RU2728785C2 - Ингибиторы лизинспецифичного гингипаина - Google Patents

Ингибиторы лизинспецифичного гингипаина Download PDF

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RU2728785C2
RU2728785C2 RU2017115726A RU2017115726A RU2728785C2 RU 2728785 C2 RU2728785 C2 RU 2728785C2 RU 2017115726 A RU2017115726 A RU 2017115726A RU 2017115726 A RU2017115726 A RU 2017115726A RU 2728785 C2 RU2728785 C2 RU 2728785C2
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amino
mixture
carbamate
mmol
carbonyl
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RU2017115726A
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RU2017115726A3 (enExample
RU2017115726A (ru
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Андрей КОНРАДИ
Стефен С. ДОМИНИ
ЛИНЧ Кейси КРОУФОРД
Крейг КОБЕРН
Джозеф ВАККА
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Кортексим, Инк.
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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RU2017115726A 2014-10-06 2015-10-05 Ингибиторы лизинспецифичного гингипаина RU2728785C2 (ru)

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US201462060483P 2014-10-06 2014-10-06
US62/060,483 2014-10-06
PCT/US2015/054050 WO2016057413A2 (en) 2014-10-06 2015-10-05 Inhibitors of lysine gingipain

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RU2017115726A RU2017115726A (ru) 2018-11-14
RU2017115726A3 RU2017115726A3 (enExample) 2019-05-08
RU2728785C2 true RU2728785C2 (ru) 2020-07-31

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RU2728785C2 (ru) 2014-10-06 2020-07-31 Кортексим, Инк. Ингибиторы лизинспецифичного гингипаина
CA3004095A1 (en) 2015-11-09 2017-05-18 Cortexyme, Inc. Inhibitors of arginine gingipain
WO2017201322A1 (en) * 2016-05-19 2017-11-23 Cortexyme, Inc. Treatment of osteoarthritis with gingipain blocking agents
CN109983012B (zh) * 2016-09-16 2023-12-01 莱特豪斯制药公司 赖氨酸牙龈蛋白酶的酮抑制剂
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