23 수용체의 지질화된 펩티드 억제제 |
| MX2024002146A (es) * | 2021-08-19 | 2024-03-08 | Merck Sharp & Dohme Llc | Compuestos para el tratamiento de afecciones relacionadas con la actividad de pcsk9. |
| SI4540267T1 (sl) | 2022-06-15 | 2026-07-31 | Merck Sharp & Dohme Llc | Ciklični peptidi za ujetje interlevkina-1 beta |
| JP7866141B2 (ja) * | 2022-08-17 | 2026-05-26 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｐｃｓｋ９阻害薬の結晶形態、組成物及び使用 |
| WO2024259310A2 (en) * | 2023-06-15 | 2024-12-19 | Merck Sharp & Dohme Llc | Passive permeable pcsk9 antagonist compounds |
| IL328311A (en) | 2023-11-14 | 2026-07-01 | Merck Sharp & Dohme Llc | Cyclic peptide for capturing Interleukin-1 Beta |
| AU2024401721A1 (en) | 2023-12-15 | 2026-07-16 | Merck Sharp & Dohme Llc | A cyclic peptide il-1beta trap for the treatment of atherosclerosis and inflammatory disorders |
| WO2025242221A1 (zh) * | 2024-05-24 | 2025-11-27 | 上海翰森生物医药科技有限公司 | 新型修饰侧链、其制备方法和应用 |
| WO2025264781A1 (en) * | 2024-06-18 | 2025-12-26 | Kemira Oy J | Cationizing agents for saccharides and methods |
| WO2026019622A1 (en) * | 2024-07-15 | 2026-01-22 | Merck Sharp & Dohme Llc | Crystal forms of a cyclictetrapeptide and processes for preparing |
| WO2026019624A1 (en) * | 2024-07-15 | 2026-01-22 | Merck Sharp & Dohme Llc | Synthesis of cyclic oligopeptides |
| WO2026032253A1 (zh) * | 2024-08-06 | 2026-02-12 | 石药集团中奇制药技术（石家庄）有限公司 | 环肽类似物及其制备方法和用途 |
| WO2026034639A1 (ja) * | 2024-08-09 | 2026-02-12 | 株式会社Spin Wave | ペプチド合成用可溶性担体およびこれを用いた合成方法 |
| CN119930471A (zh) * | 2024-12-31 | 2025-05-06 | 苏州默迪夫生物科技有限公司 | Mk-a的制备方法、所用的中间体及其合成方法 |
| CN122464947A (zh) * | 2025-01-25 | 2026-07-28 | 深圳市祥根生物有限公司 | 一种环肽类pcsk9抑制剂和用途 |
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| WO2019246405A1 (en) | 2018-06-21 | 2019-12-26 | Merck Sharp & Dohme Corp. | Cyclic polypeptides for pcsk9 inhibition |
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| KR20250161677A (ko) | 2018-06-21 | 2025-11-17 | 머크 샤프 앤드 돔 엘엘씨 | Pcsk9 길항제 화합물 |
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| EP3810178A4 (en) | 2018-06-21 | 2022-05-04 | Merck Sharp & Dohme Corp. | CYCLIC POLYPEPTIDES TO INHIBIT PCSK9 |
| EP3810129B1 (en) | 2018-06-21 | 2023-08-16 | Merck Sharp & Dohme LLC | Pcsk9 antagonist bicyclo-compounds |
| EP4021919A1 (en) | 2019-08-30 | 2022-07-06 | Merck Sharp & Dohme Corp. | Pcsk9 antagonist compounds |
| US12577259B2 (en) | 2019-12-20 | 2026-03-17 | Merck Sharp & Dohme Llc | PCSK9 antagonist compounds |
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2019
- 2019-06-20 KR KR1020257037305A patent/KR20250161677A/ko active Pending
- 2019-06-20 IL IL279363A patent/IL279363B2/en unknown
- 2019-06-20 MD MDE20210407T patent/MD3810626T2/ro unknown
- 2019-06-20 SG SG11202012451WA patent/SG11202012451WA/en unknown
- 2019-06-20 GE GEAP201915540A patent/GEP20237506B/en unknown
- 2019-06-20 RS RS20251040A patent/RS67338B1/sr unknown
- 2019-06-20 FI FIEP19739801.9T patent/FI3810626T3/fi active
- 2019-06-20 UA UAA202100205A patent/UA129467C2/uk unknown
- 2019-06-20 JP JP2020570427A patent/JP7112531B2/ja active Active
- 2019-06-20 PL PL19739801.9T patent/PL3810626T3/pl unknown
- 2019-06-20 MA MA52967A patent/MA52967B1/fr unknown
- 2019-06-20 CN CN201980041438.5A patent/CN112313243B/zh active Active
- 2019-06-20 CA CA3102629A patent/CA3102629A1/en active Pending
- 2019-06-20 BR BR112020025274A patent/BR112020025274A8/pt unknown
- 2019-06-20 WO PCT/US2019/038155 patent/WO2019246349A1/en not_active Ceased
- 2019-06-20 EA EA202190086A patent/EA202190086A1/ru unknown
- 2019-06-20 KR KR1020217001723A patent/KR102884527B1/ko active Active
- 2019-06-20 TW TW108121413A patent/TWI840376B/zh active
- 2019-06-20 AU AU2019290163A patent/AU2019290163C1/en active Active
- 2019-06-20 HR HRP20251302TT patent/HRP20251302T1/hr unknown
- 2019-06-20 US US16/446,940 patent/US11427616B2/en active Active
- 2019-06-20 MX MX2020013726A patent/MX2020013726A/es unknown
- 2019-06-20 JO JOP/2019/0150A patent/JOP20190150A1/ar unknown
- 2019-06-20 PE PE2020002109A patent/PE20211584A1/es unknown
- 2019-06-20 IL IL321719A patent/IL321719A/en unknown
- 2019-06-20 EP EP25190624.4A patent/EP4660303A3/en active Pending
- 2019-06-20 DK DK19739801.9T patent/DK3810626T3/da active
- 2019-06-20 CN CN202511151118.9A patent/CN121130044A/zh active Pending
- 2019-06-20 PT PT197398019T patent/PT3810626T/pt unknown
- 2019-06-20 CR CR20210031A patent/CR20210031A/es unknown
- 2019-06-20 SI SI201930951T patent/SI3810626T1/sl unknown
- 2019-06-20 ES ES19739801T patent/ES3047399T3/es active Active
- 2019-06-20 LT LTEPPCT/US2019/038155T patent/LT3810626T/lt unknown
- 2019-06-20 EP EP19739801.9A patent/EP3810626B1/en active Active
- 2019-06-20 GE GEAP202215540A patent/GEAP202215540A/en unknown
- 2019-06-20 HU HUE19739801A patent/HUE073367T2/hu unknown
- 2019-06-21 AR ARP190101718A patent/AR115597A1/es unknown
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2020
- 2020-12-14 NI NI202000101A patent/NI202000101A/es unknown
- 2020-12-16 PH PH12020552187A patent/PH12020552187A1/en unknown
- 2020-12-16 CL CL2020003257A patent/CL2020003257A1/es unknown
- 2020-12-17 DO DO2020000250A patent/DOP2020000250A/es unknown
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2021
- 2021-01-18 EC ECSENADI20213643A patent/ECSP21003643A/es unknown
- 2021-01-19 CO CONC2021/0000456A patent/CO2021000456A2/es unknown
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2022
- 2022-01-05 CL CL2022000027A patent/CL2022000027A1/es unknown
- 2022-06-30 US US17/854,379 patent/US12209145B2/en active Active
- 2022-07-22 JP JP2022117123A patent/JP7607615B2/ja active Active
- 2022-10-25 AU AU2022259744A patent/AU2022259744B2/en active Active
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2024
- 2024-12-16 US US18/982,279 patent/US20250206781A1/en active Pending
- 2024-12-17 JP JP2024220762A patent/JP7855670B2/ja active Active
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