HRP20150300T4 - Novi i snažni mhc-razred ii peptidi derivirani iz survivina i neurokana - Google Patents
Novi i snažni mhc-razred ii peptidi derivirani iz survivina i neurokana Download PDFInfo
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- HRP20150300T4 HRP20150300T4 HRP20150300TT HRP20150300T HRP20150300T4 HR P20150300 T4 HRP20150300 T4 HR P20150300T4 HR P20150300T T HRP20150300T T HR P20150300TT HR P20150300 T HRP20150300 T HR P20150300T HR P20150300 T4 HRP20150300 T4 HR P20150300T4
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- Prior art keywords
- peptide
- cancer
- nucleic acid
- tumor
- expression vector
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims 21
- 102000004196 processed proteins & peptides Human genes 0.000 title claims 4
- 102000000763 Survivin Human genes 0.000 title claims 2
- 108010002687 Survivin Proteins 0.000 title claims 2
- 108010043296 Neurocan Proteins 0.000 title 1
- 102100030466 Neurocan core protein Human genes 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 6
- 239000013604 expression vector Substances 0.000 claims 6
- 206010028980 Neoplasm Diseases 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 3
- 208000000172 Medulloblastoma Diseases 0.000 claims 3
- 208000007641 Pinealoma Diseases 0.000 claims 3
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 208000027831 neuroepithelial neoplasm Diseases 0.000 claims 3
- 208000029340 primitive neuroectodermal tumor Diseases 0.000 claims 3
- 206010003571 Astrocytoma Diseases 0.000 claims 2
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 201000000582 Retinoblastoma Diseases 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 201000005649 gangliocytoma Diseases 0.000 claims 2
- 201000008361 ganglioneuroma Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- 239000012931 lyophilized formulation Substances 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 claims 1
- 208000004139 Choroid Plexus Neoplasms Diseases 0.000 claims 1
- 208000037156 Choroid plexus tumor Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014967 Ependymoma Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 201000004066 Ganglioglioma Diseases 0.000 claims 1
- 208000000527 Germinoma Diseases 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 206010018338 Glioma Diseases 0.000 claims 1
- 201000005409 Gliomatosis cerebri Diseases 0.000 claims 1
- 206010068601 Glioneuronal tumour Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 208000033383 Neuroendocrine tumor of pancreas Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 201000007286 Pilocytic astrocytoma Diseases 0.000 claims 1
- 206010050487 Pinealoblastoma Diseases 0.000 claims 1
- 206010057846 Primitive neuroectodermal tumour Diseases 0.000 claims 1
- 206010043276 Teratoma Diseases 0.000 claims 1
- 201000005476 astroblastoma Diseases 0.000 claims 1
- 210000004970 cd4 cell Anatomy 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 201000007455 central nervous system cancer Diseases 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 201000004428 dysembryoplastic neuroepithelial tumor Diseases 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 201000003115 germ cell cancer Diseases 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 108010028930 invariant chain Proteins 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000008203 medulloepithelioma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000004058 mixed glioma Diseases 0.000 claims 1
- 206010073131 oligoastrocytoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000020943 pineal parenchymal cell neoplasm Diseases 0.000 claims 1
- 201000003113 pineoblastoma Diseases 0.000 claims 1
- 206010035059 pineocytoma Diseases 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (12)
1. Peptid koji se sastoji od slijeda aminokiselina SEQ ID No. 1 (TLGEFLKLDRERAKN).
2. Peptid iz zahtjeva 1, pri čemu navedeni peptid SEQ ID No. 1 ima sposobnost da se veže na molekulu HLA-DR alela HLA.
3. Peptid iz zahtjeva 2, pri čemu navedeni peptid ima sposobnost stimuliranja CD4 ili CD8 T-stanica.
4. Fuzijski protein, koji se sastoji od peptida iz bilo kojeg zahtjeva 1 do 3 spojenog na N amino kraj aminokiselina invarijantnog lanca (Ii) koji se povezuje s antigenom HLA-DR.
5. Nukleinska kiselina u koju je ukodiran peptid iz bilo kojeg zahtjeva 1 do 4 ili ekspresijski vektor koji ima sposobnost eksprimirati navedenu nukleinsku kiselinu.
6. Peptid iz bilo kojeg zahtjeva 1 do 4 ili nukleinska kiselina ili ekspresijski vektor iz zahtjeva 5 za uporabu u medicini.
7. Stanica domaćin koja se sastoji od nukleinske kiseline ili ekspresijskog vektora iz zahtjeva 5, pri čemu je bolje ako navedena stanica domaćin predstavlja antigen, naročito dendritična stanica ili antigen.
8. Metoda proizvodnje peptida iz bilo kojeg zahtjeva 1 do 4, a koja se sastoji od uzgoja kulture stanice domaćina iz zahtjeva 7 koja vrši ekspresiju nukleinske kiseline ili ekspresijskog vektora iz zahtjeva 5 te izoliranja peptida iz stanice domaćina ili podloge njezine kulture.
9. Peptid iz bilo kojeg zahtjeva 1 do 4, nukleinska kiselina ili ekspresijski vektor iz zahtjeva 5 ili stanica iz zahtjeva 7 za korištenje u liječenju karcinoma, po mogućnosti kao cjepivo.
10. Peptid za korištenje prema zahtjevu 9, pri čemu navedeni karcinom može biti astrocitom, pilocitični astrocitom, disembrioplastični neuroepitelijalni tumor, oligodendrogliom, ependimom, glioblastom multiforme, mješoviti gliom, oligoastrocitom, meduloblastom, retinoblastom, neuroblastom, germinom, teratom, gangliogliom, gangliocitom, centralni gangliocitom, primitivni neuroektodermalni tumor (PNET, npr. meduloblastom, meduloepiteliom, neuroblastom, retinoblastom, ependimoblastom), tumor pinealnog parenhima (npr. pineocitom, pineoblastom), tumor ependimalnih stanica, tumor koroidnog pleksusa, neuroepitelni tumor nepoznatog porijekla (npr. gliomatosis cerebri, astroblastom), glioblastom, tumor prostate, karcinom dojke, karcinom jednjaka, karcinom debelog crijeva, kolorektalni karcinom, karcinom bubrežnih stanica, karcinom svijetlih bubrežnih stanica, karcinom pluća, karcinom središnjeg živčanog sustava, karcinom jajnika, melanom, karcinom gušterače, karcinom rožnatih stanica, leukemija i meduloblastom te drugi tumori ili karcinomi kod kojih dolazi do povećanog lučenja survivina.
11. Peptid za korištenje prema zahtjevu 9 ili 10 u kombinaciji s barem jednim drugim peptidom izabranim iz grupe koja se sastoji od peptida SEQ ID NOs 4 do 13 za liječenje karcinoma bubrežnih stanica ili u kombinaciji s barem jednim drugim peptidom izabranim iz grupe koja se sastoji od peptida SEQ ID NOs 4, 8, 11, 12 te 15 do 23 za liječenje karcinoma debelog crijeva.
12. Komplet, koji se sastoji od sljedećeg:
(a) kutija s farmaceutskim sastavom koji se sastoji od peptida iz bilo kojeg zahtjeva od 1 do 4, nukleinske kiseline ili ekspresijskog vektora iz zahtjeva 5 ili stanice iz zahtjeva 7, u rastvoru ili liofiliziranom obliku;
(b) opcionalno, druga kutija koja sadrži razrjeđivač ili rastvor za rekonstituiranje liofilizirane formulacije;
(c) opcionalno, barem jedan peptid izabran iz grupe peptida identifikacijskih brojeva SEQ ID NOs 4 do 23, i
(d) opcionalno, upute za uporabu rastvora i/ili rekonstituiranje i/ili uporabu liofilizirane formulacije.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08008944.4A EP2119726B2 (en) | 2008-05-14 | 2008-05-14 | Novel and powerful MHC-class II peptides derived from survivin and neurocan |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20150300T1 HRP20150300T1 (hr) | 2015-04-24 |
| HRP20150300T4 true HRP20150300T4 (hr) | 2018-03-09 |
Family
ID=39789337
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20150300TT HRP20150300T4 (hr) | 2008-05-14 | 2015-03-17 | Novi i snažni mhc-razred ii peptidi derivirani iz survivina i neurokana |
| HRP20151135TT HRP20151135T4 (hr) | 2008-05-14 | 2015-10-27 | Novi i snažni peptidi mhc klase ii dobiveni od survivina |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20151135TT HRP20151135T4 (hr) | 2008-05-14 | 2015-10-27 | Novi i snažni peptidi mhc klase ii dobiveni od survivina |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US8647629B2 (hr) |
| EP (3) | EP2119726B2 (hr) |
| JP (1) | JP5663473B2 (hr) |
| KR (2) | KR101509284B1 (hr) |
| CN (1) | CN102027006B (hr) |
| AU (1) | AU2009248413B2 (hr) |
| BR (2) | BRPI0912622A2 (hr) |
| CA (1) | CA2724198C (hr) |
| CY (2) | CY1115999T1 (hr) |
| DK (2) | DK2119726T5 (hr) |
| EA (1) | EA019603B1 (hr) |
| ES (2) | ES2532896T5 (hr) |
| HK (2) | HK1156323A1 (hr) |
| HR (2) | HRP20150300T4 (hr) |
| HU (2) | HUE024541T2 (hr) |
| MX (1) | MX2010012443A (hr) |
| NO (1) | NO2119726T3 (hr) |
| NZ (1) | NZ588605A (hr) |
| PL (2) | PL2119726T5 (hr) |
| PT (2) | PT2119726E (hr) |
| RS (1) | RS53872B2 (hr) |
| SI (2) | SI2119726T2 (hr) |
| UA (1) | UA103481C2 (hr) |
| WO (1) | WO2009138236A1 (hr) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012079878A2 (en) * | 2010-12-14 | 2012-06-21 | Immatics Biotechnologies Gmbh | Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof |
| US8435507B2 (en) | 2004-08-19 | 2013-05-07 | University Of Maryland | Prostate-specific antigen-derived MHC class II restricted peptides and their use in vaccines to treat or prevent prostate cancer |
| EP2567707B1 (en) * | 2007-07-27 | 2016-10-05 | Immatics Biotechnologies GmbH | Composition of tumour-associated peptides and related anti-cancer vaccine |
| DE602008000891D1 (de) * | 2008-04-30 | 2010-05-12 | Immatics Biotechnologies Gmbh | Neuartige Formulierungen von Tumor-assoziierten Peptiden, welche an menschliche Leukozytenantigene der Klasse I oder II für Impfungen binden |
| RS53872B2 (sr) * | 2008-05-14 | 2018-06-29 | Immatics Biotechnologies Gmbh | Novi i snažni mhc peptidi klase ii izvedeni iz survivina i neurokana |
| WO2011073234A2 (en) | 2009-12-15 | 2011-06-23 | Ascendis Pharma As | Growth hormone composition |
| FR2955112B1 (fr) | 2010-01-14 | 2012-01-20 | Isp Investments Inc | Nouveaux peptides anti-age modulateurs de la survivine et compositions les comprenant |
| GB201004575D0 (en) * | 2010-03-19 | 2010-05-05 | Immatics Biotechnologies Gmbh | Composition of tumor associated peptides and related anti cancer vaccine for the treatment of gastric cancer and other cancers |
| GB201009222D0 (en) * | 2010-06-02 | 2010-07-21 | Immatics Biotechnologies Gmbh | Improved cancer therapy based on tumour associated antigens derived from cyclin D1 |
| US9109007B2 (en) * | 2010-08-18 | 2015-08-18 | Purdue Pharma L.P. | MHC-I restricted epitopes containing non-natural amino acid residues |
| CN102181401B (zh) * | 2011-02-01 | 2013-04-24 | 北京市肿瘤防治研究所 | 存活素酶联免疫试剂盒及其应用 |
| CA2841016A1 (en) * | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Wt1 peptide cancer vaccine composition for transdermal administration |
| DE102013012432A1 (de) * | 2013-07-29 | 2015-01-29 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Immuntherapie von Prostatakrebs |
| WO2015066057A2 (en) * | 2013-10-28 | 2015-05-07 | Baylor College Of Medicine | Expansion of cmv-specific t cells from cmv-seronegative donors |
| GB201319446D0 (en) | 2013-11-04 | 2013-12-18 | Immatics Biotechnologies Gmbh | Personalized immunotherapy against several neuronal and brain tumors |
| GB201321242D0 (en) * | 2013-12-02 | 2014-01-15 | Immune Targeting Systems Its Ltd | Immunogenic compound |
| WO2016079302A1 (en) | 2014-11-21 | 2016-05-26 | Ascendis Pharma Growth Disorders Division A/S | Long-acting growth hormone dosage forms |
| GB201504502D0 (en) * | 2015-03-17 | 2015-04-29 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against pancreatic cancer and other cancers |
| IL254129B2 (en) * | 2015-03-27 | 2023-10-01 | Immatics Biotechnologies Gmbh | New peptides and a combination of peptides for use in immunotherapy against various tumors |
| GB201505305D0 (en) * | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| NL2014935B1 (en) | 2015-06-08 | 2017-02-03 | Applied Immune Tech Ltd | T cell receptor like antibodies having fine specificity. |
| CN108026154B (zh) * | 2015-07-01 | 2022-03-08 | 伊玛提克斯生物技术有限公司 | 用于卵巢癌和其他癌症免疫治疗的新型肽和肽组合物 |
| PE20180259A1 (es) * | 2015-07-06 | 2018-02-05 | Immatics Biotechnologies Gmbh | Nuevos peptidos y combinacion de peptidos para usar en inmunoterapia contra el cancer esofagico y otros canceres |
| MY189596A (en) * | 2015-07-15 | 2022-02-18 | Immatics Biotechnologies Gmbh | A novel peptides for use in immunotherapy against epithelial ovarian cancer and other cancers |
| GB201513921D0 (en) | 2015-08-05 | 2015-09-23 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against prostate cancer and other cancers |
| MY198087A (en) * | 2015-10-05 | 2023-07-31 | Immatics Biotechnologies Gmbh | Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers |
| GB201521746D0 (en) * | 2015-12-10 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against CLL and other cancers |
| MY196837A (en) * | 2015-12-11 | 2023-05-03 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
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