PE20120621A1 - Analogos de la oxintomodulina - Google Patents

Analogos de la oxintomodulina

Info

Publication number
PE20120621A1
PE20120621A1 PE2011001525A PE2011001525A PE20120621A1 PE 20120621 A1 PE20120621 A1 PE 20120621A1 PE 2011001525 A PE2011001525 A PE 2011001525A PE 2011001525 A PE2011001525 A PE 2011001525A PE 20120621 A1 PE20120621 A1 PE 20120621A1
Authority
PE
Peru
Prior art keywords
peptide
amino acid
analogue
acid
group
Prior art date
Application number
PE2011001525A
Other languages
English (en)
Inventor
Paul E Carrington
George J Eiermann
Donald J Marsh
Joseph M Metzger
Alessandro Pocai
Roy Ranabir Sinha
Elisabetta Bianchi
Paolo Ingallinella
Antonello Pessi
Alessia Santoprete
Elena Capito
Richard Dimarchi
Brian Ward
Original Assignee
Merck Sharp & Dohme
Angeletti P Ist Richerche Bio
Univ Indiana Res & Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Angeletti P Ist Richerche Bio, Univ Indiana Res & Tech Corp filed Critical Merck Sharp & Dohme
Publication of PE20120621A1 publication Critical patent/PE20120621A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Physical Water Treatments (AREA)

Abstract

SE REFIERE A UN ANALOGO PEPTIDICO DE OXINTOMODULINA (OXM) QUE CONTIENE LA SECUENCIA DE AMINOACIDOS DE SEQ ID Nº 109 EN DONDE: A) EL SEGUNDO AMINOACIDO DEL EXTREMO N DEL PEPTIDO SE SUSTITUYE POR UN AMINOACIDO TAL COMO D-SERINA, ACIDO ?-AMINOISOBUTIRICO O ACIDO 1-AMINO-1-CICLOBUTANO CARBOXILICO QUE PROVOCA QUE EL PEPTIDO SEA RESISTENTE A LA SEGMENTACION Y LA INACTIVACION POR PARTE DE LA DIPEPTIDIL PEPTIDASA IV; B) EL PEPTIDO INCLUYE UNA FRACCION DE COLESTEROL UNIDA DE MANERA COVALENTE AL GRUPO TIOL DE UN RESIDUO DE CISTEINA QUE SE UNE EN FORMA COVALENTE AL GRUPO ?-AMINO DEL RESIDUO DE LISINA EN EL EXTREMO C DEL ANALOGO PEPTIDICO MEDIANTE UN ESPACIADOR QUE CONTIENE RESIDUOS DE ACIDO GAMMA-GLUTAMICO; C) EL PEPTIDO OPCIONALMENTE INCLUYE SUSTITUCIONES DE AMINOACIDO EN LAS POSICIONES 10, 12, 16, 17, 18 Y 27; Y D) EL PEPTIDO OPCIONALMENTE INCLUYE UN GRUPO DE PROTECCION QUE SE UNE AL GRUPO CARBOXILO DEL EXTREMO C DEL PEPTIDO. DICHO ANALOGO PEPTIDICO ES UN DOBLE AGONISTA DE LOS RECEPTORES GLP-1 Y DE LOS RECEPTORES DE GLUCAGON
PE2011001525A 2009-02-19 2009-12-18 Analogos de la oxintomodulina PE20120621A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2009/034448 WO2010096052A1 (en) 2009-02-19 2009-02-19 Oxyntomodulin analogs

Publications (1)

Publication Number Publication Date
PE20120621A1 true PE20120621A1 (es) 2012-06-08

Family

ID=42634127

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001525A PE20120621A1 (es) 2009-02-19 2009-12-18 Analogos de la oxintomodulina

Country Status (24)

Country Link
US (2) US20120165503A1 (es)
EP (1) EP2398483B1 (es)
JP (1) JP5756961B2 (es)
KR (1) KR101634139B1 (es)
CN (1) CN102573872B (es)
AU (1) AU2009340439B2 (es)
BR (1) BRPI0924307B8 (es)
CA (1) CA2754350C (es)
CL (1) CL2011002036A1 (es)
CY (1) CY1116917T1 (es)
DK (1) DK2398483T3 (es)
ES (1) ES2524477T3 (es)
HK (1) HK1165333A1 (es)
HR (1) HRP20141215T1 (es)
IL (1) IL214729A (es)
MX (1) MX2011008717A (es)
PE (1) PE20120621A1 (es)
PL (1) PL2398483T3 (es)
PT (1) PT2398483E (es)
RU (1) RU2542362C2 (es)
SG (1) SG173791A1 (es)
SI (1) SI2398483T1 (es)
WO (2) WO2010096052A1 (es)
ZA (1) ZA201106051B (es)

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