CO2019002950A2 - Inhibidores cetónicos de gingipain de lisina. - Google Patents

Inhibidores cetónicos de gingipain de lisina.

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Publication number
CO2019002950A2
CO2019002950A2 CONC2019/0002950A CO2019002950A CO2019002950A2 CO 2019002950 A2 CO2019002950 A2 CO 2019002950A2 CO 2019002950 A CO2019002950 A CO 2019002950A CO 2019002950 A2 CO2019002950 A2 CO 2019002950A2
Authority
CO
Colombia
Prior art keywords
gingipain
lysine gingipain
lysine
methods
well
Prior art date
Application number
CONC2019/0002950A
Other languages
English (en)
Inventor
Robert A Galemmo Jr
Stephen S Dominy
Andrei W Konradi
Casey C Lynch
Leslie J Holsinger
Original Assignee
Cortexyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cortexyme Inc filed Critical Cortexyme Inc
Publication of CO2019002950A2 publication Critical patent/CO2019002950A2/es

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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La presente invención proporciona compuestos de acuerdo con la Fórmula I como se describe en la presente, y su uso para inhibir la proteasa de gingipaina de lisina (Kgp) de la bacteria Porphyromonas gingivalis. Asimismo, se describen compuestos de sondas con actividad de las gingipainas, así como se describen métodos para ensayar la actividad de las gingipainas, así como métodos para el tratamiento de trastornos asociados a infección por P. gingivalis, que incluyen trastornos cerebrales tales como enfermedad de Alzheimer.
CONC2019/0002950A 2016-09-16 2019-03-27 Inhibidores cetónicos de gingipain de lisina. CO2019002950A2 (es)

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US201662395938P 2016-09-16 2016-09-16
US201762459456P 2017-02-15 2017-02-15
PCT/US2017/051912 WO2018053353A1 (en) 2016-09-16 2017-09-15 Ketone inhibitors of lysine gingipain

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Publication number Priority date Publication date Assignee Title
BR112019004864A8 (pt) 2016-09-16 2023-03-07 Cortexyme Inc Inibidores cetona de lisina gingipain
CN110944637A (zh) 2017-05-10 2020-03-31 库特克希米公司 氨基吡啶化合物及其制备方法和使用方法

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US20190210960A1 (en) 2019-07-11
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AU2017326466B2 (en) 2021-11-11
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BR112019004864A8 (pt) 2023-03-07
IL265389A (en) 2019-05-30
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US20230142714A1 (en) 2023-05-11
US12110263B2 (en) 2024-10-08
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US20210053908A1 (en) 2021-02-25
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PH12019500570A1 (en) 2019-08-05
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