CO6251232A2 - Compuestos de estroncio que contienen composiciones de fibrina - Google Patents

Compuestos de estroncio que contienen composiciones de fibrina

Info

Publication number
CO6251232A2
CO6251232A2 CO09119370A CO09119370A CO6251232A2 CO 6251232 A2 CO6251232 A2 CO 6251232A2 CO 09119370 A CO09119370 A CO 09119370A CO 09119370 A CO09119370 A CO 09119370A CO 6251232 A2 CO6251232 A2 CO 6251232A2
Authority
CO
Colombia
Prior art keywords
composition
strontium
containing compound
calcium
paste
Prior art date
Application number
CO09119370A
Other languages
English (en)
Inventor
John J Barry
Andreas Goessil
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of CO6251232A2 publication Critical patent/CO6251232A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/225—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/502—Plasticizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Surgery (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)

Abstract

1.- Una composición que comprende fibrina, trombina y un compuesto que contiene estroncio para uso en cicatrización ósea o crecimiento óseo. 2.- La composición de la reivindicación 1, en donde la composición está en forma de un gel, masilla, pasta o líquido. 3.- La composición de las reivindicaciones 1 o 2 que comprende adicionalmente un plastificante. 4.- La composición de la reivindicación 3 en donde el plastificante es un compuesto que contiene yodo. 5.- La composición de la reivindicación 4 en donde el compuesto que contiene yodo se selecciona del grupo que consiste de diatrizoato, yodecol, yodixanol, yofratol, yogulamida, yohexol, yomeprol, yopamidol, yopromide, yotrol, yoversol, yoxagulato y metrizamida y sus mezclas y alcoholes polivalentes. 6.- La composición de las reivindicaciones 1, 2, 3, 4, o 5 en donde la composición se puede suministrar, como un líquido, pasta o un gel antes de o durante la fase de gelificación o como un gel preformado, pasta o masilla dentro de los defectos del tejido. 7.- La composición de las reivindicaciones 1, 2, 3, 4, o 6 en donde la composición contiene una o más proteínas extracelulares seleccionadas del grupo que consiste de proteínas de matriz extracelular tal como fibronectina, proteínas asociadas a células, proteínas derivadas de plasma tal como factor XIII de coagulación sanguínea, proteasas e inhibidores proteasa. 8.- La composición de las reivindicaciones 1, 2, 3, 4, 6, o 7 en donde la composición se reabsorbe y se pone con el tejido durante el proceso de cicatrización. 9.- La composición de las reivindicaciones 1, 2, 3, 4, 5, 6, 7 o 8 en donde la composición comprende adicionalmente un agente que induce coagulación tal como protamina, veneno de serpiente, transglutaminasas, FXIla, o un sistea amortiguante alcalino fisiológicamente aceptable. 10.- La composición de las reivindicaciones 1 02 en donde el compuesto que contiene estroncio está en forma de un microparticulado soluble, granular o en una forma sólida. 11.- La composición de la reivindicación 10, en donde el compuesto que contiene estroncio se hace al agregar estroncio en un compuesto que contiene calcio para producir un material que comprende calcio y estroncio que contiene sales. 12.- La composición dele reivindicación 11, en donde dicho compuesto que contiene calcio es un fosfato de calcio.
CO09119370A 2007-04-23 2009-10-23 Compuestos de estroncio que contienen composiciones de fibrina CO6251232A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92571607P 2007-04-23 2007-04-23

Publications (1)

Publication Number Publication Date
CO6251232A2 true CO6251232A2 (es) 2011-02-21

Family

ID=39745302

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09119370A CO6251232A2 (es) 2007-04-23 2009-10-23 Compuestos de estroncio que contienen composiciones de fibrina

Country Status (17)

Country Link
US (1) US20080260714A1 (es)
EP (2) EP2823829B1 (es)
JP (2) JP5907656B2 (es)
KR (1) KR101520114B1 (es)
CN (2) CN101668549B (es)
AR (1) AR066245A1 (es)
AU (1) AU2008242867B2 (es)
BR (1) BRPI0811035B8 (es)
CA (1) CA2686820C (es)
CL (1) CL2008001171A1 (es)
CO (1) CO6251232A2 (es)
ES (2) ES2573327T3 (es)
HK (1) HK1205961A1 (es)
IL (1) IL201480A0 (es)
MX (1) MX2009011268A (es)
TW (1) TWI556842B (es)
WO (1) WO2008131154A2 (es)

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Also Published As

Publication number Publication date
CA2686820C (en) 2016-06-28
KR20100017158A (ko) 2010-02-16
TWI556842B (zh) 2016-11-11
HK1205961A1 (zh) 2015-12-31
JP2013216678A (ja) 2013-10-24
WO2008131154A2 (en) 2008-10-30
EP2142224A2 (en) 2010-01-13
MX2009011268A (es) 2009-11-02
WO2008131154A3 (en) 2008-12-24
CL2008001171A1 (es) 2008-11-03
BRPI0811035B8 (pt) 2021-05-25
BRPI0811035B1 (pt) 2018-07-31
IL201480A0 (en) 2010-05-31
US20080260714A1 (en) 2008-10-23
EP2823829A1 (en) 2015-01-14
AR066245A1 (es) 2009-08-05
CN103785058A (zh) 2014-05-14
EP2823829B1 (en) 2016-07-20
BRPI0811035A2 (pt) 2014-10-21
JP6012551B2 (ja) 2016-10-25
TW200902096A (en) 2009-01-16
AU2008242867B2 (en) 2014-01-23
CN103785058B (zh) 2016-12-07
CN101668549B (zh) 2014-04-09
ES2594081T3 (es) 2016-12-15
ES2573327T3 (es) 2016-06-07
CA2686820A1 (en) 2008-10-30
CN101668549A (zh) 2010-03-10
AU2008242867A1 (en) 2008-10-30
KR101520114B1 (ko) 2015-05-13
EP2142224B1 (en) 2016-03-23
JP2010525070A (ja) 2010-07-22
JP5907656B2 (ja) 2016-04-26

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