SG11201901228QA - Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide - Google Patents
Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptideInfo
- Publication number
- SG11201901228QA SG11201901228QA SG11201901228QA SG11201901228QA SG11201901228QA SG 11201901228Q A SG11201901228Q A SG 11201901228QA SG 11201901228Q A SG11201901228Q A SG 11201901228QA SG 11201901228Q A SG11201901228Q A SG 11201901228QA SG 11201901228Q A SG11201901228Q A SG 11201901228QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- ionic surfactant
- polypeptide
- san francisco
- south san
- Prior art date
Links
- 239000002736 nonionic surfactant Substances 0.000 title abstract 6
- 229920001184 polypeptide Polymers 0.000 title abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 238000004587 chromatography analysis Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- DZTHIGRZJZPRDV-GFCCVEGCSA-N N-acetyl-D-tryptophan Chemical compound C1=CC=C2C(C[C@@H](NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-GFCCVEGCSA-N 0.000 abstract 2
- DZTHIGRZJZPRDV-UHFFFAOYSA-N Nalpha-Acetyltryptophan Natural products C1=CC=C2C(CC(NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 229940116191 n-acetyltryptophan Drugs 0.000 abstract 2
- 238000011002 quantification Methods 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- 102100038968 WAP four-disulfide core domain protein 1 Human genes 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 239000002563 ionic surfactant Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/36—Control of physical parameters of the fluid carrier in high pressure liquid systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662375373P | 2016-08-15 | 2016-08-15 | |
| PCT/US2017/046725 WO2018035025A1 (en) | 2016-08-15 | 2017-08-14 | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201901228QA true SG11201901228QA (en) | 2019-03-28 |
Family
ID=59687053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201901228QA SG11201901228QA (en) | 2016-08-15 | 2017-08-14 | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US11333644B2 (https=) |
| EP (1) | EP3497440B1 (https=) |
| JP (1) | JP7286536B2 (https=) |
| KR (1) | KR102617148B1 (https=) |
| CN (2) | CN115598231B (https=) |
| AR (1) | AR109343A1 (https=) |
| AU (2) | AU2017312540B2 (https=) |
| BR (1) | BR112019002979B1 (https=) |
| ES (1) | ES3034020T3 (https=) |
| HR (1) | HRP20250718T1 (https=) |
| HU (1) | HUE071741T2 (https=) |
| IL (1) | IL264582B (https=) |
| MX (2) | MX2019001572A (https=) |
| PL (1) | PL3497440T3 (https=) |
| SG (1) | SG11201901228QA (https=) |
| TW (1) | TWI775770B (https=) |
| WO (1) | WO2018035025A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20210139387A1 (en) * | 2016-01-19 | 2021-05-13 | Genebiologics, Llc | Production of Arginine-Rich Proteins from Wastewater and Use as a Fertilizer |
| HRP20250718T1 (hr) | 2016-08-15 | 2025-08-15 | F. Hoffmann-La Roche Ag | Kromatografski postupak za kvantifikaciju neionskog surfaktanta u sastavu koji sadrži neionski surfaktant i polipeptid |
| TWI870390B (zh) * | 2019-02-27 | 2025-01-21 | 法商賽諾菲公司 | 以具內標之lc-ms於樣品中進行聚山梨醇酯定量之方法 |
| CN113424057B (zh) * | 2019-04-19 | 2024-04-05 | 海正生物制药有限公司 | 组合物中泊洛沙姆188的检测方法 |
| JP2022531317A (ja) | 2019-05-03 | 2022-07-06 | ジェネンテック， インコーポレイテッド | 精製プラットフォームから得られた組成物中の酵素加水分解活性速度を低下させる方法 |
| EP4090666A1 (en) | 2020-01-15 | 2022-11-23 | F. Hoffmann-La Roche AG | Methods to decrease impurities from recombinant protein manufacturing processes |
| CA3198684A1 (en) | 2020-10-30 | 2022-05-05 | Genentech, Inc. | Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate |
| BR112023016996A2 (pt) | 2021-02-24 | 2023-09-26 | Hoffmann La Roche | Métodos para purificar um polipeptídeo terapêutico e para produzir um polipeptídeo terapêutico e usos de uma solução ácida e de uma solução alcalina |
| KR102283871B1 (ko) * | 2021-03-02 | 2021-08-02 | 한국원자력연구원 | 크로마토그래피를 이용한 무담체 홀뮴-166의 분리 방법, 분리 장치 및 이에 의하여 분리된 무담체 홀뮴-166 |
| AU2022429920A1 (en) * | 2021-12-31 | 2024-07-25 | Kashiv Biosciences, Llc | A process for separation and quantification of non-ionic surfactant |
| WO2024145244A1 (en) * | 2022-12-30 | 2024-07-04 | Eli Lilly And Company | Methods for measuring levels of polysorbate(s) |
| WO2026062617A1 (en) * | 2024-09-23 | 2026-03-26 | Janssen Pharmaceuticals, Inc. | Methods for detection and quantification of surfactants |
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| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61141719A (ja) * | 1984-08-22 | 1986-06-28 | キュノ、インコ−ポレ−テッド | 変性ポリペプチド支持体 |
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| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| DE3850542T2 (de) | 1987-09-23 | 1994-11-24 | Bristol Myers Squibb Co | Antikörper-Heterokonjugate zur Töting von HIV-infizierten Zellen. |
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| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
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| HRP20250718T1 (hr) | 2016-08-15 | 2025-08-15 | F. Hoffmann-La Roche Ag | Kromatografski postupak za kvantifikaciju neionskog surfaktanta u sastavu koji sadrži neionski surfaktant i polipeptid |
-
2017
- 2017-08-14 HR HRP20250718TT patent/HRP20250718T1/hr unknown
- 2017-08-14 HU HUE17755627A patent/HUE071741T2/hu unknown
- 2017-08-14 MX MX2019001572A patent/MX2019001572A/es unknown
- 2017-08-14 AU AU2017312540A patent/AU2017312540B2/en active Active
- 2017-08-14 ES ES17755627T patent/ES3034020T3/es active Active
- 2017-08-14 WO PCT/US2017/046725 patent/WO2018035025A1/en not_active Ceased
- 2017-08-14 EP EP17755627.1A patent/EP3497440B1/en active Active
- 2017-08-14 CN CN202210633310.1A patent/CN115598231B/zh active Active
- 2017-08-14 CN CN201780057815.5A patent/CN109716127B/zh active Active
- 2017-08-14 JP JP2019507829A patent/JP7286536B2/ja active Active
- 2017-08-14 KR KR1020197007446A patent/KR102617148B1/ko active Active
- 2017-08-14 SG SG11201901228QA patent/SG11201901228QA/en unknown
- 2017-08-14 PL PL17755627.1T patent/PL3497440T3/pl unknown
- 2017-08-14 BR BR112019002979-6A patent/BR112019002979B1/pt active IP Right Grant
- 2017-08-15 TW TW106127636A patent/TWI775770B/zh active
- 2017-08-15 AR ARP170102272A patent/AR109343A1/es unknown
-
2019
- 2019-01-31 IL IL264582A patent/IL264582B/en unknown
- 2019-02-07 MX MX2024006922A patent/MX2024006922A/es unknown
- 2019-02-14 US US16/275,849 patent/US11333644B2/en active Active
-
2022
- 2022-04-11 US US17/718,162 patent/US11680931B2/en active Active
- 2022-12-21 AU AU2022291517A patent/AU2022291517B2/en active Active
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