HRP20160156T1 - Novi farmaceutski pripravci koji sadrže 4-(4-(3-(4-kloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoksi)-piridin-2-karboksilnu kiselinu za lijeäśenje hiperproliferativnih poremeä†aja - Google Patents
Novi farmaceutski pripravci koji sadrže 4-(4-(3-(4-kloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoksi)-piridin-2-karboksilnu kiselinu za lijeäśenje hiperproliferativnih poremeä†aja Download PDFInfo
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- HRP20160156T1 HRP20160156T1 HRP20160156TT HRP20160156T HRP20160156T1 HR P20160156 T1 HRP20160156 T1 HR P20160156T1 HR P20160156T T HRP20160156T T HR P20160156TT HR P20160156 T HRP20160156 T HR P20160156T HR P20160156 T1 HRP20160156 T1 HR P20160156T1
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- cellulose
- preparation according
- preparation
- hydroxypropyl
- cyclodextrin
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- 239000008194 pharmaceutical composition Substances 0.000 title claims 4
- 230000003463 hyperproliferative effect Effects 0.000 title claims 2
- BZESFMLUNMTDFR-UHFFFAOYSA-N 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid Chemical compound C1=NC(C(=O)O)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 BZESFMLUNMTDFR-UHFFFAOYSA-N 0.000 title 1
- 238000002360 preparation method Methods 0.000 claims 15
- 239000011159 matrix material Substances 0.000 claims 11
- 229920000858 Cyclodextrin Polymers 0.000 claims 6
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 5
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 5
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 5
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 5
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 4
- 239000007962 solid dispersion Substances 0.000 claims 4
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
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- 238000002560 therapeutic procedure Methods 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
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- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
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Claims (19)
1. Pripravak koji sadrži krutu disperziju naznačen time da sadrži barem metil amid 4{4-[3-(4-kloro-3-trifluorometilfenil)-ureido]-3-fluorofenoksi}-piridin-2-karboksilne kiseline u uglavnom amorfnom obliku i farmaceutski prihvatljivu matricu.
2. Pripravak prema zahtjevu 1 naznačen time da matrica sadrži farmaceutski prihvatljiv polimer odabran iz skupine koju čine polivinilpirolidon, kopolimer vinilpirolidon/vinilacetat, polialkilen glikol, polietilen glikol, hidroksialkil celuloza, hidroksipropil celuloza, hidroksialkil metil celuloza, hidroksipropil metil celuloza, karboksimetil celuloza, natrijeva karboksimetil celuloza, etil celuloza, polimetakrilati, polivinil alkohol, polivinil acetat, kopolimer vinil alkohol/vinil acetat, poliglikolizirani gliceridi, ksantan guma, karagenan, kitosan, kitin, polidekstrin, dekstrin, škrob i proteini.
3. Pripravak prema zahtjevu 1 naznačen time da matrica sadrži šećer i/ili šećerni alkohol i/ili ciklodekstrin odabran iz skupine koju čine sukroza, laktoza, fruktoza, maltoza, rafinoza, sorbitol, laktitol, manitol, maltitol, eritritol, inositol, trehaloza, izomalt, inulin, maltodekstrin, β-ciklodekstrin, hidroksipropil-β-ciklodekstrin i sulfobutil eter ciklodekstrin.
4. Pripravak prema zahtjevu 2 naznačen time da matrica sadrži farmaceutski prihvatljiv polimer odabran iz skupine koju čine polivinilpirolidon, hidroksipropil celuloza, hidroksipropil metil celuloza i polietilen glikol.
5. Pripravak prema zahtjevu 2 naznačen time da matrica sadrži polivinilpirolidon.
6. Pripravak prema zahtjevu 2 naznačen time da matrica sadrži hidroksipropil celulozu.
7. Pripravak koji sadrži krutu disperziju naznačen time da sadrži barem metil amid 4{4-[3-(4-kloro-3-trifluorometilfenil)-ureido]-3-fluorofenoksi}-piridin-2-karboksilne kiseline, njegove solvate, hidrate, farmaceutski prihvatljive soli, ili njihovu kombinaciju i farmaceutski prihvatljivu matricu pri čemu matrica sadrži farmaceutski prihvatljiv polimer odabran iz skupine koju čine polivinilpirolidon, vinilpirolidon/vinilacetat kopolimer, polialkilen glikol, polietilen glikol, hidroksialkil celuloza, hidroksipropil celuloza, hidroksialkil metil celuloza, hidroksipropil metil celuloza, karboksimetil celuloza, natrijeva karboksimetil celuloza, etil celuloza, polimetakrilati, polivinil alkohol, polivinil acetat, kopolimer vinil alkohol/vinil acetat, poliglikolizirani gliceridi, ksantan guma, karagenan, kitosan, kitin, polidekstrin, dekstrin, škrob i proteini.
8. Pripravak koji sadrži krutu disperziju naznačen time da sadrži barem metil amid 4{4-[3-(4-kloro-3-trifluorometilfenil)-ureido]-3-fluorofenoksi}-piridin-2-karboksilne kiseline, njegove solvate, hidrate, farmaceutski prihvatljive soli, ili njihovu kombinaciju i farmaceutski prihvatljivu matricu pri čemu matrica sadrži šećer i/ili šećerni alkohol i/ili ciklodekstrin odabran iz skupine koju čine sukroza, laktoza, fruktoza, maltoza, rafinoza, sorbitol, laktitol, manitol, maltitol, eritritol, inositol, trehaloza, izomalt, inulin, maltodekstrin, β-ciklodekstrin, hidroksipropil-β-ciklodekstrin i sulfobutil eter ciklodekstrin.
9. Pripravak prema zahtjevu 7 naznačen time da matrica sadrži farmaceutski prihvatljiv polimer odabran iz skupine koju čine polivinilpirolidon, hidroksipropil celuloza, hidroksipropil metil celuloza i polietilen glikol.
10. Pripravak prema zahtjevu 7 naznačen time da matrica sadrži polivinilpirolidon.
11. Pripravak prema zahtjevu 7 naznačen time da matrica sadrži hidroksipropil celulozu.
12. Pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da je farmaceutski pripravak za oralnu primjenu.
13. Pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da je farmaceutski pripravak u obliku tablete.
14. Pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da je farmaceutski pripravak u obliku kapsule.
15. Pripravak prema bilo kojem od prethodnih zahtjeva, naznačen time da je farmaceutski pripravak u obliku praška ili granulata.
16. Postupak za pripremanje krute disperzije metil amida 4{4-[3-(4-kloro-3-trifluorometilfenil)-ureido]-3-fluorofenoksi}-piridin-2-karboksilne kiseline u uglavnom amorfnom obliku koji sadrži postupak odabran iz skupine koju čine tehnologija fuzije/otapanja, ekstrudiranje vruće taljevine, uparavanje otapala, sušenje smrzavanjem, sušenje raspršivanjem, polaganje slojeva praha ili granula, ko-taloženje, tehnologija sa superkritičnom tekućinom i elektrostatsko predenje.
17. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 15 naznačen time da je za uporabu za liječenje hiper-proliferativnih poremećaja kod sisavca, uključujući čovjeka, bilo kao jedino sredstvo ili u kombinaciji s drugim terapijama.
18. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 15 naznačen time da je za uporabu za liječenje raka kod sisavca, uključujući čovjeka, bilo kao jedino sredstvo ili u kombinaciji s drugim terapijama.
19. Farmaceutski pripravak u skladu s bilo kojim od patentnih zahtjeva 1 do 15 naznačen time da je za uporabu za liječenje raka kod pacijenta koji je čovjek, u kombinaciji s citotoksičnom terapijom.
Applications Claiming Priority (3)
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| US60475204P | 2004-08-27 | 2004-08-27 | |
| PCT/US2005/030541 WO2006026500A1 (en) | 2004-08-27 | 2005-08-29 | New pharmaceutical compositions comprising 4-(4-(3-(4-chloro-3-trifluoromethyl-phenyl)-ureido)-3-fluoro-phenoxy)-pyridine-2-carboxylic acid for the treatment of hyper-proliferative disorders |
| EP05792486.2A EP1793824B1 (en) | 2004-08-27 | 2005-08-29 | New pharmaceutical compositions comprising 4-(4-(3-(4-chloro-3-trifluoromethyl-phenyl)-ureido)-3-fluoro-phenoxy)-pyridine-2-carboxylic acid for the treatment of hyper-proliferative disorders |
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| Application Number | Title | Priority Date | Filing Date |
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| HRP20160156TT HRP20160156T1 (hr) | 2004-08-27 | 2016-02-12 | Novi farmaceutski pripravci koji sadrže 4-(4-(3-(4-kloro-3-trifluorometil-fenil)-ureido)-3-fluoro-fenoksi)-piridin-2-karboksilnu kiselinu za lijeäśenje hiperproliferativnih poremeä†aja |
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| CN111166724A (zh) * | 2018-11-09 | 2020-05-19 | 北京化工大学 | 一种瑞戈非尼纳米分散体、片剂及其制备方法 |
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