HRP20150966T1 - Metoda davanja pluä†nog surfaktanta - Google Patents
Metoda davanja pluä†nog surfaktanta Download PDFInfo
- Publication number
- HRP20150966T1 HRP20150966T1 HRP20150966TT HRP20150966T HRP20150966T1 HR P20150966 T1 HRP20150966 T1 HR P20150966T1 HR P20150966T T HRP20150966T T HR P20150966TT HR P20150966 T HRP20150966 T HR P20150966T HR P20150966 T1 HRP20150966 T1 HR P20150966T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical preparation
- use according
- pulmonary surfactant
- respiratory distress
- distress syndrome
- Prior art date
Links
- 239000003580 lung surfactant Substances 0.000 title claims 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims 13
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims 4
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 2
- 208000032376 Lung infection Diseases 0.000 claims 1
- 201000005085 Meconium Aspiration Syndrome Diseases 0.000 claims 1
- 206010059033 Neonatal aspiration Diseases 0.000 claims 1
- 102000007620 Pulmonary Surfactant-Associated Protein C Human genes 0.000 claims 1
- 108010007125 Pulmonary Surfactant-Associated Protein C Proteins 0.000 claims 1
- 239000012736 aqueous medium Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 125000003473 lipid group Chemical group 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 210000003437 trachea Anatomy 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0082—Lung surfactant, artificial mucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/395—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (13)
1. Farmaceutski pripravak, naznačen time da sadrži najmanje 40 mg/mL plućnog surfaktanta suspendiranog u ne više od 3.0 mL farmaceutski prihvatljivog vodenog medija koji ima viskoznost manju od 20 mPas, koji se upotrebljava za sprječavanje i/ili liječenje pacijenata koji pate od respiratornog distresnog sindroma, pri čemu se u dišnom putu primjenjuje pozitivni kontinuirani tlak od 1 do 12 cm vode pomoću nazalne naprave, pri čemu se rečeni pripravak pacijentu daje u traheju rečenog pacijenta pomoću cijevi koja ima promjer od 5 Ft, a koja se uklanja nakon davanja.
2. Farmaceutski pripravak za primjenu prema patentnom zahtjevu 1, naznačen time da koncentracija plućnog surfaktanta jest između 40 i 80 mg/mL.
3. Farmaceutski pripravak za primjenu prema patentnom zahtjevu 1 ili 2, naznačen time da se plućni surfaktant daje u dozi koja je jednaka ili viša od 80 mg po tjelesnoj masi.
4. Farmaceutski pripravak za primjenu prema patentnom zahtjevu 3, naznačen time da doza jest između 100 i 200 mg po tjelesnoj masi.
5. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time da volumen farmaceutski prihvatljivog medija jest manji od 2 mL.
6. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time da viskoznost jest između 5 i 15 mPas.
7. Farmaceutski pripravak za primjenu prema patentnom zahtjevu 6, naznačen time da viskoznost jest između 6 i 10 mPas.
8. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time da surfaktant jest modificirani prirodni plućni surfaktant ili rekonstituirani plućni surfaktant.
9. Farmaceutski pripravak za primjenu prema patentnom zahtjevu 8, naznačen time da plućni surfaktant jest lipidni ekstrakt usitnjenog pluća sisavca kojemu su ukonjeni hirofilni proteini SPA-A i SPA-D te sadrže različite količine hidrofobnih proteina SP-B i SP-C.
10. Farmaceutski pripravak za primjenu prema patentnom zahtjevu 8, naznačen time da plućni surfaktant jest poraktant alfa.
11. Farmaceutski pripravak za primjenu prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time da je cijev odabrana iz sljedeće skupine: gastrična sonda, nazogastrična sonda, arterijski kateter i odsisni kateter.
12. Farmaceutski pripravak za primjenu prema bilo kojem od patentnih zahtjeva 1 do 11, naznačen time da respiratorni distersni sindrom jest dječji raspiratroni distresni sindrom.
13. Farmaceutski pripravak za primjenu prema bilo kojem od patentnih zahtjeva 1 do 11, naznačen time da je respiratorni distresni sindrom uzrokovan aspiracijom mekonija ili plućnom infekcijom.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/811,351 US8048043B2 (en) | 2007-06-08 | 2007-06-08 | Method of administration of a pulmonary surfactant |
| EP08758716.8A EP2164504B1 (en) | 2007-06-08 | 2008-05-23 | A method of administration of a pulmonary surfactant |
| PCT/EP2008/004120 WO2008148469A1 (en) | 2007-06-08 | 2008-05-23 | A method of administration of a pulmonary surfactant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20150966T1 true HRP20150966T1 (hr) | 2015-10-09 |
Family
ID=39832595
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150966TT HRP20150966T1 (hr) | 2007-06-08 | 2015-09-14 | Metoda davanja pluä†nog surfaktanta |
| HRP20170270TT HRP20170270T1 (hr) | 2007-06-08 | 2017-02-21 | Metoda davanja plućnog surfaktanta |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20170270TT HRP20170270T1 (hr) | 2007-06-08 | 2017-02-21 | Metoda davanja plućnog surfaktanta |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8048043B2 (hr) |
| EP (2) | EP2164504B1 (hr) |
| JP (1) | JP5490683B2 (hr) |
| KR (2) | KR101344159B1 (hr) |
| CN (1) | CN101765431B (hr) |
| AU (1) | AU2008258872B2 (hr) |
| BR (1) | BRPI0811387B8 (hr) |
| CA (1) | CA2690097C (hr) |
| CY (2) | CY1116680T1 (hr) |
| DK (2) | DK2164504T3 (hr) |
| EA (1) | EA016308B1 (hr) |
| ES (2) | ES2547489T3 (hr) |
| HK (1) | HK1141457A1 (hr) |
| HR (2) | HRP20150966T1 (hr) |
| HU (2) | HUE025957T2 (hr) |
| LT (1) | LT2719391T (hr) |
| ME (1) | ME02327B (hr) |
| MX (2) | MX359316B (hr) |
| PL (2) | PL2164504T3 (hr) |
| PT (2) | PT2719391T (hr) |
| RS (2) | RS54196B1 (hr) |
| SI (2) | SI2164504T1 (hr) |
| WO (1) | WO2008148469A1 (hr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2475373B1 (en) * | 2009-09-08 | 2013-11-13 | Chiesi Farmaceutici S.p.A. | A therapeutic combination comprising a pulmonary surfactant and antioxidant enzymes |
| RU2504395C1 (ru) * | 2012-07-13 | 2014-01-20 | ФЕДЕРАЛЬНОЕ ГОСУДАРСТВЕННОЕ БЮДЖЕТНОЕ УЧРЕЖДЕНИЕ "РОССИЙСКИЙ НАУЧНЫЙ ЦЕНТР РАДИОЛОГИИ И ХИРУРГИЧЕСКИХ ТЕХНОЛОГИЙ" МИНИСТЕРСТВА ЗДРАВООХРАНЕНИЯ И СОЦИАЛЬНОГО РАЗВИТИЯ РОССИЙСКОЙ ФЕДЕРАЦИИ/ФГБУ "РНЦРХТ" Минздравсоцразвития России | Способ профилактики бронхолегочной дисплазии у новорожденных с очень низкой и экстремально низкой массой тела при рождении |
| ITMI20150033U1 (it) * | 2015-02-13 | 2016-08-13 | Chiesi Farm Spa | Catetere per la somministrazione di un surfattante polmonare |
| EP3277351B1 (en) | 2015-04-02 | 2019-06-05 | Hill-Rom Services PTE. LTD. | Manifold for respiratory device |
| US11311691B2 (en) | 2015-04-28 | 2022-04-26 | Chiesi Farmaceutici S.P.A | Device for facilitating the administration of a medicament to the lung by a catheter |
| WO2016174269A1 (en) * | 2015-04-30 | 2016-11-03 | University Of Bremen | A novel skin medical and cosmetic care product |
| EP3490649A1 (en) | 2016-07-28 | 2019-06-05 | Chiesi Farmaceutici S.p.A. | Method and system for delivery of an aerosolized medicament |
| MA46605A (fr) | 2016-10-26 | 2021-06-02 | Chiesi Farm Spa | Dispositif permettant de faciliter l'administration d'un médicament aux poumons par l'intermédiaire d'un cathéter |
| JP2020502242A (ja) | 2016-12-22 | 2020-01-23 | キエージ・フアルマチエウテイチ・エツセ・ピ・ア | 進行性のｂｐｄの処置のための肺サーファクタント及びステロイドを含む処置的組み合わせ物 |
| AU2019260526A1 (en) | 2018-04-23 | 2020-11-19 | Chiesi Farmaceutici S.P.A. | A therapeutic combination comprising a pulmonary surfactant and a steroid for the prophylaxis of BPD |
| MA54367A (fr) | 2018-12-06 | 2021-11-10 | Chiesi Farm Spa | Dispositif de contrôle des voies aériennes à masque laryngé et procédé d'administration d'un médicament à travers un dispositif de contrôle des voies aériennes à masque laryngé |
| US11219843B2 (en) * | 2019-07-08 | 2022-01-11 | Nik Paya Karen Pharmed | Extraction of animal-derived pulmonary surfactants |
| WO2021151853A1 (en) | 2020-01-28 | 2021-08-05 | Chiesi Farmaceutici S.P.A. | Polypeptides having improved properties |
| AU2022306466A1 (en) * | 2021-07-05 | 2024-02-15 | Chiesi Farmaceutici S.P.A. | Process for the preparation of a pulmonary surfactant |
| CN115634199B (zh) * | 2022-10-18 | 2024-05-03 | 杭州汉库医药科技有限公司 | 一种混悬型肺表面活性物质注射液及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| US5164369A (en) | 1988-01-06 | 1992-11-17 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| DE3921954A1 (de) * | 1989-07-04 | 1991-01-17 | Thomae Gmbh Dr K | Niedrig-viskose, hochkonzentrierte surfactant-suspension |
| DE4418936A1 (de) | 1994-05-31 | 1996-02-08 | Byk Gulden Lomberg Chem Fab | Polypeptid |
| GB9524007D0 (en) * | 1995-11-23 | 1996-01-24 | Bangham Alec D | Endotrachael tubes with pulmonary medicaments |
| IT1308180B1 (it) | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
| WO2003035679A2 (en) * | 2001-10-25 | 2003-05-01 | Medical Research Council | Molecules |
| EP1897577B1 (de) * | 2002-08-02 | 2012-05-16 | Med In Medical Innovations GmbH | Vorrichtung zur Erzeugung eines kontinuierlichen positiven Atemwegdrucks (CPAP-Vorrichtung) |
| US20060040860A1 (en) * | 2004-06-17 | 2006-02-23 | Mario Ruediger | Intra-tracheal application of vascular endothelial growth factor (VEGF) for the prevention of lung damages caused by hperoxia |
| US20060112961A1 (en) * | 2004-11-29 | 2006-06-01 | Hany Aly | Pediatric mask, especially suited for premature infants |
| ES2380046T3 (es) * | 2005-01-06 | 2012-05-08 | Discovery Laboratories, Inc. | Régimen para el tratamiento con tensioactivos para tratar o prevenir la displasia broncopulmonar |
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2007
- 2007-06-08 US US11/811,351 patent/US8048043B2/en active Active
-
2008
- 2008-05-23 ES ES08758716.8T patent/ES2547489T3/es active Active
- 2008-05-23 MX MX2013006282A patent/MX359316B/es unknown
- 2008-05-23 CN CN2008800167252A patent/CN101765431B/zh active Active
- 2008-05-23 MX MX2009012835A patent/MX2009012835A/es not_active Application Discontinuation
- 2008-05-23 HU HUE08758716A patent/HUE025957T2/en unknown
- 2008-05-23 WO PCT/EP2008/004120 patent/WO2008148469A1/en active Application Filing
- 2008-05-23 PL PL08758716T patent/PL2164504T3/pl unknown
- 2008-05-23 HU HUE14150705A patent/HUE031750T2/en unknown
- 2008-05-23 SI SI200831485T patent/SI2164504T1/sl unknown
- 2008-05-23 ME MEP-2016-21A patent/ME02327B/me unknown
- 2008-05-23 AU AU2008258872A patent/AU2008258872B2/en active Active
- 2008-05-23 BR BRPI0811387A patent/BRPI0811387B8/pt active IP Right Grant
- 2008-05-23 LT LTEP14150705.3T patent/LT2719391T/lt unknown
- 2008-05-23 PT PT141507053T patent/PT2719391T/pt unknown
- 2008-05-23 KR KR1020097022778A patent/KR101344159B1/ko active IP Right Grant
- 2008-05-23 SI SI200831761A patent/SI2719391T1/sl unknown
- 2008-05-23 EA EA200901499A patent/EA016308B1/ru not_active IP Right Cessation
- 2008-05-23 PT PT87587168T patent/PT2164504E/pt unknown
- 2008-05-23 EP EP08758716.8A patent/EP2164504B1/en active Active
- 2008-05-23 DK DK08758716.8T patent/DK2164504T3/en active
- 2008-05-23 CA CA2690097A patent/CA2690097C/en active Active
- 2008-05-23 ES ES14150705.3T patent/ES2616727T3/es active Active
- 2008-05-23 RS RS20150558A patent/RS54196B1/en unknown
- 2008-05-23 RS RS20170162A patent/RS55733B1/sr unknown
- 2008-05-23 JP JP2010510665A patent/JP5490683B2/ja active Active
- 2008-05-23 EP EP14150705.3A patent/EP2719391B1/en active Active
- 2008-05-23 PL PL14150705T patent/PL2719391T3/pl unknown
- 2008-05-23 KR KR1020137005157A patent/KR101399738B1/ko active IP Right Grant
- 2008-05-23 DK DK14150705.3T patent/DK2719391T3/en active
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2010
- 2010-08-20 HK HK10107979.8A patent/HK1141457A1/xx unknown
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2011
- 2011-10-04 US US13/252,532 patent/US8905979B2/en active Active
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2015
- 2015-09-09 CY CY20151100781T patent/CY1116680T1/el unknown
- 2015-09-14 HR HRP20150966TT patent/HRP20150966T1/hr unknown
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2017
- 2017-02-15 CY CY20171100201T patent/CY1118635T1/el unknown
- 2017-02-21 HR HRP20170270TT patent/HRP20170270T1/hr unknown
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