HRP20201473T1 - Inhibitori lizin gingipaina - Google Patents

Inhibitori lizin gingipaina Download PDF

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Publication number
HRP20201473T1
HRP20201473T1 HRP20201473TT HRP20201473T HRP20201473T1 HR P20201473 T1 HRP20201473 T1 HR P20201473T1 HR P20201473T T HRP20201473T T HR P20201473TT HR P20201473 T HRP20201473 T HR P20201473T HR P20201473 T1 HRP20201473 T1 HR P20201473T1
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HR
Croatia
Prior art keywords
group
compound
hydrogen
pharmaceutically acceptable
nrd
Prior art date
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HRP20201473TT
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English (en)
Croatian (hr)
Inventor
Andrei Konradi
Stephen S. Dominy
Casey Crawford Lynch
Craig Coburn
Joseph Vacca
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Cortexyme, Inc.
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Publication date
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Publication of HRP20201473T1 publication Critical patent/HRP20201473T1/hr

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
HRP20201473TT 2014-10-06 2015-10-05 Inhibitori lizin gingipaina HRP20201473T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462060483P 2014-10-06 2014-10-06
PCT/US2015/054050 WO2016057413A2 (en) 2014-10-06 2015-10-05 Inhibitors of lysine gingipain
EP15849799.0A EP3204352B1 (en) 2014-10-06 2015-10-05 Inhibitors of lysine gingipain

Publications (1)

Publication Number Publication Date
HRP20201473T1 true HRP20201473T1 (hr) 2020-12-11

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HRP20201473TT HRP20201473T1 (hr) 2014-10-06 2015-10-05 Inhibitori lizin gingipaina

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US (5) US9758473B2 (enExample)
EP (1) EP3204352B1 (enExample)
JP (1) JP6642948B2 (enExample)
KR (1) KR20170068521A (enExample)
CN (2) CN107108468B (enExample)
AU (1) AU2015328385B2 (enExample)
BR (1) BR112017006920A8 (enExample)
CA (1) CA2963305A1 (enExample)
CL (1) CL2017000845A1 (enExample)
CO (1) CO2017003321A2 (enExample)
CY (1) CY1123532T1 (enExample)
DK (1) DK3204352T3 (enExample)
ES (1) ES2819218T3 (enExample)
HR (1) HRP20201473T1 (enExample)
HU (1) HUE050876T2 (enExample)
IL (2) IL251501B (enExample)
MX (1) MX378266B (enExample)
PE (1) PE20171335A1 (enExample)
PH (1) PH12017500637A1 (enExample)
PL (1) PL3204352T3 (enExample)
PT (1) PT3204352T (enExample)
RU (1) RU2728785C2 (enExample)
SG (1) SG11201702797RA (enExample)
WO (1) WO2016057413A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2728785C2 (ru) 2014-10-06 2020-07-31 Кортексим, Инк. Ингибиторы лизинспецифичного гингипаина
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
WO2017201322A1 (en) * 2016-05-19 2017-11-23 Cortexyme, Inc. Treatment of osteoarthritis with gingipain blocking agents
CN109983012B (zh) * 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂
JP7079794B2 (ja) * 2017-05-10 2022-06-02 コーテクシーミー， インコーポレイテッド アミノピリジン化合物ならびにその調製および使用のための方法
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