HRP20231277T1 - Peptid za upotrebu u prevenciji ili liječenju makularne degeneracije - Google Patents
Peptid za upotrebu u prevenciji ili liječenju makularne degeneracije Download PDFInfo
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- HRP20231277T1 HRP20231277T1 HRP20231277TT HRP20231277T HRP20231277T1 HR P20231277 T1 HRP20231277 T1 HR P20231277T1 HR P20231277T T HRP20231277T T HR P20231277TT HR P20231277 T HRP20231277 T HR P20231277T HR P20231277 T1 HRP20231277 T1 HR P20231277T1
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- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 1
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- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 claims 1
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- 229910052711 selenium Inorganic materials 0.000 claims 1
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- 238000007920 subcutaneous administration Methods 0.000 claims 1
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- SKIVFJLNDNKQPD-UHFFFAOYSA-N sulfacetamide Chemical compound CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 SKIVFJLNDNKQPD-UHFFFAOYSA-N 0.000 claims 1
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- 238000007910 systemic administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 1
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- 229960002180 tetracycline Drugs 0.000 claims 1
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- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 229960000337 tetryzoline Drugs 0.000 claims 1
- 229960002663 thioctic acid Drugs 0.000 claims 1
- 229960004605 timolol Drugs 0.000 claims 1
- 229960000707 tobramycin Drugs 0.000 claims 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims 1
- 229960002368 travoprost Drugs 0.000 claims 1
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 1
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 claims 1
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- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims 1
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- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 claims 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. Peptid predstavljen formulom D-Arg-2'6'-Dmt-Lys-Phe-NH2 ili Phe-D-Arg-Phe-Lys-NH2, za liječenje ili prevenciju oftalmološkog stanja, pri čemu je oftalmološko stanje makularna degeneracija.
2. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid D-Arg-2’6’-Dmt-Lys-Phe-NH2.
3. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid Phe-D-Arg-Phe-Lys-NH2.
4. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je subjekt čovjek.
5. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid formuliran za intraokularnu primjenu, iontoforetski, oralno, lokalno, sistemski, intravenozno, subkutano ili intramuskularno.
6. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid formuliran za primjenu s drugim aktivnim sredstvom.
7. Peptid za upotrebu sukladno patentnom zahtjevu 6, naznačen time da je drugo aktivno sredstvo odabrano iz skupine koju čine: antioksidans, metalni komplekser, protuupalni lijek, antibiotik i antihistaminik.
8. Peptid za upotrebu sukladno patentnom zahtjevu 7, naznačen time da je antioksidans vitamin A, vitamin C, vitamin E, likopen, selen, α-lipoična kiselina, koenzim Q, glutation ili karotenoid.
9. Peptid za upotrebu sukladno patentnom zahtjevu 6, gdje je drugo aktivno sredstvo odabrano iz skupine koju čine: aceklidin, acetazolamid, anekortav, apraklonidin, atropin, azapentacen, azelastin, bacitracin, befunolol, betametazon, betaksolol, bimatoprost, brimonidin, brinzolamid, karbahol, karteolol, celekoksib, kloramfenikol, klortetraciklin, ciprofloksacin, kromoglikat, kromolin, ciklopentolat, ciklosporin, dapiprazol, demekarij, deksametazon, diklofenak, diklorfenamid, dipivefrin, dorzolamid, ehotiofat, emedastin, epinastin, epinefrin, eritromicin, etokzolamid, eukatropin, fludrokortizon, fluorometolon, flurbiprofen, fomivirsen, framicetin, ganciklovir, gatifloksacin, gentamicin, homatropin, hidrokortizon, idoksuridin, indometacin, izoflurofat, ketorolak, ketotifen, latanoprost, levobetaksolol, levobunolol, levokabastin, levofloksacin, lodoksamid, loteprednol, medrizon, metazolamid, metipranolol, moksifloksacin, nafazolin, natamicin, nedokromil, neomicin, norfloksacin, ofloksacin, olopatadin, oksimetazolin, pemirolast, pegaptanib, fenilefrin, fizostigmin, pilokarpin, pindolol, pirenoksin, polimiksin B, prednizolon, proparakain, ranibizumab, rimeksolon, skopolamin, sezolamid, skvalamin, sulfacetamid, suprofen, tetrakain, tetraciklin, tetrahidrozolin, tetrizolin, timolol, tobramicin, travoprost, triamcinulon, trifluorometazolamid, trifluridin, trimetoprim, tropikamid, unoproston, vidarbin, ksilometazolin, njihove farmaceutski prihvatljive soli i njihove kombinacije.
Applications Claiming Priority (4)
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| US23774509P | 2009-08-28 | 2009-08-28 | |
| US34847010P | 2010-05-26 | 2010-05-26 | |
| EP20156769.0A EP3708178B1 (en) | 2009-08-24 | 2010-08-23 | Peptide for use in preventing or treating macular degeneration |
Publications (1)
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| HRP20231277TT HRP20231277T1 (hr) | 2009-08-24 | 2010-08-23 | Peptid za upotrebu u prevenciji ili liječenju makularne degeneracije |
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| EP (17) | EP3150215A1 (hr) |
| JP (7) | JP6120399B2 (hr) |
| CN (3) | CN105056206A (hr) |
| CA (1) | CA2772094C (hr) |
| DK (2) | DK2470191T3 (hr) |
| ES (2) | ES2487633T3 (hr) |
| FI (1) | FI3708178T3 (hr) |
| HK (5) | HK1172833A1 (hr) |
| HR (1) | HRP20231277T1 (hr) |
| HU (1) | HUE064800T2 (hr) |
| LT (1) | LT3708178T (hr) |
| PL (2) | PL3708178T3 (hr) |
| PT (2) | PT2470191E (hr) |
| SI (2) | SI3708178T1 (hr) |
| WO (1) | WO2011025734A1 (hr) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8648825B2 (en) | 2010-10-01 | 2014-02-11 | Z124 | Off-screen gesture dismissable keyboard |
| AU2009295960A1 (en) | 2008-09-29 | 2010-04-01 | Cardiaq Valve Technologies, Inc. | Heart valve |
| US8337541B2 (en) | 2008-10-01 | 2012-12-25 | Cardiaq Valve Technologies, Inc. | Delivery system for vascular implant |
| EP2810620B1 (en) | 2009-04-15 | 2022-09-14 | Edwards Lifesciences CardiAQ LLC | Vascular implant and delivery system |
| PT2470191E (pt) * | 2009-08-24 | 2014-06-12 | Stealth Peptides Int Inc | Métodos e composições para prevenção ou tratamento de doenças oftálmicas |
| EP3560508A1 (en) * | 2010-03-15 | 2019-10-30 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
| US20110269807A1 (en) * | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase |
| US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
| US10272040B2 (en) | 2010-08-12 | 2019-04-30 | Nanyang Technological University | Liposomal formulation for ocular drug delivery |
| CN107219358A (zh) * | 2011-03-24 | 2017-09-29 | 康奈尔大学 | 芳香族阳离子肽及其用途 |
| US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
| US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
| CN102327600A (zh) * | 2011-09-14 | 2012-01-25 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 用于预防和治疗辐射损伤的rx31肽 |
| US8842057B2 (en) | 2011-09-27 | 2014-09-23 | Z124 | Detail on triggers: transitional states |
| EP3656394A1 (en) * | 2011-12-09 | 2020-05-27 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| CN105343869A (zh) * | 2012-02-22 | 2016-02-24 | 康德生物医疗技术公司 | 用于预防或治疗眼科病状的方法和组合物 |
| CA2869080C (en) * | 2012-03-30 | 2020-09-01 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment neuropathy |
| US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
| WO2014022551A1 (en) * | 2012-08-02 | 2014-02-06 | Stealth Peptides International, Inc. | Methods for treatment of atherosclerosis |
| JP6284341B2 (ja) * | 2012-10-24 | 2018-02-28 | 国立大学法人東京農工大学 | 未熟児網膜症の治療又は予防剤、未熟児網膜症の検査方法及び未熟児網膜症の治療又は予防物質のスクリーニング方法 |
| US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
| JP6839490B2 (ja) * | 2013-03-01 | 2021-03-10 | ステルス バイオセラピューティックス コープ | ミトコンドリア疾患の治療のための方法 |
| CN105407906A (zh) * | 2013-03-01 | 2016-03-16 | 康德生物医疗技术公司 | 预防或治疗巴斯综合征的方法和组合物 |
| US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
| US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
| US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
| US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
| US20160193278A1 (en) * | 2013-08-01 | 2016-07-07 | Stealth Biotherapeutics Corp | Methods and compositions for preventing or treating leber's hereditary optic neuropathy |
| US20160175379A1 (en) * | 2013-08-12 | 2016-06-23 | Stealth Bio Therapeutics Corp | Combination therapy for the treatment of ischemia-reperfusion injury |
| CA2928702A1 (en) * | 2013-10-25 | 2015-04-30 | Children's Medical Center Corporation | Methods of treating or preventing vascular diseases of the retina |
| CA2932408A1 (en) * | 2013-12-02 | 2015-06-11 | Stealth Biotherapeutics Corp | Compositions and methods for treating vitiligo |
| US20160317606A1 (en) * | 2014-01-06 | 2016-11-03 | Stealth Bio Therapeutics Corp | Methods and compositions for preventing or treating dominant optic atrophy |
| US9956195B2 (en) | 2014-01-07 | 2018-05-01 | Nanyang Technological University | Stable liposomal formulations for ocular drug delivery |
| EP3129054B1 (en) | 2014-04-10 | 2020-12-09 | Lankenau Institute for Medical Research | Methods and compositions for the treatment of ocular diseases and disorders |
| US20170182117A1 (en) * | 2014-05-28 | 2017-06-29 | Stealth Biotherapeutics Corp | Therapeutic compositions including therapeutic small molecules and uses thereof |
| RU2706704C2 (ru) * | 2014-12-19 | 2019-11-20 | Кемин Индастриз, Инк. | Внутриглазная доставка биологически активных молекул с использованием ионтофореза |
| ES2903397T3 (es) | 2015-12-30 | 2022-04-01 | Marshall Univ Research Corporation | Composiciones y métodos para tratar la retinopatía |
| CN115160402A (zh) | 2016-03-11 | 2022-10-11 | 隐形生物治疗公司 | 结晶盐形式 |
| WO2017180535A1 (en) | 2016-04-11 | 2017-10-19 | Carnot, Llc | Chiral peptides |
| JP7095873B2 (ja) * | 2016-04-11 | 2022-07-05 | ユニバーシティ・オブ・キャンベラ | レボドパ、抗酸化剤及び水性担体を含む眼科用組成物 |
| US11034724B2 (en) | 2017-04-05 | 2021-06-15 | Stealth Biotherapeutics Corp. | Crystalline salt forms of Boc-D-Arg-DMT-Lys-(Boc)-Phe-NH2 |
| US20180318319A1 (en) | 2017-05-04 | 2018-11-08 | Ocular Science, Inc. | Compositions and Methods for Treating Eyes and Methods of Preparation |
| EP3651747A4 (en) * | 2017-11-17 | 2020-07-22 | Cellix Bio Private Limited | COMPOSITIONS AND METHODS OF TREATMENT OF EYE DISORDERS |
| US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
| PL424452A1 (pl) * | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
| US11400070B2 (en) * | 2018-05-03 | 2022-08-02 | Alimera Sciences, Inc. | Methods of treating retinal diseases |
| WO2020018455A1 (en) * | 2018-07-16 | 2020-01-23 | Stealth Biotherapeutics Corp | Compositions and methods for the treatment of traumatic optic neuropathy |
| JP2022501438A (ja) * | 2018-09-21 | 2022-01-06 | アウフバウ・メディカル・イノベイションズ・リミテッドAufbau Medical Innovations Limited | 緑内障用の組成物および方法 |
| WO2020214990A1 (en) * | 2019-04-17 | 2020-10-22 | Ascidian Therapeutics, Inc. | Abca4 cell line and methods of use |
| JP2020174859A (ja) * | 2019-04-17 | 2020-10-29 | 学校法人日本医科大学 | 網膜剥離が生じるリスクが低い網膜変性症（ｒｄ）モデルマウスを取得する方法 |
| US11071724B2 (en) | 2019-05-17 | 2021-07-27 | Ocular Science, Inc. | Compositions and methods for treating presbyopia |
| US20240058356A1 (en) * | 2020-12-24 | 2024-02-22 | Santen Pharmaceutical Co., Ltd. | Pharmaceutical composition for transdermal administration containing epi-nastine or salt thereof and containing sulfur-based antioxidant |
| WO2023069255A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
| WO2023069549A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
| US20230226105A1 (en) * | 2021-11-10 | 2023-07-20 | Reverspah Llc | Methods and compositions for treating cancer |
| CN114099678A (zh) * | 2021-11-23 | 2022-03-01 | 浙江大学 | 基于Keap1-Nrf2信号通路的晶状体损伤抑制剂 |
| KR102662922B1 (ko) * | 2022-05-31 | 2024-05-03 | 주식회사 세네릭스 | 신규의 d-아미노산 유도체 및 이를 포함하는 약학 조성물 |
Family Cites Families (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5602100A (en) * | 1988-06-30 | 1997-02-11 | Astra Ab | Dermorphin analogs having pharmacological activity |
| ATE136905T1 (de) * | 1988-06-30 | 1996-05-15 | Astra Ab | Dermorphin-analoge, deren herstellungsverfahren, pharmazeutische zusammensetzungen und methode zur therapeutischen behandlung unter verwendung der analoge |
| US5747641A (en) * | 1989-12-21 | 1998-05-05 | Biogen Inc | Tat-derived transport polypeptide conjugates |
| US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
| US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
| ATE255450T1 (de) * | 1995-06-09 | 2003-12-15 | Hisamitsu Pharmaceutical Co | Matrix für iontophorese |
| US5849761A (en) * | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
| US5885958A (en) * | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
| US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
| AU1818299A (en) * | 1997-12-10 | 1999-06-28 | Washington University | Anti-pathogen system and methods of use thereof |
| WO1999055321A1 (en) * | 1998-04-24 | 1999-11-04 | Mitokor | Compounds and methods for treating mitochondria-associated diseases |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| SE9900961D0 (sv) * | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
| AU7856600A (en) * | 1999-10-04 | 2001-05-10 | University Of Medicine And Dentistry Of New Jersey | Novel carbamates and ureas |
| US6759520B1 (en) * | 1999-10-28 | 2004-07-06 | The New England Medical Center Hospitals, Inc. | Chimeric analgesic peptides |
| US20050192215A1 (en) * | 2000-01-21 | 2005-09-01 | Malabika Ghosh | Methods and materials relating to novel polypeptides and polynucleotides |
| JP2001270832A (ja) * | 2000-03-27 | 2001-10-02 | Ito En Ltd | 網膜障害予防剤 |
| AU2001277908A1 (en) * | 2000-07-18 | 2002-01-30 | Cornell Research Foundation Inc. | Medicinal uses of mu-opioid receptor agonists |
| US6900178B2 (en) * | 2000-09-12 | 2005-05-31 | University Of Kentucky Research Foundation | Protection against ischemia and reperfusion injury |
| US20070015146A1 (en) * | 2001-05-22 | 2007-01-18 | Gene Logic, Inc. | Molecular nephrotoxicology modeling |
| EP1542664A4 (en) * | 2002-08-14 | 2008-04-16 | Med College Georgia Res Inst | METHODS AND COMPOSITIONS FOR TREATING MACULAR AND RETINAL DISORDERS |
| US7354574B2 (en) * | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
| US20060172972A1 (en) | 2002-12-20 | 2006-08-03 | Chakshu Research Inc | Formulation and method for administration of ophthalmologically active agents |
| DK2656854T3 (en) * | 2003-02-04 | 2015-07-06 | Cornell Res Foundation Inc | Applications of an aromatic-cationic peptide |
| JP2004323486A (ja) * | 2003-04-30 | 2004-11-18 | National Institute Of Advanced Industrial & Technology | 網膜及び／又はブドウ膜疾患の予防乃至治療用点眼薬 |
| BRPI0409911A (pt) * | 2003-05-01 | 2006-04-25 | Cornell Res Foundation Inc | método para liberar uma molécula em uma célula, e, complexo carreador |
| US7232824B2 (en) * | 2003-09-30 | 2007-06-19 | Scios, Inc. | Quinazoline derivatives as medicaments |
| CA2851972C (en) * | 2004-01-23 | 2015-06-23 | Cornell Research Foundation, Inc. | Methods for reducing oxidative damage |
| SI1755616T1 (sl) | 2004-04-08 | 2014-04-30 | Eye Co Pty Ltd. | Zdravljenje eksudativne retinopatije z mineralkortikoidi |
| US20050272101A1 (en) * | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
| JP4760111B2 (ja) | 2005-04-26 | 2011-08-31 | 株式会社セガ | 映像オブジェクト表現用データ構造生成プログラム、映像オブジェクト表現用データ構造生成方法、映像ソフト開発装置、映像処理プログラム、映像処理方法、映像処理装置、映像オブジェクト表現用データ構造、および、記録媒体 |
| US8088773B2 (en) | 2005-05-12 | 2012-01-03 | The Texas A&M University System | Therapeutic compositions and methods |
| JP2007043629A (ja) * | 2005-06-30 | 2007-02-15 | Sony Corp | グラフィック・ユーザ・インタフェース装置と操作入力処理方法及び双方向コミュニケーション装置 |
| CA2615360A1 (en) | 2005-07-15 | 2007-01-25 | Chakshu Research Inc. | Formulation and method for administration of ophthalmologically active agents |
| EP3725324A1 (en) * | 2005-09-16 | 2020-10-21 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method for reducing cd36 expression |
| KR20080066916A (ko) | 2005-10-05 | 2008-07-17 | 아쿠멘 바이오파마수티칼즈 케이.케이. | 에프린 비2를 이용한 혈관신생 억제 방법 |
| US20070259377A1 (en) * | 2005-10-11 | 2007-11-08 | Mickey Urdea | Diabetes-associated markers and methods of use thereof |
| TW200744627A (en) | 2006-02-21 | 2007-12-16 | Pfizer Prod Inc | Methods for the treatment of macular degeneration and related eye conditions |
| WO2007120828A1 (en) * | 2006-04-14 | 2007-10-25 | Novartis Ag | Use of il-i antibodies for treating ophthalmic disorders |
| US20080027082A1 (en) * | 2006-06-19 | 2008-01-31 | Berthold Hocher | Use of adenosine a1 antagonists in radiocontrast media induced nephropathy |
| DE102006042329B4 (de) * | 2006-09-01 | 2008-08-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zum selektiven plasmachemischen Trockenätzen von auf Oberflächen von Silicium-Wafern ausgebildetem Phosphorsilikatglas |
| CN101600451A (zh) | 2006-12-11 | 2009-12-09 | 犹他大学研究基金会 | 用于治疗病理性血管生成和血管通透性的组合物和方法 |
| JP2008195655A (ja) * | 2007-02-14 | 2008-08-28 | Kitasato Institute | 糖尿病白内障の治療剤 |
| WO2008111497A1 (ja) * | 2007-03-08 | 2008-09-18 | Santen Pharmaceutical Co., Ltd. | トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤 |
| JP5314931B2 (ja) * | 2007-05-25 | 2013-10-16 | 参天製薬株式会社 | 加齢黄斑変性の予防又は治療剤 |
| SI2252312T1 (sl) * | 2008-02-07 | 2014-08-29 | Cornell University, | Postopki za preprečevanje ali zdravljenje insulinske rezistence |
| WO2009108695A2 (en) * | 2008-02-26 | 2009-09-03 | Cornell University | Methods for prevention and treatment of acute renal injury |
| US20100331265A1 (en) | 2009-03-20 | 2010-12-30 | Tompkins Ronald G | Methods for the prevention and treatment of burn injuries and secondary complications |
| FR2945540B1 (fr) | 2009-05-15 | 2012-06-08 | Rhodia Operations | Procede de preparation de mousse polyamide et mousse susceptible d'etre obtenue par ce procede |
| HUE029550T2 (en) | 2009-08-12 | 2017-03-28 | Univ Cornell | Methods of preventing or treating metabolic syndrome |
| PT2470191E (pt) * | 2009-08-24 | 2014-06-12 | Stealth Peptides Int Inc | Métodos e composições para prevenção ou tratamento de doenças oftálmicas |
| AU2011207432A1 (en) * | 2010-01-25 | 2012-08-02 | Cornell University | Aromatic-cationic peptides and uses of same |
| US20130040901A1 (en) * | 2010-02-26 | 2013-02-14 | University Of Florida Research Foundation Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
| EP3290433A1 (en) | 2010-05-03 | 2018-03-07 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
| CN105126071A (zh) | 2011-06-14 | 2015-12-09 | 康肽德生物医药技术有限公司 | 芳香族阳离子肽及其用途 |
| WO2014210056A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
| US20160199437A1 (en) * | 2015-01-08 | 2016-07-14 | D. Travis Wilson | Therapeutic compositions including iron chelators and uses thereof |
| US20160228491A1 (en) * | 2015-02-09 | 2016-08-11 | Stealth Biotherapeutics Corp | Therapeutic compositions including phenazine-3-one and phenothiazine-3-one derivatives and uses thereof |
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2010
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- 2010-08-23 HR HRP20231277TT patent/HRP20231277T1/hr unknown
- 2010-08-23 LT LTEP20156769.0T patent/LT3708178T/lt unknown
- 2010-08-23 WO PCT/US2010/046338 patent/WO2011025734A1/en active Application Filing
- 2010-08-23 DK DK10812524.6T patent/DK2470191T3/da active
- 2010-08-23 EP EP16186448.3A patent/EP3150215A1/en not_active Withdrawn
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