HRP20161713T1 - Derivat cikloalkana - Google Patents

Derivat cikloalkana Download PDF

Info

Publication number
HRP20161713T1
HRP20161713T1 HRP20161713TT HRP20161713T HRP20161713T1 HR P20161713 T1 HRP20161713 T1 HR P20161713T1 HR P20161713T T HRP20161713T T HR P20161713TT HR P20161713 T HRP20161713 T HR P20161713T HR P20161713 T1 HRP20161713 T1 HR P20161713T1
Authority
HR
Croatia
Prior art keywords
pain
oxy
pyrazol
benzenesulfonamide
pyrimidin
Prior art date
Application number
HRP20161713TT
Other languages
English (en)
Croatian (hr)
Inventor
Tsuyoshi Shinozuka
Hiroyuki Kobayashi
Sayaka SUZUKI
Kyosuke TANAKA
Hiroko KIMOTO
Yuki Domon
Original Assignee
Daiichi Sankyo Company, Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Company, Limited filed Critical Daiichi Sankyo Company, Limited
Publication of HRP20161713T1 publication Critical patent/HRP20161713T1/hr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/06Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/427Thiazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433Thidiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/081,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Anesthesiology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HRP20161713TT 2012-02-09 2013-02-08 Derivat cikloalkana HRP20161713T1 (hr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2012025754 2012-02-09
JP2012259122 2012-11-27
PCT/JP2013/052985 WO2013118854A1 (ja) 2012-02-09 2013-02-08 シクロアルカン誘導体
EP13746373.3A EP2813491B1 (en) 2012-02-09 2013-02-08 Cycloalkane derivative

Publications (1)

Publication Number Publication Date
HRP20161713T1 true HRP20161713T1 (hr) 2017-02-10

Family

ID=48947609

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20161713TT HRP20161713T1 (hr) 2012-02-09 2013-02-08 Derivat cikloalkana

Country Status (30)

Country Link
US (3) US8889741B2 (cg-RX-API-DMAC7.html)
EP (2) EP2813491B1 (cg-RX-API-DMAC7.html)
JP (2) JP5997710B2 (cg-RX-API-DMAC7.html)
KR (1) KR20140127238A (cg-RX-API-DMAC7.html)
CN (1) CN104185629B (cg-RX-API-DMAC7.html)
AU (1) AU2013218592B2 (cg-RX-API-DMAC7.html)
BR (1) BR112014019478A2 (cg-RX-API-DMAC7.html)
CA (1) CA2864222C (cg-RX-API-DMAC7.html)
CO (1) CO7151511A2 (cg-RX-API-DMAC7.html)
CY (1) CY1118572T1 (cg-RX-API-DMAC7.html)
DK (1) DK2813491T3 (cg-RX-API-DMAC7.html)
ES (2) ES2613078T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20161713T1 (cg-RX-API-DMAC7.html)
HU (2) HUE037048T2 (cg-RX-API-DMAC7.html)
IL (1) IL234014A (cg-RX-API-DMAC7.html)
IN (1) IN2014MN01577A (cg-RX-API-DMAC7.html)
LT (1) LT2813491T (cg-RX-API-DMAC7.html)
MX (1) MX349354B (cg-RX-API-DMAC7.html)
NZ (1) NZ628096A (cg-RX-API-DMAC7.html)
PH (2) PH12014501804B1 (cg-RX-API-DMAC7.html)
PL (1) PL2813491T3 (cg-RX-API-DMAC7.html)
PT (1) PT2813491T (cg-RX-API-DMAC7.html)
RS (1) RS55671B1 (cg-RX-API-DMAC7.html)
RU (1) RU2635354C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201404707VA (cg-RX-API-DMAC7.html)
SI (1) SI2813491T1 (cg-RX-API-DMAC7.html)
SM (2) SMT201700053T1 (cg-RX-API-DMAC7.html)
TW (1) TWI612042B (cg-RX-API-DMAC7.html)
WO (1) WO2013118854A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201405801B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104093716B (zh) 2011-10-31 2017-06-23 克赛农制药股份有限公司 联芳醚磺酰胺化合物及其作为治疗剂的用途
ES2586213T3 (es) * 2011-10-31 2016-10-13 Xenon Pharmaceuticals Inc. Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
US8889741B2 (en) * 2012-02-09 2014-11-18 Daiichi Sankyo Company, Limited Cycloalkane derivatives
HK1209100A1 (en) 2012-05-22 2016-03-24 基因泰克有限公司 N-substituted benzamides and their use in the treatment of pain
KR101663436B1 (ko) 2012-07-06 2016-10-06 제넨테크, 인크. N-치환된 벤즈아미드 및 이의 사용 방법
JP6208212B2 (ja) * 2013-03-14 2017-10-04 第一三共株式会社 呼吸器疾患用薬
KR20150131233A (ko) 2013-03-14 2015-11-24 제넨테크, 인크. 치환된 트리아졸로피리딘 및 이의 사용 방법
WO2014144545A2 (en) 2013-03-15 2014-09-18 Genentech, Inc. Substituted benzoxazoles and methods of use thereof
CN105793238B (zh) 2013-11-27 2019-12-24 基因泰克公司 经取代的苯甲酰胺及其使用方法
EP3166939B1 (en) 2014-07-07 2019-06-05 Genentech, Inc. Therapeutic compounds and methods of use thereof
US10179767B2 (en) 2015-05-22 2019-01-15 Genentech, Inc. Substituted benzamides and methods of use thereof
EP3341353A1 (en) 2015-08-27 2018-07-04 Genentech, Inc. Therapeutic compounds and methods of use thereof
EP3356360A1 (en) 2015-09-28 2018-08-08 Genentech, Inc. Therapeutic compounds and methods of use thereof
BR112018008448A2 (pt) 2015-11-06 2018-11-06 Daiichi Sankyo Company, Limited ?método para produzir um composto?
MA43304A (fr) 2015-11-25 2018-10-03 Genentech Inc Benzamides substitués utiles en tant que bloqueurs de canaux sodiques
EP3436432B1 (en) 2016-03-30 2021-01-27 Genentech, Inc. Substituted benzamides and methods of use thereof
US10246453B2 (en) 2016-05-20 2019-04-02 Xenon Pharmaceuticals Inc. Benzenesulfonamide compounds and their use as therapeutic agents
BR112019007763A2 (pt) * 2016-10-17 2019-07-02 Genentech Inc composto de fórmula, composição farmacêutica, métodos para tratar uma doença ou condição, para tratar dores, para diminuir o fluxo de íons e para tratar prurido, uso de um composto e invenção
ES2897998T3 (es) * 2016-10-27 2022-03-03 Bristol Myers Squibb Co Inhibidores de la acilsulfonamida del NaV1.7
RU2760303C2 (ru) * 2016-12-09 2021-11-23 Ксенон Фармасьютикалз Инк. Соединения бензолсульфонамидов и их использование в качестве терапевтических средств
CN110546148A (zh) 2017-03-24 2019-12-06 基因泰克公司 作为钠通道抑制剂的4-哌啶-n-(嘧啶-4-基)色满-7-磺酰胺衍生物
BR112020005455A2 (pt) 2017-09-20 2020-09-24 Abm Therapeutics Corporation derivados de iminopirimidina cíclica como inibidores de cinase
AR114263A1 (es) * 2018-02-26 2020-08-12 Genentech Inc Compuestos terapéuticos y métodos para utilizarlos
CN111936494A (zh) 2018-03-30 2020-11-13 豪夫迈·罗氏有限公司 作为钠通道抑制剂的取代的氢-吡啶并-吖嗪
TW202003490A (zh) 2018-05-22 2020-01-16 瑞士商赫孚孟拉羅股份公司 治療性化合物及其使用方法
KR102833674B1 (ko) 2018-06-13 2025-07-14 제논 파마슈티칼스 인크. 벤젠술폰아미드 화합물 및 치료제로서의 그의 용도
CN112638879B (zh) 2018-08-31 2024-06-18 泽农医药公司 杂芳基取代的磺酰胺化合物及其作为治疗剂的用途
WO2020047312A1 (en) 2018-08-31 2020-03-05 Xenon Pharmaceuticals Inc. Heteroaryl-substituted sulfonamide compounds and their use as sodium channel inhibitors
EP3902544A1 (en) * 2018-12-26 2021-11-03 RaQualia Pharma Inc. Heterocyclic derivatives as nav1.7 and nav1.8 blockers
US20240241265A1 (en) * 2023-01-18 2024-07-18 Qualcomm Incorporated Virtual positioning signal measurements

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6222048B1 (en) 1995-12-18 2001-04-24 Merck Frosst Canada & Co. Diaryl-2-(5H)-furanones as Cox-2 inhibitors
WO2006038594A1 (ja) 2004-10-04 2006-04-13 Ono Pharmaceutical Co., Ltd. N型カルシウムチャネル阻害薬
RU2007146769A (ru) * 2005-05-16 2009-06-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Бициклические производные и их применение в качестве модуляторов ионых каналов
EP2173743A2 (en) 2007-07-13 2010-04-14 Icagen, Inc. Sodium channel inhibitors
WO2010035166A1 (en) 2008-09-23 2010-04-01 Pfizer Limited Benzamide derivatives
PL2385938T3 (pl) * 2009-01-12 2015-07-31 Pfizer Ltd Pochodne sulfonamidu
CA2804173C (en) * 2010-07-09 2015-01-13 Pfizer Limited Sulfonamide nav1.7 inhibitors
CA2804593C (en) * 2010-07-09 2015-11-24 Pfizer Limited Biphenyloxybenzensulphonamide derivatives useful as sodium channel inhibitors
JP5860045B2 (ja) 2010-07-09 2016-02-16 ファイザー・リミテッドPfizer Limited 化合物
ES2586213T3 (es) 2011-10-31 2016-10-13 Xenon Pharmaceuticals Inc. Compuestos de bencenosulfonamida y su uso como agentes terapéuticos
US8889741B2 (en) * 2012-02-09 2014-11-18 Daiichi Sankyo Company, Limited Cycloalkane derivatives

Also Published As

Publication number Publication date
SI2813491T1 (sl) 2017-02-28
US9845313B2 (en) 2017-12-19
IL234014A (en) 2017-09-28
CN104185629A (zh) 2014-12-03
AU2013218592A1 (en) 2014-09-18
US20140045862A1 (en) 2014-02-13
DK2813491T3 (en) 2017-02-13
IN2014MN01577A (cg-RX-API-DMAC7.html) 2015-05-08
HUE031450T2 (en) 2017-07-28
JP2017008093A (ja) 2017-01-12
TW201339152A (zh) 2013-10-01
PT2813491T (pt) 2017-02-10
CA2864222A1 (en) 2013-08-15
PL2813491T3 (pl) 2017-08-31
BR112014019478A2 (pt) 2019-05-28
SMT201700053B (it) 2017-03-08
EP2813491A1 (en) 2014-12-17
SMT201700053T1 (it) 2017-03-08
CO7151511A2 (es) 2014-12-29
JPWO2013118854A1 (ja) 2015-05-11
ES2613078T3 (es) 2017-05-22
JP5997710B2 (ja) 2016-09-28
TWI612042B (zh) 2018-01-21
ES2659434T3 (es) 2018-03-15
LT2813491T (lt) 2017-02-10
ZA201405801B (en) 2015-12-23
CN104185629B (zh) 2017-10-13
US9493448B2 (en) 2016-11-15
US8889741B2 (en) 2014-11-18
CY1118572T1 (el) 2017-07-12
MX349354B (es) 2017-07-24
NZ628096A (en) 2016-06-24
PH12014501804A1 (en) 2014-11-17
IL234014A0 (en) 2014-09-30
CA2864222C (en) 2016-10-25
KR20140127238A (ko) 2014-11-03
RS55671B1 (sr) 2017-06-30
EP2813491A4 (en) 2015-08-12
AU2013218592B2 (en) 2016-12-22
US20150018551A1 (en) 2015-01-15
MX2014009637A (es) 2015-06-23
WO2013118854A1 (ja) 2013-08-15
EP3144300A1 (en) 2017-03-22
EP3144300B1 (en) 2017-12-20
HUE037048T2 (hu) 2018-08-28
RU2014136463A (ru) 2016-03-27
JP6154052B2 (ja) 2017-06-28
PH12015502675A1 (en) 2017-04-24
RU2635354C2 (ru) 2017-11-13
US20170001984A1 (en) 2017-01-05
EP2813491B1 (en) 2016-11-02
SG11201404707VA (en) 2014-10-30
PH12014501804B1 (en) 2014-11-17
HK1203503A1 (en) 2015-10-30

Similar Documents

Publication Publication Date Title
HRP20161713T1 (hr) Derivat cikloalkana
HRP20130935T1 (hr) Bicikliäśki derivat aminokiseline
MD20140037A2 (ro) Derivaţi de (4-fenilimidazol-2-il)etilamină utili ca modulatori ai canalului de sodiu
RU2016105436A (ru) Нейроактивные стероиды, композиции и их использование
EP4467549A3 (en) Intermediates of n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)benzamide derivatives
HRP20251220T1 (hr) Derivati bipirazola kao jak inhibitori
JP2018505898A5 (cg-RX-API-DMAC7.html)
RU2014119711A (ru) Трициклические соединения, композиции, содержащие указанные соединения, и их применения
HRP20190815T1 (hr) Piridonski derivati korišteni kao inhibitori kinaze reorganizirane tijekom transfekcije (ret)
HRP20170363T1 (hr) Derivati piridina kao inhibitori kinaze pregrađene prilikom transfekcije (ret)
MX2012007273A (es) Pteridinonas como inhibidores de la quinasa tipo polo.
MX384868B (es) Composiciones para tratar atrofia muscular espinal.
RU2014103587A (ru) Производные циклических аминов в качестве антагонистов рецептора ер4
MX348548B (es) Derivado heterociclico y farmaceutico.
PH12012502120B1 (en) Low-oil pharmaceutical emulsion compositions comprising progestogen
CA2574600A1 (en) Pyridine derivatives
BR112019021868A2 (pt) Sal de um composto derivado de aminopiridina, forma cristalina do mesmo, e processo para a preparação do mesmo
CA2758474A1 (en) Novel p2x7r antagonists and their use
HRP20240173T1 (hr) Fluorofenil beta-hidroksietilamini i njihova upotreba u liječenju hiperglikemije
UY31885A (es) Derivados de las 1, 3, 5-triazina-2, 4-diaminas-6-sustituidas-n-sustituidas y sales farmacéuticamente aceptables de los mismos, composiciones y aplicaciones.
HRP20100573T1 (hr) Triazolopiridinkarboksamidni derivati, njihovo dobivanje i njihova upotreba u terapiji
MY184433A (en) 2,6-substituted purine derivatives and their use in the treatment of proliferative disorders
HRP20191734T1 (hr) Pirimidinski derivati korisni kao selektivni jak3 i/ili jak1 inhibitori
MY206359A (en) Heteroaryl-substituted pyrazole compound and medicinal use thereof
PH12021551035A1 (en) Pyrazoles as modulators of hemoglobin