EA201591290A3 - Креноланиб для лечения пролиферативных расстройств, связанных с мутацией flt3 - Google Patents
Креноланиб для лечения пролиферативных расстройств, связанных с мутацией flt3Info
- Publication number
- EA201591290A3 EA201591290A3 EA201591290A EA201591290A EA201591290A3 EA 201591290 A3 EA201591290 A3 EA 201591290A3 EA 201591290 A EA201591290 A EA 201591290A EA 201591290 A EA201591290 A EA 201591290A EA 201591290 A3 EA201591290 A3 EA 201591290A3
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment
- proliferative disorders
- crenololibs
- disorders related
- flt3 mutation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Предлагаемое изобретение относится к применению креноланиба в фармацевтически приемлемой форме соли для лечения пролиферативных расстройств с мутацией FLT3, обусловленных конститутивно активированной мутантной FLT3, и к способу лечения теплокровных животных, предпочтительно людей, у которых терапевтически эффективная доза креноланиба вводится животному с вышеупомянутым заболеванием или состоянием.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361749695P | 2013-01-07 | 2013-01-07 | |
| US14/053,011 US9101624B2 (en) | 2013-01-07 | 2013-10-14 | Crenolanib for treating FLT3 mutated proliferative disorders |
| PCT/US2013/064821 WO2014107209A2 (en) | 2013-01-07 | 2013-10-14 | Crenolanib for treating flt3 mutated proliferative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EA201591290A2 EA201591290A2 (ru) | 2016-03-31 |
| EA201591290A3 true EA201591290A3 (ru) | 2016-07-29 |
| EA033910B1 EA033910B1 (ru) | 2019-12-09 |
Family
ID=51061430
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201591290A EA033910B1 (ru) | 2013-01-07 | 2013-10-14 | Применение креноланиба для лечения острого миелоидного лейкоза (омл), связанного с мутацией flt3, и способ лечения |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US9101624B2 (ru) |
| EP (1) | EP2941251B1 (ru) |
| JP (1) | JP6288726B2 (ru) |
| KR (1) | KR101885952B1 (ru) |
| CN (4) | CN112138010A (ru) |
| AP (1) | AP2015008628A0 (ru) |
| AU (1) | AU2013371624B2 (ru) |
| BR (1) | BR112015016282A2 (ru) |
| CA (1) | CA2897445C (ru) |
| CL (1) | CL2015001923A1 (ru) |
| CY (1) | CY1120026T1 (ru) |
| DK (1) | DK2941251T3 (ru) |
| EA (1) | EA033910B1 (ru) |
| ES (1) | ES2667958T3 (ru) |
| HK (1) | HK1224211A1 (ru) |
| HR (1) | HRP20180478T1 (ru) |
| HU (1) | HUE038594T2 (ru) |
| IL (1) | IL239802B (ru) |
| LT (1) | LT2941251T (ru) |
| MX (1) | MX369137B (ru) |
| NO (1) | NO3019692T3 (ru) |
| NZ (1) | NZ710720A (ru) |
| PE (1) | PE20151525A1 (ru) |
| PH (1) | PH12015501531B1 (ru) |
| PL (1) | PL2941251T3 (ru) |
| PT (1) | PT2941251T (ru) |
| RS (1) | RS57076B1 (ru) |
| SG (2) | SG11201505327SA (ru) |
| SI (1) | SI2941251T1 (ru) |
| WO (1) | WO2014107209A2 (ru) |
| ZA (1) | ZA201505545B (ru) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法 |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
| GB201311891D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compound |
| GB201311888D0 (en) | 2013-07-03 | 2013-08-14 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| CN109069410B (zh) * | 2016-02-26 | 2022-05-31 | 安吉奥斯医药品有限公司 | 用于治疗血液恶性肿瘤和实体瘤的idh1抑制剂 |
| JP7466308B2 (ja) | 2016-09-20 | 2024-04-12 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | Ｕｓｐ１０バイオマーカーおよびモジュレーターを用いたａｍｌの同定、評価、予防および処置のための組成物および方法 |
| JP2019532011A (ja) * | 2016-11-02 | 2019-11-07 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | Ｆｌｔ３突然変異増殖性疾患および関連する突然変異を治療するためのクレノラニブ |
| WO2018118598A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| CN114828842A (zh) * | 2019-10-21 | 2022-07-29 | 理森制药股份公司 | 用于治疗急性髓系白血病的包含dhodh抑制剂的组合物 |
| US11713310B2 (en) | 2020-07-20 | 2023-08-01 | Arog Pharmaceuticals, Inc. | Crystal forms of crenolanib and methods of use thereof |
| US20220047574A1 (en) * | 2020-08-15 | 2022-02-17 | Arog Pharmaceuticals, Inc. | Crenolanib for treating pdgfr alpha mutated proliferative disorders |
| WO2022051429A1 (en) | 2020-09-02 | 2022-03-10 | Daniel Choi | Systems and methods for augmented reality environments and tokens |
| US11969420B2 (en) | 2020-10-30 | 2024-04-30 | Arog Pharmaceuticals, Inc. | Combination therapy of crenolanib and apoptosis pathway agents for the treatment of proliferative disorders |
| JP2023063189A (ja) * | 2021-10-22 | 2023-05-09 | アログ・ファーマシューティカルズ・インコーポレイテッド | 以前の治療に対して再発性／不応性のｆｌｔ３突然変異増殖性障害を治療するためのクレノラニブ |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990146A (en) | 1997-08-20 | 1999-11-23 | Warner-Lambert Company | Benzimidazoles for inhibiting protein tyrosine kinase mediated cellular proliferation |
| WO1999016755A1 (en) | 1997-09-26 | 1999-04-08 | Merck & Co., Inc. | Novel angiogenesis inhibitors |
| UA75055C2 (ru) | 1999-11-30 | 2006-03-15 | Пфайзер Продактс Інк. | Производные бензоимидазола, которые применяются как антипролиферативное средство, фармацевтическая композиция на их основании |
| CA2424689A1 (en) | 2000-10-17 | 2002-04-25 | Merck & Co., Inc. | Orally active salts with tyrosine kinase activity |
| AU2363902A (en) * | 2000-10-31 | 2002-05-15 | Ciba Sc Holding Ag | Crystalline forms of fluvastatin sodium |
| AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
| US7101884B2 (en) | 2001-09-14 | 2006-09-05 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| WO2003024931A1 (en) | 2001-09-14 | 2003-03-27 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
| TWI259081B (en) | 2001-10-26 | 2006-08-01 | Sugen Inc | Treatment of acute myeloid leukemia with indolinone compounds |
| TWI302836B (en) | 2001-10-30 | 2008-11-11 | Novartis Ag | Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity |
| WO2003057690A1 (en) | 2001-12-27 | 2003-07-17 | Theravance, Inc. | Indolinone derivatives useful as protein kinase inhibitors |
| TW200406374A (en) | 2002-05-29 | 2004-05-01 | Novartis Ag | Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases |
| MY141867A (en) | 2002-06-20 | 2010-07-16 | Vertex Pharma | Substituted pyrimidines useful as protein kinase inhibitors |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| CA2495386C (en) | 2002-08-14 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Protein kinase inhibitors and uses thereof |
| EP1539754A4 (en) | 2002-08-23 | 2009-02-25 | Novartis Vaccines & Diagnostic | BENZIMIDAZOLE QUINOLINONES AND USES THEREOF |
| PA8580301A1 (es) | 2002-08-28 | 2005-05-24 | Pfizer Prod Inc | Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos |
| EP1566379A4 (en) | 2002-10-29 | 2005-11-09 | Kirin Brewery | QUINOLINE AND QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FLT3 AND MEDICAL COMPOSITIONS CONTAINING SAME |
| JP2006511616A (ja) | 2002-11-13 | 2006-04-06 | カイロン コーポレイション | 癌の処置方法およびその関連方法 |
| TWI335913B (en) | 2002-11-15 | 2011-01-11 | Vertex Pharma | Diaminotriazoles useful as inhibitors of protein kinases |
| AU2003297160A1 (en) | 2002-12-18 | 2004-07-22 | Vertex Pharmaceuticals Incorporated | Benzisoxazole derivatives useful as inhibitors of protein kinases |
| BRPI0411794A (pt) | 2003-06-24 | 2006-08-08 | Pfizer Prod Inc | processos para a preparação de derivados de 1-[(benzoimidazol-1-il)quinolin-8-il]piperidin-4-ilamina |
| AU2006309171A1 (en) * | 2005-10-28 | 2007-05-10 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2012052757A1 (en) * | 2010-10-20 | 2012-04-26 | Astrazeneca Ab | Tumour phenotype patient selection method |
| AU2012345666A1 (en) * | 2011-11-30 | 2014-06-19 | Cedars-Sinai Medical Center | Targeting microRNAs miR-409-5p, miR-379 and miR-154* to treat prostate cancer bone metastasis and drug resistant lung cancer |
| JP6407504B2 (ja) | 2012-09-21 | 2018-10-17 | アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法 |
| KR20140040594A (ko) | 2012-09-26 | 2014-04-03 | 아로그 파마슈티칼스, 엘엘씨 | 돌연변이체 c-kit의 억제 방법 |
| BR112015016282A2 (pt) | 2013-01-07 | 2017-07-11 | Arog Pharmaceuticals Inc | crenolanibe para tratamento de distúrbios proliferativos de flt3 mutado |
-
2013
- 2013-07-10 BR BR112015016282A patent/BR112015016282A2/pt not_active Application Discontinuation
- 2013-10-14 AU AU2013371624A patent/AU2013371624B2/en active Active
- 2013-10-14 ES ES13869984.8T patent/ES2667958T3/es active Active
- 2013-10-14 CN CN202011110066.8A patent/CN112138010A/zh active Pending
- 2013-10-14 EP EP13869984.8A patent/EP2941251B1/en active Active
- 2013-10-14 EA EA201591290A patent/EA033910B1/ru unknown
- 2013-10-14 CA CA2897445A patent/CA2897445C/en active Active
- 2013-10-14 PT PT138699848T patent/PT2941251T/pt unknown
- 2013-10-14 MX MX2015008777A patent/MX369137B/es active IP Right Grant
- 2013-10-14 NZ NZ710720A patent/NZ710720A/en unknown
- 2013-10-14 AP AP2015008628A patent/AP2015008628A0/xx unknown
- 2013-10-14 SG SG11201505327SA patent/SG11201505327SA/en unknown
- 2013-10-14 CN CN201910222133.6A patent/CN109966292A/zh active Pending
- 2013-10-14 DK DK13869984.8T patent/DK2941251T3/en active
- 2013-10-14 HU HUE13869984A patent/HUE038594T2/hu unknown
- 2013-10-14 JP JP2015551670A patent/JP6288726B2/ja active Active
- 2013-10-14 KR KR1020157021078A patent/KR101885952B1/ko active IP Right Grant
- 2013-10-14 SI SI201330974T patent/SI2941251T1/en unknown
- 2013-10-14 RS RS20180287A patent/RS57076B1/sr unknown
- 2013-10-14 US US14/053,011 patent/US9101624B2/en active Active
- 2013-10-14 CN CN201910222143.XA patent/CN110200970A/zh active Pending
- 2013-10-14 LT LTEP13869984.8T patent/LT2941251T/lt unknown
- 2013-10-14 WO PCT/US2013/064821 patent/WO2014107209A2/en active Application Filing
- 2013-10-14 PL PL13869984T patent/PL2941251T3/pl unknown
- 2013-10-14 SG SG10201705611PA patent/SG10201705611PA/en unknown
- 2013-10-14 PE PE2015001247A patent/PE20151525A1/es not_active Application Discontinuation
- 2013-10-14 CN CN201380069700.XA patent/CN105555272A/zh active Pending
-
2014
- 2014-07-03 NO NO14742440A patent/NO3019692T3/no unknown
-
2015
- 2015-05-04 US US14/703,500 patent/US9393240B2/en active Active
- 2015-07-06 IL IL239802A patent/IL239802B/en active IP Right Grant
- 2015-07-07 PH PH12015501531A patent/PH12015501531B1/en unknown
- 2015-07-07 CL CL2015001923A patent/CL2015001923A1/es unknown
- 2015-07-31 ZA ZA2015/05545A patent/ZA201505545B/en unknown
-
2016
- 2016-06-28 US US15/195,297 patent/US9801870B2/en active Active
- 2016-11-02 HK HK16112610.7A patent/HK1224211A1/zh unknown
-
2017
- 2017-09-26 US US15/715,274 patent/US10213423B2/en active Active
-
2018
- 2018-03-12 CY CY20181100293T patent/CY1120026T1/el unknown
- 2018-03-22 HR HRP20180478TT patent/HRP20180478T1/hr unknown
-
2019
- 2019-02-22 US US16/282,716 patent/US11007188B2/en active Active
-
2020
- 2020-08-18 US US16/996,400 patent/US11458131B2/en active Active
-
2022
- 2022-08-30 US US17/898,632 patent/US20220409610A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA201591290A3 (ru) | Креноланиб для лечения пролиферативных расстройств, связанных с мутацией flt3 | |
| EA201690212A8 (ru) | Способы лечения или профилактики офтальмологических патологических состояний | |
| EA201691872A1 (ru) | Гетероциклические соединения для применения в лечении pi3k-гамма-опосредованных расстройств | |
| MX2016004030A (es) | Inhibidores sustituidos de nicotinamida de btk y su preparacion y uso en el tratamiento del cancer, inflamacion y enfermedad autoinmune. | |
| EA201592250A1 (ru) | Пиразолопирролидиновые производные и их применение в лечение заболеваний | |
| EA201690287A1 (ru) | 1,4-дизамещенные аналоги пиридазин хинолина и способы лечения состояний, связанных с smn-дефицитом | |
| MY197558A (en) | Methods of treating depression using orexin-2 receptor antagonists | |
| EA201691656A2 (ru) | Терапевтические способы с применением норибогаина и родственных соединений | |
| MX2021002321A (es) | Nuevos metodos. | |
| MX2016009306A (es) | Reequilibrado inmunologico epicutaneo. | |
| EA201492102A1 (ru) | Антагонисты lingo-2 для лечения заболеваний, в которых участвуют двигательные нейроны | |
| MX2021002322A (es) | Nuevos metodos. | |
| EA201691385A1 (ru) | Комбинированная терапия рака | |
| EA201692111A1 (ru) | Фармацевтические композиции, содержащие данириксин, для лечения инфекционных заболеваний | |
| EA201690974A1 (ru) | Гидроморфон и налоксон для лечения боли и индуцированного опиоидами синдрома дисфункции кишечника | |
| EA201790352A1 (ru) | Терапевтическое лечение на основе анаморелина | |
| SG10201809673RA (en) | Treatment of androgen deprivation therapy associated symptoms | |
| MX2014014817A (es) | Compuestos para el tratamiento de inflamacion y dolor. | |
| EA201992414A1 (ru) | Комбинация nk1-антагониста и способ лечения синуклеинопатий | |
| AR102494A1 (es) | Métodos para tratar enfermedades oculares | |
| PH12016502107A1 (en) | Combination of brexpiprazole and nalmefene and use thereof for treating substance-related disorders | |
| EA201990341A1 (ru) | Замещенные диазагетеробициклические соединения и их применение | |
| MX2020007183A (es) | Inhibidores de ret9 y vegfr2. | |
| EA201992284A1 (ru) | Композиции и способы лечения синуклеинопатий | |
| RU2014104644A (ru) | Способ повышения эффективности лечения коров, больных острым гнойно-катаральным эндометритом |