PT3209698T - Ratinhos transgénicos - Google Patents
Ratinhos transgénicosInfo
- Publication number
- PT3209698T PT3209698T PT14790686T PT14790686T PT3209698T PT 3209698 T PT3209698 T PT 3209698T PT 14790686 T PT14790686 T PT 14790686T PT 14790686 T PT14790686 T PT 14790686T PT 3209698 T PT3209698 T PT 3209698T
- Authority
- PT
- Portugal
- Prior art keywords
- transgenic mice
- transgenic
- mice
- Prior art date
Links
- 241000699660 Mus musculus Species 0.000 title 1
- 238000011830 transgenic mouse model Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Humanized animals, e.g. knockin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14790686.1A EP3209698B2 (en) | 2014-10-22 | 2014-10-22 | Transgenic mice |
| PCT/GB2014/053146 WO2016062990A1 (en) | 2014-10-22 | 2014-10-22 | Transgenic mice |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3209698T true PT3209698T (pt) | 2018-12-14 |
Family
ID=51842672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT14790686T PT3209698T (pt) | 2014-10-22 | 2014-10-22 | Ratinhos transgénicos |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US11547099B2 (pt) |
| EP (2) | EP3461848B1 (pt) |
| JP (1) | JP6641379B2 (pt) |
| KR (1) | KR20170073647A (pt) |
| CN (2) | CN107002092A (pt) |
| AU (1) | AU2014409276A1 (pt) |
| CA (1) | CA2963752A1 (pt) |
| DK (1) | DK3209698T4 (pt) |
| ES (1) | ES2701061T5 (pt) |
| GB (1) | GB2547587B (pt) |
| HR (1) | HRP20181892T4 (pt) |
| IL (1) | IL251010B2 (pt) |
| PL (1) | PL3209698T5 (pt) |
| PT (1) | PT3209698T (pt) |
| SG (1) | SG11201702502XA (pt) |
| WO (1) | WO2016062990A1 (pt) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201500463D0 (en) | 2015-01-12 | 2015-02-25 | Cresendo Biolog Ltd | Therapeutic molecules |
| EP3402825A1 (en) | 2016-01-12 | 2018-11-21 | Crescendo Biologics Limited | Molecules that bind prostate specific membrane antigen (psma) |
| AU2017281034B2 (en) | 2016-06-21 | 2024-03-14 | Teneobio, Inc. | CD3 binding antibodies |
| GB201612043D0 (en) | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
| WO2018052503A1 (en) | 2016-09-14 | 2018-03-22 | Teneobio, Inc. | Cd3 binding antibodies |
| EP4215548A1 (en) | 2016-12-21 | 2023-07-26 | Teneobio, Inc. | Anti-bcma heavy chain-only antibodies |
| WO2018127710A1 (en) | 2017-01-06 | 2018-07-12 | Crescendo Biologics Limited | Single domain antibodies to programmed cell death (pd-1) |
| WO2018237037A2 (en) * | 2017-06-20 | 2018-12-27 | Teneobio, Inc. | HEAVY CHAIN ANTIBODY ONLY ANTI-BCMA |
| AU2018288803A1 (en) | 2017-06-20 | 2020-02-06 | Teneoone, Inc. | Anti-BCMA heavy chain-only antibodies |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| KR20200083574A (ko) * | 2017-11-13 | 2020-07-08 | 크레센도 바이오로직스 리미티드 | Cd137 및 psma에 결합하는 분자 |
| GB201802573D0 (en) | 2018-02-16 | 2018-04-04 | Crescendo Biologics Ltd | Therapeutic molecules that bind to LAG3 |
| CN108486125B (zh) * | 2018-03-27 | 2024-01-05 | 重庆金迈博生物科技有限公司 | 一种核酸分子及其在制备人源单域抗体中的应用 |
| GB201818460D0 (en) | 2018-11-13 | 2018-12-26 | Crescendo Biologics Ltd | Single domain antibodies that bind human serum albumin |
| JP2022532370A (ja) | 2019-05-15 | 2022-07-14 | クレシェンド・バイオロジックス・リミテッド | 結合分子 |
| JP2022537931A (ja) | 2019-06-14 | 2022-08-31 | テネオバイオ， インコーポレイテッド | Ｃｄ２２及びｃｄ３に結合する多重特異性重鎖抗体 |
| GB201914468D0 (en) | 2019-10-07 | 2019-11-20 | Crescendo Biologics Ltd | Binding Molecules |
| AU2021342159A1 (en) | 2020-09-11 | 2023-03-02 | Regeneron Pharmaceuticals, Inc. | Identification and production of antigen-specific antibodies |
| WO2022132943A1 (en) | 2020-12-16 | 2022-06-23 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| WO2023199069A1 (en) | 2022-04-14 | 2023-10-19 | Crescendo Biologics Limited | Chimeric antigen receptor that binds mesothelin |
| GB202205589D0 (en) | 2022-04-14 | 2022-06-01 | Crescendo Biologics Ltd | Mesothelin binders |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2495083A (en) * | 1947-09-19 | 1950-01-17 | Ashaway Line & Twine Mfg | Vise for tying leader ends |
| US6833268B1 (en) * | 1999-06-10 | 2004-12-21 | Abgenix, Inc. | Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| JP4149748B2 (ja) | 2002-06-24 | 2008-09-17 | 三菱商事プラスチック株式会社 | ロータリー型量産用ｃｖｄ成膜装置及びプラスチック容器内表面へのｃｖｄ膜成膜方法 |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| EP1864998B2 (en) | 2004-07-22 | 2022-06-22 | Erasmus University Medical Center Rotterdam | Binding molecules |
| PT2954779T (pt) | 2009-12-10 | 2019-05-29 | Regeneron Pharma | Ratinhos que produzem anticorpos de cadeia pesada |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| GB2495083A (en) * | 2011-09-26 | 2013-04-03 | Kymab Ltd | Human VpreB and chimaeric surrogate light chains in transgenic non-human vertebrates |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| EP2931030B2 (en) | 2012-12-14 | 2024-01-17 | OmniAb, Inc. | Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same |
| WO2014141192A1 (en) | 2013-03-15 | 2014-09-18 | Erasmus University Medical Center | Generation of heavy chain-only antibodies |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| SG11201607203XA (en) | 2014-03-21 | 2016-09-29 | Regeneron Pharma | Non-human animals that make single domain binding proteins |
-
2014
- 2014-10-22 CN CN201480082416.0A patent/CN107002092A/zh active Pending
- 2014-10-22 PT PT14790686T patent/PT3209698T/pt unknown
- 2014-10-22 HR HRP20181892TT patent/HRP20181892T4/hr unknown
- 2014-10-22 KR KR1020177013704A patent/KR20170073647A/ko not_active Application Discontinuation
- 2014-10-22 IL IL251010A patent/IL251010B2/en unknown
- 2014-10-22 US US15/520,627 patent/US11547099B2/en active Active
- 2014-10-22 CN CN202210143798.XA patent/CN114774466A/zh active Pending
- 2014-10-22 SG SG11201702502XA patent/SG11201702502XA/en unknown
- 2014-10-22 GB GB1708074.8A patent/GB2547587B/en active Active
- 2014-10-22 WO PCT/GB2014/053146 patent/WO2016062990A1/en active Application Filing
- 2014-10-22 EP EP18192313.7A patent/EP3461848B1/en active Active
- 2014-10-22 PL PL14790686T patent/PL3209698T5/pl unknown
- 2014-10-22 DK DK14790686.1T patent/DK3209698T4/da active
- 2014-10-22 EP EP14790686.1A patent/EP3209698B2/en active Active
- 2014-10-22 CA CA2963752A patent/CA2963752A1/en not_active Abandoned
- 2014-10-22 JP JP2017541172A patent/JP6641379B2/ja active Active
- 2014-10-22 AU AU2014409276A patent/AU2014409276A1/en not_active Abandoned
- 2014-10-22 ES ES14790686T patent/ES2701061T5/es active Active
-
2022
- 2022-10-19 US US18/047,673 patent/US20230133028A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3461848C0 (en) | 2023-10-11 |
| CN107002092A (zh) | 2017-08-01 |
| PL3209698T3 (pl) | 2019-03-29 |
| EP3209698B2 (en) | 2022-02-09 |
| JP2017537653A (ja) | 2017-12-21 |
| AU2014409276A1 (en) | 2017-04-06 |
| CN114774466A (zh) | 2022-07-22 |
| JP6641379B2 (ja) | 2020-02-05 |
| IL251010A0 (en) | 2017-04-30 |
| US11547099B2 (en) | 2023-01-10 |
| HRP20181892T4 (hr) | 2022-04-15 |
| EP3209698A1 (en) | 2017-08-30 |
| EP3461848B1 (en) | 2023-10-11 |
| ES2701061T5 (es) | 2022-05-09 |
| PL3209698T5 (pl) | 2022-04-25 |
| SG11201702502XA (en) | 2017-05-30 |
| EP3209698B1 (en) | 2018-09-05 |
| US20180362666A1 (en) | 2018-12-20 |
| KR20170073647A (ko) | 2017-06-28 |
| IL251010B1 (en) | 2023-09-01 |
| DK3209698T3 (en) | 2019-01-07 |
| WO2016062990A1 (en) | 2016-04-28 |
| EP3461848A1 (en) | 2019-04-03 |
| GB2547587A (en) | 2017-08-23 |
| ES2701061T3 (es) | 2019-02-20 |
| GB2547587B (en) | 2020-12-09 |
| DK3209698T4 (da) | 2022-04-04 |
| CA2963752A1 (en) | 2016-04-28 |
| GB201708074D0 (en) | 2017-07-05 |
| US20230133028A1 (en) | 2023-05-04 |
| IL251010B2 (en) | 2024-01-01 |
| HRP20181892T1 (hr) | 2019-01-11 |
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