KR20170068521A - 리신 진지페인의 억제제 - Google Patents
리신 진지페인의 억제제 Download PDFInfo
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- KR20170068521A KR20170068521A KR1020177012278A KR20177012278A KR20170068521A KR 20170068521 A KR20170068521 A KR 20170068521A KR 1020177012278 A KR1020177012278 A KR 1020177012278A KR 20177012278 A KR20177012278 A KR 20177012278A KR 20170068521 A KR20170068521 A KR 20170068521A
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- pharmaceutically acceptable
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
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| WO2024262927A1 (ko) * | 2023-06-19 | 2024-12-26 | 한국과학기술연구원 | 신규한 형광 화합물 및 이를 이용한 진지페인 검출용 조성물, 포르피로모나스 진지발리스 감염 진단용 조성물 또는 포르피로모나스 진지발리스에 대한 항균용 조성물 |
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| WO2016057413A2 (en) | 2014-10-06 | 2016-04-14 | Cortexyme, Inc. | Inhibitors of lysine gingipain |
| CA3004095A1 (en) | 2015-11-09 | 2017-05-18 | Cortexyme, Inc. | Inhibitors of arginine gingipain |
| WO2017201322A1 (en) * | 2016-05-19 | 2017-11-23 | Cortexyme, Inc. | Treatment of osteoarthritis with gingipain blocking agents |
| EP4480541A3 (en) | 2016-09-16 | 2025-04-30 | Lighthouse Pharmaceuticals, Inc. | Ketone inhibitors of lysine gingipain |
| WO2018209132A1 (en) * | 2017-05-10 | 2018-11-15 | Cortexyme, Inc. | Aminopyridine compounds and methods for the preparation and use thereof |
| US20210355527A1 (en) * | 2018-09-27 | 2021-11-18 | Cortexyme, Inc. | Methods for detection of microbial nucleic acids in body fluids |
| US20240400654A1 (en) * | 2020-11-03 | 2024-12-05 | Keystone Bio, Inc. | Antigen-binding molecules that bind to porphyromonas gingivalis |
| CN119912460A (zh) * | 2025-03-31 | 2025-05-02 | 上海光声制药有限公司 | 卟啉衍生物、其制备方法及其用于抑菌的用途 |
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| WO1993000926A1 (en) | 1991-07-02 | 1993-01-21 | Children's Medical Center Corporation | Treatment of periodontal disease with protease inhibitors |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
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| US5827866A (en) | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
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| US5827860A (en) | 1995-06-07 | 1998-10-27 | Ortho Pharmaceutical Corporation | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
| IL119466A (en) * | 1995-11-03 | 2001-08-26 | Akzo Nobel Nv | Thrombin inhibitors, their preparation and pharmaceutical compositions containing them |
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| WO2016057413A2 (en) | 2014-10-06 | 2016-04-14 | Cortexyme, Inc. | Inhibitors of lysine gingipain |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024262927A1 (ko) * | 2023-06-19 | 2024-12-26 | 한국과학기술연구원 | 신규한 형광 화합물 및 이를 이용한 진지페인 검출용 조성물, 포르피로모나스 진지발리스 감염 진단용 조성물 또는 포르피로모나스 진지발리스에 대한 항균용 조성물 |
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| JP2022526897A (ja) | アルギニンジンジパイン阻害剤 |
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