HRP20201160T1 - Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže - Google Patents
Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže Download PDFInfo
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- HRP20201160T1 HRP20201160T1 HRP20201160TT HRP20201160T HRP20201160T1 HR P20201160 T1 HRP20201160 T1 HR P20201160T1 HR P20201160T T HRP20201160T T HR P20201160TT HR P20201160 T HRP20201160 T HR P20201160T HR P20201160 T1 HRP20201160 T1 HR P20201160T1
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- Prior art keywords
- seq
- chimeric polynucleotide
- polynucleotide according
- region
- human
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- 108091033319 polynucleotide Proteins 0.000 title claims 16
- 102000040430 polynucleotide Human genes 0.000 title claims 16
- 239000002157 polynucleotide Substances 0.000 title claims 16
- 241000283984 Rodentia Species 0.000 title claims 3
- 241001465754 Metazoa Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 150000007523 nucleic acids Chemical group 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- 108010009817 Immunoglobulin Constant Regions Proteins 0.000 claims 3
- 108700005091 Immunoglobulin Genes Proteins 0.000 claims 2
- 210000004436 artificial bacterial chromosome Anatomy 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 102000009786 Immunoglobulin Constant Regions Human genes 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (14)
1. Kimerni polinukleotid koji sadrži, u redoslijedu od 5' do 3', gen ljudske imunoglobulinske (Ig) varijabilne (V) regije, ljudski gen Ig regije raznolikosti (D), najmanje jedan ljudski imunoglobulin (Ig) koji povezuje gen regije (J), gen konstantne Ig regije (C), i 'štakorski pojačivač 3' koji sadrži sekvencu koja je navedena kao SEQ ID NO:1.
2. Kimerni polinukleotid prema patentnom zahtjevu 1, naznačen time što se gen konstantne regije bira iz skupine koja sadrži ljudski gen konstantne regije i štakorski gen konstantne regije.
3. Kimerni polinukleotid prema patentnom zahtjevu 1 ili zahtjevu 2, naznačen time što gen konstantne regije Ig (C) sadrži štakorski gen konstantne regije (C).
4. Kimerni polinukleotid prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što Ig gen konstantne regije sadrži Ig gen konstantne regije (C) odabran iz skupine koja sadrži Cµ. i Cγ.
5. Kimerni polinukleotid prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što sadrži sekvencu nukleinske kiseline koja ima najmanje 85% identičnosti sekvence sa SEQ ID NO. 10, ili njezinim dijelom.
6. Kimerni polinukleotid prema bilo kojem od patentnih zahtjeva 1 do 5 naznačen time što navedena ljudska Ig V regija sadrži najmanje jedan gen ljudske V regije koji se može izdvojiti iz BAC6-VH3-11 (BAC6 (SEQ ID NO. 8) produženog za VH3-11 da se dobije 10.6kb preklapanje s BAC3 (SEQ ID NO 9)) i/ili SEQ ID NO. 9.
7. Kimerni polinukleotid prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što sadrži sekvence nukleinske kiseline (a) i (b) u redoslijedu od 5' do 3':
a) ljudsku Ig V regiju koja sadrži gene ljudske Ig V regije u prirodnoj konfiguraciji koji se mogu izdvojiti iz BAC6-VH3-11 (BAC6 (SEQ ID NO. 8) produženog za VH3-11 da se dobije 10.6 kb preklapanje s BAC3 (SEQ ID NO 9)) i/ili SEQ ID No. 9; i
b) preklapanje Ig J regiju koja sadrži gene ljudske Ig J regije u prirodnoj konfiguraciji koji se mogu izdvojiti iz umjetnog bakterijskog kromosoma (BAC) koji ima sekvencu navedenu u SEQ ID No. 10.
8. Kimerni polinukleotid prema bilo kojem od patentnih zahtjeva 1 do 7, naznačen time što su relativni položaji svake od ljudske imunoglobulinske varijabilne regije, ljudske imunoglobulinske regije raznolikosti, ljudske imunoglobulinske povezujuće regije, imunoglobulinske konstantne regije, i 'štakorski pojačivač 3' prikazani na Slici 1a.
9. Kimerni polinukleotid prema patentnom zahtjevu 8, naznačen time što sadrži sekvencu nukleinske kiseline koja ima najmanje 85% identičnosti sekvence sa sekvencom nukleinske kiseline koja je navedena kao SEQ ID NO:2.
10. Kimerni polinukleotid prema patentnom zahtjevu 8, naznačen time što sadrži sekvencu nukleinske kiseline koja ima najmanje 85% identičnosti sekvence sa sekvencom nukleinske kiseline koja je navedena kao SEQ ID NO:11.
11. Kimerni polinukleotid prema bilo kojem od patentnih zahtjeva 1 do 10, naznačen time što su navedene Ig V-D-J regije funkcionalne i sposobne su za preuređenje gena.
12. Kimerni polinukleotid prema bilo kojem od patentnih zahtjeva 1 do 10, naznačen time što su navedene V-D-J regije preuređene i tvore potpuni egzon koji kodira varijabilnu domenu teškog lanca.
13. Izolirana stanica glodavaca naznačena time što sadrži a) kimerni polinukleotid prema bilo kojem od patentnih zahtjeva 1 do 11, ili b) kimerni polinukleotid prema patentnom zahtjevu 12.
14. Izolirana stanica glodavaca u skladu s patentnim zahtjevom 13(a), naznačena time što sadrži polinukleotid koji kodira funkcionalni imunoglobulin koji sadrži gene Ig V-, J- i (C) regije i sekvencu nukleinske kiseline koja je uglavnom homologna sekvenci nukleinske kiseline odabranoj iz skupine koja sadrži SEQ ID NO:6 i SEQ ID NO:7.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261737371P | 2012-12-14 | 2012-12-14 | |
EP13843056.6A EP2931030B2 (en) | 2012-12-14 | 2013-12-13 | Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same |
PCT/US2013/075157 WO2014093908A2 (en) | 2012-12-14 | 2013-12-13 | Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20201160T1 true HRP20201160T1 (hr) | 2020-12-11 |
Family
ID=50935093
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20231356TT HRP20231356T1 (hr) | 2012-12-14 | 2013-12-13 | Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže |
HRP20201160TT HRP20201160T1 (hr) | 2012-12-14 | 2020-07-24 | Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20231356TT HRP20231356T1 (hr) | 2012-12-14 | 2013-12-13 | Polinukleotidi koji kodiraju protutijela glodavaca s ljudskim idiotipovima i životinje koje ih sadrže |
Country Status (20)
Country | Link |
---|---|
US (2) | US9475859B2 (hr) |
EP (3) | EP2931030B2 (hr) |
JP (1) | JP6705650B2 (hr) |
KR (3) | KR20210040189A (hr) |
CN (2) | CN110042105B (hr) |
AU (2) | AU2013358958B2 (hr) |
CA (1) | CA2895144C (hr) |
CY (1) | CY1123215T1 (hr) |
DK (2) | DK2931030T4 (hr) |
ES (2) | ES2813609T3 (hr) |
FI (2) | FI3653049T3 (hr) |
HR (2) | HRP20231356T1 (hr) |
HU (2) | HUE064063T2 (hr) |
IL (2) | IL239300B (hr) |
LT (2) | LT2931030T (hr) |
PL (1) | PL3653049T3 (hr) |
PT (2) | PT2931030T (hr) |
SG (1) | SG11201504676VA (hr) |
SI (2) | SI2931030T1 (hr) |
WO (1) | WO2014093908A2 (hr) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2007000921A (es) | 2004-07-22 | 2007-11-09 | Univ Erasmus Medical Ct | Moleculas de union. |
US10993420B2 (en) * | 2013-03-15 | 2021-05-04 | Erasmus University Medical Center | Production of heavy chain only antibodies in transgenic mammals |
PT3209698T (pt) | 2014-10-22 | 2018-12-14 | Crescendo Biologics Ltd | Ratinhos transgénicos |
MX2017008190A (es) * | 2014-12-19 | 2018-03-23 | Regeneron Pharma | Metodos y composiciones para la modificacion genetica dirigida a traves de direccionamiento multiple de una sola etapa. |
CN107921128B (zh) | 2015-08-05 | 2022-04-26 | 詹森生物科技公司 | 抗cd154抗体及其使用方法 |
PL3337824T3 (pl) | 2015-08-17 | 2021-04-19 | Janssen Pharmaceutica Nv | Przeciwciała anty-bcma, bispecyficzne cząsteczki wiążące antygen, które wiążą bcma i cd3, oraz ich zastosowania |
AU2016329057A1 (en) | 2015-09-30 | 2018-04-12 | Janssen Biotech, Inc. | Antagonistic antibodies specifically binding human CD40 and methods of use |
CA3003899A1 (en) | 2015-11-02 | 2017-05-11 | Janssen Pharmaceutica Nv | Anti-il1rap antibodies, bispecific antigen binding molecules that bind il1rap and cd3, and uses thereof |
AU2017272337C1 (en) | 2016-06-03 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Non-human animals expressing exogenous terminal deoxynucleotidyltransferase |
CN109641049B (zh) * | 2016-06-21 | 2023-07-07 | 特尼奥生物股份有限公司 | Cd3结合抗体 |
CR20220578A (es) | 2016-09-14 | 2023-01-17 | Teneobio Inc | Anticuerpos de unión a cd3 |
WO2018095932A1 (en) * | 2016-11-22 | 2018-05-31 | Merck Patent Gmbh | Monoclonal antibody directed to fgfr1 |
AU2017365367A1 (en) * | 2016-11-22 | 2019-05-30 | Merck Patent Gmbh | Monoclonal antibody directed to FGFR1 |
CN110662421B (zh) * | 2017-01-19 | 2023-03-24 | 欧莫诺艾比公司 | 来自具有多个重链免疫球蛋白基因座的转基因啮齿类动物的人抗体 |
JP7303126B2 (ja) | 2017-06-20 | 2023-07-04 | テネオバイオ, インコーポレイテッド | 抗bcma重鎖のみ抗体 |
US11427642B2 (en) | 2017-06-20 | 2022-08-30 | Teneoone, Inc. | Anti-BCMA heavy chain-only antibodies |
AU2018392088A1 (en) | 2017-12-22 | 2020-08-13 | Teneobio, Inc. | Heavy chain antibodies binding to CD22 |
US11591399B2 (en) | 2018-02-14 | 2023-02-28 | Abba Therapeutics Ag | Anti-human PD-L2 antibodies |
CN116874591A (zh) | 2018-03-24 | 2023-10-13 | 瑞泽恩制药公司 | 用于产生针对肽-mhc复合物的治疗性抗体的经过基因修饰的非人动物、其制造方法和用途 |
JP7411575B2 (ja) | 2018-05-11 | 2024-01-11 | ウーシー・バイオロジクス・(シャンハイ)・カンパニー・リミテッド | Ox40に対する完全ヒト抗体、それを調製する方法、およびその使用 |
JOP20190116A1 (ar) | 2018-05-24 | 2019-11-24 | Janssen Biotech Inc | الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها |
JOP20200302A1 (ar) | 2018-05-24 | 2020-11-23 | Janssen Biotech Inc | الأجسام المضادة لـ cd3 واستخداماتها |
PE20210634A1 (es) | 2018-05-24 | 2021-03-23 | Janssen Biotech Inc | Anticuerpos anti-tmeff2 monoespecificos y multiespecificos y sus usos |
US20190380316A1 (en) | 2018-06-14 | 2019-12-19 | Regeneron Pharmaceuticals, Inc. | Non-human animals capable of engineered dh-dh rearrangement and uses thereof |
CA3125380A1 (en) * | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
AU2020291938A1 (en) | 2019-06-14 | 2022-01-20 | Teneobio, Inc. | Multispecific heavy chain antibodies binding to CD22 and CD3 |
JP2022541332A (ja) | 2019-07-26 | 2022-09-22 | ヤンセン バイオテツク,インコーポレーテツド | カリクレイン関連ペプチダーゼ2抗原結合ドメインを含むタンパク質及びその使用 |
CN114174346A (zh) | 2019-07-26 | 2022-03-11 | 詹森生物科技公司 | 抗hk2嵌合抗原受体(car) |
WO2021059075A1 (en) | 2019-09-27 | 2021-04-01 | Janssen Biotech, Inc. | Anti-ceacam antibodies and uses thereof |
AU2020359070A1 (en) | 2019-10-03 | 2022-04-21 | Janssen Biotech, Inc. | Methods for producing biotherapeutics with increased stability by sequence optimization |
EP4069722A1 (en) | 2019-12-02 | 2022-10-12 | Regeneron Pharmaceuticals, Inc. | Peptide-mhc ii protein constructs and uses thereof |
EP4121172A1 (en) | 2020-04-29 | 2023-01-25 | Teneobio, Inc. | Multispecific heavy chain antibodies with modified heavy chain constant regions |
IL298046A (en) | 2020-05-11 | 2023-01-01 | Janssen Biotech Inc | Treatment methods for multiple myeloma |
MX2022014938A (es) | 2020-05-27 | 2023-03-06 | Janssen Biotech Inc | Proteínas que comprenden dominios de unión al antígeno de cd3 y usos de éstas. |
CA3190307A1 (en) | 2020-07-29 | 2022-02-03 | Janssen Biotech, Inc. | Proteins comprising hla-g antigen binding domains and their uses |
IL301137A (en) | 2020-09-11 | 2023-05-01 | Regeneron Pharma | Identification and production of antigen-specific antibodies |
KR20230147048A (ko) | 2020-12-16 | 2023-10-20 | 리제너론 파마슈티칼스 인코포레이티드 | 인간화 Fc 알파 수용체를 발현하는 마우스 |
EP4051700A1 (en) | 2020-12-23 | 2022-09-07 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding anchor modified antibodies and uses thereof |
MX2023008803A (es) | 2021-01-27 | 2023-08-04 | Janssen Biotech Inc | Inmunoconjugados que comprenden dominios de union al antigeno de la peptidasa 2 relacionada con la calicreina y sus usos. |
WO2023144723A1 (en) | 2022-01-26 | 2023-08-03 | Janssen Biotech, Inc. | Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses |
WO2024064713A1 (en) | 2022-09-21 | 2024-03-28 | Seagen Inc. | Novel fusion protein specific for cd137 and cd228 |
WO2024064714A2 (en) | 2022-09-21 | 2024-03-28 | Seagen Inc. | Antibodies that bind cd228 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4977081A (en) | 1987-05-04 | 1990-12-11 | Adi Diagnostics, Inc. | Stable rabbit-mouse hybridomas and secretion products thereof |
ATE175234T1 (de) | 1990-07-10 | 1999-01-15 | Nippon Kokan Kk | Geflügelspezifischen immunglobulin g produzierende hybridomas |
US6255458B1 (en) * | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US7041871B1 (en) * | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
EP0814159B1 (en) * | 1990-08-29 | 2005-07-27 | GenPharm International, Inc. | Transgenic mice capable of producing heterologous antibodies |
EP0583980A1 (en) | 1992-08-20 | 1994-02-23 | Eli Lilly And Company | Method for generating monoclonal antibodies from rabbits |
US6005079A (en) | 1992-08-21 | 1999-12-21 | Vrije Universiteit Brussels | Immunoglobulins devoid of light chains |
PT1498427E (pt) | 1992-08-21 | 2010-03-22 | Univ Bruxelles | Imunoglobulinas desprovidas de cadeias leves |
US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
JPH08140528A (ja) * | 1993-12-03 | 1996-06-04 | Genpharm Internatl Inc | 異種抗体を産生することができるトランスジェニック非ヒト動物 |
WO1997016537A1 (en) | 1995-10-30 | 1997-05-09 | Spectral Diagnostics, Inc. | Stable chicken b-cell line and method of use thereof |
US5716081A (en) | 1996-03-11 | 1998-02-10 | Automotive Products (Usa), Inc. | Spring clip for quick connect coupling |
EP0942968B1 (en) * | 1996-12-03 | 2008-02-27 | Amgen Fremont Inc. | Fully human antibodies that bind EGFR |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
GB0110029D0 (en) * | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
MX2007000921A (es) | 2004-07-22 | 2007-11-09 | Univ Erasmus Medical Ct | Moleculas de union. |
ES2679282T3 (es) * | 2004-10-22 | 2018-08-23 | Revivicor Inc. | Porcinos transgénicos que carecen de cadena ligera de inmunoglobulina endógena |
CA2638117A1 (en) | 2006-01-25 | 2007-08-30 | Erasmus University Medical Center Rotterdam | Generation of heavy-chain only antibodies in transgenic animals |
EP2505058A1 (en) * | 2006-03-31 | 2012-10-03 | Medarex, Inc. | Transgenic animals expressing chimeric antibodies for use in preparing human antibodies |
AU2008259939B2 (en) * | 2007-06-01 | 2014-03-13 | Open Monoclonal Technology, Inc. | Compositions and methods for inhibiting endogenous immunoglobulin genes and producing transgenic human idiotype antibodies |
PL2564695T3 (pl) * | 2009-07-08 | 2015-10-30 | Kymab Ltd | Modele zwierzęce i cząsteczki terapeutyczne |
US20120204278A1 (en) | 2009-07-08 | 2012-08-09 | Kymab Limited | Animal models and therapeutic molecules |
WO2011158009A1 (en) * | 2010-06-17 | 2011-12-22 | Kymab Limited | Animal models and therapeutic molecules |
EP2638155A1 (en) | 2010-11-08 | 2013-09-18 | Kymab Limited | Cells & vertebrates for enhanced somatic hypermutation and class switch recombination |
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