HRP20210493T1 - Čvrsti pripravak za oralnu primjenu boja te njegova dijagnostička uporaba - Google Patents
Čvrsti pripravak za oralnu primjenu boja te njegova dijagnostička uporaba Download PDFInfo
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- HRP20210493T1 HRP20210493T1 HRP20210493TT HRP20210493T HRP20210493T1 HR P20210493 T1 HRP20210493 T1 HR P20210493T1 HR P20210493T T HRP20210493T T HR P20210493TT HR P20210493 T HRP20210493 T HR P20210493T HR P20210493 T1 HRP20210493 T1 HR P20210493T1
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- 239000008247 solid mixture Substances 0.000 title claims 2
- 239000000975 dye Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 claims 13
- 239000011159 matrix material Substances 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 6
- 239000001913 cellulose Substances 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 3
- 150000002433 hydrophilic molecules Chemical class 0.000 claims 3
- 150000002634 lipophilic molecules Chemical class 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 2
- 229920002472 Starch Polymers 0.000 claims 2
- 229940106189 ceramide Drugs 0.000 claims 2
- 150000001783 ceramides Chemical class 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 150000004665 fatty acids Chemical class 0.000 claims 2
- -1 glycol alkyl ethers Chemical class 0.000 claims 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 230000008018 melting Effects 0.000 claims 2
- 238000002844 melting Methods 0.000 claims 2
- 230000007170 pathology Effects 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 235000019698 starch Nutrition 0.000 claims 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims 1
- SBASXUCJHJRPEV-UHFFFAOYSA-N 2-(2-methoxyethoxy)ethanol Chemical group COCCOCCO SBASXUCJHJRPEV-UHFFFAOYSA-N 0.000 claims 1
- SJZRECIVHVDYJC-UHFFFAOYSA-M 4-hydroxybutyrate Chemical compound OCCCC([O-])=O SJZRECIVHVDYJC-UHFFFAOYSA-M 0.000 claims 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 claims 1
- 229920001353 Dextrin Polymers 0.000 claims 1
- 239000004375 Dextrin Substances 0.000 claims 1
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 1
- 244000043261 Hevea brasiliensis Species 0.000 claims 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 206010056626 Pseudopolyp Diseases 0.000 claims 1
- 229920001800 Shellac Polymers 0.000 claims 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 150000001298 alcohols Chemical class 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 235000010443 alginic acid Nutrition 0.000 claims 1
- 229920000615 alginic acid Polymers 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 229920013820 alkyl cellulose Polymers 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000008051 alkyl sulfates Chemical class 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 235000012730 carminic acid Nutrition 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- 150000001841 cholesterols Chemical class 0.000 claims 1
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 235000019425 dextrin Nutrition 0.000 claims 1
- 238000007435 diagnostic evaluation Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 229920013821 hydroxy alkyl cellulose Polymers 0.000 claims 1
- 229940097275 indigo Drugs 0.000 claims 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 235000010445 lecithin Nutrition 0.000 claims 1
- 239000000787 lecithin Substances 0.000 claims 1
- 229940067606 lecithin Drugs 0.000 claims 1
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 1
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 claims 1
- 229960000907 methylthioninium chloride Drugs 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- 229920003052 natural elastomer Polymers 0.000 claims 1
- 229920001194 natural rubber Polymers 0.000 claims 1
- 230000001613 neoplastic effect Effects 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 1
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000004804 polysaccharides Chemical class 0.000 claims 1
- 230000001855 preneoplastic effect Effects 0.000 claims 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 1
- 239000004208 shellac Substances 0.000 claims 1
- 229940113147 shellac Drugs 0.000 claims 1
- 235000013874 shellac Nutrition 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 229920003051 synthetic elastomer Polymers 0.000 claims 1
- 239000005061 synthetic rubber Substances 0.000 claims 1
- 229950003937 tolonium Drugs 0.000 claims 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 claims 1
- 150000003626 triacylglycerols Chemical class 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 239000001993 wax Substances 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/31—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the rectum, e.g. proctoscopes, sigmoidoscopes, colonoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/003—Thiazine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0073—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form semi-solid, gel, hydrogel, ointment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0089—Particulate, powder, adsorbate, bead, sphere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/005—Devices for introducing or retaining media, e.g. remedies, in cavities of the body for contrast media
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Surgery (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Radiology & Medical Imaging (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Claims (14)
1. Čvrsti pripravak za oralnu primjenu u obliku tablete koja sadrži najmanje jednu boju u kombinaciji s najmanje jednim fiziološki prihvatljivim pomoćnim sastojkom, naznačen time što sadrži:
a) matricu koja se sastoji od najmanje jednog lipofilnog spoja s talištem ispod 90 ° C, i prema želji najmanje jednog amfifilnog spoja, u koji je navedena barem jedna boja barem djelomično ugrađena;
b) matricu koja se sastoji od najmanje jednog hidrofilnog spoja, u kojem su raspršeni lipofilni matriks i po potrebi amfifilni matriks;
c) opcionalno druge fiziološki prihvatljive pomoćne tvari;
d) gastrorezistentna prevlaka;
za upotrebu u endoskopskoj procjeni,
pri čemu je navedena najmanje jedna boja odabrana između metilen plave, kongo crvene, karmin indigo, toluidin plave ili njihovih smjesa, i
pri čemu je navedena najmanje jedna boja sadržana u količini koja se kreće između 10 mg i 1500 mg.
2. Čvrsta smjesa za uporabu prema zahtjevu 1, naznačena time, da sadrži:
a) matricu koja se sastoji od lipofilnih spojeva s talištem ispod 90 ° C, i po izboru amfifilnih spojeva, u kojemu je navedeno barem jedno bojilo barem djelomično ugrađeno;
b) vanjski matriks koji se sastoji od hidrofilnih spojeva, u kojem su raspršeni lipofilni matriks, a prema potrebi i amfifilni matriks;
c) opcionalno druge fiziološki prihvatljive pomoćne tvari;
d) gastrorezistentna prevlaka.
3. Pripravak za uporabu u skladu s bilo kojim od prethodnih zahtjeva, naznačen time, da je navedena bar jedna boja sadržana u količini koja se kreće između 50 mg i 1200 mg.
4. Pripravak za uporabu u skladu s bilo kojim od prethodnih zahtjeva, naznačen time, da je navedena najmanje jedna boja sadržana u količini koja se kreće između 20 mg i 500 mg.
5. Pripravak za uporabu u skladu s bilo kojim od prethodnih zahtjeva, naznačen time, da je navedena najmanje jedna boja sadržana u količini ekvivalentnoj 25 mg.
6. Pripravak za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time, da je navedena bar jedna boja sadržana u količini ekvivalentnoj 50 mg.
7. Pripravak za uporabu u skladu s bilo kojim od prethodnih zahtjeva, naznačen time što se navedeni lipofilni spoj bira između zasićenih, nezasićenih ili hidrogeniranih alkohola s dugim lancem, zasićenih, nezasićenih ili hidrogeniranih masnih kiselina, njihovih soli, estera ili amida, mono-, di- ili trigliceridi masnih kiselina, njihovi polietoksilirani derivati, voskovi, ceramidi, kolesterol, derivati kolesterola ili njihove smjese.
8. Pripravak za uporabu u skladu s bilo kojim od prethodnih zahtjeva, naznačen time, što je navedeni amfifilni spoj odabran između polarnih lipida tipa I ili II, ceramida, glikol alkil etera, soli alkil sulfata ili sulfosukcinata ili njihovih smjesa
9. Pripravak za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time, što su spomenuti polarni lipidi tipa I ili II odabrani između lecitina, fosfatidilkolina, fosfatidiletanolamina ili njihovih smjesa, a spomenuti glikol alkil eter je dietilen glikol monometil eter.
10. Pripravak za uporabu prema bilo kojem od prethodnih zahtjeva, naznačen time, da je navedeni hidrofilni spoj spoj koji tvori hidrogel, poželjno odabran između polimera ili kopolimera akrilne ili metakrilne kiseline, alkil vinil polimera, alkil celuloza, hidroksialkil celuloza, karboksialkil celuloza , modificirane celuloze, plurisupstituirane celuloze, polisaharidi, dekstrini, pektini, škrobovi, složeni škrobovi, derivati škroba, alginska kiselina, sintetička guma, prirodna guma, polialkohol ili njihove smjese.
11. Pripravak za uporabu u skladu s bilo kojim od prethodnih zahtjeva, naznačen time što je spomenuta gastrorezistentna prevlaka odabrana između polimera akrilne ili metakrilne kiseline, kopolimera akrilne ili metakrilne kiseline, derivata celuloze, polimera na bazi hidroksibutirata, šelaka ili njihove smjese.
12. Pripravak prema bilo kojem od prethodnih zahtjeva, za uporabu u endoskopskoj dijagnostičkoj procjeni gastrointestinalnog trakta.
13. Pripravak prema bilo kojem od prethodnih zahtjeva, namijenjen uporabi u endoskopskoj dijagnostičkoj procjeni upalnih, ulcerativnih, displastičnih, pred-neoplastičnih i neoplastičnih patologija gastrointestinalnog trakta.
14. Pripravak prema bilo kojem od prethodnih zahtjeva, namijenjen uporabi u endoskopskoj dijagnostičkoj procjeni kancerogenih oblika, prekanceroznih oblika, polipa, pseudopolipa ili različitih upalnih patologija gastrointestinalnog trakta.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2010A000345A IT1398643B1 (it) | 2010-03-04 | 2010-03-04 | Composizione solida per la somministrazione orale di coloranti, e utilizzo diagnostico della stessa |
US32755710P | 2010-04-23 | 2010-04-23 | |
EP15186682.9A EP3011975B1 (en) | 2010-03-04 | 2011-03-02 | Solid composition for the oral administration of dyes and diagnostic use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20210493T1 true HRP20210493T1 (hr) | 2021-05-14 |
Family
ID=42647312
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20161366TT HRP20161366T1 (hr) | 2010-03-04 | 2016-10-19 | Čvrsti pripravci za oralnu primjenu boja te njihova dijagnostička uporaba |
HRP20210493TT HRP20210493T1 (hr) | 2010-03-04 | 2021-03-26 | Čvrsti pripravak za oralnu primjenu boja te njegova dijagnostička uporaba |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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HRP20161366TT HRP20161366T1 (hr) | 2010-03-04 | 2016-10-19 | Čvrsti pripravci za oralnu primjenu boja te njihova dijagnostička uporaba |
Country Status (26)
Country | Link |
---|---|
US (6) | US8545811B2 (hr) |
EP (2) | EP2542268B1 (hr) |
JP (1) | JP5770752B2 (hr) |
KR (1) | KR101763700B1 (hr) |
CN (1) | CN102811747B (hr) |
AU (1) | AU2011222496B2 (hr) |
BR (1) | BR112012022373B1 (hr) |
CA (1) | CA2790143C (hr) |
CY (1) | CY1123967T1 (hr) |
DK (2) | DK3011975T3 (hr) |
ES (2) | ES2863986T3 (hr) |
FR (1) | FR21C1009I1 (hr) |
HR (2) | HRP20161366T1 (hr) |
HU (3) | HUE053977T2 (hr) |
IL (1) | IL221541A (hr) |
IT (1) | IT1398643B1 (hr) |
LT (2) | LT3011975T (hr) |
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SI (1) | SI3011975T1 (hr) |
WO (1) | WO2011107945A1 (hr) |
ZA (1) | ZA201206360B (hr) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
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PT1183014E (pt) | 1999-06-14 | 2003-12-31 | Cosmo Spa | Composicoes farmaceuticas orais de libertacao controlada e de dissimulacao de sabor |
US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
US10154964B2 (en) | 2011-09-07 | 2018-12-18 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
EP2722058A1 (en) * | 2012-10-19 | 2014-04-23 | Cosmo Technologies Ltd | Solid oral composition containing dyes for use in endoscopic diagnosis |
CA2936792C (en) * | 2014-01-29 | 2022-03-29 | Cosmo Technologies Limited | Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum |
US10124074B2 (en) * | 2014-02-26 | 2018-11-13 | Toufic Kachaamy | Indirect chromoendoscopy with an oral indigo carmine base preparation |
CN106999618A (zh) | 2014-12-08 | 2017-08-01 | 金诺斯公司 | 用于颜料消毒的添加剂组合物及其方法 |
WO2016171763A1 (en) * | 2015-04-23 | 2016-10-27 | Obalon Therapeutics, Inc. | Systems and methods for determining failure of intragastric devices |
US10344251B2 (en) | 2016-02-12 | 2019-07-09 | Kinnos, Inc. | Compositions and methods for use in surface decontamination |
EA201892365A1 (ru) | 2016-04-19 | 2019-03-29 | Конарис Рисерч Инститьют Аг | Составы и композиции шеллачных микрокапсул |
CN109715777B (zh) | 2016-07-25 | 2022-04-19 | 金诺斯公司 | 用于表面净化的装置和相关组合物及方法 |
CA3043451A1 (en) | 2016-11-28 | 2018-05-31 | Cosmo Technologies Ltd. | Solid oral composition containing dyes |
FR3059664B1 (fr) | 2016-12-01 | 2019-01-25 | Provepharm Life Solutions | Procede de preparation du carmin d’indigo |
CA3104884A1 (en) | 2018-07-12 | 2020-01-16 | Kinnos Inc. | Devices, compositions, and methods for use in surface decontamination |
CN108888765B (zh) * | 2018-07-16 | 2021-02-26 | 山东理工大学 | 一种释放亚甲基蓝聚集体的含亚甲基蓝的二氧化硅/虫胶复合颗粒的制备方法 |
CN111184876B (zh) * | 2020-02-20 | 2022-03-04 | 沈伟 | 一种消化道黏膜染色剂、制备方法及其应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
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US3361632A (en) * | 1964-05-08 | 1968-01-02 | Hoechst Ag | Medicinal preparations having a protracted activity and method of making them |
JP3549880B2 (ja) * | 1991-10-31 | 2004-08-04 | ジラ・インコーポレーテッド | 生物学的染料組成物、調製方法および上皮癌描写への使用方法 |
US6405070B1 (en) * | 1998-06-16 | 2002-06-11 | Bhaskar Banerjee | Detection of cancer using cellular autofluorescence |
ITMI991316A1 (it) | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
US8895064B2 (en) | 1999-06-14 | 2014-11-25 | Cosmo Technologies Limited | Controlled release and taste masking oral pharmaceutical composition |
PT1183014E (pt) | 1999-06-14 | 2003-12-31 | Cosmo Spa | Composicoes farmaceuticas orais de libertacao controlada e de dissimulacao de sabor |
US6584630B1 (en) | 2000-04-06 | 2003-07-01 | Ohio Medical Instrument Company, Inc. | Radiolucent surgical table extension assembly and method |
WO2001076478A1 (en) | 2000-04-10 | 2001-10-18 | Nordisk Terapi As | System for testing and exercising sensorimotoric control of the neck |
FR2829933B3 (fr) * | 2001-09-21 | 2004-03-12 | Ellipse Pharmaceuticals | Procede de fabrication d'un produit pharmaceutique administrable par voie orale avec des agents detrompeurs notamment de gout et produit obtenu |
US7217410B2 (en) | 2003-06-17 | 2007-05-15 | The Board Of Trustees Of The Universtiy Of Illinois | Surface modified protein microparticles |
US20070077202A1 (en) * | 2005-06-12 | 2007-04-05 | Pentax Corporation | Histostain composition for endoscope |
US20070116757A1 (en) * | 2005-11-08 | 2007-05-24 | Collegium Pharmaceutical, Inc. | Methylene Blue Derivatives |
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