|
WO2007056362A2
(en)
|
2005-11-07 |
2007-05-18 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
CA2674354A1
(en)
|
2007-01-05 |
2008-07-17 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
|
|
EA017849B1
(ru)
|
2007-02-15 |
2013-03-29 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Соагонисты глюкагоновых/glp-1-рецепторов
|
|
AU2008318986B2
(en)
|
2007-10-30 |
2014-12-04 |
Indiana University Research And Technology Corporation |
Glucagon antagonists
|
|
WO2009058734A1
(en)
|
2007-10-30 |
2009-05-07 |
Indiana University Research And Technology Corporation |
Compounds exhibiting glucagon antagonist and glp-1 agonist activity
|
|
EA020326B9
(ru)
|
2008-06-17 |
2015-03-31 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Агонисты смешанного действия на основе глюкозозависимого инсулинотропного пептида для лечения нарушений обмена веществ и ожирения
|
|
US8450270B2
(en)
|
2008-06-17 |
2013-05-28 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting enhanced solubility and stability in physiological pH buffers
|
|
PA8830501A1
(es)
|
2008-06-17 |
2010-07-27 |
Univ Indiana Res & Tech Corp |
Co-agonistas del receptor de glucagon/glp-1
|
|
CN102325539A
(zh)
|
2008-12-19 |
2012-01-18 |
印第安纳大学研究及科技有限公司 |
基于酰胺的胰高血糖素超家族肽前药
|
|
WO2010096052A1
(en)
|
2009-02-19 |
2010-08-26 |
Merck Sharp & Dohme Corp. |
Oxyntomodulin analogs
|
|
CN102459325B
(zh)
|
2009-06-16 |
2015-03-25 |
印第安纳大学科技研究有限公司 |
胃抑胜肽受体活化的胰高血糖素化合物
|
|
PT2454282E
(pt)
|
2009-07-13 |
2015-06-23 |
Zealand Pharma As |
Análogos de glucagão acilados
|
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
|
AR079345A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina
|
|
EP2528618A4
(en)
|
2010-01-27 |
2015-05-27 |
Univ Indiana Res & Tech Corp |
GLUCAGON ANTAGONISTE AND GIP AGONISTS CONJUGATES AND COMPOSITIONS FOR THE TREATMENT OF METABOLISM DISEASES AND ADIPOSITAS
|
|
BR112012027759A2
(pt)
|
2010-04-27 |
2017-08-15 |
Zealand Pharma As |
Conjugados de peptídeos de agonistas de receptores glp-1 e gastrina e seu uso
|
|
CN103179976A
(zh)
|
2010-05-13 |
2013-06-26 |
印第安纳大学研究及科技有限公司 |
呈现g蛋白偶联受体活性的胰高血糖素超家族肽
|
|
EP2569000B1
(en)
|
2010-05-13 |
2017-09-27 |
Indiana University Research and Technology Corporation |
Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
|
|
RU2580317C2
(ru)
|
2010-06-24 |
2016-04-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Пептидные пролекарства, принадлежащие к суперсемейству амид-содержащих глюкагонов
|
|
BR112013015389A2
(pt)
|
2010-12-22 |
2016-11-22 |
Univ Indiana Res & Tech Corp |
análogo de glucagon exibindo atividade de receptor gip
|
|
WO2012150503A2
(en)
*
|
2011-05-03 |
2012-11-08 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
EP2707713A2
(en)
*
|
2011-05-10 |
2014-03-19 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
RU2739209C2
(ru)
*
|
2011-06-10 |
2020-12-21 |
Ханми Сайенс Ко., Лтд. |
Новые производные оксинтомодулина и содержащая их фармацевтическая композиция для лечения ожирения
|
|
SI2721062T1
(sl)
|
2011-06-17 |
2019-03-29 |
Hanmi Science Co., Ltd. |
Konjugat, obsegajoč oksintomodulinski in imunoglobinski fragment, in uporaba le-tega
|
|
PE20140724A1
(es)
|
2011-06-22 |
2014-07-10 |
Univ Indiana Res & Tech Corp |
Coagonistas del receptor de glucagon/glp-1
|
|
CA2839867A1
(en)
|
2011-06-22 |
2012-12-27 |
Indiana University Research And Technology Corporation |
Glucagon/glp-1 receptor co-agonists
|
|
EP2729493B1
(en)
|
2011-07-04 |
2020-06-10 |
IP2IPO Innovations Limited |
Novel compounds and their effects on feeding behaviour
|
|
AU2012331053A1
(en)
|
2011-11-03 |
2014-05-29 |
Zealand Pharma A/S |
GLP-1 receptor agonist peptide gastrin conjugates
|
|
US8859491B2
(en)
*
|
2011-11-17 |
2014-10-14 |
Indiana University Research And Technology Corporation |
Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
|
|
AR091422A1
(es)
|
2012-06-14 |
2015-02-04 |
Sanofi Sa |
Analogos peptidicos de la exendina 4
|
|
JP6311708B2
(ja)
|
2012-06-21 |
2018-04-18 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
Gip受容体活性を示すグルカゴンアナローグ
|
|
BR112015001451B1
(pt)
|
2012-07-23 |
2022-03-29 |
Zealand Pharma A/S |
Composto, construção de ácido nucleico, vetor de expressão, célula hospedeira, composição farmacêutica, utilização de um composto ou de seu sal ou solvato farmaceuticamente aceitável
|
|
KR101968344B1
(ko)
|
2012-07-25 |
2019-04-12 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
|
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
|
AR092873A1
(es)
|
2012-09-26 |
2015-05-06 |
Cadila Healthcare Ltd |
Peptidos como agonistas triples de los receptores de gip, glp-1 y glugagon
|
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
|
KR101993393B1
(ko)
*
|
2012-11-06 |
2019-10-01 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
|
|
US9724420B2
(en)
|
2012-11-06 |
2017-08-08 |
Hanmi Pharm. Co., Ltd. |
Liquid formulation of protein conjugate comprising an oxyntomodulin derivative covalently linked to a non-peptidyl polymer to an immunoglobulin FC region
|
|
CN104968674A
(zh)
*
|
2012-12-19 |
2015-10-07 |
诺和诺德股份有限公司 |
具有胆固醇流出活性的新颖的glp-1受体激动剂
|
|
PT2934568T
(pt)
|
2012-12-21 |
2018-01-04 |
Sanofi Sa |
Agonistas duplos de glp1/gip ou trigonais de glp1/gip/glucagina
|
|
HK1219477A1
(zh)
|
2013-03-21 |
2017-04-07 |
Sanofi-Aventis Deutschland Gmbh |
合成含有乙内酰脲的肽产物
|
|
SG11201506885UA
(en)
|
2013-03-21 |
2015-09-29 |
Sanofi Aventis Deutschland |
Synthesis of cyclic imide containing peptide products
|
|
WO2014161835A1
(en)
|
2013-04-03 |
2014-10-09 |
Sanofi |
Modified blood glucose regulating proteins with altered pharmacological activity profile and preparation thereof
|
|
CN105792851B
(zh)
*
|
2013-09-13 |
2023-10-10 |
斯克利普斯研究所 |
修饰的治疗剂及其组合物
|
|
MX368436B
(es)
|
2013-10-17 |
2019-10-03 |
Zealand Pharma As |
Analogos de glucagon acilados.
|
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
|
CA2929459C
(en)
|
2013-11-06 |
2022-05-03 |
Zealand Pharma A/S |
Gip-glp-1 dual agonist compounds and methods
|
|
KR102310392B1
(ko)
|
2013-11-06 |
2021-10-13 |
질랜드 파마 에이/에스 |
글루카곤-glp-1-gip 삼원 효능제 화합물
|
|
TW201609797A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
雙重glp-1/升糖素受體促效劑
|
|
WO2015086731A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
|
|
TW201609796A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
非醯化之艾塞那肽-4(exendin-4)胜肽類似物
|
|
TW201609799A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
雙重glp-1/gip受體促效劑
|
|
TW201609795A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物
|
|
AU2014364589B2
(en)
|
2013-12-18 |
2020-02-27 |
The California Institute For Biomedical Research |
Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
|
|
BR112016016321A2
(pt)
*
|
2014-02-18 |
2017-10-03 |
Novo Nordisk As |
Derivados de análogos de glucagon estáveis, seus usos, e composição farmacêutica
|
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自exendin-4之雙重glp-1/升糖素受體促效劑
|
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
|
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
|
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
|
TWI802396B
(zh)
|
2014-09-16 |
2023-05-11 |
南韓商韓美藥品股份有限公司 |
長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
|
|
CN104926934B
(zh)
*
|
2014-09-23 |
2016-11-09 |
蒋先兴 |
胃泌酸调节素类似物
|
|
MX382408B
(es)
|
2014-10-24 |
2025-03-13 |
Merck Sharp & Dohme Llc |
Coagonistas de los receptores de glucagón y de glp-1.
|
|
ES2883345T3
(es)
|
2014-10-29 |
2021-12-07 |
Zealand Pharma As |
Compuestos agonistas del GIP y métodos
|
|
KR102418477B1
(ko)
|
2014-12-30 |
2022-07-08 |
한미약품 주식회사 |
글루카곤 유도체
|
|
AR103322A1
(es)
*
|
2014-12-30 |
2017-05-03 |
Hanmi Pharm Ind Co Ltd |
Derivados de glucagón con estabilidad mejorada
|
|
PL3283507T3
(pl)
|
2015-04-16 |
2020-05-18 |
Zealand Pharma A/S |
Acylowany analog glukagonu
|
|
AR105319A1
(es)
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
|
WO2016198624A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
|
|
WO2016198628A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
|
|
CR20180034A
(es)
*
|
2015-06-30 |
2018-04-16 |
Hanmi Pharm Ind Co Ltd |
Derivados de glucagón y una composición que comprende un conjugado de acción prolongada del mismo.
|
|
TW201706291A
(zh)
|
2015-07-10 |
2017-02-16 |
賽諾菲公司 |
作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物
|
|
EP3359191A4
(en)
|
2015-10-05 |
2019-05-29 |
Merck Sharp & Dohme Corp. |
ANTIBODY PEPTIDE CONJUGATES WITH AGONISTEACTIVITY ON GLUCAGON RECEPTORS AND GLUCAGON-LIKE PEPTIDE-1
|
|
EP3359194A4
(en)
|
2015-10-06 |
2019-04-24 |
Merck Sharp & Dohme Corp. |
ANTIBODY-ACTIVE CONJUGATE FOR ANTI-INFLAMMATORY APPLICATIONS
|
|
EP3377521A4
(en)
|
2015-10-27 |
2019-05-01 |
Merck Sharp & Dohme Corp. |
LONG-ACTING CO AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS
|
|
US10493125B2
(en)
|
2015-12-09 |
2019-12-03 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and GLP-1 receptors
|
|
AU2016382394B2
(en)
|
2015-12-31 |
2019-07-04 |
Hanmi Pharm. Co., Ltd. |
Long-acting conjugate of triple glucagon/GLP-1/GIP receptor agonist
|
|
WO2017132103A2
(en)
|
2016-01-29 |
2017-08-03 |
Merck Sharp & Dohme Corp. |
Phosphonate linkers and their use to facilitate cellular retention of compounds
|
|
PE20190355A1
(es)
*
|
2016-06-29 |
2019-03-07 |
Hanmi Pharm Ind Co Ltd |
Derivado de glucagon, conjugado del mismo, composicion que comprende el mismo y uso terapeutico del mismo
|
|
TW201832783A
(zh)
|
2016-12-02 |
2018-09-16 |
法商賽諾菲公司 |
包含glp-1/胰高血糖素雙重激動劑、連接子和透明質酸的接合物
|
|
CA3043151A1
(en)
|
2016-12-09 |
2018-06-14 |
Zealand Pharma A/S |
Acylated glp-1/glp-2 dual agonists
|
|
CN108299553B
(zh)
*
|
2017-01-13 |
2021-07-16 |
博瑞生物医药(苏州)股份有限公司 |
胃泌酸调节素修饰物
|
|
CN106986924A
(zh)
*
|
2017-03-23 |
2017-07-28 |
中国药科大学 |
胃泌酸调节素(oxm)类似物及其应用
|
|
US11236142B2
(en)
*
|
2017-08-16 |
2022-02-01 |
Dong-A St Co., Ltd. |
Acylated oxyntomodulin peptide analog
|
|
WO2019060660A1
(en)
|
2017-09-25 |
2019-03-28 |
Merck Sharp & Dohme Corp. |
CO-AGONISTS WITH EXTENDED ACTION OF GLUCAGON AND GLP-1 RECEPTORS
|
|
CN120887972A
(zh)
*
|
2017-11-24 |
2025-11-04 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的胰高血糖素类似物
|
|
CN109836504B
(zh)
*
|
2017-11-24 |
2022-08-02 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的多结构域活性蛋白
|
|
WO2020098657A1
(zh)
*
|
2018-11-12 |
2020-05-22 |
天津药物研究院有限公司 |
具有双重受体激动作用的胰高血糖素衍生肽及其用途
|
|
CN115947849A
(zh)
|
2018-12-21 |
2023-04-11 |
江苏恒瑞医药股份有限公司 |
双特异性蛋白
|
|
US11471512B2
(en)
|
2019-03-01 |
2022-10-18 |
Merck Sharp & Dohme Llc |
Pharmaceutical compositions of a peptide
|
|
CN110684082B
(zh)
*
|
2019-10-08 |
2021-12-10 |
江苏诺泰澳赛诺生物制药股份有限公司 |
Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途
|
|
EP3842060A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled lactam co-agonists of the glucagon and glp-1 receptors
|
|
EP3842061A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled triazole co-agonists of the glucagon and glp-1 receptors
|
|
EP3842449A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled olefin co-agonists of the glucagon and glp-1 receptors
|
|
KR102154959B1
(ko)
*
|
2020-04-29 |
2020-09-10 |
동아에스티 주식회사 |
지속형 glp-1 및 글루카곤 수용체 이중작용제
|
|
CN113621045A
(zh)
*
|
2020-05-09 |
2021-11-09 |
天津药物研究院有限公司 |
具有双受体激动作用的多肽衍生物及其用途
|
|
CN112898405B
(zh)
*
|
2021-01-22 |
2023-02-28 |
深圳市图微安创科技开发有限公司 |
多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用
|
|
AU2022289610A1
(en)
|
2021-06-09 |
2024-01-25 |
The Scripps Research Institute |
Long-acting dual gip/glp-1 peptide conjugates and methods of use
|
|
CN119930789A
(zh)
*
|
2023-11-06 |
2025-05-06 |
成都奥达生物科技有限公司 |
一种gcg激动剂化合物
|