BR112017006920A2 - inibidores de lisina gingipaína - Google Patents

inibidores de lisina gingipaína

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Publication number
BR112017006920A2
BR112017006920A2 BR112017006920A BR112017006920A BR112017006920A2 BR 112017006920 A2 BR112017006920 A2 BR 112017006920A2 BR 112017006920 A BR112017006920 A BR 112017006920A BR 112017006920 A BR112017006920 A BR 112017006920A BR 112017006920 A2 BR112017006920 A2 BR 112017006920A2
Authority
BR
Brazil
Prior art keywords
lysine
gingipain
inhibitors
gingivalis
kgp
Prior art date
Application number
BR112017006920A
Other languages
English (en)
Other versions
BR112017006920A8 (pt
Inventor
Konradi Andrei
Crawford Lynch Casey
Coburn Craig
Vacca Joseph
S Dominy Stephen
Original Assignee
Cortexyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortexyme Inc filed Critical Cortexyme Inc
Publication of BR112017006920A2 publication Critical patent/BR112017006920A2/pt
Publication of BR112017006920A8 publication Critical patent/BR112017006920A8/pt

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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/164—Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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Abstract

a presente invenção refere-se geralmente aos terapêuticos alvejando a bactéria porphyromonas gingivalis, incluindo sua protease lisina gingipaína (kgp), e seu uso para o tratamento de transtornos associados à infecção por p. gingivalis, incluindo transtornos cerebrais tal como a doença de alzheimer. em certas modalidades, a invenção fornece compostos de acordo com a fórmula (i), (i) como descrito aqui, e sais farmaceuticamente aceitáveis dos mesmos.
BR112017006920A 2014-10-06 2015-10-05 Inibidores de lisina gingipaína BR112017006920A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462060483P 2014-10-06 2014-10-06
PCT/US2015/054050 WO2016057413A2 (en) 2014-10-06 2015-10-05 Inhibitors of lysine gingipain

Publications (2)

Publication Number Publication Date
BR112017006920A2 true BR112017006920A2 (pt) 2017-12-12
BR112017006920A8 BR112017006920A8 (pt) 2023-03-07

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US (5) US9758473B2 (pt)
EP (1) EP3204352B1 (pt)
JP (1) JP6642948B2 (pt)
KR (1) KR20170068521A (pt)
CN (2) CN111349053A (pt)
AU (1) AU2015328385B2 (pt)
BR (1) BR112017006920A8 (pt)
CA (1) CA2963305A1 (pt)
CL (1) CL2017000845A1 (pt)
CO (1) CO2017003321A2 (pt)
CY (1) CY1123532T1 (pt)
DK (1) DK3204352T3 (pt)
ES (1) ES2819218T3 (pt)
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IL (2) IL251501B (pt)
MX (1) MX2017004569A (pt)
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PH (1) PH12017500637A1 (pt)
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RU (1) RU2728785C2 (pt)
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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111349053A (zh) * 2014-10-06 2020-06-30 库特克希米公司 赖氨酸牙龈卟啉菌蛋白酶的抑制剂
WO2017083433A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
WO2017201322A1 (en) * 2016-05-19 2017-11-23 Cortexyme, Inc. Treatment of osteoarthritis with gingipain blocking agents
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