HRP20240120T1 - Nova farmaceutska formulacija koja sadrži dvojne antagoniste nk-1/nk-3 receptora - Google Patents
Nova farmaceutska formulacija koja sadrži dvojne antagoniste nk-1/nk-3 receptora Download PDFInfo
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- HRP20240120T1 HRP20240120T1 HRP20240120TT HRP20240120T HRP20240120T1 HR P20240120 T1 HRP20240120 T1 HR P20240120T1 HR P20240120T T HRP20240120T T HR P20240120TT HR P20240120 T HRP20240120 T HR P20240120T HR P20240120 T1 HRP20240120 T1 HR P20240120T1
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- soft gelatin
- gelatin capsule
- capsule formulation
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- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
- 102000002003 Neurokinin-3 Receptors Human genes 0.000 title 1
- 108010040716 Neurokinin-3 Receptors Proteins 0.000 title 1
- 230000009977 dual effect Effects 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 21
- 239000007903 gelatin capsule Substances 0.000 claims 20
- 238000009472 formulation Methods 0.000 claims 18
- 229940126062 Compound A Drugs 0.000 claims 8
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 8
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 7
- 229920000053 polysorbate 80 Polymers 0.000 claims 7
- 229940068968 polysorbate 80 Drugs 0.000 claims 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical group OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 6
- 125000005456 glyceride group Chemical group 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 6
- 239000000263 2,3-dihydroxypropyl (Z)-octadec-9-enoate Substances 0.000 claims 5
- RZRNAYUHWVFMIP-GDCKJWNLSA-N 3-oleoyl-sn-glycerol Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-GDCKJWNLSA-N 0.000 claims 5
- RZRNAYUHWVFMIP-UHFFFAOYSA-N monoelaidin Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-UHFFFAOYSA-N 0.000 claims 5
- 239000003963 antioxidant agent Substances 0.000 claims 3
- 230000003078 antioxidant effect Effects 0.000 claims 3
- 235000006708 antioxidants Nutrition 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003163 gonadal steroid hormone Substances 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims 2
- 206010027566 Micturition urgency Diseases 0.000 claims 2
- 206010033307 Overweight Diseases 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 2
- 210000000577 adipose tissue Anatomy 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims 2
- 206010013990 dysuria Diseases 0.000 claims 2
- 239000003995 emulsifying agent Substances 0.000 claims 2
- 206010022437 insomnia Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000001575 pathological effect Effects 0.000 claims 2
- 201000010065 polycystic ovary syndrome Diseases 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 230000001457 vasomotor Effects 0.000 claims 2
- 201000009273 Endometriosis Diseases 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229920002685 Polyoxyl 35CastorOil Polymers 0.000 claims 1
- 206010046798 Uterine leiomyoma Diseases 0.000 claims 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 201000010260 leiomyoma Diseases 0.000 claims 1
- 230000009245 menopause Effects 0.000 claims 1
- 208000007106 menorrhagia Diseases 0.000 claims 1
- DWRIJNIPBUFCQS-DQEYMECFSA-N n-[6-[(7s,9as)-7-(hydroxymethyl)-3,4,6,7,9,9a-hexahydro-1h-pyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-2-[3,5-bis(trifluoromethyl)phenyl]-n,2-dimethylpropanamide Chemical compound C=1N=C(N2[C@@H](CN3CCOC[C@@H]3C2)CO)C=C(C=2C(=CC(F)=CC=2)C)C=1N(C)C(=O)C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 DWRIJNIPBUFCQS-DQEYMECFSA-N 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000022925 sleep disturbance Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 208000010579 uterine corpus leiomyoma Diseases 0.000 claims 1
- 201000007954 uterine fibroid Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (18)
1. Formulacija meke želatinske kapsule, koja sadrži:
(a) 2-[3,5-Bis(trifluorometil)fenil]-N-{4-(4-fluoro-2-metilfenil)-6-[(7S,9aS)-7-(hidroksimetil)heksahidropirazino[2,1-c] [1,4]oksazin-8(1H)-il]-3-piridinil}-N,2-dimetilpropanamid (Spoj A):
[image]
ili njegovu farmaceutski prihvatljivu sol; i
(b) najmanje jedan solubilizator odabran između kaprilokaproil polioksil-8 glicerida, glicerol monokaprilokaprata, polioksil 35 ricinusovog ulja, polisorbata 80 ili njihovih smjesa.
2. Formulacija meke želatinske kapsule prema zahtjevu 1, naznačena time što nadalje sadrži antioksidant.
3. Formulacija meke želatinske kapsule prema zahtjevu 1 ili 2, naznačena time što nadalje sadrži emulgator.
4. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 1-3, naznačena time što nadalje sadrži jedno ili više dodatnih terapijskih sredstava.
5. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 1-4, naznačena time što je količina Spoja A u farmaceutskoj formulaciji u rasponu od 10 mg do 80 mg.
6. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 1-5 , naznačena time što je solubilizator smjesa glicerol monokaprilokaprata kaprilokaproil polioksil-8 glicerida i polisorbata 80, pri čemu se koncentracija glicerol monokaprilokapratera kreće u rasponu od 30% m/m do 40% m/m, koncentracija kaprilokaproil polioksil-8 glicerida se kreće u rasponu od 9% m/m do 10% m/m, koncentracija polisorbata 80 se kreće u rasponu od 9% m/m do 10% m/m.
7. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 3-6, naznačena time što je emulgator gliceril monooleat
8. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 2-7, naznačena time što je antioksidant odabran između DL-alfa tokoferola (vitamin E), butiliranog hidroksitoluena (BHT) i butiliranog hidroksianizola (BHA) ili njihovih smjesa.
9. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 2- 8, naznačena time što je antioksidant DL-alfa tokoferol (vitamin E) u koncentraciji u rasponu od 0,05% m/m do 1,5% m/m.
10. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 1-9, naznačena time što sadrži spoj A, glicerol monokaprilokaprat, polisorbat 80, gliceril monooleat i DL-alfa tokoferol (vitamin E).
11. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 1-10, naznačena time što sadrži spoj A, glicerol monokaprilokaprat, kaprilokaproil polioksil-8 gliceride, polisorbat 80, gliceril monooleat i DL-alfa tokoferol (vitamin E).
12. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 1-11, naznačena time što sadrži:
(a) Spoj A od oko 1% m/m do oko 10% m/m;
(b1) glicerol monokaprilokaprat prisutan u koncentraciji u rasponu od 30% m/m do 40% m/m;
(b2) kaprilokaproil polioksil-8 gliceride prisutne u koncentraciji u rasponu od 7% m/m do 13% m/m;
(b3) Polisorbat 80 prisutan u koncentraciji od 7% m/m do 13% m/m
(c) gliceril monooleat prisutan u koncentraciji u rasponu od oko 33% m/m do 43% m/m; i
(d) DL-alfa tokoferol (vitamin E) prisutan u koncentraciji u rasponu od 0,05% m/m do 1,5% m/m.
13. Formulacija meke želatinske kapsule prema bilo kojem od zahtjeva 1-12, naznačena time što sadrži:
(a) Spoj A prisutan u koncentraciji od 5 % m/m;
(b1) glicerol monokaprilokaprat prisutan u koncentraciji od 37,05 % m/m;
(b2) kaprilokaproil polioksil-8 gliceride prisutne u koncentraciji od 9,5 % m/m;
(b3) Polisorbat 80 prisutan u koncentraciji od 9,5 % m/m;
(c) gliceril monooleat prisutan u koncentraciji od 38 % m/m; i
(d) DL-alfa tokoferol (vitamin E) prisutan u koncentraciji od 0,95 % m/m.
14. Formulacija meke želatinske kapsule prema zahtjevima 1-13, za upotrebu u liječenju ili prevenciji bolesti ovisne o spolnim hormonima, ili u liječenju ili prevenciji stanja, gdje je stanje simptom povezan s perimenopauzom, menopauza, ili postmenopauza odabrana od patološkog porasta prekomjerne tjelesne masti i/ili prekomjerne tjelesne težine, nesanice, poremećaja spavanja i noćnih buđenja, tjeskobe i depresije, simptoma hitnosti mokrenja i disurije; ili pri čemu je stanje simptom povezan s andropauzom odabran od patološkog porasta viška tjelesne masti i/ili prekomjerne tjelesne težine, nesanice, poremećaja spavanja i noćnih buđenja, anksioznosti i depresije, simptoma hitnosti mokrenja i disurije.
15. Formulacija meke želatinske kapsule za upotrebu prema zahtjevu 14, naznačena time što je bolest ovisna o spolnim hormonima odabrana između endometrioze, fibroidnog tumora maternice, teškog menstrualnog krvarenja, sindroma policističnih jajnika (PCOS) i vazomotornih simptoma.
16. Formulacija meke želatinske kapsule za upotrebu prema zahtjevu 14, naznačena time što je bolest ovisna o spolnim hormonima vazomotorni simptomi.
17. Postupak za proizvodnju meke želatinske kapsule, koji se sastoji od koraka osiguravanja ovojnice meke želatinske kapsule, miješanja formulacije meke želatinske kapsule koja sadrži spoj A ili njegove farmaceutski prihvatljive soli i najmanje jednu pomoćnu tvar, i ugradnje formulacije meke želatinske kapsule u želatinsku ovojnicu kapsule.
18. Postupak prema zahtjevu 17, naznačen time što je Spoj A u bezvodnom kristalnom obliku 1.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862642622P | 2018-03-14 | 2018-03-14 | |
| PCT/EP2019/056303 WO2019175253A1 (en) | 2018-03-14 | 2019-03-13 | Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists |
| EP19711866.4A EP3765024B1 (en) | 2018-03-14 | 2019-03-13 | Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240120T1 true HRP20240120T1 (hr) | 2024-04-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| HRP20240120TT HRP20240120T1 (hr) | 2018-03-14 | 2019-03-13 | Nova farmaceutska formulacija koja sadrži dvojne antagoniste nk-1/nk-3 receptora |
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| Country | Link |
|---|---|
| US (5) | US10774091B2 (hr) |
| EP (1) | EP3765024B1 (hr) |
| JP (1) | JP7433252B2 (hr) |
| KR (1) | KR20200139138A (hr) |
| CN (1) | CN112292132A (hr) |
| AU (1) | AU2019233606A1 (hr) |
| BR (1) | BR112020017388A2 (hr) |
| CA (1) | CA3092238A1 (hr) |
| CL (1) | CL2020002350A1 (hr) |
| CO (1) | CO2020011262A2 (hr) |
| CR (1) | CR20200385A (hr) |
| DK (1) | DK3765024T3 (hr) |
| EA (1) | EA202092131A1 (hr) |
| EC (1) | ECSP20057488A (hr) |
| FI (1) | FI3765024T3 (hr) |
| GE (1) | GEP20237503B (hr) |
| HR (1) | HRP20240120T1 (hr) |
| IL (1) | IL276959B1 (hr) |
| JO (1) | JOP20200227A1 (hr) |
| LT (1) | LT3765024T (hr) |
| MA (1) | MA51999B1 (hr) |
| MX (2) | MX2020009438A (hr) |
| PE (1) | PE20210395A1 (hr) |
| PH (1) | PH12020551457A1 (hr) |
| PT (1) | PT3765024T (hr) |
| RS (1) | RS65257B1 (hr) |
| SG (1) | SG11202008226YA (hr) |
| WO (1) | WO2019175253A1 (hr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2017326611A1 (en) | 2016-09-18 | 2019-05-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | YAP1 inhibitors that target the interaction of YAP1 with Oct4 |
| EP3765015A4 (en) | 2018-03-14 | 2021-12-15 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | YAP1 INHIBITORS AGAINST INTERACTION OF YAP1 WITH OCT4 |
| EP3765024B1 (en) | 2018-03-14 | 2023-11-22 | KaNDy Therapeutics Limited | Novel pharmaceutical formulation comprising dual nk-1/nk-3 receptor antagonists. |
| JP2023501666A (ja) | 2019-11-15 | 2023-01-18 | カンディー セラピューティクス リミテッド | Ｎｔ－８１４の重要な中間体である６－クロロ－４－（４－フルオロ－２－メチルフェニル）ピリジン－３－アミンを作製するための新規な化学的方法 |
| KR102484687B1 (ko) * | 2022-03-04 | 2023-01-05 | (주)씨앤엘디 | 페노피브레이트를 포함하는 이상지질혈증의 예방 또는 치료용 약학 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US3097618A (en) | 1960-12-01 | 1963-07-16 | Raymond Bag Corp | Manufacture of multi-wall bag having heat-sealed liner |
| DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
| GB9907571D0 (en) | 1999-04-06 | 1999-05-26 | Zeneca Ltd | Compounds |
| AU7552401A (en) | 2000-06-12 | 2001-12-24 | Univ Rochester | Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist |
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