PL2504353T3 - Kompozycje lipopeptydowe i związane metody - Google Patents

Kompozycje lipopeptydowe i związane metody

Info

Publication number
PL2504353T3
PL2504353T3 PL10832379T PL10832379T PL2504353T3 PL 2504353 T3 PL2504353 T3 PL 2504353T3 PL 10832379 T PL10832379 T PL 10832379T PL 10832379 T PL10832379 T PL 10832379T PL 2504353 T3 PL2504353 T3 PL 2504353T3
Authority
PL
Poland
Prior art keywords
related methods
lipopeptide compositions
lipopeptide
compositions
methods
Prior art date
Application number
PL10832379T
Other languages
English (en)
Other versions
PL2504353T5 (pl
Inventor
Sophie Sun
Gaauri Naik
Sandra O'connor
Original Assignee
Cubist Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44060422&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2504353(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cubist Pharmaceuticals Llc filed Critical Cubist Pharmaceuticals Llc
Publication of PL2504353T3 publication Critical patent/PL2504353T3/pl
Publication of PL2504353T5 publication Critical patent/PL2504353T5/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
PL10832379.1T 2009-11-23 2010-11-23 Kompozycje lipopeptydowe i związane metody PL2504353T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26378409P 2009-11-23 2009-11-23
EP10832379.1A EP2504353B2 (en) 2009-11-23 2010-11-23 Lipopeptide compositions and related methods
PCT/US2010/057910 WO2011063419A2 (en) 2009-11-23 2010-11-23 Lipopeptide compositions and related methods

Publications (2)

Publication Number Publication Date
PL2504353T3 true PL2504353T3 (pl) 2018-11-30
PL2504353T5 PL2504353T5 (pl) 2023-11-20

Family

ID=44060422

Family Applications (1)

Application Number Title Priority Date Filing Date
PL10832379.1T PL2504353T5 (pl) 2009-11-23 2010-11-23 Kompozycje lipopeptydowe i związane metody

Country Status (33)

Country Link
US (3) US8835382B2 (pl)
EP (2) EP3417849A1 (pl)
JP (3) JP6041673B2 (pl)
CN (3) CN104056250A (pl)
AR (2) AR079127A1 (pl)
AU (1) AU2010321531C1 (pl)
BR (1) BR112012012406B1 (pl)
CA (1) CA2781666C (pl)
CL (2) CL2012001336A1 (pl)
CO (1) CO6541585A2 (pl)
CR (1) CR20120271A (pl)
CY (1) CY1120854T1 (pl)
DK (1) DK2504353T4 (pl)
DO (1) DOP2012000140A (pl)
EC (1) ECSP12011939A (pl)
ES (1) ES2686331T5 (pl)
FI (1) FI2504353T4 (pl)
HR (1) HRP20181380T4 (pl)
HU (1) HUE039967T2 (pl)
IL (1) IL219891B (pl)
LT (1) LT2504353T (pl)
MX (1) MX2012005993A (pl)
NZ (1) NZ600118A (pl)
PE (2) PE20151717A1 (pl)
PL (1) PL2504353T5 (pl)
PT (1) PT2504353T (pl)
RS (1) RS57566B2 (pl)
RU (1) RU2607526C2 (pl)
SG (1) SG10201407724YA (pl)
SI (1) SI2504353T2 (pl)
TR (1) TR201812823T4 (pl)
TW (2) TWI606838B (pl)
WO (1) WO2011063419A2 (pl)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
TWI606838B (zh) 2009-11-23 2017-12-01 庫比斯特製藥有限責任公司 達托黴素（ｄａｐｔｏｍｙｃｉｎ）組合物及相關方法
DK2661254T3 (da) 2011-01-05 2017-11-06 Hospira Inc Sprøjtetørring af vancomycin
RU2013157188A (ru) * 2011-05-26 2015-07-10 Кьюбист Фармасьютикалз, Инк. Композиции св-183,315 и относящиеся к ним способы
EP2802340B1 (en) * 2012-01-12 2020-10-28 Celgene Corporation Romidepsin formulations and uses thereof
EP2887953B1 (en) * 2012-08-23 2017-10-11 Agila Specialties Private Limited Improved daptomycin injectable formulation
ES2552754T1 (es) 2012-09-11 2015-12-02 Hospira Australia Pty Ltd Formulaciones de daptomicina y usos de la misma
CN104027791B (zh) * 2013-03-06 2016-08-10 浙江海正药业股份有限公司 药物组合物
CN104511011A (zh) * 2013-09-29 2015-04-15 山东新时代药业有限公司 一种达托霉素无菌粉末及其制备方法
US11667674B2 (en) 2016-04-08 2023-06-06 Versitech Limited Antibacterial cyclic lipopeptides
US10647746B2 (en) 2016-04-08 2020-05-12 Versitech Limited Antibacterial cyclic lipopeptides
ES2946600T3 (es) 2016-10-21 2023-07-21 Xellia Pharmaceuticals Aps Formulaciones líquidas de daptomicina
CN111093625A (zh) * 2017-08-31 2020-05-01 埃克斯利亚制药有限公司 达托霉素制剂
CN110339341A (zh) * 2018-04-03 2019-10-18 江苏恒瑞医药股份有限公司 一种达托霉素或其盐的组合物
CN110548130A (zh) * 2018-06-04 2019-12-10 浙江医药股份有限公司新昌制药厂 含达托霉素的喷雾干粉及其工业化制备方法
US11058745B1 (en) 2018-10-04 2021-07-13 Good Health, Llc Stable liquid pharmaceutical compositions of daptomycin
CN111840511A (zh) * 2019-04-30 2020-10-30 江苏恒瑞医药股份有限公司 一种含有精氨酸的达托霉素或其盐的组合物
CN114828873A (zh) * 2019-12-26 2022-07-29 尼普洛株式会社 含有达托霉素的稳定的冷冻干燥制剂
EP4110303A1 (en) 2020-02-28 2023-01-04 Xellia Pharmaceuticals ApS Daptomycin formulation
JP2023517926A (ja) * 2020-03-12 2023-04-27 バクスター・インターナショナル・インコーポレイテッド ソルビトールとマンニトールの組み合わせを含むダプトマイシン製剤
US11362190B2 (en) 2020-05-22 2022-06-14 Raytheon Company Depletion mode high electron mobility field effect transistor (HEMT) semiconductor device having beryllium doped Schottky contact layers
KR102218688B1 (ko) * 2020-06-25 2021-02-22 주식회사 클린텍 무선제어기능을 구비한 고압세척기
RU2770481C1 (ru) * 2021-06-25 2022-04-18 федеральное государственное автономное образовательное учреждение высшего образования «Казанский (Приволжский) федеральный университет» (ФГАОУ ВО КФУ) Способ получения суммарной фракции липопептидов бактерий Bacillus subtilis MG-8 ВКПМ В-12476 и его использование в качестве профилактического средства от болезней сельскохозяйственных птиц

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4331594A (en) 1978-10-16 1982-05-25 Eli Lilly And Company A-21978 Antibiotics and process for their production
EP0014815A3 (de) 1978-12-20 1980-10-29 Ciba-Geigy Ag Peptidderivate, Verfahren zu deren Herstellung und Zwischenprodukte sowie pharmazeutische Präparate mit einer dieser Verbindungen
US4432487A (en) 1982-01-18 1984-02-21 Chugai Denki Kogyo Kabushiki Kaisha Method of overlaying stainless steel material for decorative articles and ornaments with a precious metal alloy
US4482487A (en) 1982-05-21 1984-11-13 Eli Lilly And Company A-21978C cyclic peptides
US4537717A (en) 1982-05-21 1985-08-27 Eli Lilly And Company Derivatives of A-21978C cyclic peptides
HU196845B (en) 1984-10-09 1989-01-30 Lilly Co Eli Process for producing a-21978 c derivatives
CA1319886C (en) 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions
US4874843A (en) * 1987-12-03 1989-10-17 Eli Lilly And Company Chromatographic purification process
CA1315229C (en) 1987-06-10 1993-03-30 Patrick J. Baker Chromatographic purification process
EP0294990A3 (en) 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US5271935A (en) 1988-02-05 1993-12-21 Hoechst Aktiengesellschaft Antibiotic, cammunocin, a process for the preparation thereof, and the use thereof as a pharmaceutical
IL93618A0 (en) * 1989-03-06 1990-12-23 Lilly Co Eli Improved diluent formulation for daptomycin
DE69031730T2 (de) 1990-01-26 1998-04-23 Hoechst Ag Neues Antibiotikum, Deoxymulündocandin, Verfahren zu seiner Produktion und Verwendung als Medikament
JPH04224197A (ja) 1990-12-26 1992-08-13 Fujitsu Ltd 生体高分子結晶化方法および装置
US5336756A (en) 1991-05-01 1994-08-09 Merck & Co., Inc. Process for crystalline cyclic lipopeptides
TW213468B (pl) 1991-06-29 1993-09-21 Hoechst Ag
JP2948708B2 (ja) * 1991-11-27 1999-09-13 ニューヨーク・ブラッド・センター・インコーポレーテッド フィブロネクチン含有点眼液
JP3421338B2 (ja) 1992-04-20 2003-06-30 アボツト・ラボラトリーズ バンコマイシンの製造方法
TW455591B (en) 1993-06-08 2001-09-21 Hoechst Ag Lipopeptides from actinoplanes sp. with pharmacological action, process for their production and the use thereof
DE4411025A1 (de) 1994-03-30 1995-10-05 Hoechst Ag Lipopeptid-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US5952300A (en) 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
US5955509A (en) 1996-05-01 1999-09-21 Board Of Regents, The University Of Texas System pH dependent polymer micelles
JPH10212241A (ja) 1996-05-27 1998-08-11 Sumitomo Pharmaceut Co Ltd Ｂｄｎｆを安定に含有する製剤
AU5528198A (en) 1997-12-03 1999-06-16 Immune Response Corporation, The Vaccination and methods against multiple sclerosis using specific tcr vbeta peptides
FR2771640B1 (fr) 1997-12-03 2000-02-11 Inst Nat Sante Rech Med Micelles mixtes de lipopeptides pour l'induction d'une reponse immunitaire et leurs utilisations a des fins therapeutiques
FR2774687B1 (fr) 1998-02-06 2002-03-22 Inst Nat Sante Rech Med Lipopeptides contenant un fragment de l'interferon gamma, et leur utilisation dans des compositions pharmaceutiques
DE19807972A1 (de) 1998-02-25 1999-08-26 Hoechst Marion Roussel De Gmbh Lipopeptidantibiotika-Calciumsalze, Verfahren zu ihrer Herstellung und Verwendung
WO2000018419A2 (en) 1998-09-25 2000-04-06 Cubist Pharmaceuticals, Inc. Methods for administration of antibiotics
US7129274B1 (en) 1999-11-05 2006-10-31 Emisphere Technologies Inc. Phenoxy carboxylic acid compounds and compositions for delivering active agents
US7279597B1 (en) 1999-11-05 2007-10-09 Emisphere Technologies, Inc. Phenyl amine carboxylic acid compounds and compositions for delivering active agents
US7408025B2 (en) 1999-12-15 2008-08-05 Cubist Pharmaceuticals, Inc. Lipopeptides as antibacterial agents
US6696412B1 (en) 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
JP4969013B2 (ja) * 2000-06-21 2012-07-04 キュービスト ファーマスーティカルズ インコーポレイテッド 抗菌剤の経口吸収を改善するための組成物および方法
US6716962B2 (en) 2000-07-17 2004-04-06 Micrologix Biotech Inc. Extractive purification of lipopeptide antibiotics
WO2002059145A1 (en) 2000-12-18 2002-08-01 Cubist Pharmaceuticals, Inc. Methods for preparing purified lipopeptides
KR20080036661A (ko) 2000-12-18 2008-04-28 큐비스트 파마슈티컬즈 인코포레이티드 정제된 리포펩티드의 제조 방법
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
US20080220441A1 (en) 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
JP3932272B2 (ja) * 2001-06-28 2007-06-20 明治乳業株式会社 多重ｔ細胞エピトープポリペプチドの酢酸塩組成物
WO2003009817A2 (en) 2001-07-25 2003-02-06 Protein Design Labs, Inc. Stable lyophilized pharmaceutical formulation of igg antibodies
JP2005508622A (ja) 2001-08-06 2005-04-07 キュービスト ファーマシューティカルズ， インコーポレイテッド ダプトマイシン生合成遺伝子クラスターに関する組成物および方法
JP2005514498A (ja) 2002-01-17 2005-05-19 アルケマ 超分子ポリマー
AU2003248921A1 (en) 2002-07-09 2004-01-23 Point Therapeutics, Inc. Boroproline compound combination therapy
US7985422B2 (en) 2002-08-05 2011-07-26 Torrent Pharmaceuticals Limited Dosage form
US8216609B2 (en) 2002-08-05 2012-07-10 Torrent Pharmaceuticals Limited Modified release composition of highly soluble drugs
US8268352B2 (en) 2002-08-05 2012-09-18 Torrent Pharmaceuticals Limited Modified release composition for highly soluble drugs
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US8912174B2 (en) 2003-04-16 2014-12-16 Mylan Pharmaceuticals Inc. Formulations and methods for treating rhinosinusitis
JP2005060377A (ja) * 2003-07-28 2005-03-10 Yamanouchi Pharmaceut Co Ltd インターロイキン−１１含有凍結乾燥製剤
US20050152979A1 (en) * 2003-09-05 2005-07-14 Cell Therapeutics, Inc. Hydrophobic drug compositions containing reconstitution enhancer
US20050196418A1 (en) 2004-03-04 2005-09-08 Yu Ruey J. Bioavailability and improved delivery of alkaline pharmaceutical drugs
CN1616083A (zh) * 2004-09-01 2005-05-18 魏雪纹 注射用达托霉素冻干制剂及制备方法
NZ555077A (en) * 2005-02-14 2010-03-26 Venus Remedies Ltd Parenteral combination therpy for infective conditions with drug resistant bacterium
WO2006130629A2 (en) 2005-05-31 2006-12-07 Cubist Pharmaceuticals, Inc. Daptomycin for the treatment of biofilm and catheter salvage
EP1919449A2 (en) 2005-06-07 2008-05-14 Foamix Ltd. Antibiotic kit and composition and uses thereof
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
KR101536781B1 (ko) * 2006-07-26 2015-07-14 산도즈 아게 카스포펀진 제형
DK2084519T3 (da) 2006-10-10 2012-08-20 Los Alamos Nat Security Llc Røntgenfluorescens-analysefremgangsmåde
DE102007004968B4 (de) * 2007-01-26 2011-03-10 Heraeus Kulzer Gmbh Revisions-Polymethylmethacrylat-Knochenzement
WO2008102452A1 (ja) 2007-02-22 2008-08-28 Kringle Pharma Inc. Ｈｇｆ製剤
MX2009012964A (es) * 2007-06-01 2010-01-14 Acologix Inc Formulacion de peptido estable a alta temperatura.
WO2009002481A1 (en) 2007-06-26 2008-12-31 Merck & Co., Inc. Lyophilized anti-fungal composition
JP5350388B2 (ja) * 2007-10-25 2013-11-27 ノバルティス アーゲー 単位用量薬物パッケージの粉体調整
WO2009144739A1 (en) 2008-05-26 2009-12-03 Biocon Limited Amorphous daptomycin and a method of purification thereof
WO2011019839A2 (en) 2009-08-12 2011-02-17 The Medicines Company Glycopeptide and lipoglycopeptide antibiotics with improved solubility
WO2011035108A1 (en) 2009-09-17 2011-03-24 Eagle Pharmaceuticals, Inc. Formulations of daptomycin
TWI606838B (zh) 2009-11-23 2017-12-01 庫比斯特製藥有限責任公司 達托黴素（ｄａｐｔｏｍｙｃｉｎ）組合物及相關方法
JP2013511522A (ja) 2009-11-23 2013-04-04 イーグル・ファーマシューティカルズ・インコーポレーテッド ダプトマイシン製剤
CN103379917B (zh) 2010-11-01 2016-10-12 梅琳塔治疗公司 药物组合物
CA2822447C (en) 2010-12-23 2018-05-01 Alkermes Pharma Ireland Limited Multi-api loading prodrugs
CN103347532A (zh) 2011-02-04 2013-10-09 爱奇司治疗公司 口服可生物利用肽药物组合物及其方法

Also Published As

Publication number Publication date
AR079127A1 (es) 2011-12-28
JP2013511557A (ja) 2013-04-04
US8835382B2 (en) 2014-09-16
BR112012012406A2 (pt) 2019-12-03
CY1120854T1 (el) 2019-12-11
CL2012001336A1 (es) 2012-10-05
TR201812823T4 (tr) 2019-02-21
JP6088681B2 (ja) 2017-03-01
ES2686331T3 (es) 2018-10-17
WO2011063419A2 (en) 2011-05-26
TW201141506A (en) 2011-12-01
TWI606838B (zh) 2017-12-01
CN108785654A (zh) 2018-11-13
US9662397B2 (en) 2017-05-30
EP2504353B1 (en) 2018-07-11
US20160030577A1 (en) 2016-02-04
DK2504353T4 (da) 2023-11-20
US20120270772A1 (en) 2012-10-25
DOP2012000140A (es) 2012-10-30
RU2607526C2 (ru) 2017-01-10
WO2011063419A3 (en) 2011-10-13
SI2504353T2 (sl) 2023-11-30
LT2504353T (lt) 2018-09-25
PT2504353T (pt) 2018-10-18
PE20121517A1 (es) 2012-11-26
IL219891A0 (en) 2012-07-31
CR20120271A (es) 2012-08-01
ES2686331T5 (es) 2024-03-27
AR123846A2 (es) 2023-01-18
ECSP12011939A (es) 2012-07-31
MX2012005993A (es) 2012-11-23
SI2504353T1 (sl) 2018-10-30
RS57566B2 (sr) 2023-12-29
RU2012126076A (ru) 2013-12-27
SG10201407724YA (en) 2014-12-30
TWI548414B (zh) 2016-09-11
EP2504353B2 (en) 2023-09-13
HUE039967T2 (hu) 2019-02-28
NZ600118A (en) 2014-08-29
EP2504353A2 (en) 2012-10-03
DK2504353T3 (en) 2018-09-10
HRP20181380T1 (hr) 2018-10-19
EP2504353A4 (en) 2014-04-02
JP2017075186A (ja) 2017-04-20
FI2504353T4 (fi) 2023-11-30
PE20151717A1 (es) 2015-11-19
BR112012012406B1 (pt) 2021-11-16
JP6041673B2 (ja) 2016-12-14
AU2010321531C1 (en) 2020-10-01
TW201703791A (zh) 2017-02-01
US20140364380A1 (en) 2014-12-11
JP6239167B2 (ja) 2017-11-29
CN102712677B (zh) 2015-06-03
AU2010321531B2 (en) 2016-11-03
HRP20181380T4 (hr) 2023-11-10
US9138456B2 (en) 2015-09-22
CN102712677A (zh) 2012-10-03
CO6541585A2 (es) 2012-10-16
PL2504353T5 (pl) 2023-11-20
CN104056250A (zh) 2014-09-24
CL2015002412A1 (es) 2016-02-05
AU2010321531A1 (en) 2012-06-14
AU2010321531A2 (en) 2014-10-30
CA2781666A1 (en) 2011-05-26
CA2781666C (en) 2017-02-21
RS57566B1 (sr) 2018-10-31
JP2016147874A (ja) 2016-08-18
IL219891B (en) 2018-01-31
EP3417849A1 (en) 2018-12-26

Similar Documents

Publication Publication Date Title
IL219891A0 (en) Lipopeptide compositions and related methods
IL210153A0 (en) Nutrigenomics methods and compositions
IL212822A0 (en) Anti-cxcr1 compositions and methods
IL218212A0 (en) Therapeutic methods and compositions
EP2442656A4 (en) REDUCED VAPORIZATION COMPOSITIONS AND CORRESPONDING METHODS
GB0819530D0 (en) Methods and compositions
EP2629742A4 (en) HAIR CARE COMPOSITIONS AND RELATED METHODS
EP2285405A4 (en) VACCINE COMPOSITIONS AND METHODS
GB0903299D0 (en) Composition and methods
EP2512483A4 (en) BALAGLITAZON COMPOSITIONS AND METHOD THEREFOR
EP2515940A4 (en) IMMUNOGENIC COMPOSITIONS AND CORRESPONDING METHODS
EP2490536A4 (en) COMPOSITION AND METHOD
GB0902429D0 (en) Compositions and their use
HK1201451A1 (en) Compositions and methods
GB201018650D0 (en) Methods and compositions
GB0901494D0 (en) Compositions and Methods
EP2461870A4 (en) THERAPEUTIC COMPOSITIONS AND METHOD
ZA201200260B (en) Polyphenylsulphone-polytetrafluroethylene compositions and use thereof
GB0811250D0 (en) Methods and compositions
EP2488624A4 (en) STABILIZED SURFACTANT-OXIDANT COMPOSITIONS AND METHODS THEREOF
GB0909720D0 (en) Compositions and methods
GB0908498D0 (en) Compositions and methods
GB0907616D0 (en) Methods and compositions
GB0903913D0 (en) Compositions and methods
GB0901899D0 (en) Compositions and uses