HRP20131052T1 - Agonisti mglu2 - Google Patents
Agonisti mglu2 Download PDFInfo
- Publication number
- HRP20131052T1 HRP20131052T1 HRP20131052AT HRP20131052T HRP20131052T1 HR P20131052 T1 HRP20131052 T1 HR P20131052T1 HR P20131052A T HRP20131052A T HR P20131052AT HR P20131052 T HRP20131052 T HR P20131052T HR P20131052 T1 HRP20131052 T1 HR P20131052T1
- Authority
- HR
- Croatia
- Prior art keywords
- amino
- bicyclo
- hexane
- triazol
- ylsulfanyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09382290 | 2009-12-21 | ||
| US30523910P | 2010-02-17 | 2010-02-17 | |
| PCT/US2010/060371 WO2011084437A1 (en) | 2009-12-21 | 2010-12-15 | Mglu2 agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20131052T1 true HRP20131052T1 (hr) | 2013-12-06 |
Family
ID=42026702
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20131052AT HRP20131052T1 (hr) | 2009-12-21 | 2010-12-15 | Agonisti mglu2 |
Country Status (35)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2790284C (en) | 2010-02-17 | 2019-01-08 | Takeda Pharmaceutical Company Limited | Thieno-pyrimidine compounds having cdc7 inhibitory activity |
| WO2012068041A1 (en) * | 2010-11-18 | 2012-05-24 | Eli Lilly And Company | 4-SUBSTITUTED-3-BENZYLOXY-BICYCLO[3.1.0]HEXANE COMPOUNDS AS mGluR 2/3 ANTAGONISTS |
| TWI520935B (zh) * | 2010-11-18 | 2016-02-11 | 美國禮來大藥廠 | 作為ｍＧｌｕＲ２／３拮抗劑之４－經取代－３－苯基磺醯基甲基－雙環［３.１.０］己烷化合物 |
| BR112013031928B1 (pt) * | 2011-06-17 | 2022-05-24 | Eli Lilly And Company | Derivados de ácido biciclo (3.1.0) hexano-2,6-dicarboxílico, seu uso, e composição farmacêutica |
| AR089718A1 (es) * | 2012-02-01 | 2014-09-10 | Lilly Co Eli | AGONISTAS DE mGlu2/3 |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| LT3431106T (lt) | 2014-01-21 | 2021-02-10 | Janssen Pharmaceutica Nv | Deriniai, apimantys 2 potipio metabotropinio glutamaterginio receptoriaus teigiamus alosterinius moduliatorius arba ortosterinius agonistus, ir jų panaudojimas |
| KR102414246B1 (ko) | 2014-01-21 | 2022-06-27 | 얀센 파마슈티카 엔.브이. | 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도 |
| PL3277270T3 (pl) | 2015-04-01 | 2022-02-14 | Akebia Therapeutics, Inc. | Kompozycje i sposoby leczenia niedokrwistości |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5576323A (en) * | 1993-12-03 | 1996-11-19 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| GB9605429D0 (en) * | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| US5688826A (en) | 1995-11-16 | 1997-11-18 | Eli Lilly And Company | Excitatory amino acid derivatives |
| ZA983930B (en) | 1997-05-14 | 1999-11-08 | Lilly Co Eli | Excitatory amino acid receptor modulators. |
| HUP0400620A3 (en) * | 2001-01-11 | 2012-09-28 | Lilly Co Eli | Prodrugs of excitatory amino acids and pharmaceutical compositions containing them and process for preparation the compounds |
| WO2002055485A1 (en) * | 2001-01-11 | 2002-07-18 | Eli Lilly And Company | Prodrugs of excitatory amino acids |
| EP1370519A1 (en) * | 2001-02-22 | 2003-12-17 | Eli Lilly And Company | Synthetic excitatory amino acids |
| DK1517915T3 (da) | 2002-06-11 | 2009-03-16 | Lilly Co Eli | Promedikamenter af excitatoriske aminosyrer |
| WO2005000790A1 (ja) * | 2003-06-26 | 2005-01-06 | Taisho Pharmaceutical Co., Ltd. | ２－アミノビシクロ[３．１．０]ヘキサン－２，６－ジカルボン酸誘導体 |
| WO2012068041A1 (en) * | 2010-11-18 | 2012-05-24 | Eli Lilly And Company | 4-SUBSTITUTED-3-BENZYLOXY-BICYCLO[3.1.0]HEXANE COMPOUNDS AS mGluR 2/3 ANTAGONISTS |
| TWI520935B (zh) * | 2010-11-18 | 2016-02-11 | 美國禮來大藥廠 | 作為ｍＧｌｕＲ２／３拮抗劑之４－經取代－３－苯基磺醯基甲基－雙環［３.１.０］己烷化合物 |
-
2010
- 2010-12-09 JO JO2010439A patent/JO2978B1/en active
- 2010-12-09 AR ARP100104553A patent/AR079343A1/es active IP Right Grant
- 2010-12-10 TW TW099143362A patent/TWI477490B/zh active
- 2010-12-15 UA UAA201206909A patent/UA107684C2/ru unknown
- 2010-12-15 DK DK10798419.7T patent/DK2516406T3/da active
- 2010-12-15 NZ NZ600305A patent/NZ600305A/en unknown
- 2010-12-15 PT PT107984197T patent/PT2516406E/pt unknown
- 2010-12-15 MX MX2012007332A patent/MX2012007332A/es active IP Right Grant
- 2010-12-15 ES ES10798419T patent/ES2435651T3/es active Active
- 2010-12-15 KR KR1020127015935A patent/KR101395356B1/ko active Active
- 2010-12-15 SI SI201030387T patent/SI2516406T1/sl unknown
- 2010-12-15 PL PL10798419T patent/PL2516406T3/pl unknown
- 2010-12-15 CN CN201080058183.2A patent/CN102695701B/zh active Active
- 2010-12-15 SG SG2012045563A patent/SG181836A1/en unknown
- 2010-12-15 AU AU2010340039A patent/AU2010340039B2/en active Active
- 2010-12-15 EP EP10798419.7A patent/EP2516406B1/en active Active
- 2010-12-15 BR BR112012017188-7A patent/BR112012017188B1/pt active IP Right Grant
- 2010-12-15 WO PCT/US2010/060371 patent/WO2011084437A1/en not_active Ceased
- 2010-12-15 US US12/968,352 patent/US8318184B2/en active Active
- 2010-12-15 CA CA2784667A patent/CA2784667C/en active Active
- 2010-12-15 PH PH1/2012/501253A patent/PH12012501253A1/en unknown
- 2010-12-15 JP JP2012544727A patent/JP5779190B2/ja active Active
- 2010-12-15 PE PE2012000856A patent/PE20121688A1/es active IP Right Grant
- 2010-12-15 MY MYPI2012002794A patent/MY160618A/en unknown
- 2010-12-15 RS RS20130530A patent/RS53063B/sr unknown
- 2010-12-15 HR HRP20131052AT patent/HRP20131052T1/hr unknown
- 2010-12-15 EA EA201290558A patent/EA020229B1/ru not_active IP Right Cessation
-
2012
- 2012-05-24 IL IL220011A patent/IL220011A/en active IP Right Grant
- 2012-05-30 HN HN2012001160A patent/HN2012001160A/es unknown
- 2012-06-01 TN TNP2012000281A patent/TN2012000281A1/en unknown
- 2012-06-13 CR CR20120322A patent/CR20120322A/es unknown
- 2012-06-14 MA MA34967A patent/MA33824B1/fr unknown
- 2012-06-19 DO DO2012000173A patent/DOP2012000173A/es unknown
- 2012-06-20 EC ECSP12011989 patent/ECSP12011989A/es unknown
-
2013
- 2013-11-14 CY CY20131101012T patent/CY1114880T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2558477T3 (es) | Triazoles sustituidos útiles como inhibidores de AXL | |
| AU2020294196B2 (en) | Estrogen receptor modulators | |
| ES2442905T3 (es) | Derivados de oxazina y su uso en el tratamiento de trastornos neurólógicos | |
| ES2606752T3 (es) | Método para la preparación de (2S,3R)-N-(2-((3-piridinil)metil)-1-azabiciclo[2.2.2]oct-3-il)benzofuran-2- carboxamida | |
| EP3740487B1 (en) | Benzamide compounds as bci inhibitors for the treatment of hiv | |
| ES2808988T3 (es) | Composiciones y métodos para inhibir la actividad arginasa | |
| ES2670571T3 (es) | Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis B | |
| ES2811119T3 (es) | Derivados de naftiridina como antagonistas de integrina alfa v beta 6 para el tratamiento de, por ejemplo, enfermedades fibróticas | |
| HRP20151218T1 (hr) | Sredstva za induciranje apoptoze za lijeäśenje raka te imunih i autoimunih bolesti | |
| JP2013514974A5 (enExample) | ||
| HRP20180746T4 (hr) | Supstituirani spojevi pirazolo[1,5-]pirimidina kao inhibitori trk kinaze | |
| ES2295924T3 (es) | Derivados de tropano imidazopirina sustituidos con actividad antagonista de los receptores ccr5 para el tratamiento de vih y de la inflamacion. | |
| ES2784250T3 (es) | Derivados de alquilo y arilo de compuestos de 1-oxa-4,9-diazaespiro undecano que tienen actividad multimodal contra el dolor | |
| WO2019186164A1 (en) | Factor xiia inhibitors | |
| CA3143489A1 (en) | Aminopyrimidine amide autophagy inhibitors and methods of use thereof | |
| NZ594930A (en) | Heterocyclic compounds, pharmaceutical compositions containing them, and their use as inhibitors of the glycine transporter 1 | |
| PH12015500457B1 (en) | Alkoxy pyrazoles as soluble guanylate cyclase activators | |
| TW200745111A (en) | New compounds | |
| ES2662026T3 (es) | Nuevo inhibidor de renina | |
| MX2013009709A (es) | Derivados de heteroarilo como moduladores de nachr alfa 7. | |
| RU2009133262A (ru) | Нападизилатная соль антагониста мускаринового мз-рецептора | |
| HRP20240361T1 (hr) | Analozi benzoazepina kao sredstva za inhibiciju brutonove tirozin kinaze | |
| NZ600305A (en) | Mglu2 agonists | |
| MX2009010165A (es) | Nuevas imidazo[4,5-b]piridina-7-carboxamidas 704. | |
| BR112018014302A2 (en) | 3- (carboxyethyl) -8-amino-2-oxo-1,3-diaza-spiro [4.5] decane derivatives |