HRP20231277T1 - Peptid za upotrebu u prevenciji ili liječenju makularne degeneracije - Google Patents
Peptid za upotrebu u prevenciji ili liječenju makularne degeneracije Download PDFInfo
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- HRP20231277T1 HRP20231277T1 HRP20231277TT HRP20231277T HRP20231277T1 HR P20231277 T1 HRP20231277 T1 HR P20231277T1 HR P20231277T T HRP20231277T T HR P20231277TT HR P20231277 T HRP20231277 T HR P20231277T HR P20231277 T1 HRP20231277 T1 HR P20231277T1
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- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 claims 1
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- PHUTUTUABXHXLW-UHFFFAOYSA-N pindolol Chemical compound CC(C)NCC(O)COC1=CC=CC2=NC=C[C]12 PHUTUTUABXHXLW-UHFFFAOYSA-N 0.000 claims 1
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- 229910052711 selenium Inorganic materials 0.000 claims 1
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- SKIVFJLNDNKQPD-UHFFFAOYSA-N sulfacetamide Chemical compound CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 SKIVFJLNDNKQPD-UHFFFAOYSA-N 0.000 claims 1
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- 238000007910 systemic administration Methods 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 claims 1
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- 229960002180 tetracycline Drugs 0.000 claims 1
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- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 229960000337 tetryzoline Drugs 0.000 claims 1
- 229960002663 thioctic acid Drugs 0.000 claims 1
- 229960004605 timolol Drugs 0.000 claims 1
- 229960000707 tobramycin Drugs 0.000 claims 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 claims 1
- 229960002368 travoprost Drugs 0.000 claims 1
- MKPLKVHSHYCHOC-AHTXBMBWSA-N travoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(C(F)(F)F)=C1 MKPLKVHSHYCHOC-AHTXBMBWSA-N 0.000 claims 1
- VSQQQLOSPVPRAZ-RRKCRQDMSA-N trifluridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C(F)(F)F)=C1 VSQQQLOSPVPRAZ-RRKCRQDMSA-N 0.000 claims 1
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- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims 1
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- TVHAZVBUYQMHBC-SNHXEXRGSA-N unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O TVHAZVBUYQMHBC-SNHXEXRGSA-N 0.000 claims 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/07—Tetrapeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
- C07K5/0817—Tripeptides with the first amino acid being basic the first amino acid being Arg
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. Peptid predstavljen formulom D-Arg-2'6'-Dmt-Lys-Phe-NH2 ili Phe-D-Arg-Phe-Lys-NH2, za liječenje ili prevenciju oftalmološkog stanja, pri čemu je oftalmološko stanje makularna degeneracija.
2. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid D-Arg-2’6’-Dmt-Lys-Phe-NH2.
3. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid Phe-D-Arg-Phe-Lys-NH2.
4. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je subjekt čovjek.
5. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid formuliran za intraokularnu primjenu, iontoforetski, oralno, lokalno, sistemski, intravenozno, subkutano ili intramuskularno.
6. Peptid za upotrebu sukladno patentnom zahtjevu 1, naznačen time da je peptid formuliran za primjenu s drugim aktivnim sredstvom.
7. Peptid za upotrebu sukladno patentnom zahtjevu 6, naznačen time da je drugo aktivno sredstvo odabrano iz skupine koju čine: antioksidans, metalni komplekser, protuupalni lijek, antibiotik i antihistaminik.
8. Peptid za upotrebu sukladno patentnom zahtjevu 7, naznačen time da je antioksidans vitamin A, vitamin C, vitamin E, likopen, selen, α-lipoična kiselina, koenzim Q, glutation ili karotenoid.
9. Peptid za upotrebu sukladno patentnom zahtjevu 6, gdje je drugo aktivno sredstvo odabrano iz skupine koju čine: aceklidin, acetazolamid, anekortav, apraklonidin, atropin, azapentacen, azelastin, bacitracin, befunolol, betametazon, betaksolol, bimatoprost, brimonidin, brinzolamid, karbahol, karteolol, celekoksib, kloramfenikol, klortetraciklin, ciprofloksacin, kromoglikat, kromolin, ciklopentolat, ciklosporin, dapiprazol, demekarij, deksametazon, diklofenak, diklorfenamid, dipivefrin, dorzolamid, ehotiofat, emedastin, epinastin, epinefrin, eritromicin, etokzolamid, eukatropin, fludrokortizon, fluorometolon, flurbiprofen, fomivirsen, framicetin, ganciklovir, gatifloksacin, gentamicin, homatropin, hidrokortizon, idoksuridin, indometacin, izoflurofat, ketorolak, ketotifen, latanoprost, levobetaksolol, levobunolol, levokabastin, levofloksacin, lodoksamid, loteprednol, medrizon, metazolamid, metipranolol, moksifloksacin, nafazolin, natamicin, nedokromil, neomicin, norfloksacin, ofloksacin, olopatadin, oksimetazolin, pemirolast, pegaptanib, fenilefrin, fizostigmin, pilokarpin, pindolol, pirenoksin, polimiksin B, prednizolon, proparakain, ranibizumab, rimeksolon, skopolamin, sezolamid, skvalamin, sulfacetamid, suprofen, tetrakain, tetraciklin, tetrahidrozolin, tetrizolin, timolol, tobramicin, travoprost, triamcinulon, trifluorometazolamid, trifluridin, trimetoprim, tropikamid, unoproston, vidarbin, ksilometazolin, njihove farmaceutski prihvatljive soli i njihove kombinacije.
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EP20156769.0A EP3708178B1 (en) | 2009-08-24 | 2010-08-23 | Peptide for use in preventing or treating macular degeneration |
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US (8) | US8470784B2 (hr) |
EP (17) | EP2962695A1 (hr) |
JP (7) | JP6120399B2 (hr) |
CN (3) | CN105056206A (hr) |
CA (1) | CA2772094C (hr) |
DK (2) | DK3708178T3 (hr) |
ES (2) | ES2964555T3 (hr) |
FI (1) | FI3708178T3 (hr) |
HK (5) | HK1172833A1 (hr) |
HR (1) | HRP20231277T1 (hr) |
HU (1) | HUE064800T2 (hr) |
LT (1) | LT3708178T (hr) |
PL (2) | PL2470191T3 (hr) |
PT (2) | PT3708178T (hr) |
SI (2) | SI3708178T1 (hr) |
WO (1) | WO2011025734A1 (hr) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8907904B2 (en) | 2010-10-01 | 2014-12-09 | Z124 | Smartpad split screen desktop |
WO2010037141A1 (en) | 2008-09-29 | 2010-04-01 | Cardiaq Valve Technologies, Inc. | Heart valve |
WO2010040009A1 (en) | 2008-10-01 | 2010-04-08 | Cardiaq Valve Technologies, Inc. | Delivery system for vascular implant |
EP2419050B2 (en) | 2009-04-15 | 2023-10-18 | Edwards Lifesciences CardiAQ LLC | Vascular implant and delivery system |
US8470784B2 (en) * | 2009-08-24 | 2013-06-25 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
EP2808029A3 (en) * | 2010-03-15 | 2015-04-01 | Stealth Peptides International, Inc. | Combination therapies using cyclosporine and aromatic cationic peptides |
US20110269807A1 (en) * | 2010-04-30 | 2011-11-03 | Allergan, Inc. | Novel treatment for age related macular degeneration and ocular ischemic disease associated with complement activation by targeting 5-lipoxygenase |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
WO2012021107A2 (en) | 2010-08-12 | 2012-02-16 | Nanyang Technological University | A liposomal formulation for ocular drug delivery |
JP2014520246A (ja) * | 2011-03-24 | 2014-08-21 | コーネル ユニヴァーシティー | 芳香族カチオン性ペプチド及びその使用 |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
CN102327600A (zh) * | 2011-09-14 | 2012-01-25 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 用于预防和治疗辐射损伤的rx31肽 |
US8842057B2 (en) | 2011-09-27 | 2014-09-23 | Z124 | Detail on triggers: transitional states |
CA2858550A1 (en) * | 2011-12-09 | 2013-06-13 | Stealth Peptides International, Inc. | Aromatic-cationic peptides and uses of same |
AU2013222423A1 (en) * | 2012-02-22 | 2014-09-11 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
EP3406257B1 (en) * | 2012-03-30 | 2020-04-22 | Stealth Peptides International, Inc. | Methods and compositions for the prevention and treatment neuropathy |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
EP3300740A1 (en) * | 2012-08-02 | 2018-04-04 | Stealth Peptides International, Inc. | Methods for treatment of atherosclerosis |
CA2888899C (en) * | 2012-10-24 | 2023-02-21 | Japan Innovative Therapeutics, Inc. | Use of tryptase inhibitors in the treatment retinopathy of prematurity |
US9265458B2 (en) | 2012-12-04 | 2016-02-23 | Sync-Think, Inc. | Application of smooth pursuit cognitive testing paradigms to clinical drug development |
CN110339339A (zh) * | 2013-03-01 | 2019-10-18 | 康德生物医疗技术公司 | 治疗线粒体疾病的方法 |
JP6518197B2 (ja) * | 2013-03-01 | 2019-05-22 | ステルス バイオセラピューティックス コープ | バース症候群の予防または治療のための方法及び組成物 |
US9380976B2 (en) | 2013-03-11 | 2016-07-05 | Sync-Think, Inc. | Optical neuroinformatics |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
CA2919992C (en) * | 2013-08-01 | 2022-08-09 | Stealth Biotherapeutics Corp | Methods and compositions for preventing or treating leber's hereditary optic neuropathy |
US20160175379A1 (en) * | 2013-08-12 | 2016-06-23 | Stealth Bio Therapeutics Corp | Combination therapy for the treatment of ischemia-reperfusion injury |
WO2015061658A1 (en) * | 2013-10-25 | 2015-04-30 | Children's Medical Center Corporation | Methods of treating or preventing vascular diseases of the retina |
CN105939759B (zh) * | 2013-12-02 | 2020-01-17 | 康德生物医疗技术公司 | 用于治疗白癜风的组合物和方法 |
CA2936146A1 (en) * | 2014-01-06 | 2015-07-09 | Stealth Biotherapeutics Corp | Methods and compositions for preventing or treating dominant optic atrophy |
US9956195B2 (en) | 2014-01-07 | 2018-05-01 | Nanyang Technological University | Stable liposomal formulations for ocular drug delivery |
US11447568B2 (en) | 2014-04-10 | 2022-09-20 | Lankenau Institute For Medical Research | Methods and compositions for the treatment of ocular diseases and disorders |
EP3149035A4 (en) * | 2014-05-28 | 2018-05-16 | Stealth BioTherapeutics Corp | Therapeutic compositions including therapeutic small molecules and uses thereof |
JP2017538728A (ja) * | 2014-12-19 | 2017-12-28 | ケミン、インダストリーズ、インコーポレーテッドKemin Industries, Inc. | イオントフォレシスを用いた生物活性分子の眼内送達 |
EP3397271B1 (en) | 2015-12-30 | 2021-11-03 | Marshall University Research Corporation | Compositions and methods for treating retinopathy |
WO2017156403A1 (en) * | 2016-03-11 | 2017-09-14 | Stealth Biotherapeutics | Crystalline salt forms |
CA3020393A1 (en) | 2016-04-11 | 2017-10-19 | Carnot, Llc | Chiral peptides |
WO2017177262A1 (en) * | 2016-04-11 | 2017-10-19 | University Of Canberra | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier |
WO2018187400A1 (en) | 2017-04-05 | 2018-10-11 | Stealth Biotherapeutics Corp. | Crystalline salt forms of boc-d-arg-dmt-lys-(boc)-phe-nh2 |
US20180318319A1 (en) | 2017-05-04 | 2018-11-08 | Ocular Science, Inc. | Compositions and Methods for Treating Eyes and Methods of Preparation |
RU2761436C1 (ru) * | 2017-11-17 | 2021-12-08 | Целликс Био Прайвет Лимитед | Композиции и способы лечения нарушений со стороны органа зрения |
US10676506B2 (en) | 2018-01-26 | 2020-06-09 | Stealth Biotherapeutics Corp. | Crystalline bis- and tris-hydrochloride salt of elamipretide |
PL424452A1 (pl) * | 2018-01-31 | 2019-08-12 | Forty-Four Pharmaceuticals Spółka Z Ograniczoną Odpowiedzialnością | Inhibitory obojętnej endopeptydazy (NEP) i ludzkiej rozpuszczalnej endopeptydazy (hSEP) do profilaktyki i leczenia chorób oczu |
EP3787749A4 (en) * | 2018-05-03 | 2022-01-26 | Alimera Sciences, Inc. | METHODS OF TREATMENT OF RETINAL DISEASES |
US20210330735A1 (en) * | 2018-07-16 | 2021-10-28 | Stealth Biotherapeutics Corp | Compositions and methods for the treatment of traumatic optic neuropathy |
AU2019343188A1 (en) * | 2018-09-21 | 2021-05-20 | Aufbau Medical Innovations Limited | Compositions and methods for glaucoma |
WO2020214990A1 (en) * | 2019-04-17 | 2020-10-22 | Ascidian Therapeutics, Inc. | Abca4 cell line and methods of use |
JP2020174859A (ja) * | 2019-04-17 | 2020-10-29 | 学校法人日本医科大学 | 網膜剥離が生じるリスクが低い網膜変性症(rd)モデルマウスを取得する方法 |
US11071724B2 (en) | 2019-05-17 | 2021-07-27 | Ocular Science, Inc. | Compositions and methods for treating presbyopia |
JP7171971B1 (ja) * | 2020-12-24 | 2022-11-15 | 参天製薬株式会社 | エピナスチン又はその塩と硫黄系抗酸化剤を含有する経皮投与用医薬組成物 |
WO2023069255A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
WO2023069549A1 (en) * | 2021-10-20 | 2023-04-27 | Stealth Biotherapeutics Inc. | Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions |
WO2023086873A1 (en) * | 2021-11-10 | 2023-05-19 | Reverspah Llc | Methods and compositions for treating cancer |
CN114099678A (zh) * | 2021-11-23 | 2022-03-01 | 浙江大学 | 基于Keap1-Nrf2信号通路的晶状体损伤抑制剂 |
KR102662922B1 (ko) * | 2022-05-31 | 2024-05-03 | 주식회사 세네릭스 | 신규의 d-아미노산 유도체 및 이를 포함하는 약학 조성물 |
Family Cites Families (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US5602100A (en) | 1988-06-30 | 1997-02-11 | Astra Ab | Dermorphin analogs having pharmacological activity |
DE68926269T2 (de) | 1988-06-30 | 1996-08-14 | Astra Ab | Dermorphin-Analoge, deren Herstellungsverfahren, pharmazeutische Zusammensetzungen und Methode zur therapeutischen Behandlung unter Verwendung der Analoge |
US5747641A (en) | 1989-12-21 | 1998-05-05 | Biogen Inc | Tat-derived transport polypeptide conjugates |
US5858784A (en) | 1991-12-17 | 1999-01-12 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol- and liposome-based delivery |
US5674534A (en) | 1992-06-11 | 1997-10-07 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
US5716644A (en) | 1992-06-11 | 1998-02-10 | Alkermes, Inc. | Composition for sustained release of non-aggregated erythropoietin |
DE69630918T2 (de) | 1995-06-09 | 2004-10-28 | Hisamitsu Pharmaceutical Co., Inc., Tosu | Matrix für Iontophorese |
US5849761A (en) | 1995-09-12 | 1998-12-15 | Regents Of The University Of California | Peripherally active anti-hyperalgesic opiates |
US5885958A (en) | 1997-03-25 | 1999-03-23 | Administrators Of The Tulane Educational Fund | Mu-opiate receptor peptides |
US5989463A (en) | 1997-09-24 | 1999-11-23 | Alkermes Controlled Therapeutics, Inc. | Methods for fabricating polymer-based controlled release devices |
JP2002505077A (ja) | 1997-12-10 | 2002-02-19 | ワシントン大学 | 抗病原体システムおよびその使用方法 |
AU3965699A (en) | 1998-04-24 | 1999-11-16 | Mitokor | Compounds and methods for treating mitochondria-associated diseases |
US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
SE9900961D0 (sv) | 1999-03-16 | 1999-03-16 | Astra Ab | Novel compounds |
AU7855900A (en) | 1999-10-04 | 2001-05-10 | University Of Medicine And Dentistry Of New Jersey | Methods for identifying rna binding compounds |
US6759520B1 (en) | 1999-10-28 | 2004-07-06 | The New England Medical Center Hospitals, Inc. | Chimeric analgesic peptides |
US20050192215A1 (en) | 2000-01-21 | 2005-09-01 | Malabika Ghosh | Methods and materials relating to novel polypeptides and polynucleotides |
JP2001270832A (ja) * | 2000-03-27 | 2001-10-02 | Ito En Ltd | 網膜障害予防剤 |
DE60143945D1 (de) | 2000-07-18 | 2011-03-10 | Cornell Res Foundation Inc | Medizinische verwendung von agonisten des mu-opioid rezeptors |
US6900178B2 (en) | 2000-09-12 | 2005-05-31 | University Of Kentucky Research Foundation | Protection against ischemia and reperfusion injury |
US20070015146A1 (en) | 2001-05-22 | 2007-01-18 | Gene Logic, Inc. | Molecular nephrotoxicology modeling |
AU2003259793A1 (en) * | 2002-08-14 | 2004-03-03 | Medical College Of Georgia Research Institute, Inc. | Methods and compositions for treatment of macular and retinal disease |
US7354574B2 (en) * | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
US20060172972A1 (en) | 2002-12-20 | 2006-08-03 | Chakshu Research Inc | Formulation and method for administration of ophthalmologically active agents |
HUE027110T2 (en) | 2003-02-04 | 2016-08-29 | Cornell Res Foundation Inc | Use of an aromatic cationic peptide |
JP2004323486A (ja) * | 2003-04-30 | 2004-11-18 | National Institute Of Advanced Industrial & Technology | 網膜及び/又はブドウ膜疾患の予防乃至治療用点眼薬 |
CN100506841C (zh) | 2003-05-01 | 2009-07-01 | 科内尔研究基金会 | 将分子递送到细胞的方法和载体复合物 |
US7232824B2 (en) | 2003-09-30 | 2007-06-19 | Scios, Inc. | Quinazoline derivatives as medicaments |
RU2376028C2 (ru) | 2004-01-23 | 2009-12-20 | Корнелл Рисеч Фаундейшн, Инк. | Способ уменьшения окислительного повреждения (варианты) |
WO2005099715A2 (en) | 2004-04-08 | 2005-10-27 | Retmed Pty Ltd. | Treatment of ophthalmic conditions with mineralcorticoids |
US20050272101A1 (en) | 2004-06-07 | 2005-12-08 | Prasad Devarajan | Method for the early detection of renal injury |
JP4760111B2 (ja) | 2005-04-26 | 2011-08-31 | 株式会社セガ | 映像オブジェクト表現用データ構造生成プログラム、映像オブジェクト表現用データ構造生成方法、映像ソフト開発装置、映像処理プログラム、映像処理方法、映像処理装置、映像オブジェクト表現用データ構造、および、記録媒体 |
US8088773B2 (en) | 2005-05-12 | 2012-01-03 | The Texas A&M University System | Therapeutic compositions and methods |
JP2007043629A (ja) * | 2005-06-30 | 2007-02-15 | Sony Corp | グラフィック・ユーザ・インタフェース装置と操作入力処理方法及び双方向コミュニケーション装置 |
EP1904108B1 (en) | 2005-07-15 | 2011-11-30 | Chakshu Research, Inc. | Ophthalmological formulation comprising methylsulfonylmethane and ciprofloxacin |
EP1931369B1 (en) * | 2005-09-16 | 2016-08-17 | Cornell Research Foundation, Inc. | Aromatic-cationic peptide for use in a method for reducing CD36 expression |
EP1932534A1 (en) | 2005-10-05 | 2008-06-18 | Aqumen Biopharmaceuticals K.K. | Method of inhibiting angiogenesis by using ephrin b2 |
US20070259377A1 (en) | 2005-10-11 | 2007-11-08 | Mickey Urdea | Diabetes-associated markers and methods of use thereof |
TW200744627A (en) | 2006-02-21 | 2007-12-16 | Pfizer Prod Inc | Methods for the treatment of macular degeneration and related eye conditions |
US20100047204A1 (en) * | 2006-04-14 | 2010-02-25 | Dana Sue Yoo | Use of organic compounds |
US20080027082A1 (en) | 2006-06-19 | 2008-01-31 | Berthold Hocher | Use of adenosine a1 antagonists in radiocontrast media induced nephropathy |
DE102006042329B4 (de) * | 2006-09-01 | 2008-08-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zum selektiven plasmachemischen Trockenätzen von auf Oberflächen von Silicium-Wafern ausgebildetem Phosphorsilikatglas |
CA2672297A1 (en) | 2006-12-11 | 2008-06-19 | University Of Utah Research Foundation | Compositions and methods for treating pathologic angiogenesis and vascular permeability |
JP2008195655A (ja) * | 2007-02-14 | 2008-08-28 | Kitasato Institute | 糖尿病白内障の治療剤 |
WO2008111497A1 (ja) * | 2007-03-08 | 2008-09-18 | Santen Pharmaceutical Co., Ltd. | トリテルペノイドを有効成分として含有する酸化ストレスが関連する眼疾患の予防又は治療剤 |
ES2370751T3 (es) | 2007-05-25 | 2011-12-22 | Santen Pharmaceutical Co., Ltd | Agente profiláctico o terapéutico para la degeneración macular asociada a la edad. |
EP2712620A1 (en) * | 2008-02-07 | 2014-04-02 | Cornell University | Methods for Preventing or Treating Insulin Resistance |
EP2262520B1 (en) * | 2008-02-26 | 2017-05-03 | Cornell University | Compositions for prevention and treatment of renal injury |
US20100331265A1 (en) | 2009-03-20 | 2010-12-30 | Tompkins Ronald G | Methods for the prevention and treatment of burn injuries and secondary complications |
FR2945540B1 (fr) | 2009-05-15 | 2012-06-08 | Rhodia Operations | Procede de preparation de mousse polyamide et mousse susceptible d'etre obtenue par ce procede |
EP3251686A1 (en) | 2009-08-12 | 2017-12-06 | Cornell University | Methods for preventing or treating metabolic syndrome |
US8470784B2 (en) * | 2009-08-24 | 2013-06-25 | Stealth Peptides International, Inc. | Methods and compositions for preventing or treating ophthalmic conditions |
AU2011207432A1 (en) * | 2010-01-25 | 2012-08-02 | Cornell University | Aromatic-cationic peptides and uses of same |
US20130040901A1 (en) * | 2010-02-26 | 2013-02-14 | University Of Florida Research Foundation Inc. | Mitochondrial-targeted antioxidants protect against mechanical ventilation-induced diaphragm dysfunction and skeletal muscle atrophy |
JP2013532124A (ja) | 2010-05-03 | 2013-08-15 | ステルス ペプチドズ インターナショナル インコーポレイテッド | 芳香族系陽イオンペプチド及びその使用 |
CN105126071A (zh) | 2011-06-14 | 2015-12-09 | 康肽德生物医药技术有限公司 | 芳香族阳离子肽及其用途 |
WO2014210056A1 (en) * | 2013-06-27 | 2014-12-31 | Stealth Peptides International, Inc. | Peptide therapeutics and methods for using same |
US20160199437A1 (en) * | 2015-01-08 | 2016-07-14 | D. Travis Wilson | Therapeutic compositions including iron chelators and uses thereof |
US20160228491A1 (en) * | 2015-02-09 | 2016-08-11 | Stealth Biotherapeutics Corp | Therapeutic compositions including phenazine-3-one and phenothiazine-3-one derivatives and uses thereof |
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