|
US8338368B2
(en)
|
2005-11-07 |
2012-12-25 |
Indiana University Research And Technology Corporation |
Glucagon analogs exhibiting physiological solubility and stability
|
|
EP2124974B1
(en)
|
2007-01-05 |
2017-03-15 |
Indiana University Research and Technology Corporation |
Glucagon analogs exhibiting enhanced solubility in physiological ph buffers
|
|
US8454971B2
(en)
|
2007-02-15 |
2013-06-04 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
MX2010004297A
(es)
|
2007-10-30 |
2010-05-03 |
Univ Indiana Res & Tech Corp |
Antagonistas de glucagon.
|
|
ES2558155T3
(es)
|
2007-10-30 |
2016-02-02 |
Indiana University Research And Technology Corporation |
Compuestos que muestran actividad antagonista de glucacón y agonista de GLP-1
|
|
JP5775450B2
(ja)
|
2008-06-17 |
2015-09-09 |
インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションIndiana University Research And Technology Corporation |
グルカゴン/glp−1受容体コアゴニスト
|
|
KR20110039230A
(ko)
|
2008-06-17 |
2011-04-15 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
생리학적 pH 완충액에서 강화된 용해도 및 안정성을 나타내는 글루카곤 유사체
|
|
TWI474835B
(zh)
|
2008-06-17 |
2015-03-01 |
Univ Indiana Res & Tech Corp |
用於治療代謝病症及肥胖症之基於gip之混合激動劑
|
|
RU2550696C2
(ru)
|
2008-12-19 |
2015-05-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Основанные на амидах пролекарства пептидов глюкагонового надсемейства
|
|
WO2010096052A1
(en)
|
2009-02-19 |
2010-08-26 |
Merck Sharp & Dohme Corp. |
Oxyntomodulin analogs
|
|
EP2443146B1
(en)
|
2009-06-16 |
2016-10-05 |
Indiana University Research And Technology Corporation |
Gip receptor-active glucagon compounds
|
|
AP3329A
(en)
|
2009-07-13 |
2015-06-30 |
Zealand Pharma As |
Acylated glucagon analogues
|
|
US8703701B2
(en)
|
2009-12-18 |
2014-04-22 |
Indiana University Research And Technology Corporation |
Glucagon/GLP-1 receptor co-agonists
|
|
AR079344A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina, composicion farmaceutica que lo comprende y uso para preparar un medicamento util para tratar diabetes no insulinodependiente y/u obesidad
|
|
AR079345A1
(es)
|
2009-12-22 |
2012-01-18 |
Lilly Co Eli |
Analogo peptidico de oxintomodulina
|
|
IN2012DN06437A
(enExample)
|
2010-01-27 |
2015-10-09 |
Univ Indiana Res & Tech Corp |
|
|
NZ603169A
(en)
|
2010-04-27 |
2015-02-27 |
Zealand Pharma As |
Peptide conjugates of glp-1 receptor agonists and gastrin and their use
|
|
CN103079587B
(zh)
|
2010-05-13 |
2016-05-11 |
印第安纳大学研究及科技有限公司 |
呈现核激素受体活性的胰高血糖素超家族肽
|
|
KR20130111923A
(ko)
|
2010-05-13 |
2013-10-11 |
인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 |
G-단백결합 수용체 활성을 나타내는 글루카곤 슈퍼패밀리 펩티드
|
|
RU2580317C2
(ru)
|
2010-06-24 |
2016-04-10 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Пептидные пролекарства, принадлежащие к суперсемейству амид-содержащих глюкагонов
|
|
EA201390941A1
(ru)
|
2010-12-22 |
2013-12-30 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Аналоги глюкагона, проявляющие активность на рецепторе gip
|
|
WO2012150503A2
(en)
*
|
2011-05-03 |
2012-11-08 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
WO2012153196A2
(en)
*
|
2011-05-10 |
2012-11-15 |
Zealand Pharma A/S |
Glu-glp-1 dual agonist signaling-selective compounds
|
|
PE20140765A1
(es)
*
|
2011-06-10 |
2014-06-14 |
Hanmi Science Co Ltd |
Derivados de oxintomodulina novedosos y composicion farmaceutica para tratar la obesidad que comprende los mismos
|
|
UA125895C2
(uk)
*
|
2011-06-17 |
2022-07-06 |
Ханмі Сайенс Ко., Лтд. |
КОН'ЮГАТ, ЩО МІСТИТЬ ПОХІДНУ ОКСИНТОМОДУЛІНУ ТА Fc-ДІЛЯНКУ ІМУНОГЛОБУЛІНУ, ТА ЙОГО ЗАСТОСУВАННЯ
|
|
BR112013032717A2
(pt)
|
2011-06-22 |
2017-01-24 |
Univ Indiana Res & Tech Corp |
coagonistas do receptor de glucagon/glp-1
|
|
EA031230B1
(ru)
|
2011-06-22 |
2018-12-28 |
Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн |
Агонисты глюкагонового рецептора/glp-1-рецептора
|
|
WO2013004983A1
(en)
|
2011-07-04 |
2013-01-10 |
Imperial Innovations Limited |
Novel compounds and their effects on feeding behaviour
|
|
CA2853884A1
(en)
|
2011-11-03 |
2013-05-10 |
Zealand Pharma A/S |
Glp-1 receptor agonist peptide gastrin conjugates
|
|
CN103957927B
(zh)
*
|
2011-11-17 |
2016-11-09 |
印第安纳大学研究及科技有限公司 |
呈现糖皮质激素受体活性的胰高血糖素超家族肽
|
|
IN2014KN02830A
(enExample)
|
2012-06-14 |
2015-05-08 |
Sanofi Sa |
|
|
EP2864351B1
(en)
|
2012-06-21 |
2016-08-10 |
Indiana University Research and Technology Corporation |
Glucagon analogs exhibiting gip receptor activity
|
|
ES2620111T3
(es)
|
2012-07-23 |
2017-06-27 |
Zealand Pharma A/S |
Análogos de glucagón
|
|
KR101968344B1
(ko)
*
|
2012-07-25 |
2019-04-12 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 고지혈증 치료용 조성물
|
|
TWI608013B
(zh)
|
2012-09-17 |
2017-12-11 |
西蘭製藥公司 |
升糖素類似物
|
|
WO2014049610A2
(en)
|
2012-09-26 |
2014-04-03 |
Cadila Healthcare Limited |
Peptides as gip, glp-1 and glucagon receptors triple-agonist
|
|
UA116217C2
(uk)
|
2012-10-09 |
2018-02-26 |
Санофі |
Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
|
|
WO2014073842A1
(en)
|
2012-11-06 |
2014-05-15 |
Hanmi Pharm. Co., Ltd. |
Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
|
|
KR101993393B1
(ko)
*
|
2012-11-06 |
2019-10-01 |
한미약품 주식회사 |
옥신토모듈린 유도체를 포함하는 당뇨병 또는 비만성 당뇨병 치료용 조성물
|
|
US20150344540A1
(en)
*
|
2012-12-19 |
2015-12-03 |
Novo Nordisk A/S |
Novel glp-1 receptor agonists with cholesterol efflux activity
|
|
RS57531B1
(sr)
|
2012-12-21 |
2018-10-31 |
Sanofi Sa |
Derivati eksendina-4 kao dualni glp1/gip- ili trigonalni glp1/gip/glukagon agonisti
|
|
AU2014234314B2
(en)
|
2013-03-21 |
2018-02-15 |
Sanofi-Aventis Deutschland Gmbh |
Synthesis of cyclic imide containing peptide products
|
|
US10087221B2
(en)
|
2013-03-21 |
2018-10-02 |
Sanofi-Aventis Deutschland Gmbh |
Synthesis of hydantoin containing peptide products
|
|
AR095986A1
(es)
|
2013-04-03 |
2015-11-25 |
Sanofi Sa |
Proteínas modificadas que regulan glucosa en sangre con perfil alterado de actividad farmacológica y preparación de las mismas
|
|
JP6822839B2
(ja)
*
|
2013-09-13 |
2021-01-27 |
ザ・スクリップス・リサーチ・インスティテュート |
修飾された治療剤、及びその組成物
|
|
US9896495B2
(en)
|
2013-10-17 |
2018-02-20 |
Zealand Pharma A/S |
Acylated glucagon analogues
|
|
US9988429B2
(en)
|
2013-10-17 |
2018-06-05 |
Zealand Pharma A/S |
Glucagon analogues
|
|
CA2929107C
(en)
|
2013-11-06 |
2023-09-26 |
Zealand Pharma A/S |
Glucagon-glp-1-gip triple agonist compounds
|
|
AU2014345569B2
(en)
|
2013-11-06 |
2020-08-13 |
Zealand Pharma A/S |
GIP-GLP-1 dual agonist compounds and methods
|
|
WO2015086729A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Dual glp-1/gip receptor agonists
|
|
WO2015086733A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Dual glp-1/glucagon receptor agonists
|
|
WO2015086731A1
(en)
|
2013-12-13 |
2015-06-18 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
|
|
TW201609796A
(zh)
|
2013-12-13 |
2016-03-16 |
賽諾菲公司 |
非醯化之艾塞那肽-4(exendin-4)胜肽類似物
|
|
EP3080150B1
(en)
|
2013-12-13 |
2018-08-01 |
Sanofi |
Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
|
|
CA2933701C
(en)
|
2013-12-18 |
2022-05-31 |
The California Institute For Biomedical Research |
Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof
|
|
US9963496B2
(en)
|
2014-02-18 |
2018-05-08 |
Novo Nordisk A/S |
Stable glucagon analogues and use for treatment of hypoglycaemia
|
|
TW201625669A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑
|
|
TW201625668A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物
|
|
TW201625670A
(zh)
|
2014-04-07 |
2016-07-16 |
賽諾菲公司 |
衍生自exendin-4之雙重glp-1/升糖素受體促效劑
|
|
US9932381B2
(en)
|
2014-06-18 |
2018-04-03 |
Sanofi |
Exendin-4 derivatives as selective glucagon receptor agonists
|
|
TWI802396B
(zh)
|
2014-09-16 |
2023-05-11 |
南韓商韓美藥品股份有限公司 |
長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途
|
|
CN106519015B
(zh)
*
|
2014-09-23 |
2020-04-17 |
深圳市图微安创科技开发有限公司 |
胃泌酸调节素类似物
|
|
EP3825324A1
(en)
|
2014-10-24 |
2021-05-26 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and glp-1 receptors
|
|
MX381640B
(es)
|
2014-10-29 |
2025-03-04 |
Zealand Pharma As |
Metodos y compuestos agonistas de gip.
|
|
PE20171154A1
(es)
*
|
2014-12-30 |
2017-08-16 |
Hanmi Pharm Ind Co Ltd |
Derivados de glucagon con estabilidad mejorada
|
|
KR102418477B1
(ko)
|
2014-12-30 |
2022-07-08 |
한미약품 주식회사 |
글루카곤 유도체
|
|
ES2763329T3
(es)
|
2015-04-16 |
2020-05-28 |
Zealand Pharma As |
Análogo de glucagón acilado
|
|
AR105319A1
(es)
|
2015-06-05 |
2017-09-27 |
Sanofi Sa |
Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
|
|
WO2016198628A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
|
|
WO2016198624A1
(en)
|
2015-06-12 |
2016-12-15 |
Sanofi |
Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
|
|
KR102005456B1
(ko)
|
2015-06-30 |
2019-07-30 |
한미약품 주식회사 |
신규 글루카곤 유도체 및 이의 지속형 결합체를 포함하는 조성물
|
|
TW201706291A
(zh)
|
2015-07-10 |
2017-02-16 |
賽諾菲公司 |
作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物
|
|
EP3359191A4
(en)
|
2015-10-05 |
2019-05-29 |
Merck Sharp & Dohme Corp. |
ANTIBODY PEPTIDE CONJUGATES WITH AGONISTEACTIVITY ON GLUCAGON RECEPTORS AND GLUCAGON-LIKE PEPTIDE-1
|
|
WO2017062271A2
(en)
|
2015-10-06 |
2017-04-13 |
Merck Sharp & Dohme Corp. |
Antibody drug conjugate for anti-inflammatory applications
|
|
US10793615B2
(en)
|
2015-10-27 |
2020-10-06 |
Merck Sharp & Dohme Corp. |
Long-acting co-agonists of the glucagon and GLP-1 receptors
|
|
WO2017100107A2
(en)
*
|
2015-12-09 |
2017-06-15 |
Merck Sharp & Dohme Corp. |
Co-agonists of the glucagon and glp-1 receptors
|
|
MX2018008128A
(es)
|
2015-12-31 |
2018-12-06 |
Hanmi Pharm Ind Co Ltd |
Conjugado persistente de triple activador que activa el receptor de glucagon, glp-1 y gip.
|
|
US10869929B2
(en)
|
2016-01-29 |
2020-12-22 |
Merck Sharp & Dohme Corp. |
Phosphonate linkers and their use to facilitate cellular retention of compounds
|
|
MX2019000019A
(es)
*
|
2016-06-29 |
2019-05-06 |
Hanmi Pharm Ind Co Ltd |
Derivado de glucagon, conjugado del mismo, composicion que comprende el mismo y uso terapeutico del mismo.
|
|
TW201832783A
(zh)
|
2016-12-02 |
2018-09-16 |
法商賽諾菲公司 |
包含glp-1/胰高血糖素雙重激動劑、連接子和透明質酸的接合物
|
|
DK3551651T3
(da)
|
2016-12-09 |
2024-05-13 |
Zealand Pharma As |
Acylerede glp-1/glp-2-dobbeltagonister
|
|
CN108299553B
(zh)
*
|
2017-01-13 |
2021-07-16 |
博瑞生物医药(苏州)股份有限公司 |
胃泌酸调节素修饰物
|
|
CN106986924A
(zh)
*
|
2017-03-23 |
2017-07-28 |
中国药科大学 |
胃泌酸调节素(oxm)类似物及其应用
|
|
PL3670529T3
(pl)
*
|
2017-08-16 |
2024-06-10 |
Dong-A St Co., Ltd. |
Acylowany analog peptydowy oksyntomoduliny
|
|
BR112020005841A8
(pt)
|
2017-09-25 |
2023-04-11 |
Merck Sharp & Dohme |
Peptídeo coagonista do receptor de gcg/glp-1, composição, método para tratar um paciente de uma doença ou distúrbio metabólico, e, uso de um ou mais peptídeos coagonistas.
|
|
CN115304666B
(zh)
*
|
2017-11-24 |
2025-09-19 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的胰高血糖素类似物
|
|
CN109836504B
(zh)
*
|
2017-11-24 |
2022-08-02 |
浙江道尔生物科技有限公司 |
一种治疗代谢疾病的多结构域活性蛋白
|
|
WO2020098657A1
(zh)
*
|
2018-11-12 |
2020-05-22 |
天津药物研究院有限公司 |
具有双重受体激动作用的胰高血糖素衍生肽及其用途
|
|
US20220153853A1
(en)
|
2018-12-21 |
2022-05-19 |
Jiangsu Hengrui Medicine Co., Ltd. |
Bispecific protein
|
|
US11471512B2
(en)
|
2019-03-01 |
2022-10-18 |
Merck Sharp & Dohme Llc |
Pharmaceutical compositions of a peptide
|
|
CN110684082B
(zh)
*
|
2019-10-08 |
2021-12-10 |
江苏诺泰澳赛诺生物制药股份有限公司 |
Gip和glp-1双激动多肽化合物及药学上可接受的盐与用途
|
|
EP3842061A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled triazole co-agonists of the glucagon and glp-1 receptors
|
|
EP3842449A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled olefin co-agonists of the glucagon and glp-1 receptors
|
|
EP3842060A1
(en)
|
2019-12-23 |
2021-06-30 |
Merck Sharp & Dohme Corp. |
Stapled lactam co-agonists of the glucagon and glp-1 receptors
|
|
KR102154959B1
(ko)
*
|
2020-04-29 |
2020-09-10 |
동아에스티 주식회사 |
지속형 glp-1 및 글루카곤 수용체 이중작용제
|
|
CN113621045A
(zh)
*
|
2020-05-09 |
2021-11-09 |
天津药物研究院有限公司 |
具有双受体激动作用的多肽衍生物及其用途
|
|
CN112898405B
(zh)
*
|
2021-01-22 |
2023-02-28 |
深圳市图微安创科技开发有限公司 |
多肽化合物及其在预防或治疗糖尿病或糖尿病并发症中的应用
|
|
JP2024522196A
(ja)
|
2021-06-09 |
2024-06-11 |
ザ スクリプス リサーチ インスティテュート |
長時間作用型デュアルgip/glp-1ペプチドコンジュゲートおよび使用方法
|
|
CN119930789A
(zh)
*
|
2023-11-06 |
2025-05-06 |
成都奥达生物科技有限公司 |
一种gcg激动剂化合物
|