HRP20192345T1 - Medicinski tretmani na bazi anamorelina - Google Patents

Medicinski tretmani na bazi anamorelina Download PDF

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Publication number
HRP20192345T1
HRP20192345T1 HRP20192345TT HRP20192345T HRP20192345T1 HR P20192345 T1 HRP20192345 T1 HR P20192345T1 HR P20192345T T HRP20192345T T HR P20192345TT HR P20192345 T HRP20192345 T HR P20192345T HR P20192345 T1 HRP20192345 T1 HR P20192345T1
Authority
HR
Croatia
Prior art keywords
anamorelin
use according
patient
cachexia
procedure
Prior art date
Application number
HRP20192345TT
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English (en)
Inventor
William Mann
John Friend
William Polvino
Suzan ALLEN
Ming Lu
Elizabeth DUUS
Ruben Giorgino
Enrico Baroni
Original Assignee
Helsinn Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55436476&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20192345(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Helsinn Healthcare Sa filed Critical Helsinn Healthcare Sa
Publication of HRP20192345T1 publication Critical patent/HRP20192345T1/hr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06Anabolic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/02Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (15)

1. Anamorelin za uporabu u postupku za tretman zamora koji nastaje uslijed tumorske kaheksije kod ljudskog pacijenta s rakom, pri čemu je navedena kaheksija definirana kao indeks tjelesne mase manji od 20 Kg/m2, pri čemu postupak sadrži svakodnevnu primjenu anamorelina kod navedenog pacijenta tijekom terapeutski efikasnog vremenskog perioda.
2. Anamorelin za uporabu u postupku za poboljšanje kvalitete života, mjereno pomoću FAACT u domeni anoreksije/kaheksije, kod ljudskog pacijenta s rakom, pri čemu je navedena kaheksija definirana kao indeks tjelesne mase manji od 20 Kg/m2, naznačen time što postupak sadrži svakodnevnu primjenu anamorelina kod navedenog pacijenta tokom terapeutski efikasnog vremenskog perioda.
3. Anamorelin za uporabu u postupku za povećanje ukupne tjelesne mase, čiste tjelesne mase, mase masnog tkiva kod ljudskog pacijenta koji pati od tumorske kaheksije, pri čemu je navedena kaheksija definirana kao indeks tjelesne mase manji od 20 kg/m2, pri čemu postupak sadrži svakodnevnu primjenu anamorelina kod navedenog pacijenta tijekom terapeutski efikasnog vremenskog perioda.
4. Anamorelin za uporabu prema patentnom zahtjevu 1 naznačen time što je navedeni zamor izazvan depresijom, anemijom, sarkopenijom, anoreksijom, neuhranjenošću u vezi s povraćanjem, hemotoksičnošću, upotrebom opijata, i/ili poremećajima spavanja.
5. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što ljudski pacijent pati od neoperabilnog nesitnoćelijskog raka pluća, stadijuma III ili IV.
6. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni anamorelin predstavlja anamorelin HCl u količini od 100 mg, na osnovu težine soli.
7. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni anamorelin predstavlja anamorelin HCl u količini od 100 mg, na osnovu težine soli, primijenjen oralno jednom dnevno, najmanje jedan sat prije prvog obroka.
8. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni efikasan vremenski period iznosi dvanaest tjedana.
9. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni efikasan vremenski period iznosi od 13 do 24 tjedna.
10. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni pacijent ima funkcionalni status na ECOG od 2 ili više.
11. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni pacijent ima skvamoznu histologiju tumora.
12. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što je navedeni rak metastazirao.
13. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni pacijent ne prima hemioterapiju ili radioterapiju.
14. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni pacijent prima hemioterapiju ili radioterapiju.
15. Anamorelin za uporabu prema bilo kojem od patentnih zahtjeva 1-3 naznačen time što navedeni pacijent prima opijate i/ili antiemetike.
HRP20192345TT 2014-09-04 2019-12-30 Medicinski tretmani na bazi anamorelina HRP20192345T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462045976P 2014-09-04 2014-09-04
EP15838548.4A EP3188599B1 (en) 2014-09-04 2015-08-28 Medical treatments based on anamorelin
PCT/US2015/047435 WO2016036598A1 (en) 2014-09-04 2015-08-28 Medical treatments based on anamorelin

Publications (1)

Publication Number Publication Date
HRP20192345T1 true HRP20192345T1 (hr) 2020-03-20

Family

ID=55436476

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20192345TT HRP20192345T1 (hr) 2014-09-04 2019-12-30 Medicinski tretmani na bazi anamorelina

Country Status (44)

Country Link
US (5) US9675600B2 (hr)
EP (2) EP3188599B1 (hr)
JP (3) JP6356907B2 (hr)
KR (3) KR101881264B1 (hr)
CN (5) CN107375285A (hr)
AP (1) AP2017009772A0 (hr)
AR (1) AR103118A1 (hr)
AU (1) AU2015312231B2 (hr)
BR (1) BR112017003552A2 (hr)
CA (1) CA2959158A1 (hr)
CL (1) CL2017000494A1 (hr)
CO (1) CO2017003263A2 (hr)
CR (1) CR20170121A (hr)
CY (1) CY1122746T1 (hr)
DK (1) DK3188599T3 (hr)
DO (1) DOP2017000055A (hr)
EA (1) EA035578B1 (hr)
EC (1) ECSP17019893A (hr)
ES (1) ES2761777T3 (hr)
GE (1) GEP20186939B (hr)
HR (1) HRP20192345T1 (hr)
HU (1) HUE046894T2 (hr)
IL (1) IL250692B (hr)
JO (1) JO3541B1 (hr)
LT (1) LT3188599T (hr)
MA (1) MA40607B1 (hr)
MD (1) MD4710C1 (hr)
ME (1) ME03597B (hr)
MX (1) MX361741B (hr)
MY (1) MY187167A (hr)
NI (1) NI201700024A (hr)
PE (1) PE20171109A1 (hr)
PH (1) PH12017500392A1 (hr)
PL (1) PL3188599T3 (hr)
PT (1) PT3188599T (hr)
RS (1) RS59751B1 (hr)
SG (1) SG11201701567UA (hr)
SI (1) SI3188599T1 (hr)
SV (1) SV2017005400A (hr)
TN (1) TN2017000040A1 (hr)
TW (1) TWI639429B (hr)
UA (1) UA120765C2 (hr)
UY (1) UY36286A (hr)
WO (1) WO2016036598A1 (hr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014159609A1 (en) 2013-03-14 2014-10-02 Allergen Research Corporation Peanut formulations and uses thereof
US9675600B2 (en) 2014-09-04 2017-06-13 Helsinn Healthcare Sa Medical treatments based on anamorelin
US11229673B2 (en) 2019-05-10 2022-01-25 Société des Produits Nestlé S.A. Methods for improving the quality of life of a patient with a peanut allergy
WO2021038519A1 (en) 2019-08-30 2021-03-04 Helsinn Healthcare Sa Methods of manufacturing anamorelin tablets having improved stability
JPWO2021079978A1 (hr) * 2019-10-24 2021-04-29
TW202327596A (zh) * 2021-09-17 2023-07-16 瑞士商赫爾辛保健公司 於厭食/惡病體質患者針對患者自述結果判定及提供臨床有意義改善之方法

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ECSP993020A (es) 1999-06-16 1999-08-12 Terapia de combinacion para la fragilidad musculoesqueletica
ECSP993021A (es) 1999-06-16 1999-08-12 Combinaciones terapeuticas para la fragilidad musculoesqueletica
US20010020012A1 (en) 2000-02-01 2001-09-06 Andersen Maibritt Bansholm Use of compounds for the regulation of food intake
CN1863550A (zh) * 2003-08-06 2006-11-15 加斯特罗泰克药物公司 促分泌素样生长素释放肽在癌症恶病质中以及在刺激食欲方面的应用
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WO2005097261A1 (en) 2004-03-30 2005-10-20 Sapphire Therapeutics, Inc. Method of reducing c-reactive protein using growth hormone secretagogues
KR101324340B1 (ko) * 2004-06-29 2013-10-31 헬신 세라퓨틱스 (유.에스.) 인크. (3r)-1-(2-메틸알라닐-d-트립토필)-3-(페닐메틸)-3-피페리딘카르복실산 1,2,2-트리메틸하이드라지드의 결정 형태
JP2010518158A (ja) * 2007-02-13 2010-05-27 ヘルシン セラピューティクス(ユー.エス.),インコーポレイティド 成長ホルモン分泌促進物質を用いた細胞増殖性障害の治療方法
TWI429436B (zh) 2007-04-10 2014-03-11 Helsinn Therapeutics Us Inc 使用生長激素促泌素治療或預防嘔吐之方法
JO3353B1 (ar) * 2012-04-20 2019-03-13 Ono Pharmaceutical Co شكل صلب معزول من أحادي هيدروكلوريد أناموريلين بنسبة مولارية منخفضة من الكلوريد: أناموريلين ومحتوى منخفض من مذيب عضوي متبقي
EP2854810A4 (en) 2012-05-25 2016-04-06 Raqualia Pharma Inc GHRELIN RECEPTOR AGONISTS FOR THE TREATMENT OF ACHLORHYDRIA
US9675600B2 (en) 2014-09-04 2017-06-13 Helsinn Healthcare Sa Medical treatments based on anamorelin

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Publication number Publication date
JO3541B1 (ar) 2020-07-05
US20240024303A1 (en) 2024-01-25
TN2017000040A1 (en) 2018-07-04
IL250692B (en) 2019-05-30
CN107205389A (zh) 2017-09-26
KR102234319B1 (ko) 2021-04-01
SI3188599T1 (sl) 2020-02-28
GEP20186939B (en) 2018-12-25
EA035578B1 (ru) 2020-07-09
JP7044918B2 (ja) 2022-03-30
CY1122746T1 (el) 2021-03-12
EP3188599A4 (en) 2017-10-11
EP3188599B1 (en) 2019-10-02
DOP2017000055A (es) 2017-08-15
EP3590338A3 (en) 2020-03-18
MD20170025A2 (ro) 2017-07-31
CL2017000494A1 (es) 2017-09-15
CN107375285A (zh) 2017-11-24
MA40607B1 (fr) 2019-11-29
KR20170047372A (ko) 2017-05-04
US20210093627A1 (en) 2021-04-01
RS59751B1 (sr) 2020-02-28
DK3188599T3 (da) 2019-11-25
EA201790352A1 (ru) 2017-07-31
PL3188599T3 (pl) 2020-06-01
US10278964B2 (en) 2019-05-07
SG11201701567UA (en) 2017-03-30
US10894041B2 (en) 2021-01-19
ME03597B (me) 2020-07-20
AU2015312231A1 (en) 2017-03-23
HUE046894T2 (hu) 2020-04-28
UA120765C2 (uk) 2020-02-10
JP2017526695A (ja) 2017-09-14
MD4710C1 (ro) 2021-04-30
KR20180085047A (ko) 2018-07-25
JP6923486B2 (ja) 2021-08-18
CA2959158A1 (en) 2016-03-10
CN113577073A (zh) 2021-11-02
LT3188599T (lt) 2019-12-10
ECSP17019893A (es) 2017-05-31
US9675600B2 (en) 2017-06-13
NZ729673A (en) 2023-09-29
MY187167A (en) 2021-09-07
US20160067236A1 (en) 2016-03-10
MX2017002825A (es) 2017-09-28
UY36286A (es) 2016-02-29
AU2015312231B2 (en) 2017-10-19
SV2017005400A (es) 2017-04-20
JP2021080281A (ja) 2021-05-27
BR112017003552A2 (pt) 2017-12-05
EP3188599A1 (en) 2017-07-12
KR101881264B1 (ko) 2018-07-23
US11723902B2 (en) 2023-08-15
AP2017009772A0 (en) 2017-02-28
IL250692A0 (en) 2017-04-30
CO2017003263A2 (es) 2017-07-28
NI201700024A (es) 2017-07-18
PT3188599T (pt) 2020-01-15
MX361741B (es) 2018-12-14
PH12017500392B1 (en) 2017-07-17
JP2018154655A (ja) 2018-10-04
TWI639429B (zh) 2018-11-01
WO2016036598A1 (en) 2016-03-10
PH12017500392A1 (en) 2017-07-17
US20170296526A1 (en) 2017-10-19
MD4710B1 (ro) 2020-09-30
US20190175574A1 (en) 2019-06-13
KR20210035923A (ko) 2021-04-01
TW201613587A (en) 2016-04-16
PE20171109A1 (es) 2017-08-07
ES2761777T3 (es) 2020-05-21
CR20170121A (es) 2017-07-17
EP3590338A2 (en) 2020-01-08
CN113577074A (zh) 2021-11-02
KR102307275B1 (ko) 2021-09-30
AR103118A1 (es) 2017-04-19
JP6356907B2 (ja) 2018-07-11
CN109172575A (zh) 2019-01-11

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