HRP20250718T1 - Kromatografski postupak za kvantifikaciju neionskog surfaktanta u sastavu koji sadrži neionski surfaktant i polipeptid - Google Patents
Kromatografski postupak za kvantifikaciju neionskog surfaktanta u sastavu koji sadrži neionski surfaktant i polipeptidInfo
- Publication number
- HRP20250718T1 HRP20250718T1 HRP20250718TT HRP20250718T HRP20250718T1 HR P20250718 T1 HRP20250718 T1 HR P20250718T1 HR P20250718T T HRP20250718T T HR P20250718TT HR P20250718 T HRP20250718 T HR P20250718T HR P20250718 T1 HRP20250718 T1 HR P20250718T1
- Authority
- HR
- Croatia
- Prior art keywords
- mobile phase
- polypeptide
- process according
- nonionic surfactant
- composition
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375373P | 2016-08-15 | 2016-08-15 | |
| EP17755627.1A EP3497440B1 (en) | 2016-08-15 | 2017-08-14 | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
| PCT/US2017/046725 WO2018035025A1 (en) | 2016-08-15 | 2017-08-14 | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20250718T1 true HRP20250718T1 (hr) | 2025-08-15 |
Family
ID=59687053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20250718TT HRP20250718T1 (hr) | 2016-08-15 | 2017-08-14 | Kromatografski postupak za kvantifikaciju neionskog surfaktanta u sastavu koji sadrži neionski surfaktant i polipeptid |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11333644B2 (https=) |
| EP (1) | EP3497440B1 (https=) |
| JP (1) | JP7286536B2 (https=) |
| KR (1) | KR102617148B1 (https=) |
| CN (2) | CN115598231B (https=) |
| AR (1) | AR109343A1 (https=) |
| AU (2) | AU2017312540B2 (https=) |
| BR (1) | BR112019002979B1 (https=) |
| ES (1) | ES3034020T3 (https=) |
| HR (1) | HRP20250718T1 (https=) |
| HU (1) | HUE071741T2 (https=) |
| IL (1) | IL264582B (https=) |
| MX (2) | MX2019001572A (https=) |
| PL (1) | PL3497440T3 (https=) |
| SG (1) | SG11201901228QA (https=) |
| TW (1) | TWI775770B (https=) |
| WO (1) | WO2018035025A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210139387A1 (en) * | 2016-01-19 | 2021-05-13 | Genebiologics, Llc | Production of Arginine-Rich Proteins from Wastewater and Use as a Fertilizer |
| HRP20250718T1 (hr) | 2016-08-15 | 2025-08-15 | F. Hoffmann-La Roche Ag | Kromatografski postupak za kvantifikaciju neionskog surfaktanta u sastavu koji sadrži neionski surfaktant i polipeptid |
| TWI870390B (zh) * | 2019-02-27 | 2025-01-21 | 法商賽諾菲公司 | 以具內標之lc-ms於樣品中進行聚山梨醇酯定量之方法 |
| CN113424057B (zh) * | 2019-04-19 | 2024-04-05 | 海正生物制药有限公司 | 组合物中泊洛沙姆188的检测方法 |
| JP2022531317A (ja) | 2019-05-03 | 2022-07-06 | ジェネンテック， インコーポレイテッド | 精製プラットフォームから得られた組成物中の酵素加水分解活性速度を低下させる方法 |
| EP4090666A1 (en) | 2020-01-15 | 2022-11-23 | F. Hoffmann-La Roche AG | Methods to decrease impurities from recombinant protein manufacturing processes |
| CA3198684A1 (en) | 2020-10-30 | 2022-05-05 | Genentech, Inc. | Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate |
| BR112023016996A2 (pt) | 2021-02-24 | 2023-09-26 | Hoffmann La Roche | Métodos para purificar um polipeptídeo terapêutico e para produzir um polipeptídeo terapêutico e usos de uma solução ácida e de uma solução alcalina |
| KR102283871B1 (ko) * | 2021-03-02 | 2021-08-02 | 한국원자력연구원 | 크로마토그래피를 이용한 무담체 홀뮴-166의 분리 방법, 분리 장치 및 이에 의하여 분리된 무담체 홀뮴-166 |
| AU2022429920A1 (en) * | 2021-12-31 | 2024-07-25 | Kashiv Biosciences, Llc | A process for separation and quantification of non-ionic surfactant |
| WO2024145244A1 (en) * | 2022-12-30 | 2024-07-04 | Eli Lilly And Company | Methods for measuring levels of polysorbate(s) |
| WO2026062617A1 (en) * | 2024-09-23 | 2026-03-26 | Janssen Pharmaceuticals, Inc. | Methods for detection and quantification of surfactants |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61141719A (ja) * | 1984-08-22 | 1986-06-28 | キュノ、インコ−ポレ−テッド | 変性ポリペプチド支持体 |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE3850542T2 (de) | 1987-09-23 | 1994-11-24 | Bristol Myers Squibb Co | Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen. |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| ES2096590T3 (es) | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| US7018809B1 (en) | 1991-09-19 | 2006-03-28 | Genentech, Inc. | Expression of functional antibody fragments |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572A7 (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenete lmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ATE207080T1 (de) | 1991-11-25 | 2001-11-15 | Enzon Inc | Multivalente antigen-bindende proteine |
| CA2372813A1 (en) | 1992-02-06 | 1993-08-19 | L.L. Houston | Biosynthetic binding protein for cancer marker |
| WO1993016177A1 (en) | 1992-02-11 | 1993-08-19 | Cell Genesys, Inc. | Homogenotization of gene-targeting events |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| CA2140280A1 (en) | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
| DK0752248T3 (da) | 1992-11-13 | 2000-11-13 | Idec Pharma Corp | Terapeutisk anvendelse af kimæriske og radioaktivt mærkede antistoffer mod humant B-lymfocytbegrænset differentieringsantig |
| US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| JPH0943218A (ja) * | 1995-08-04 | 1997-02-14 | Kao Corp | 非イオン界面活性剤の分析方法 |
| WO1999050655A1 (en) * | 1998-03-30 | 1999-10-07 | Cell Therapeutics, Inc. | Methods of separation and detection |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| US8372954B2 (en) | 2000-12-22 | 2013-02-12 | National Research Council Of Canada | Phage display libraries of human VH fragments |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| GB0310347D0 (en) * | 2003-05-07 | 2003-06-11 | Delta Biotechnology Ltd | Assay |
| DE602004017726D1 (de) | 2003-06-30 | 2008-12-24 | Domantis Ltd | Pegylierte Single-domain-antikörper (dAb) |
| AU2005285347A1 (en) | 2004-08-19 | 2006-03-23 | Genentech, Inc. | Polypeptide variants with altered effector function |
| DK1791565T3 (en) | 2004-09-23 | 2016-08-01 | Genentech Inc | Cysteingensplejsede antibodies and conjugates |
| EP1833877A2 (en) * | 2004-12-21 | 2007-09-19 | Baxter International Inc. | (polyalkoxy)sulfonate surface modifiers |
| US7241586B2 (en) * | 2005-02-17 | 2007-07-10 | Medtronic Minimed, Inc. | Polypeptide formulations and methods for making, using and characterizing them |
| WO2010141426A1 (en) | 2009-06-01 | 2010-12-09 | Waters Technologies Corporation | Hybrid material for chromatographic separations |
| US20120294866A1 (en) * | 2010-01-19 | 2012-11-22 | F. Hoffmann-La Roche Ag | Pharmaceutical formulation for proteins |
| KR101976853B1 (ko) | 2010-05-25 | 2019-05-09 | 제넨테크, 인크. | 폴리펩티드의 정제 방법 |
| JP5193266B2 (ja) | 2010-11-16 | 2013-05-08 | 株式会社ミノファーゲン製薬 | 生薬由来成分の高感度定量方法 |
| SG10201606218WA (en) * | 2011-07-29 | 2016-09-29 | Eleven Biotherapeutics Inc | Purified Proteins |
| HUE035685T2 (en) * | 2011-11-02 | 2018-05-28 | Hoffmann La Roche | Overload and elute chromatography |
| JP6129302B2 (ja) * | 2012-05-23 | 2017-05-17 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 混合物中のポリソルベート種の濃度を決定するための方法 |
| HRP20250718T1 (hr) | 2016-08-15 | 2025-08-15 | F. Hoffmann-La Roche Ag | Kromatografski postupak za kvantifikaciju neionskog surfaktanta u sastavu koji sadrži neionski surfaktant i polipeptid |
-
2017
- 2017-08-14 HR HRP20250718TT patent/HRP20250718T1/hr unknown
- 2017-08-14 HU HUE17755627A patent/HUE071741T2/hu unknown
- 2017-08-14 MX MX2019001572A patent/MX2019001572A/es unknown
- 2017-08-14 AU AU2017312540A patent/AU2017312540B2/en active Active
- 2017-08-14 ES ES17755627T patent/ES3034020T3/es active Active
- 2017-08-14 WO PCT/US2017/046725 patent/WO2018035025A1/en not_active Ceased
- 2017-08-14 EP EP17755627.1A patent/EP3497440B1/en active Active
- 2017-08-14 CN CN202210633310.1A patent/CN115598231B/zh active Active
- 2017-08-14 CN CN201780057815.5A patent/CN109716127B/zh active Active
- 2017-08-14 JP JP2019507829A patent/JP7286536B2/ja active Active
- 2017-08-14 KR KR1020197007446A patent/KR102617148B1/ko active Active
- 2017-08-14 SG SG11201901228QA patent/SG11201901228QA/en unknown
- 2017-08-14 PL PL17755627.1T patent/PL3497440T3/pl unknown
- 2017-08-14 BR BR112019002979-6A patent/BR112019002979B1/pt active IP Right Grant
- 2017-08-15 TW TW106127636A patent/TWI775770B/zh active
- 2017-08-15 AR ARP170102272A patent/AR109343A1/es unknown
-
2019
- 2019-01-31 IL IL264582A patent/IL264582B/en unknown
- 2019-02-07 MX MX2024006922A patent/MX2024006922A/es unknown
- 2019-02-14 US US16/275,849 patent/US11333644B2/en active Active
-
2022
- 2022-04-11 US US17/718,162 patent/US11680931B2/en active Active
- 2022-12-21 AU AU2022291517A patent/AU2022291517B2/en active Active
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