HRP20230695T1 - Povećanje prinosa virusu sličnih čestica u biljkama - Google Patents
Povećanje prinosa virusu sličnih čestica u biljkama Download PDFInfo
- Publication number
- HRP20230695T1 HRP20230695T1 HRP20230695TT HRP20230695T HRP20230695T1 HR P20230695 T1 HRP20230695 T1 HR P20230695T1 HR P20230695T T HRP20230695T T HR P20230695TT HR P20230695 T HRP20230695 T HR P20230695T HR P20230695 T1 HRP20230695 T1 HR P20230695T1
- Authority
- HR
- Croatia
- Prior art keywords
- plant
- seq
- influenza
- protein
- vlp
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—RNA viruses
- C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16223—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16251—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161541780P | 2011-09-30 | 2011-09-30 | |
| PCT/CA2012/050681 WO2013044390A1 (en) | 2011-09-30 | 2012-09-28 | Increasing virus-like particle yield in plants |
| EP12836545.9A EP2760882B1 (en) | 2011-09-30 | 2012-09-28 | Increasing virus-like particle yield in plants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20230695T1 true HRP20230695T1 (hr) | 2023-12-22 |
Family
ID=47994080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20230695TT HRP20230695T1 (hr) | 2011-09-30 | 2012-09-28 | Povećanje prinosa virusu sličnih čestica u biljkama |
Country Status (27)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11390878B2 (en) | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| RU2682752C2 (ru) | 2011-09-30 | 2019-03-21 | Медикаго Инк. | Повышение выхода вирусоподобных частиц в растениях |
| US12467058B2 (en) | 2013-03-28 | 2025-11-11 | Aramis Biotechnologies Inc. | Influenza virus-like particle production in plants |
| KR102199018B1 (ko) | 2013-03-28 | 2021-01-07 | 메디카고 인코포레이티드 | 식물에서 인플루엔자 바이러스-유사 입자 생산 |
| WO2015103704A1 (en) * | 2014-01-10 | 2015-07-16 | Medicago Inc. | Cpmv enhancer elements |
| US10563213B2 (en) | 2014-03-27 | 2020-02-18 | Medicago Inc. | Modified CPMV enhancer elements |
| MX2020009495A (es) * | 2018-03-14 | 2020-12-07 | Medicago Inc | Potenciador de la expresion en plantas. |
| JP2021528970A (ja) | 2018-06-27 | 2021-10-28 | メディカゴ インコーポレイテッド | インフルエンザウイルスヘマグルチニン変異体 |
| WO2020181354A1 (en) * | 2019-03-14 | 2020-09-17 | Mitsubishi Tanabe Pharma Corporation | Endogenous plant expression enhancer |
| WO2021236908A2 (en) * | 2020-05-20 | 2021-11-25 | Biomarin Pharmaceutical Inc. | Use of regulatory proteins for the production of adeno-associated virus |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5428147A (en) | 1983-04-15 | 1995-06-27 | Mycogen Plant Science, Inc. | Octopine T-DNA promoters |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5100792A (en) | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US4962028A (en) | 1986-07-09 | 1990-10-09 | Dna Plant Technology Corporation | Plant promotors |
| US5232833A (en) | 1988-09-14 | 1993-08-03 | Stressgen Biotechnologies Corporation | Accumulation of heat shock proteins for evaluating biological damage due to chronic exposure of an organism to sublethal levels of pollutants |
| US5805417A (en) | 1995-10-13 | 1998-09-08 | Hitachi, Ltd. | Heat dissipation structure in a portable computer including a heat dissipation block extending from a heat dissipation plate through a first circuit board to a CPU on a second circuit board |
| US6392121B1 (en) | 1998-10-07 | 2002-05-21 | Boyce Thompson Institute For Plant Research | Gemini virus vectors for gene expression in plants |
| US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
| RU2164148C1 (ru) * | 2000-08-09 | 2001-03-20 | Петров Рэм Викторович | Вакцина против вируса гриппа и способ ее получения |
| KR20060029214A (ko) | 2003-05-05 | 2006-04-05 | 다우 아그로사이언시즈 엘엘씨 | 이식 유전자 식물 세포들로부터 유래된 안정한 면역예방적및 치료적 조성물들 및 생산방법 |
| KR20060035596A (ko) * | 2003-05-05 | 2006-04-26 | 보이스 톰슨 인스터튜트 포 플랜트 리서치 | 외래유전자도입 식물로부터 유래된 면역보호성 조성물을제조하기 위한 벡터와 세포 |
| CN101166827B (zh) * | 2005-04-29 | 2013-09-04 | 开普敦大学 | 在植物中表达蛋白质 |
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| PT1937301E (pt) | 2005-10-18 | 2015-09-14 | Novavax Inc | Partículas idênticas a vírus (vlps) da gripe funcionais |
| US20090169576A1 (en) * | 2005-10-26 | 2009-07-02 | Roberto Crea | Influenza combinatorial antigen vaccine |
| SG169996A1 (en) * | 2006-02-16 | 2011-04-29 | Us Gov Health & Human Serv | Antiviral agents and vaccines against influenza |
| ES2555544T3 (es) | 2006-03-07 | 2016-01-04 | Vaxinnate Corporation | Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas |
| US20100143393A1 (en) | 2006-05-11 | 2010-06-10 | Gale Smith | Novel influenza m2 vaccines |
| US8519113B2 (en) | 2006-05-22 | 2013-08-27 | Plant Bioscience Limited | Bipartite system, method and composition for the constitutive and inducible expression of high levels of foreign proteins in plants |
| JP2009540801A (ja) * | 2006-06-16 | 2009-11-26 | ダウ・アグロサイエンス・エル・エル・シー | トリインフルエンザ赤血球凝集素の新規なｄｎａ配列、ベクターおよびタンパク質 |
| US8697088B2 (en) | 2007-05-25 | 2014-04-15 | Novavax, Inc. | VLPs derived from cells that do not express a viral matrix or core protein |
| PL2155880T3 (pl) | 2007-06-15 | 2017-06-30 | Medicago Inc. | Modyfikacja wytwarzania glikoproteiny w roślinach |
| CA2615372A1 (en) * | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
| WO2009076778A1 (en) | 2007-11-27 | 2009-06-25 | Medicago Inc. | Recombinant influenza virus-like particles (vlps) produced in transgenic plants expressing hemagglutinin |
| GB0800272D0 (en) | 2008-01-08 | 2008-02-13 | Plant Bioscience Ltd | Protein expression systems |
| EA034733B1 (ru) | 2008-01-21 | 2020-03-13 | Медикаго Инк. | Нуклеиновая кислота для увеличенной экспрессии гемагглютинина вируса гриппа в растении и ее применение |
| WO2010003235A1 (en) | 2008-07-08 | 2010-01-14 | Medicago Inc. | Soluble recombinant influenza antigens |
| DK2318530T3 (en) | 2008-07-18 | 2016-10-03 | Medicago Inc | Ny epitope to immunization against influenza |
| WO2010025285A1 (en) | 2008-08-27 | 2010-03-04 | Arizona Board Of Regents For And On Behalf Of Arizona State University | A dna replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
| CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
| BRPI1015053A2 (pt) | 2009-06-24 | 2019-07-09 | Medicago Inc | partículas similares a vírus da influenza quiméricas compreendendo hemaglutinina |
| FR2947875B1 (fr) | 2009-07-10 | 2011-07-08 | Raymond A & Cie | Dispositif de fixation a elements de fixation multiples dont l'un est flottant |
| WO2011011390A1 (en) | 2009-07-20 | 2011-01-27 | Novavax, Inc. | Purified recombinant influenza virus ha proteins |
| SI3354657T1 (sl) | 2009-09-22 | 2022-05-31 | Medicago Inc. | Postopek za pripravo iz rastlin izpeljanih beljakovin |
| WO2011102900A1 (en) | 2010-02-18 | 2011-08-25 | Technovax, Inc. | Universal virus-like particle (vlp) influenza vaccines |
| AU2011312178B2 (en) | 2010-10-04 | 2016-05-12 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| TWI526539B (zh) | 2010-12-22 | 2016-03-21 | 苜蓿股份有限公司 | 植物中生產類病毒顆粒(vlp)的方法及以該方法生產之vlp |
| PL220281B1 (pl) | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
| RU2682752C2 (ru) | 2011-09-30 | 2019-03-21 | Медикаго Инк. | Повышение выхода вирусоподобных частиц в растениях |
| US11390878B2 (en) * | 2011-09-30 | 2022-07-19 | Medicago Inc. | Increasing protein yield in plants |
| US9555094B2 (en) | 2012-07-23 | 2017-01-31 | The Institute Of Biological Resources | Isolated nucleic acid for the production of a vaccine against virus |
| KR102199018B1 (ko) | 2013-03-28 | 2021-01-07 | 메디카고 인코포레이티드 | 식물에서 인플루엔자 바이러스-유사 입자 생산 |
-
2012
- 2012-09-28 RU RU2014116371A patent/RU2682752C2/ru active
- 2012-09-28 PH PH1/2014/500640A patent/PH12014500640A1/en unknown
- 2012-09-28 SI SI201232036T patent/SI2760882T1/sl unknown
- 2012-09-28 FI FIEP12836545.9T patent/FI2760882T3/fi active
- 2012-09-28 WO PCT/CA2012/050681 patent/WO2013044390A1/en not_active Ceased
- 2012-09-28 SG SG11201400712VA patent/SG11201400712VA/en unknown
- 2012-09-28 PL PL12836545.9T patent/PL2760882T3/pl unknown
- 2012-09-28 CN CN202310130025.2A patent/CN116218900A/zh active Pending
- 2012-09-28 HR HRP20230695TT patent/HRP20230695T1/hr unknown
- 2012-09-28 CA CA2850407A patent/CA2850407C/en active Active
- 2012-09-28 AU AU2012315421A patent/AU2012315421C1/en active Active
- 2012-09-28 BR BR112014007474A patent/BR112014007474A2/pt not_active Application Discontinuation
- 2012-09-28 EP EP12836545.9A patent/EP2760882B1/en active Active
- 2012-09-28 MX MX2014003776A patent/MX358883B/es active IP Right Grant
- 2012-09-28 PT PT128365459T patent/PT2760882T/pt unknown
- 2012-09-28 KR KR1020147011886A patent/KR101974017B1/ko active Active
- 2012-09-28 MY MYPI2014700716A patent/MY184072A/en unknown
- 2012-09-28 JP JP2014532198A patent/JP6248040B2/ja active Active
- 2012-09-28 HU HUE12836545A patent/HUE062759T2/hu unknown
- 2012-09-28 CN CN201280047819.2A patent/CN103930435A/zh active Pending
- 2012-09-28 TW TW101135891A patent/TWI700368B/zh not_active IP Right Cessation
- 2012-09-28 SG SG10201708052XA patent/SG10201708052XA/en unknown
- 2012-09-28 ES ES12836545T patent/ES2951259T3/es active Active
- 2012-09-28 NZ NZ622731A patent/NZ622731A/en not_active IP Right Cessation
- 2012-09-28 DK DK12836545.9T patent/DK2760882T5/da active
- 2012-09-28 US US14/347,804 patent/US11155581B2/en active Active
- 2012-09-28 EP EP19205918.6A patent/EP3626733B1/en active Active
- 2012-09-28 IN IN3077CHN2014 patent/IN2014CN03077A/en unknown
-
2014
- 2014-03-19 IL IL231587A patent/IL231587B/en active IP Right Grant
- 2014-03-28 MX MX2018006627A patent/MX2018006627A/es unknown
- 2014-04-29 ZA ZA2014/03059A patent/ZA201403059B/en unknown
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