HRP20170721T1 - Sastav za obnovu hrskavičnog tkiva i metoda za njegovu proizvodnju - Google Patents
Sastav za obnovu hrskavičnog tkiva i metoda za njegovu proizvodnju Download PDFInfo
- Publication number
- HRP20170721T1 HRP20170721T1 HRP20170721TT HRP20170721T HRP20170721T1 HR P20170721 T1 HRP20170721 T1 HR P20170721T1 HR P20170721T T HRP20170721T T HR P20170721TT HR P20170721 T HRP20170721 T HR P20170721T HR P20170721 T1 HRP20170721 T1 HR P20170721T1
- Authority
- HR
- Croatia
- Prior art keywords
- solution
- concentration
- composition
- mixing
- thrombin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 230000017423 tissue regeneration Effects 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 claims 4
- 102000008186 Collagen Human genes 0.000 claims 3
- 108010035532 Collagen Proteins 0.000 claims 3
- 108010049003 Fibrinogen Proteins 0.000 claims 3
- 102000008946 Fibrinogen Human genes 0.000 claims 3
- 108090000190 Thrombin Proteins 0.000 claims 3
- 229920001436 collagen Polymers 0.000 claims 3
- 229940012952 fibrinogen Drugs 0.000 claims 3
- 229960004072 thrombin Drugs 0.000 claims 3
- 108010039627 Aprotinin Proteins 0.000 claims 2
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 claims 2
- 229960004405 aprotinin Drugs 0.000 claims 2
- 239000001963 growth medium Substances 0.000 claims 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 claims 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 229910001628 calcium chloride Inorganic materials 0.000 claims 1
- 239000001110 calcium chloride Substances 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 210000003321 cartilage cell Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30756—Cartilage endoprostheses
- A61F2002/30766—Scaffolds for cartilage ingrowth and regeneration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Claims (1)
1. Metoda za proizvodnju sastava za obnovu hrskavičnog tkiva, obuhvaća korake (a) otapanja liofiliziranog fibrinogena u otopini aprotinina; (b) otapanje liofiliziranog trombina u stabilizirajućoj otopini; (c) miješanje obogaćene otopine kolagena s trombinom i stabilizirajućom otopinom; i postavljanje otopine fibrinogena (a) na jednu stranu dvodijelnog kompleta te otopine (c) koja sadrži kolagen na drugu stranu, a zatim miješanje (a) i (c), pri čemu je vrijeme geliranja nakon miješanja (a) i (c) 3 minute i najveći je protok iznad 10 N, mjereno reometrom CR-500DX,
gdje je koncentracija fibrinogena u rasponu od 35 do 55 mg/L, koncentracija otopine aprotinina je 1500 KIU/mL, koncentracija trombina je 29.41 IU/mL, koncentracija stabilizirajuće otopine je 0.65 mg/mL i koncentracija kolagena je 13.23 mg/mL,
gdje je stabilizirajuća otopina pripravljena dodavanjem kalcijevog klorida u DMEM medij za kultiviranje za stanične kulture hrskavice, a DMEM medij za kultiviranje sadrži soli, aminokiseline i vitamine.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020090101388A KR101114773B1 (ko) | 2009-10-23 | 2009-10-23 | 연골조직 수복용 조성물의 제조방법 |
| EP09850624.9A EP2491960B1 (en) | 2009-10-23 | 2009-12-03 | Composition for cartilaginous tissue repair and a production method therefor |
| PCT/KR2009/007188 WO2011049265A1 (ko) | 2009-10-23 | 2009-12-03 | 연골조직 수복용 조성물 및 그 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20170721T1 true HRP20170721T1 (hr) | 2017-07-28 |
Family
ID=43900478
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170721TT HRP20170721T1 (hr) | 2009-10-23 | 2017-05-15 | Sastav za obnovu hrskavičnog tkiva i metoda za njegovu proizvodnju |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20120207736A1 (hr) |
| EP (1) | EP2491960B1 (hr) |
| JP (1) | JP5739894B2 (hr) |
| KR (1) | KR101114773B1 (hr) |
| CN (1) | CN102573942A (hr) |
| AU (2) | AU2009354235A1 (hr) |
| BR (1) | BR112012009558B8 (hr) |
| CA (1) | CA2778367C (hr) |
| CY (1) | CY1118960T1 (hr) |
| DK (1) | DK2491960T3 (hr) |
| ES (1) | ES2625479T3 (hr) |
| HR (1) | HRP20170721T1 (hr) |
| HU (1) | HUE032776T2 (hr) |
| LT (1) | LT2491960T (hr) |
| MX (1) | MX341709B (hr) |
| PL (1) | PL2491960T3 (hr) |
| PT (1) | PT2491960T (hr) |
| SI (1) | SI2491960T1 (hr) |
| WO (1) | WO2011049265A1 (hr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101279812B1 (ko) | 2012-05-16 | 2013-06-28 | 세원셀론텍(주) | 연골조직 수복용 조성물의 제조방법 |
| KR101401944B1 (ko) * | 2012-12-11 | 2014-05-30 | 세원셀론텍(주) | 콜라겐과 피브린이 혼합된 조직 실란트 및 그 제조방법 |
| KR101540691B1 (ko) * | 2013-01-09 | 2015-07-31 | 원광대학교산학협력단 | 피브리노겐, 아프로티닌, 리도카인, 에피네프린 및 콜라겐 막을 포함하는 서방성 국소 약물전달체, 키트 및 이를 이용한 골병증 치료용 조성물 |
| KR101525733B1 (ko) * | 2014-02-28 | 2015-06-03 | 가톨릭대학교 산학협력단 | 자기 콜라겐 유래 연골재생술을 위한 수술 키트 |
| US11439731B2 (en) | 2016-09-14 | 2022-09-13 | Revotek Co., Ltd. | Artificial tissue progenitor and method for preparing the same |
| CN107432955B (zh) * | 2016-09-14 | 2020-09-04 | 四川蓝光英诺生物科技股份有限公司 | 用于制备生物构建体的方法和试剂盒 |
| KR101863532B1 (ko) | 2017-06-15 | 2018-06-01 | 세원셀론텍(주) | 연골조직 수복용 콜라겐의 제조 및 사용방법 |
| WO2019151597A1 (ko) * | 2018-01-31 | 2019-08-08 | 주식회사 로킷헬스케어 | 연골 재생용 바이오 잉크 조성물, 이를 이용한 맞춤형 연골 재생용 스캐폴드의 제조방법, 및 상기 제조방법을 이용하여 제조된 맞춤형 연골 재생용 스캐폴드 |
| WO2019211873A2 (en) * | 2018-05-02 | 2019-11-07 | Pandorum Technologies Private Limited | A liquid cornea composition |
| WO2019211874A2 (en) * | 2018-05-02 | 2019-11-07 | Pandorum Technologies Private Limited | A liquid cornea hydrogel composition |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5290552A (en) * | 1988-05-02 | 1994-03-01 | Matrix Pharmaceutical, Inc./Project Hear | Surgical adhesive material |
| US7687462B2 (en) * | 1999-10-05 | 2010-03-30 | The Regents Of The University Of California | Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition |
| DE19956503A1 (de) * | 1999-11-24 | 2001-06-21 | Universitaetsklinikum Freiburg | Spritzbares Knochenersatzmaterial |
| WO2004110512A2 (en) * | 2003-06-12 | 2004-12-23 | Interface Biotech A/S | A method for cell implantation |
| KR100531922B1 (ko) * | 2003-12-23 | 2005-11-29 | 주식회사 셀론텍 | 연골치료제 조성물 및 그 사용방법 |
| EP1833522B1 (en) * | 2005-01-06 | 2016-06-22 | Kuros Biosurgery AG | Supplemented matrices for the repair of bone fractures |
| KR100774089B1 (ko) * | 2005-07-20 | 2007-11-06 | 세원셀론텍(주) | 주입형 연골세포치료제의 이식방법 |
| CA2672651C (en) * | 2006-12-15 | 2014-03-11 | Lifebond Ltd. | Gelatin-transglutaminase hemostatic dressings and sealants |
| BRPI0722363B8 (pt) * | 2006-12-22 | 2021-06-22 | Laboratoire Medidom S A | patch de correção de cartilagem laminado implantável |
| US20080294261A1 (en) * | 2007-05-24 | 2008-11-27 | Kevin Pauza | Method for treating herniated discs |
-
2009
- 2009-10-23 KR KR1020090101388A patent/KR101114773B1/ko active IP Right Grant
- 2009-12-03 LT LTEP09850624.9T patent/LT2491960T/lt unknown
- 2009-12-03 PL PL09850624T patent/PL2491960T3/pl unknown
- 2009-12-03 CA CA2778367A patent/CA2778367C/en not_active Expired - Fee Related
- 2009-12-03 JP JP2012535102A patent/JP5739894B2/ja active Active
- 2009-12-03 SI SI200931660T patent/SI2491960T1/sl unknown
- 2009-12-03 PT PT98506249T patent/PT2491960T/pt unknown
- 2009-12-03 BR BR112012009558A patent/BR112012009558B8/pt not_active IP Right Cessation
- 2009-12-03 WO PCT/KR2009/007188 patent/WO2011049265A1/ko active Application Filing
- 2009-12-03 HU HUE09850624A patent/HUE032776T2/en unknown
- 2009-12-03 US US13/503,228 patent/US20120207736A1/en not_active Abandoned
- 2009-12-03 DK DK09850624.9T patent/DK2491960T3/en active
- 2009-12-03 AU AU2009354235A patent/AU2009354235A1/en not_active Abandoned
- 2009-12-03 ES ES09850624.9T patent/ES2625479T3/es active Active
- 2009-12-03 MX MX2012004634A patent/MX341709B/es active IP Right Grant
- 2009-12-03 CN CN2009801620954A patent/CN102573942A/zh active Pending
- 2009-12-03 EP EP09850624.9A patent/EP2491960B1/en active Active
-
2014
- 2014-08-13 AU AU2014213500A patent/AU2014213500B2/en not_active Ceased
-
2017
- 2017-05-15 HR HRP20170721TT patent/HRP20170721T1/hr unknown
- 2017-05-22 CY CY20171100534T patent/CY1118960T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2009354235A1 (en) | 2012-06-07 |
| KR101114773B1 (ko) | 2012-03-05 |
| LT2491960T (lt) | 2017-07-25 |
| WO2011049265A1 (ko) | 2011-04-28 |
| EP2491960A4 (en) | 2013-09-04 |
| PL2491960T3 (pl) | 2017-09-29 |
| EP2491960B1 (en) | 2017-03-15 |
| MX341709B (es) | 2016-08-30 |
| SI2491960T1 (sl) | 2017-08-31 |
| US20120207736A1 (en) | 2012-08-16 |
| HUE032776T2 (en) | 2017-10-30 |
| CA2778367A1 (en) | 2011-04-28 |
| BR112012009558B1 (pt) | 2021-02-02 |
| BR112012009558B8 (pt) | 2021-06-22 |
| AU2014213500A1 (en) | 2014-09-04 |
| CA2778367C (en) | 2015-02-17 |
| JP5739894B2 (ja) | 2015-06-24 |
| CN102573942A (zh) | 2012-07-11 |
| ES2625479T3 (es) | 2017-07-19 |
| KR20110044616A (ko) | 2011-04-29 |
| PT2491960T (pt) | 2017-06-02 |
| JP2013508067A (ja) | 2013-03-07 |
| DK2491960T3 (en) | 2017-06-06 |
| MX2012004634A (es) | 2012-08-03 |
| BR112012009558A2 (pt) | 2020-10-13 |
| EP2491960A1 (en) | 2012-08-29 |
| CY1118960T1 (el) | 2018-01-10 |
| AU2014213500B2 (en) | 2015-12-24 |
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