HRP20181892T4 - Transgeni miševi - Google Patents

Transgeni miševi Download PDF

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Publication number
HRP20181892T4
HRP20181892T4 HRP20181892TT HRP20181892T HRP20181892T4 HR P20181892 T4 HRP20181892 T4 HR P20181892T4 HR P20181892T T HRP20181892T T HR P20181892TT HR P20181892 T HRP20181892 T HR P20181892T HR P20181892 T4 HRP20181892 T4 HR P20181892T4
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HR
Croatia
Prior art keywords
mouse
vector
transgenic mouse
cell
gene
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Application number
HRP20181892TT
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English (en)
Inventor
Yumin TENG
Joyce YOUNG
Brian Mcguinness
Mike ROMANOS
Marianne Brueggemann
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Crescendo Biologics Limited
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51842672&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20181892(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Crescendo Biologics Limited filed Critical Crescendo Biologics Limited
Publication of HRP20181892T1 publication Critical patent/HRP20181892T1/hr
Publication of HRP20181892T4 publication Critical patent/HRP20181892T4/hr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Humanized animals, e.g. knockin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/20—Pseudochromosomes, minichrosomosomes
    • C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region

Claims (15)

1. Vektor naznačen time što sadrži a) najmanje 10 funkcionalnih V gena za ljudski teški lanac pri čemu je najmanje 10 funkcionalnih V gena za ljudski teški lanac u istom redoslijedu u kojem se mogu naći u ljudskoj zametnoj liniji i sastoje se od intervencijskih sekvenci; b) najmanje jedan D gen ljudskog teškog lanca i najmanje jedan J gen ljudskog teškog lanca; c) mišji µ pojačivač; d) mišji preklopni µ element; e) mišji C gen koji nema CH1 egzon pri čemu je C gen odabran od Cγ1, Cγ2b i/ili Cγ2a i f) mišju regiju 3' pojačivača. pri čemu vektor ne sadrži daljnji mišji C gen.
2. Vektor prema zahtjevu 1 naznačen time što navedena mišja regija 3' pojačivača je veličine barem oko 42kb.
3. Vektor prema zahtjevu 2 naznačen time što navedena mišja regija 3' pojačivača 'sadrži jedan ili više ili svih pojačivačkih elemenata koji su odabrani od hs3A, hs1.2, hs3B, hs4, hs5, hs6 i hs7.
4. Vektor prema prethodnom zahtjevu naznačen time što sadrži 10 do oko 44 funkcionalnih ljudskih V gena.
5. Vektor prema bilo kojem prethodnom zahtjevu naznačen time što navedeni vektor je umjetni kromosom kvasca (YAC).
6. Stanica domaćina transgenog miša naznačena time što je transformirana s vektorom prema prethodnom zahtjevu.
7. Stanica domaćina transgenog miša prema zahtjevu 6 naznačena time što navedena stanica je ES stanica.
8. Transgeni miš naznačen time što sadrži vektor prema bilo kojem od zahtjeva 1 do 5 ili stanicu prema zahtjevu 6 ili 7.
9. Transgeni miš prema zahtjevu 8 naznačen time što navedeni miš sadrži jedan ili više nefunkcionalnih endogenih imunoglobulinskih lokusa.
10. Transgeni miš prema zahtjevu 9 naznačen time što navedeni miš sadrži nefunkcionalni endogeni lokus lambda laganog lanca, nefunkcionalni endogeni lokus kapa laganog lanca i/ili nefunkcionalni endogeni lokus teškog lanca.
11. Uporaba transgenog miša prema bilo kojem od zahtjeva 8 do 10 ili stanice prema zahtjevu 6 ili 7 naznačena time što je za proizvodnju HCAb ili VH domena.
12. Uporaba transgenog miša prema bilo kojem od zahtjeva 8 do 10 naznačena time što je za izgradnja biblioteke.
13. Postupak za dobivanje biblioteke koji obuhvaća ex vivo imunizaciju transgenog miša prema bilo kojem od zahtjeva 8 do 10 ili ex vivo tkiva ili stanica transgenog miša prema bilo kojem od zahtjeva 8 do 10.
14. Postupak za dobivanje HCAb ili VH domene koji obuhvaća uvođenje i ekspresiju vektora prema bilo kojem od zahtjeva 1 do 5 u mišu ili u mišjoj stanici domaćinu.
15. Postupak za proizvodnju topive VH vezujuće domene naznačen time što sadrži slijedeće korake: a) ekspresiju vektora iz bilo kojeg od zahtjeva 1 do 5 u transgenom mišu, b) izoliranje stanice ili tkiva koje eksprimira HCAb, c) kloniranje sekvence koja kodira VH domenu iz mRNA dobivene iz izolirane stanice ili tkiva, d) izgradnja biblioteke iz kloniranih transkripata i e) izoliranje VH domene.
HRP20181892TT 2014-10-22 2014-10-22 Transgeni miševi HRP20181892T4 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14790686.1A EP3209698B2 (en) 2014-10-22 2014-10-22 Transgenic mice
PCT/GB2014/053146 WO2016062990A1 (en) 2014-10-22 2014-10-22 Transgenic mice

Publications (2)

Publication Number Publication Date
HRP20181892T1 HRP20181892T1 (hr) 2019-01-11
HRP20181892T4 true HRP20181892T4 (hr) 2022-04-15

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ID=51842672

Family Applications (1)

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HRP20181892TT HRP20181892T4 (hr) 2014-10-22 2014-10-22 Transgeni miševi

Country Status (16)

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US (2) US11547099B2 (hr)
EP (2) EP3461848B1 (hr)
JP (1) JP6641379B2 (hr)
KR (1) KR20170073647A (hr)
CN (2) CN114774466A (hr)
AU (1) AU2014409276A1 (hr)
CA (1) CA2963752A1 (hr)
DK (1) DK3209698T4 (hr)
ES (1) ES2701061T5 (hr)
GB (1) GB2547587B (hr)
HR (1) HRP20181892T4 (hr)
IL (1) IL251010B2 (hr)
PL (1) PL3209698T5 (hr)
PT (1) PT3209698T (hr)
SG (1) SG11201702502XA (hr)
WO (1) WO2016062990A1 (hr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201500463D0 (en) 2015-01-12 2015-02-25 Cresendo Biolog Ltd Therapeutic molecules
CN116478293A (zh) 2016-01-12 2023-07-25 克雷森多生物制剂有限公司 治疗分子
KR20190053835A (ko) 2016-06-21 2019-05-20 테네오바이오, 인코포레이티드 Cd3 결합 항체
GB201612043D0 (en) 2016-07-11 2016-08-24 Crescendo Biologics Ltd Composition for treatment of disorders
WO2018052503A1 (en) 2016-09-14 2018-03-22 Teneobio, Inc. Cd3 binding antibodies
JP7254699B2 (ja) 2016-12-21 2023-04-10 テネオバイオ， インコーポレイテッド 抗ｂｃｍａ重鎖のみ抗体
EP3565841A1 (en) 2017-01-06 2019-11-13 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
CN117567624A (zh) 2017-06-20 2024-02-20 特纳奥尼股份有限公司 仅有重链的抗bcma抗体
KR20200018498A (ko) * 2017-06-20 2020-02-19 테네오바이오, 인코포레이티드 항-bcma 중쇄-단독 항체
GB201711068D0 (en) 2017-07-10 2017-08-23 Crescendo Biologics Ltd Therapeutic molecules binding PSMA
CA3082321A1 (en) * 2017-11-13 2019-05-16 Crescendo Biologics Limited Single domain antibodies that bind to cd137
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
CN108486125B (zh) * 2018-03-27 2024-01-05 重庆金迈博生物科技有限公司 一种核酸分子及其在制备人源单域抗体中的应用
GB201818460D0 (en) 2018-11-13 2018-12-26 Crescendo Biologics Ltd Single domain antibodies that bind human serum albumin
CA3136598A1 (en) 2019-05-15 2021-11-19 Grainne Dunlevy Binding molecules
AR119746A1 (es) 2019-06-14 2022-01-05 Teneobio Inc Anticuerpos multiespecíficos de cadena pesada que se unen a cd22 y cd3
GB201914468D0 (en) 2019-10-07 2019-11-20 Crescendo Biologics Ltd Binding Molecules
US20220090060A1 (en) 2020-09-11 2022-03-24 Regeneron Pharmaceuticals, Inc. Identification and production of antigen-specific antibodies
EP4262373A1 (en) 2020-12-16 2023-10-25 Regeneron Pharmaceuticals, Inc. Mice expressing humanized fc alpha receptors
GB202205589D0 (en) 2022-04-14 2022-06-01 Crescendo Biologics Ltd Mesothelin binders
WO2023199069A1 (en) 2022-04-14 2023-10-19 Crescendo Biologics Limited Chimeric antigen receptor that binds mesothelin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2495083A (en) * 1947-09-19 1950-01-17 Ashaway Line & Twine Mfg Vise for tying leader ends
US6833268B1 (en) * 1999-06-10 2004-12-21 Abgenix, Inc. Transgenic animals for producing specific isotypes of human antibodies via non-cognate switch regions
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
JP4149748B2 (ja) 2002-06-24 2008-09-17 三菱商事プラスチック株式会社 ロータリー型量産用ｃｖｄ成膜装置及びプラスチック容器内表面へのｃｖｄ膜成膜方法
GB2398784B (en) * 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
SI2311874T1 (sl) 2004-07-22 2017-12-29 Erasmus University Medical Center Rotterdam Department of Cell Biology and Genetics Vezavne molekule
LT2954779T (lt) 2009-12-10 2019-05-27 Regeneron Pharmaceuticals, Inc. Pelės, gaminančios sunkiosios grandinės antikūnus
GB2495083A (en) 2011-09-26 2013-04-03 Kymab Ltd Human VpreB and chimaeric surrogate light chains in transgenic non-human vertebrates
WO2013045916A1 (en) * 2011-09-26 2013-04-04 Kymab Limited Chimaeric surrogate light chains (slc) comprising human vpreb
GB2502127A (en) * 2012-05-17 2013-11-20 Kymab Ltd Multivalent antibodies and in vivo methods for their production
LT2931030T (lt) 2012-12-14 2020-11-10 Open Monoclonal Technology, Inc. Polinukleotidai, koduojantys graužikų antikūnus su žmogaus idiotipais, ir juos apimantys gyvūnai
US10993420B2 (en) * 2013-03-15 2021-05-04 Erasmus University Medical Center Production of heavy chain only antibodies in transgenic mammals
US9788534B2 (en) * 2013-03-18 2017-10-17 Kymab Limited Animal models and therapeutic molecules
KR20210088756A (ko) 2014-03-21 2021-07-14 리제너론 파마슈티칼스 인코포레이티드 단일 도메인 결합 단백질을 생산하는 비-인간 동물

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Publication number Publication date
WO2016062990A1 (en) 2016-04-28
ES2701061T3 (es) 2019-02-20
GB2547587B (en) 2020-12-09
US20230133028A1 (en) 2023-05-04
DK3209698T4 (da) 2022-04-04
CN107002092A (zh) 2017-08-01
CA2963752A1 (en) 2016-04-28
EP3209698B2 (en) 2022-02-09
PL3209698T5 (pl) 2022-04-25
GB201708074D0 (en) 2017-07-05
SG11201702502XA (en) 2017-05-30
EP3209698B1 (en) 2018-09-05
JP6641379B2 (ja) 2020-02-05
EP3461848A1 (en) 2019-04-03
PL3209698T3 (pl) 2019-03-29
HRP20181892T1 (hr) 2019-01-11
GB2547587A (en) 2017-08-23
JP2017537653A (ja) 2017-12-21
EP3461848C0 (en) 2023-10-11
ES2701061T5 (es) 2022-05-09
IL251010B2 (en) 2024-01-01
IL251010A0 (en) 2017-04-30
DK3209698T3 (en) 2019-01-07
EP3461848B1 (en) 2023-10-11
EP3209698A1 (en) 2017-08-30
IL251010B1 (en) 2023-09-01
CN114774466A (zh) 2022-07-22
US11547099B2 (en) 2023-01-10
AU2014409276A1 (en) 2017-04-06
PT3209698T (pt) 2018-12-14
US20180362666A1 (en) 2018-12-20
KR20170073647A (ko) 2017-06-28

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