MX348548B - Derivado heterociclico y farmaceutico. - Google Patents

Derivado heterociclico y farmaceutico.

Info

Publication number
MX348548B
MX348548B MX2014001665A MX2014001665A MX348548B MX 348548 B MX348548 B MX 348548B MX 2014001665 A MX2014001665 A MX 2014001665A MX 2014001665 A MX2014001665 A MX 2014001665A MX 348548 B MX348548 B MX 348548B
Authority
MX
Mexico
Prior art keywords
pharmaceutically acceptable
acceptable salt
heterocyclic derivative
mpges
present
Prior art date
Application number
MX2014001665A
Other languages
English (en)
Other versions
MX2014001665A (es
Inventor
Otsu Hironori
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of MX2014001665A publication Critical patent/MX2014001665A/es
Publication of MX348548B publication Critical patent/MX348548B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

La presente invención se refiere a un nuevo derivado heterocíclico o una sal del mismo farmacéuticamente aceptable. Por ejemplo, la presente invención proporciona un derivado heterocíclico de la fórmula general [1] o sus tautómeros, o una sal del mismo farmacéuticamente aceptable: (ver Fórmula) en donde R1 y R2 son el mismo o diferentes anillos aromáticos, etc., y el anillo A es un anillo heterocíclico. El compuesto de la invención o una sal del mismo farmacéuticamente aceptable tiene potente actividad inhibidora de mPGES-1 y es útil como un agente para el tratamiento o prevención de una enfermedad, tal como artritis reumatoide, osteoartritis, trastornos de la articulación temporomandibular, dolor de espalda baja, endometriosis, dismenorrea, vejiga hiperactiva, tumores malignos o enfermedad neurodegenerativa.
MX2014001665A 2011-08-18 2012-08-17 Derivado heterociclico y farmaceutico. MX348548B (es)

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PCT/JP2012/070902 WO2013024898A1 (ja) 2011-08-18 2012-08-17 ヘテロ環誘導体及び医薬

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