HRP20181380T1 - Lipopeptidne kompozicije i s njima povezani postupci - Google Patents

Lipopeptidne kompozicije i s njima povezani postupci

Info

Publication number
HRP20181380T1
HRP20181380T1 HRP20181380TT HRP20181380T HRP20181380T1 HR P20181380 T1 HRP20181380 T1 HR P20181380T1 HR P20181380T T HRP20181380T T HR P20181380TT HR P20181380 T HRP20181380 T HR P20181380T HR P20181380 T1 HRP20181380 T1 HR P20181380T1
Authority
HR
Croatia
Prior art keywords
related methods
lipopeptide compositions
lipopeptide
compositions
methods
Prior art date
Application number
HRP20181380TT
Other languages
English (en)
Inventor
Sophie Sun
Gaauri Naik
Sandra O'connor
Original Assignee
Cubist Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44060422&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20181380(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cubist Pharmaceuticals Llc filed Critical Cubist Pharmaceuticals Llc
Publication of HRP20181380T1 publication Critical patent/HRP20181380T1/hr
Publication of HRP20181380T4 publication Critical patent/HRP20181380T4/hr

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K11/00Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HRP20181380TT 2009-11-23 2010-11-23 Lipopeptidne kompozicije i s njima povezani postupci HRP20181380T4 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26378409P 2009-11-23 2009-11-23
EP10832379.1A EP2504353B2 (en) 2009-11-23 2010-11-23 Lipopeptide compositions and related methods
PCT/US2010/057910 WO2011063419A2 (en) 2009-11-23 2010-11-23 Lipopeptide compositions and related methods

Publications (2)

Publication Number Publication Date
HRP20181380T1 true HRP20181380T1 (hr) 2018-10-19
HRP20181380T4 HRP20181380T4 (hr) 2023-11-10

Family

ID=44060422

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20181380TT HRP20181380T4 (hr) 2009-11-23 2010-11-23 Lipopeptidne kompozicije i s njima povezani postupci

Country Status (33)

Country Link
US (3) US8835382B2 (hr)
EP (2) EP2504353B2 (hr)
JP (3) JP6041673B2 (hr)
CN (3) CN102712677B (hr)
AR (2) AR079127A1 (hr)
AU (1) AU2010321531C1 (hr)
BR (1) BR112012012406B1 (hr)
CA (1) CA2781666C (hr)
CL (2) CL2012001336A1 (hr)
CO (1) CO6541585A2 (hr)
CR (1) CR20120271A (hr)
CY (1) CY1120854T1 (hr)
DK (1) DK2504353T4 (hr)
DO (1) DOP2012000140A (hr)
EC (1) ECSP12011939A (hr)
ES (1) ES2686331T5 (hr)
FI (1) FI2504353T4 (hr)
HR (1) HRP20181380T4 (hr)
HU (1) HUE039967T2 (hr)
IL (1) IL219891B (hr)
LT (1) LT2504353T (hr)
MX (1) MX2012005993A (hr)
NZ (1) NZ600118A (hr)
PE (2) PE20151717A1 (hr)
PL (1) PL2504353T5 (hr)
PT (1) PT2504353T (hr)
RS (1) RS57566B2 (hr)
RU (1) RU2607526C2 (hr)
SG (1) SG10201407724YA (hr)
SI (1) SI2504353T2 (hr)
TR (1) TR201812823T4 (hr)
TW (2) TWI548414B (hr)
WO (1) WO2011063419A2 (hr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
LT2504353T (lt) 2009-11-23 2018-09-25 Cubist Pharmaceuticals Llc Lipopeptidų kompozicijos ir susiję būdai
US8709310B2 (en) 2011-01-05 2014-04-29 Hospira, Inc. Spray drying vancomycin
WO2012162567A1 (en) * 2011-05-26 2012-11-29 Cubist Pharmaceuticals, Inc. Cb-183,315 compositions and related methods
US20130184225A1 (en) * 2012-01-12 2013-07-18 Lianfeng Huang Romidepsin formulations and uses thereof
US20150216928A1 (en) * 2012-08-23 2015-08-06 Agila Special Ties Private Limited Daptomycin injectable formulation
US9655946B2 (en) 2012-09-11 2017-05-23 Hospira Australia Pty Ltd. Daptomycin formulations and uses thereof
CN104027791B (zh) * 2013-03-06 2016-08-10 浙江海正药业股份有限公司 药物组合物
CN104511011A (zh) * 2013-09-29 2015-04-15 山东新时代药业有限公司 一种达托霉素无菌粉末及其制备方法
US11667674B2 (en) 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
US10647746B2 (en) 2016-04-08 2020-05-12 Versitech Limited Antibacterial cyclic lipopeptides
WO2018073269A1 (en) 2016-10-21 2018-04-26 Xellia Pharmaceuticals Aps Liquid formulations of daptomycin
EP3675815A1 (en) * 2017-08-31 2020-07-08 Xellia Pharmaceuticals ApS Daptomycin formulations
CN110339341A (zh) * 2018-04-03 2019-10-18 江苏恒瑞医药股份有限公司 一种达托霉素或其盐的组合物
CN110548130A (zh) * 2018-06-04 2019-12-10 浙江医药股份有限公司新昌制药厂 含达托霉素的喷雾干粉及其工业化制备方法
US11058745B1 (en) 2018-10-04 2021-07-13 Good Health, Llc Stable liquid pharmaceutical compositions of daptomycin
CN111840511A (zh) * 2019-04-30 2020-10-30 江苏恒瑞医药股份有限公司 一种含有精氨酸的达托霉素或其盐的组合物
WO2021131314A1 (ja) * 2019-12-26 2021-07-01 ニプロ株式会社 ダプトマイシンを含有する安定した凍結乾燥製剤
BR112022015571A2 (pt) 2020-02-28 2022-09-27 Xellia Pharmaceuticals Aps Formulação de daptomicina.
CA3170514A1 (en) 2020-03-12 2021-09-16 Baxter International Inc. Daptomycin formulations containing a combination of sorbitol and mannitol
US11362190B2 (en) 2020-05-22 2022-06-14 Raytheon Company Depletion mode high electron mobility field effect transistor (HEMT) semiconductor device having beryllium doped Schottky contact layers
KR102218688B1 (ko) * 2020-06-25 2021-02-22 주식회사 클린텍 무선제어기능을 구비한 고압세척기
RU2770481C1 (ru) * 2021-06-25 2022-04-18 федеральное государственное автономное образовательное учреждение высшего образования «Казанский (Приволжский) федеральный университет» (ФГАОУ ВО КФУ) Способ получения суммарной фракции липопептидов бактерий Bacillus subtilis MG-8 ВКПМ В-12476 и его использование в качестве профилактического средства от болезней сельскохозяйственных птиц

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331594A (en) 1978-10-16 1982-05-25 Eli Lilly And Company A-21978 Antibiotics and process for their production
EP0014815A3 (de) 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen
US4432487A (en) 1982-01-18 1984-02-21 Chugai Denki Kogyo Kabushiki Kaisha Method of overlaying stainless steel material for decorative articles and ornaments with a precious metal alloy
US4482487A (en) 1982-05-21 1984-11-13 Eli Lilly And Company A-21978C cyclic peptides
US4537717A (en) 1982-05-21 1985-08-27 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
PT81265B (pt) 1984-10-09 1988-02-17 Lilly Co Eli Processo aperfeicoado para a producao de antibioticos derivados do peptideo ciclico a-21978c
CA1319886C (en) 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
EP0294990A3 (en) 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
CA1315229C (en) 1987-06-10 1993-03-30 Patrick J. Baker Chromatographic purification process
US5271935A (en) 1988-02-05 1993-12-21 Hoechst Aktiengesellschaft Antibiotic, cammunocin, a process for the preparation thereof, and the use thereof as a pharmaceutical
ZA901622B (en) * 1989-03-06 1991-11-27 Lilly Co Eli An improved diluent formulation for daptomycin
DK0438813T3 (da) 1990-01-26 1998-07-27 Hoechst Ag Nyt antibiotikum, deoxymulundocandin, en fremgangsmåde til dets fremstilling samt dets anvendelse som lægemiddel
JPH04224197A (ja) 1990-12-26 1992-08-13 Fujitsu Ltd 生体高分子結晶化方法および装置
US5336756A (en) 1991-05-01 1994-08-09 Merck & Co., Inc. Process for crystalline cyclic lipopeptides
TW213468B (hr) 1991-06-29 1993-09-21 Hoechst Ag
JP2948708B2 (ja) 1991-11-27 1999-09-13 ニューヨーク・ブラッド・センター・インコーポレーテッド フィブロネクチン含有点眼液
ATE167871T1 (de) 1992-04-20 1998-07-15 Abbott Lab Verfahren zur herstellung von vancomycin
TW455591B (en) 1993-06-08 2001-09-21 Hoechst Ag Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
DE4411025A1 (de) 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US5952300A (en) 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
US5955509A (en) 1996-05-01 1999-09-21 Board Of Regents, The University Of Texas System pH dependent polymer micelles
JPH10212241A (ja) * 1996-05-27 1998-08-11 Sumitomo Pharmaceut Co Ltd Bdnfを安定に含有する製剤
AU5528198A (en) 1997-12-03 1999-06-16 Immune Response Corporation, The Vaccination and methods against multiple sclerosis using specific tcr vbeta peptides
FR2771640B1 (fr) 1997-12-03 2000-02-11 Inst Nat Sante Rech Med Micelles mixtes de lipopeptides pour l'induction d'une reponse immunitaire et leurs utilisations a des fins therapeutiques
FR2774687B1 (fr) 1998-02-06 2002-03-22 Inst Nat Sante Rech Med Lipopeptides contenant un fragment de l'interferon gamma, et leur utilisation dans des compositions pharmaceutiques
DE19807972A1 (de) 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
EP1115417B1 (en) 1998-09-25 2006-04-05 Cubist Pharmaceuticals, Inc. Use of daptomycin
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
MXPA02006030A (es) 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos como agentes antibacterianos.
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
PL206492B1 (pl) * 2000-06-21 2010-08-31 Cubist Pharm Inc Kompozycja farmaceutyczna do doustnego dostarczania cefalosporyny i jej zastosowania
US6716962B2 (en) 2000-07-17 2004-04-06 Micrologix Biotech Inc. Extractive purification of lipopeptide antibiotics
IL156394A0 (en) 2000-12-18 2004-01-04 Cubist Pharm Inc Methods for preparing purified lipopeptides
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
WO2002059145A1 (en) * 2000-12-18 2002-08-01 Cubist Pharmaceuticals, Inc. Methods for preparing purified lipopeptides
US20080220441A1 (en) 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
JP3932272B2 (ja) * 2001-06-28 2007-06-20 明治乳業株式会社 多重t細胞エピトープポリペプチドの酢酸塩組成物
CA2454587C (en) 2001-07-25 2012-11-13 Protein Design Labs, Inc. Stable lyophilized pharmaceutical formulation of igg antibodies
AR036202A1 (es) 2001-08-06 2004-08-18 Cubist Pharm Inc Composiciones y metodos relacionados con el cluster genico biosintetico de daptomicina
WO2003059964A2 (fr) 2002-01-17 2003-07-24 Atofina Polymeres supramoleculaires
US20050084490A1 (en) 2002-07-09 2005-04-21 Point Therapeutics, Inc. Boroproline compound combination therapy
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
US7985422B2 (en) 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
JP2005060377A (ja) * 2003-07-28 2005-03-10 Yamanouchi Pharmaceut Co Ltd インターロイキン−11含有凍結乾燥製剤
US20050152979A1 (en) * 2003-09-05 2005-07-14 Cell Therapeutics, Inc. Hydrophobic drug compositions containing reconstitution enhancer
US20050196418A1 (en) 2004-03-04 2005-09-08 Yu Ruey J. Bioavailability and improved delivery of alkaline pharmaceutical drugs
CN1616083A (zh) * 2004-09-01 2005-05-18 魏雪纹 注射用达托霉素冻干制剂及制备方法
WO2006085337A1 (en) * 2005-02-14 2006-08-17 Venus Remedies Limited Parenteral combination therpy for infective conditions with drug resistant bacterium
WO2006130629A2 (en) 2005-05-31 2006-12-07 Cubist Pharmaceuticals, Inc. Daptomycin for the treatment of biofilm and catheter salvage
AU2006339311A1 (en) 2005-06-07 2007-09-07 Foamix Ltd. Antibiotic kit and composition and uses thereof
US8158152B2 (en) 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
BRPI0715113A2 (pt) 2006-07-26 2013-06-04 Sandoz Ag Sandoz Sa Sandoz Ltd formulaÇço de caspofungina
WO2008127291A2 (en) 2006-10-10 2008-10-23 Los Alamos National Security, Llc Advanced drug development and manufacturing
DE102007004968B4 (de) * 2007-01-26 2011-03-10 Heraeus Kulzer Gmbh Revisions-Polymethylmethacrylat-Knochenzement
WO2008102452A1 (ja) 2007-02-22 2008-08-28 Kringle Pharma Inc. Hgf製剤
CA2687246A1 (en) * 2007-06-01 2008-12-11 Acologix, Inc. High temperature stable peptide formulation
US20100137197A1 (en) 2007-06-26 2010-06-03 Sachin Mittal Lyophilized anti-fungal composition
US20100287884A1 (en) * 2007-10-25 2010-11-18 Sangita Seshadri Powder conditioning of unit dose drug packages
WO2009144739A1 (en) 2008-05-26 2009-12-03 Biocon Limited Amorphous daptomycin and a method of purification thereof
WO2011019839A2 (en) 2009-08-12 2011-02-17 The Medicines Company Glycopeptide and lipoglycopeptide antibiotics with improved solubility
US8431539B2 (en) 2009-09-17 2013-04-30 Eagle Pharmaceuticals, Inc. Formulations of daptomycin
LT2504353T (lt) 2009-11-23 2018-09-25 Cubist Pharmaceuticals Llc Lipopeptidų kompozicijos ir susiję būdai
EP2504020A4 (en) 2009-11-23 2013-05-29 Eagle Pharmaceuticals Inc DAPTOMYCIN FORMULATIONS
BR112013010714A2 (pt) 2010-11-01 2024-01-16 Rib X Pharmaceuticals Inc Composição farmacêutica e uso de um composto antibiótico
WO2012088441A1 (en) 2010-12-23 2012-06-28 Alkermes, Inc. Multi- api loading prodrugs
CN103347532A (zh) 2011-02-04 2013-10-09 爱奇司治疗公司 口服可生物利用肽药物组合物及其方法

Also Published As

Publication number Publication date
TWI548414B (zh) 2016-09-11
TW201703791A (zh) 2017-02-01
JP2017075186A (ja) 2017-04-20
US20120270772A1 (en) 2012-10-25
SI2504353T2 (sl) 2023-11-30
CL2012001336A1 (es) 2012-10-05
CN104056250A (zh) 2014-09-24
US20140364380A1 (en) 2014-12-11
SI2504353T1 (sl) 2018-10-30
JP6041673B2 (ja) 2016-12-14
JP2016147874A (ja) 2016-08-18
DK2504353T4 (da) 2023-11-20
US9662397B2 (en) 2017-05-30
RU2012126076A (ru) 2013-12-27
PT2504353T (pt) 2018-10-18
AR079127A1 (es) 2011-12-28
US20160030577A1 (en) 2016-02-04
IL219891B (en) 2018-01-31
HRP20181380T4 (hr) 2023-11-10
HUE039967T2 (hu) 2019-02-28
IL219891A0 (en) 2012-07-31
CN102712677B (zh) 2015-06-03
AR123846A2 (es) 2023-01-18
US9138456B2 (en) 2015-09-22
FI2504353T4 (fi) 2023-11-30
ECSP12011939A (es) 2012-07-31
TR201812823T4 (tr) 2019-02-21
WO2011063419A3 (en) 2011-10-13
NZ600118A (en) 2014-08-29
JP6239167B2 (ja) 2017-11-29
WO2011063419A2 (en) 2011-05-26
SG10201407724YA (en) 2014-12-30
JP6088681B2 (ja) 2017-03-01
AU2010321531A2 (en) 2014-10-30
RU2607526C2 (ru) 2017-01-10
ES2686331T5 (es) 2024-03-27
LT2504353T (lt) 2018-09-25
CN102712677A (zh) 2012-10-03
AU2010321531B2 (en) 2016-11-03
PL2504353T3 (pl) 2018-11-30
CL2015002412A1 (es) 2016-02-05
TW201141506A (en) 2011-12-01
TWI606838B (zh) 2017-12-01
DOP2012000140A (es) 2012-10-30
CY1120854T1 (el) 2019-12-11
ES2686331T3 (es) 2018-10-17
EP2504353A4 (en) 2014-04-02
AU2010321531C1 (en) 2020-10-01
PL2504353T5 (pl) 2023-11-20
DK2504353T3 (en) 2018-09-10
RS57566B1 (sr) 2018-10-31
CA2781666A1 (en) 2011-05-26
MX2012005993A (es) 2012-11-23
CO6541585A2 (es) 2012-10-16
PE20121517A1 (es) 2012-11-26
US8835382B2 (en) 2014-09-16
BR112012012406A2 (pt) 2019-12-03
EP2504353B1 (en) 2018-07-11
EP2504353B2 (en) 2023-09-13
CR20120271A (es) 2012-08-01
CA2781666C (en) 2017-02-21
PE20151717A1 (es) 2015-11-19
AU2010321531A1 (en) 2012-06-14
EP3417849A1 (en) 2018-12-26
RS57566B2 (sr) 2023-12-29
CN108785654A (zh) 2018-11-13
JP2013511557A (ja) 2013-04-04
BR112012012406B1 (pt) 2021-11-16
EP2504353A2 (en) 2012-10-03

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