HRP20140895T1 - Novi spojevi i metode za lijeäśenje - Google Patents
Novi spojevi i metode za lijeäśenje Download PDFInfo
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- HRP20140895T1 HRP20140895T1 HRP20140895AT HRP20140895T HRP20140895T1 HR P20140895 T1 HRP20140895 T1 HR P20140895T1 HR P20140895A T HRP20140895A T HR P20140895AT HR P20140895 T HRP20140895 T HR P20140895T HR P20140895 T1 HRP20140895 T1 HR P20140895T1
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- 150000001875 compounds Chemical class 0.000 title claims 12
- 238000000034 method Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 11
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 claims 7
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 7
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 7
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 6
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 6
- RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 claims 5
- 108010038379 sargramostim Proteins 0.000 claims 5
- WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 claims 5
- 229960005267 tositumomab Drugs 0.000 claims 5
- COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 claims 4
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 claims 4
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 4
- 108010069236 Goserelin Proteins 0.000 claims 4
- XOGTZOOQQBDUSI-UHFFFAOYSA-M Mesna Chemical compound [Na+].[O-]S(=O)(=O)CCS XOGTZOOQQBDUSI-UHFFFAOYSA-M 0.000 claims 4
- NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 claims 4
- NAVMQTYZDKMPEU-UHFFFAOYSA-N Targretin Chemical compound CC1=CC(C(CCC2(C)C)(C)C)=C2C=C1C(=C)C1=CC=C(C(O)=O)C=C1 NAVMQTYZDKMPEU-UHFFFAOYSA-N 0.000 claims 4
- 229960000975 daunorubicin Drugs 0.000 claims 4
- 229960004679 doxorubicin Drugs 0.000 claims 4
- NOTIQUSPUUHHEH-UXOVVSIBSA-N dromostanolone propionate Chemical compound C([C@@H]1CC2)C(=O)[C@H](C)C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](OC(=O)CC)[C@@]2(C)CC1 NOTIQUSPUUHHEH-UXOVVSIBSA-N 0.000 claims 4
- 230000003287 optical effect Effects 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- UQQHOWKTDKKTHO-ICQCTTRCSA-N (2r,3s,4s,5r)-2-(hydroxymethyl)-5-(6-methoxypurin-9-yl)oxolane-3,4-diol Chemical compound C1=NC=2C(OC)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O UQQHOWKTDKKTHO-ICQCTTRCSA-N 0.000 claims 3
- 108010092160 Dactinomycin Proteins 0.000 claims 3
- 108010078049 Interferon alpha-2 Proteins 0.000 claims 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 3
- RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 claims 3
- 108700025316 aldesleukin Proteins 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229960005243 carmustine Drugs 0.000 claims 3
- 229960004397 cyclophosphamide Drugs 0.000 claims 3
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 3
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 claims 3
- 229960002949 fluorouracil Drugs 0.000 claims 3
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 claims 3
- 239000007943 implant Substances 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000002347 injection Methods 0.000 claims 3
- 239000007924 injection Substances 0.000 claims 3
- 229960001691 leucovorin Drugs 0.000 claims 3
- HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 claims 3
- 229960004961 mechlorethamine Drugs 0.000 claims 3
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 3
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 claims 3
- 229960000485 methotrexate Drugs 0.000 claims 3
- CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 claims 3
- 229960003171 plicamycin Drugs 0.000 claims 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
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- 229960001055 uracil mustard Drugs 0.000 claims 3
- BMKDZUISNHGIBY-ZETCQYMHSA-N (+)-dexrazoxane Chemical compound C([C@H](C)N1CC(=O)NC(=O)C1)N1CC(=O)NC(=O)C1 BMKDZUISNHGIBY-ZETCQYMHSA-N 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 claims 2
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 2
- IDPUKCWIGUEADI-UHFFFAOYSA-N 5-[bis(2-chloroethyl)amino]uracil Chemical compound ClCCN(CCCl)C1=CNC(=O)NC1=O IDPUKCWIGUEADI-UHFFFAOYSA-N 0.000 claims 2
- NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 claims 2
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims 2
- BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 claims 2
- 108010024976 Asparaginase Proteins 0.000 claims 2
- 102000015790 Asparaginase Human genes 0.000 claims 2
- MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 claims 2
- 108010006654 Bleomycin Proteins 0.000 claims 2
- ODZBBRURCPAEIQ-DJLDLDEBSA-N Brivudine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(C=CBr)=C1 ODZBBRURCPAEIQ-DJLDLDEBSA-N 0.000 claims 2
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 2
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 2
- JWBOIMRXGHLCPP-UHFFFAOYSA-N Chloditan Chemical compound C=1C=CC=C(Cl)C=1C(C(Cl)Cl)C1=CC=C(Cl)C=C1 JWBOIMRXGHLCPP-UHFFFAOYSA-N 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108010019673 Darbepoetin alfa Proteins 0.000 claims 2
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 claims 2
- MWWSFMDVAYGXBV-RUELKSSGSA-N Doxorubicin hydrochloride Chemical compound Cl.O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 MWWSFMDVAYGXBV-RUELKSSGSA-N 0.000 claims 2
- 108010074604 Epoetin Alfa Proteins 0.000 claims 2
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- BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims 2
- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 2
- 239000005511 L01XE05 - Sorafenib Substances 0.000 claims 2
- HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 claims 2
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
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- SHGAZHPCJJPHSC-UHFFFAOYSA-N Panrexin Chemical compound OC(=O)C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-UHFFFAOYSA-N 0.000 claims 2
- BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims 2
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 claims 2
- AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 claims 2
- 229960005310 aldesleukin Drugs 0.000 claims 2
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- OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 claims 2
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- 230000000259 anti-tumor effect Effects 0.000 claims 2
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- GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 claims 2
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 2
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- 239000003183 carcinogenic agent Substances 0.000 claims 2
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- 210000004027 cell Anatomy 0.000 claims 2
- JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 2
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- 229960000684 cytarabine Drugs 0.000 claims 2
- 229960000640 dactinomycin Drugs 0.000 claims 2
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- 201000010099 disease Diseases 0.000 claims 2
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- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
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- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Communicable Diseases (AREA)
- Plasma & Fusion (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (15)
1. Spoj strukture (5):
[image]
gdje je svaki Rb nezavisan C1-C8 alkil, ili C2-C8 alkenil, ili C2-C8 alkinil, ili C6-C10 aril-C1-C4 alkil--; R10 je C1-C8 alkil, ili C2-C8 alkenil, ili C2-C8 alkinil, gdje je C1-C8 alkil opciono zamjenjen jednom C1-C4 alkoksi grupom; gdje alkil označava razgranat (račvast), normalan ili ciklični zasićeni ugljikovodik; i terapeutski prihvatljive soli i/ili njihovi obogaćeni optički izomeri.
2. Spoj patentnog zahtjeva 1, gdje je svaki Rb nezavisan C1-C4 alkil, ili benzil, R10 je C1-C4 alkil; i terapeutski prihvatljive soli i/ili njihovi obogaćeni optički izomeri.
3. Spoj patentnog zahtjeva 1 izabran iz
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i
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i terapeutski prihvatljive soli i/ili njihovi obogaćeni optički izomeri.
4. Spoj izabran iz:
[image]
[image]
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i
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i terapeutski prihvatljive soli i/ili njihovi obogaćeni optički izomeri.
5. Farmaceutski sastav koja obuhvaća terapeutski djelotvornu količinu spoja prema bilo kojem od patentnih zahtjeva 1 do 4.
6. Farmaceutski sastav patentnog zahtjeva 5 dalje obuhvaća drugi terapeutski agens izabran iz anti-viralnih agensa ili anti-tumorskih/kancerogenih agensa.
7. Farmaceutski sastav patentnog zahtjeva 6, gdje je anti-viralni agens izabran iz grupe koja obuhvaća 3'-azido-3'- deoksitimidin (zidovudin, AZT), 2'-deoksi-3'-tiacitidin (3TC), 2',3'-dideoksi-2',3'-didehidroadenozin (D4A), 2',3'-dideoksi-2',3'-didehidrotimidin (D4T), karbovir (karbocikli 2',3'-dideoksi-2',3'-didehidroguanozin), 3'-azido-2',3'-dideoksiuridin, 5-fluorotimidin, (E)-5-(2-bromovinil)-2'-deoksiuridin (BVDU), 2-kloro-2'-deoksiadenozin, 2-deoksikoformicin, 5-fluorouracil, 5-fluorouridin, 5-fluoro-2'-deoksiuridin, 5-trifluorometil-2'-deoksiuridin, 6-azauridin, 5-fluoroorotičnu kiselinu, metotreksat, triacetiluridin, 1-(2'-deoksi-2'-fluoro-1-beta-D-arabinozil)-5-jodocitidin (FIAC), tetrahidroimidazo(4,5,1-jk)-(1,4)-benzodiazepin-2(1H)-tion (TIBO), 2'-nor-ciclikGMP, 6-metoksipurin arabinozid (ara-M), 6-metoksipurin arabinozid 2'-O-valerat, citozin arabinozid (ara-C), 2',3'-dideoksinukleozide, aciklične nukleozide, aciklične nukleotide, ribavirin (adenin arabinozid), 2-tio-6-azauridin, tubercidin, aurin trikarboksilnu kiselinu, 3-deazaneoplanocin, neoplanocin, rimantidin, adamantin, foskamet (trinatrij fosfonoformat), citokine, interferone uključujući, interleukine, stimulirajuće faktore kolonija makrofaga/granulocita, antagoniste citokina, topive receptore interleukina, i inhibitore protein kinaze C.
8. Farmaceutski sastav patentnog zahtjeva 6, gdje je anti-tumorski/kancerogeni agens izabran iz grupe koja se sastoji iz abareliksa (Plenaksis depot®); aldesleukina (Prokine®); Aldesleukina (Proleukin®); Alemtuzumaba (Campath®); alitretinoina (Panretin®); alopurinola (Zyloprim®); altretamina (Hexalen®); amifostina (Ethyol®); anastrozola (Arimidex®); arsenik trioksida (Trisenox®); asparaginaza (Elspar®); azacitidina (Vidaza®); bevacuzimaba (Avastin®); beksaroten kapsula (Targretin®); beksaroten gela (Targretin®); bleomicina (Blenoxane®); bortezomiba (Velcade®); intravenoznog busulfana (Busulfex®); busulfana za oralnu primjenu (Myleran®); kalusterona (Methosarb®); kapecitabina (Xeloda®); karboplatina (Paraplatin®); karmustina (BCNU®, BiCNU®); karmustina (Gliadel®); karmustina sa Polifeprosan Implant 20 (Gliadel Wafer®); celekoksiba (Celebrex®); cetuksimaba (Erbitux®); klorambucila (Leukeran®); cisplatina (Platinol®); kladribina (Leustatin®, 2-CdA®); kofarabina (Clolar®); ciklofosfamida (Cytoxan®, Neosar®); ciklofosfamida (Cytoxan Injection®); ciklofosfamida (Cytoxan Tablet®); citarabina (Cytosar-U®); liposomalnog citarabina (DepoCyt®); dakarbazina (DTIC-Dome®); daktinomicina, aktinomicina D (Cosmegen®); Darbepoetina alfa (Aranesp®); liposomalnog daunorubicina (DanuoXome®); daunorubicina, daunomicina (Daunorubicin®); daunorubicina, daunomicina (Cerubidine®); Denileukin diftitoksa (Ontak®); deksrazoksana (Zinecard®); docetaksela (Taxotere®); doksorubicina (Adriamycin PFS®); doksorubicina (Adriamycin®, Rubex®); doksorubicina (Adriamycin PFS Injection®); liposomalnog doksorubicina (Doxil®); dromostanolon propionata (dromostanolone®); dromostanolon propionata (masterone injection®); Elliott B solucija (Elliott's B Solution®); epirubicina (Ellence®); Epoetina alfa (epogen®); erlotiniba (Tarceva®); estramustina (Emcyt®); etopozid fosfata (Etopophos®); etopozida, VP-16 (Vepesid®); eksemestana (Aromasin®); Filgrastima (Neupogen®); floksuridina (intraarterial) (FUDR®); fludarabina (Fludara®); fluorouracila, 5-FU (Adrucil®); folvestranta (Faslodex®); gefitiniba (Iressa®); gemcitabina (Gemzar®); gemtuzumab ozogamicina (Mylotarg®); goserelin acetata (Zoladex Implant®); goserelin acetata (Zoladex®); histrelin acetata (Histrelin implant®); hidroksiurea (Hydrea®); Ibritumomab Tiuksetana (Zevalin®); idarubicina (Idamycin®); ifosfamida (IFEX®); imatinib mesilata (Gleevec®); interferona alfa 2a (Roferon A®); Interferona alfa-2b (Intron A®); irinotekana (Camptosar®); lenalidomida (Revlimid®); letrozola (Femara®); leukovorina (Wellcovorin®, Leucovorin®); Leuprolid Acetata (Eligard®); levamisola (Ergamisol®); lomustina- CCNU (CeeBU®); mekloretamina, nitrogen mustarda - Mekloretamina (Mustargen®); megestrol acetata (Megace®); melfalana, L-PAM (Alkeran®); merkaptopurina, 6-MP (Purinethol®); mesna (Mesnex®); mesna (Mesnex tabs®); metotreksata (Methotrexate®); metoksalena (Uvadex®); mitomicina C (Mutamycin®); mitotana (Lysodren®); mitoksantrona (Novantrone®); nandrolon fenpropionata (Durabolin-50®); nelarabina (Arranon®); Nofetumomaba (Verluma®); Oprelvekina (Neumega®); oksaliplatina (Eloxatin®); paklitaksela (Paxene®); paklitaksela (Taxol®); paklitaksela proteinski vezanih čestica (Abraxane®); palifermina (Kepivance®); pamidronata (Aredia®); pegademaza (Adagen (Pegademase Bovine)®); pegaspargaza (Oncaspar®); Pegfilgrastima (Neulasta®); pemetreksed dinatrija (Alimta®); pentostatina (Nipent®); pipobromana (Vercyte®); plikamicina, mitramicina (Mithracin®); pofimer natrija (Photofrin®); prokarbazina (Matulane®); kinakrina (Atabrine®); Razburikaze (Elitek®); Rituksimaba (Rituxan®); sargramostima (Leukine®); Sargramostima (Prokine®); sorafeniba (Nexavar®); streptozocina (Zanosar®); sunitinib maleata (Sutent®); talka (Sclerosol®); tamoksifena (Nolvadex®); temozolomida (Temodar®); teniposida, VM-26 (Vumon®); testolaktona (Teslac®); tioguanina, 6-TG (Thioguanine®); tiotepa (Thioplex®); topotekana (Hycamtin®); toremifena (Fareston®); Tositumomaba (Bexxar®); Tositumomab/I-131 tositumomaba (Bexxar®); Trastuzumaba (Herceptin®); tretinoina, ATRA (Vesanoid®); Uracil Mustarda - uramustina (Uracil Mustard Capsules®); valrubicina (Valstar®); vinblastina (Velban®); vinkristina (Oncovir®); vinorelbina (Navelbine®); i zoledronata (Zometa®).
9. Spoj prema bilo kojem od zahtjeva 1 do 4 za upotrebu u inhibiciji rasta tumora/karcinoma kod subjekta.
10. Spoj prema bilo kojem od zahtjeva 1 do 4 za upotrebu u inhibiciji proliferacije tumorskih/kancerogenih stanica kod subjekta.
11. Spoj prema bilo kojem od zahtjeva 1 do 4 za upotrebu pri liječenju bolesti stanične proliferacije kod subjekta.
12. Spoj prema bilo kojem od zahtjeva 1 do 4 za upotrebu pri liječenju neoplastičnih bolesti kod subjekta.
13. Spoj prema bilo kojem od zahtjeva 1 do 4 za upotrebu pri liječenju hematoloških malignih bolesti kod subjekta.
14. Spoj prema bilo kojem od zahtjeva 1 do 4 za upotrebu pri liječenju Ne-Hodgkinovog limfoma (NHL).
15. Farmaceutski spoj prema bilo kojem od zahtjeva 5 do 8 za upotrebu u inhibiciji rasta tumora/ karcinoma kod subjekta.
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