HRP20231356T1 - Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže - Google Patents
Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže Download PDFInfo
- Publication number
- HRP20231356T1 HRP20231356T1 HRP20231356TT HRP20231356T HRP20231356T1 HR P20231356 T1 HRP20231356 T1 HR P20231356T1 HR P20231356T T HRP20231356T T HR P20231356TT HR P20231356 T HRP20231356 T HR P20231356T HR P20231356 T1 HRP20231356 T1 HR P20231356T1
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- Prior art keywords
- rodent
- heavy chain
- human
- constant region
- region
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- 241000283984 Rodentia Species 0.000 title claims 23
- 241001465754 Metazoa Species 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 230000009261 transgenic effect Effects 0.000 claims 5
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 4
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 210000004408 hybridoma Anatomy 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (9)
1. Transgeni glodavac, te glodavac u svojoj zametnoj liniji sadrži lokus imunoglobulina teškog lanca koji sadrži, u redoslijedu od 5' do 3', genske segmente ljudskog nepreuređenog teškog lanca varijabilnosti (V), raznolikosti (D) i regije spajanja (J), konstantnu regiju teškog lanca glodavca i 3' pojačivač štakora koji sadrže sekvencu navedenu kao SEQ ID NO:1, pri čemu lokus imunoglobulina teškog lanca ne sadrži gen konstantne regije ljudskog imunoglobulina, i pri čemu je glodavac miš ili štakor.
2. Glodavac prema zahtjevu 1, naznačen time što su genski segmenti ljudskog teškog lanca varijabilnosti, raznolikosti i regije spajanja sadržani na segmentu DNA koji je oko 50 do 500 kb ili veći, ili pri čemu su genski segmenti human ljudskog teškog lanca varijabilnosti, raznolikosti i regije spajanja sadržani na segmentu DNA koji ima do 2 megabaze.
3. Glodavac prema zahtjevu 1 ili zahtjevu 2, naznačen time što je glodavac štakor.
4. Glodavac prema bilo kojem od zahtjeva 1 do 3, naznačen time što je konstantna regija teškog lanca glodavca Fc regija glodavca.
5. Postupak za proizvodnju protutijela koje ima ljudsku varijabilnu regiju i konstantnu regiju glodavca koji se sastoji od izlaganja transgenog glodavca antigenu, pri čemu glodavac u svojoj zametnoj liniji sadrži lokus imunoglobulina teškog lanca koji sadrži, u 5' do 3' redoslijedu, genske segmente ljudskog nepreuređenog teškog lanca varijabilnosti (V), raznolikosti (D) i regije spajanja, konstantnu regiju teškog lanca glodavca, te 3' pojačivač štakora koji sadrže sekvencu navedenu kao SEQ ID NO:1, pri čemu lokus imunoglobulina teškog lanca ne sadrži gen konstantne regije ljudskog imunoglobulina, pri čemu je izloženost antigenu takva da transgeni glodavac proizvodi protutijelo za antigen, pri čemu protutijelo ima varijabilnu regiju teškog lanca čovjeka i konstantnu regiju teškog lanca glodavca, te pri čemu glodavac je miš ili štakor.
6. Postupak prema zahtjevu 5, naznačen time što su genski segmenti ljudskog teškog lanca varijabilnosti, raznolikosti i regije spajanja sadržani na segmentu DNA koji je oko 50 do 500 kb ili veći, ili pri čemu su genski segmenti ljudskog teškog lanca varijabilnosti, raznolikosti i regije spajanja sadržani na segmentu DNA koji ima do 2 megabaze.
7. Postupak prema zahtjevu 5 ili zahtjevu 6, naznačen time što je glodavac štakor.
8. Postupak prema bilo kojem od zahtjeva 5 do 7, naznačen time što je konstantna regija teškog lanca glodavca Fc regija glodavca.
9. Postupak prema bilo kojem od zahtjeva 5 do 8, naznačen time što dalje obuhvaća korak izrade hibridoma iz transgenog glodavca, te hibridom sadrži DNA koja kodira protutijelo, pri čemu je hibridom napravljen iz slezene transgenog glodavca.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261737371P | 2012-12-14 | 2012-12-14 | |
EP19204021.0A EP3653049B1 (en) | 2012-12-14 | 2013-12-13 | Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20231356T1 true HRP20231356T1 (hr) | 2024-02-16 |
Family
ID=50935093
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20231356TT HRP20231356T1 (hr) | 2012-12-14 | 2013-12-13 | Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže |
HRP20201160TT HRP20201160T1 (hr) | 2012-12-14 | 2020-07-24 | Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20201160TT HRP20201160T1 (hr) | 2012-12-14 | 2020-07-24 | Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže |
Country Status (20)
Country | Link |
---|---|
US (2) | US9475859B2 (hr) |
EP (3) | EP2931030B2 (hr) |
JP (1) | JP6705650B2 (hr) |
KR (3) | KR20210040189A (hr) |
CN (2) | CN110042105B (hr) |
AU (2) | AU2013358958B2 (hr) |
CA (1) | CA2895144C (hr) |
CY (1) | CY1123215T1 (hr) |
DK (2) | DK2931030T4 (hr) |
ES (2) | ES2813609T3 (hr) |
FI (2) | FI3653049T3 (hr) |
HR (2) | HRP20231356T1 (hr) |
HU (2) | HUE064063T2 (hr) |
IL (2) | IL239300B (hr) |
LT (2) | LT2931030T (hr) |
PL (1) | PL3653049T3 (hr) |
PT (2) | PT2931030T (hr) |
SG (1) | SG11201504676VA (hr) |
SI (2) | SI2931030T1 (hr) |
WO (1) | WO2014093908A2 (hr) |
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