BR112017006920A8 - Inibidores de lisina gingipaína - Google Patents

Inibidores de lisina gingipaína

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Publication number
BR112017006920A8
BR112017006920A8 BR112017006920A BR112017006920A BR112017006920A8 BR 112017006920 A8 BR112017006920 A8 BR 112017006920A8 BR 112017006920 A BR112017006920 A BR 112017006920A BR 112017006920 A BR112017006920 A BR 112017006920A BR 112017006920 A8 BR112017006920 A8 BR 112017006920A8
Authority
BR
Brazil
Prior art keywords
lysine
gingipaine
inhibitors
gingivalis
kgp
Prior art date
Application number
BR112017006920A
Other languages
English (en)
Other versions
BR112017006920A2 (pt
Inventor
Konradi Andrei
S Dominy Stephen
Crawford Lynch Casey
Coburn Craig
Vacca Joseph
Original Assignee
Quince Therapeutics Inc
Cortexyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quince Therapeutics Inc, Cortexyme Inc filed Critical Quince Therapeutics Inc
Publication of BR112017006920A2 publication Critical patent/BR112017006920A2/pt
Publication of BR112017006920A8 publication Critical patent/BR112017006920A8/pt

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
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    • C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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Abstract

"INIBIDORES DE LISINA GINGIPAÍNA". A presente invenção refere-se geralmente aos terapêuticos alvejando a bactéria Porphyromonas gingivalis, incluindo sua protease Lisina gingipaína (Kgp), e seu uso para o tratamento de transtornos associados à infecção por P. gingivalis, incluindo transtornos cerebrais tal como a doença de Alzheimer. Em certas modalidades, a invenção fornece compostos de acordo com a Fórmula (I), (I) como descrito aqui, e sais farmaceuticamente aceitáveis dos mesmos.
BR112017006920A 2014-10-06 2015-10-05 Inibidores de lisina gingipaína BR112017006920A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462060483P 2014-10-06 2014-10-06
PCT/US2015/054050 WO2016057413A2 (en) 2014-10-06 2015-10-05 Inhibitors of lysine gingipain

Publications (2)

Publication Number Publication Date
BR112017006920A2 BR112017006920A2 (pt) 2017-12-12
BR112017006920A8 true BR112017006920A8 (pt) 2023-03-07

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BR112017006920A BR112017006920A8 (pt) 2014-10-06 2015-10-05 Inibidores de lisina gingipaína

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US (5) US9758473B2 (pt)
EP (1) EP3204352B1 (pt)
JP (1) JP6642948B2 (pt)
KR (1) KR20170068521A (pt)
CN (2) CN107108468B (pt)
AU (1) AU2015328385B2 (pt)
BR (1) BR112017006920A8 (pt)
CA (1) CA2963305A1 (pt)
CL (1) CL2017000845A1 (pt)
CO (1) CO2017003321A2 (pt)
CY (1) CY1123532T1 (pt)
DK (1) DK3204352T3 (pt)
ES (1) ES2819218T3 (pt)
HR (1) HRP20201473T1 (pt)
HU (1) HUE050876T2 (pt)
IL (2) IL251501B (pt)
MX (1) MX2017004569A (pt)
PE (1) PE20171335A1 (pt)
PH (1) PH12017500637A1 (pt)
PL (1) PL3204352T3 (pt)
PT (1) PT3204352T (pt)
RU (1) RU2728785C2 (pt)
SG (1) SG11201702797RA (pt)
WO (1) WO2016057413A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170068521A (ko) 2014-10-06 2017-06-19 코텍자임, 인코포레이티드 리신 진지페인의 억제제
EP3374352A4 (en) 2015-11-09 2019-10-02 Cortexyme, Inc. GINGIPAINE ARGININE INHIBITORS
WO2017201322A1 (en) * 2016-05-19 2017-11-23 Cortexyme, Inc. Treatment of osteoarthritis with gingipain blocking agents
JP7113815B2 (ja) * 2016-09-16 2022-08-05 コーテクシーミー， インコーポレイテッド リシンジンジパインのケトン阻害剤
WO2018209132A1 (en) 2017-05-10 2018-11-15 Cortexyme, Inc. Aminopyridine compounds and methods for the preparation and use thereof
WO2020069397A1 (en) * 2018-09-27 2020-04-02 Cortexyme, Inc. Methods for detection of microbial nucleic acids in body fluids
CA3200407A1 (en) * 2020-11-03 2022-05-12 Keystone Bio, Inc. Antigen-binding molecules that bind to porphyromonas gingivalis

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341029C (en) * 1985-02-04 2000-06-20 Michael Kolb Peptidase inhibitors
US5055451A (en) 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
JPH01163162A (ja) * 1987-12-18 1989-06-27 Showa Denko Kk アミノ酸誘導体および酵素阻害剤
US5451410A (en) * 1993-04-22 1995-09-19 Emisphere Technologies, Inc. Modified amino acids for encapsulating active agents
GB9019558D0 (en) 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
AU2299592A (en) 1991-07-02 1993-02-11 Children's Medical Center Corporation Treatment of periodontal disease with protease inhibitors
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
US5374623A (en) 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
AU4250596A (en) 1994-12-22 1996-07-10 Biochem Pharma Inc. Low molecular weight bicyclic thrombin inhibitors
JPH10508035A (ja) 1995-03-24 1998-08-04 モレキュメティックス リミテッド βシート模倣物およびプロテアーゼインヒビターとしてのその使用
WO1996030396A1 (en) 1995-03-24 1996-10-03 Molecumetics Ltd. β-SHEET MIMETICS AND USE THEREOF AS PROTEASE INHIBITORS
GB9510264D0 (en) 1995-05-22 1995-07-19 Iaf Biochem Int Low molecular weight bicyclic-urea type thrombin inhibitors
US5827866A (en) 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5827860A (en) 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
US5523308A (en) 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
IL119466A (en) * 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them
DE69735545T2 (de) 1996-08-05 2006-08-10 Myriad Genetics, Inc., Salt Lake City Verwendung von beta-blatt mimetika als protease und kinase hemmer und alshemmer eines transkriptionsfaktors
WO1998009987A1 (en) 1996-09-06 1998-03-12 Biochem Pharma, Inc. Lactam inhibitors of thrombin
WO1999026925A1 (fr) 1997-11-26 1999-06-03 Yoshitomi Pharmaceutical Industries, Ltd. Inhibiteurs de tryptase comprenant des composants d'amide heterocycliques
WO1999041276A1 (en) 1998-02-12 1999-08-19 Molecumetics Ltd. β-SHEET MIMETICS AND METHODS RELATING TO THE USE THEREOF
US6323219B1 (en) 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
US7053056B2 (en) * 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
WO2000044731A1 (en) * 1999-01-27 2000-08-03 G.D. Searle & Co. Novel hydroxyamidino carboxylate derivatives useful as nitric oxide synthase inhibitors
EE200100391A (et) * 1999-01-27 2002-10-15 Ortho-Mcneil Pharmaceutical, Inc. Peptidüül-heterotsüklilised ketoonid, nende kasutamine ja farmatseutiline kompositsioon
JP2002539190A (ja) 1999-03-15 2002-11-19 アクシス・ファーマシューティカルズ・インコーポレイテッド プロテアーゼ阻害剤としての新規化合物および組成物
US6790989B2 (en) * 2000-01-13 2004-09-14 Idun Pharmaceuticals, Inc. Inhibitors of the ICE/ced-3 family of cysteine proteases
US7205384B2 (en) 2003-08-05 2007-04-17 Ortho-Mcneil Pharmaceutical Inc. Process for preparing peptidyl heterocyclic ketone derivatives
WO2007046781A1 (en) 2004-07-23 2007-04-26 Smith, Judith Furin inhibitors
BRPI0712021A2 (pt) * 2006-05-23 2012-01-03 Irm Llc composto e composiÇÕes como inibidores da protease ativadora de canal
WO2009103432A2 (en) * 2008-02-21 2009-08-27 Sanofi-Aventis Covalently binding imaging probes
AU2013305759C1 (en) * 2012-08-23 2018-01-18 Janssen Biopharma, Inc. Compounds for the treatment of paramoxyvirus viral infections
EP4218829A3 (en) 2013-03-15 2023-08-16 The Board of Trustees of the Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
KR20170068521A (ko) 2014-10-06 2017-06-19 코텍자임, 인코포레이티드 리신 진지페인의 억제제

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