HRP20120187T1 - Derivati 2-oksoalkil-1-piperazin-2-ona, njihovo dobivanje i njihova upotreba u terapiji - Google Patents
Derivati 2-oksoalkil-1-piperazin-2-ona, njihovo dobivanje i njihova upotreba u terapiji Download PDFInfo
- Publication number
- HRP20120187T1 HRP20120187T1 HR20120187T HRP20120187T HRP20120187T1 HR P20120187 T1 HRP20120187 T1 HR P20120187T1 HR 20120187 T HR20120187 T HR 20120187T HR P20120187 T HRP20120187 T HR P20120187T HR P20120187 T1 HRP20120187 T1 HR P20120187T1
- Authority
- HR
- Croatia
- Prior art keywords
- pyridin
- dihydro
- connection
- oxoethyl
- trifluoromethylpyridin
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title claims 2
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 150000003839 salts Chemical class 0.000 claims abstract 13
- 239000002253 acid Substances 0.000 claims abstract 12
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 7
- 239000001257 hydrogen Substances 0.000 claims abstract 7
- -1 COOalkyl Chemical group 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 6
- 125000005843 halogen group Chemical group 0.000 claims abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 6
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims abstract 6
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims abstract 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract 5
- 125000003709 fluoroalkyl group Chemical group 0.000 claims abstract 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract 2
- 229910052736 halogen Inorganic materials 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 150000007513 acids Chemical class 0.000 claims 10
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 230000006378 damage Effects 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 claims 2
- 210000001525 retina Anatomy 0.000 claims 2
- FGXSKTSBCPFCFI-UHFFFAOYSA-N 1-(6-chloropyridin-3-yl)-4-[2-[4-[4-chloro-3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridin-1-yl]-2-oxoethyl]piperazin-2-one Chemical compound C1=C(Cl)C(C(F)(F)F)=CC(C=2CCN(CC=2)C(=O)CN2CC(=O)N(CC2)C=2C=NC(Cl)=CC=2)=C1 FGXSKTSBCPFCFI-UHFFFAOYSA-N 0.000 claims 1
- GSLGDCPSILDSJM-UHFFFAOYSA-N 1-[4-(4-bromophenyl)-3,6-dihydro-2h-pyridin-1-yl]-2-chloroethanone Chemical compound C1N(C(=O)CCl)CCC(C=2C=CC(Br)=CC=2)=C1 GSLGDCPSILDSJM-UHFFFAOYSA-N 0.000 claims 1
- HQIOKKAJAOKFAA-UHFFFAOYSA-N 2-chloro-1-[4-(2-methoxyphenyl)-3,6-dihydro-2h-pyridin-1-yl]ethanone Chemical compound COC1=CC=CC=C1C1=CCN(C(=O)CCl)CC1 HQIOKKAJAOKFAA-UHFFFAOYSA-N 0.000 claims 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- WJNNAFBKEQFCET-UHFFFAOYSA-N 4-[2-[4-(4-chlorophenyl)-3,6-dihydro-2h-pyridin-1-yl]-2-oxoethyl]-1-pyridin-2-ylpiperazin-2-one Chemical compound C1=CC(Cl)=CC=C1C1=CCN(C(=O)CN2CC(=O)N(CC2)C=2N=CC=CC=2)CC1 WJNNAFBKEQFCET-UHFFFAOYSA-N 0.000 claims 1
- GNNFVSFMZIKJFM-UHFFFAOYSA-N 4-[2-[5-(2,3-dichlorophenyl)-3,6-dihydro-2h-pyridin-1-yl]-2-oxoethyl]-1-[5-(trifluoromethyl)pyridin-2-yl]piperazin-2-one Chemical compound N1=CC(C(F)(F)F)=CC=C1N1C(=O)CN(CC(=O)N2CC(=CCC2)C=2C(=C(Cl)C=CC=2)Cl)CC1 GNNFVSFMZIKJFM-UHFFFAOYSA-N 0.000 claims 1
- IIJFQMIESAUXIX-UHFFFAOYSA-N 4-[2-oxo-2-(4-phenyl-3,6-dihydro-2h-pyridin-1-yl)ethyl]-1-[5-(trifluoromethyl)pyridin-2-yl]piperazin-2-one Chemical compound N1=CC(C(F)(F)F)=CC=C1N1C(=O)CN(CC(=O)N2CC=C(CC2)C=2C=CC=CC=2)CC1 IIJFQMIESAUXIX-UHFFFAOYSA-N 0.000 claims 1
- KQMLFBRCASWVOT-UHFFFAOYSA-N 4-[2-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-3,6-dihydro-2h-pyridin-1-yl]ethyl]-1-pyridin-2-ylpiperazin-2-one Chemical compound FC(F)(F)OC1=CC=CC(C=2CCN(CC=2)C(=O)CN2CC(=O)N(CC2)C=2N=CC=CC=2)=C1 KQMLFBRCASWVOT-UHFFFAOYSA-N 0.000 claims 1
- PVENPGLHUBKUKK-UHFFFAOYSA-N 4-[2-oxo-2-[4-[3-(trifluoromethyl)phenyl]-3,6-dihydro-2h-pyridin-1-yl]ethyl]-1-pyridin-2-ylpiperazin-2-one Chemical compound FC(F)(F)C1=CC=CC(C=2CCN(CC=2)C(=O)CN2CC(=O)N(CC2)C=2N=CC=CC=2)=C1 PVENPGLHUBKUKK-UHFFFAOYSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 208000000044 Amnesia Diseases 0.000 claims 1
- 208000031091 Amnestic disease Diseases 0.000 claims 1
- 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 208000010392 Bone Fractures Diseases 0.000 claims 1
- 208000020084 Bone disease Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 206010065390 Inflammatory pain Diseases 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
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- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000031481 Pathologic Constriction Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 208000024777 Prion disease Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 201000001263 Psoriatic Arthritis Diseases 0.000 claims 1
- 208000036824 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 231100000360 alopecia Toxicity 0.000 claims 1
- 230000006986 amnesia Effects 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000003683 cardiac damage Effects 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 238000006471 dimerization reaction Methods 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 206010015037 epilepsy Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
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- 208000032839 leukemia Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 230000002981 neuropathic effect Effects 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
- 208000027232 peripheral nervous system disease Diseases 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 208000032253 retinal ischemia Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000037390 scarring Effects 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 210000003625 skull Anatomy 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 208000020431 spinal cord injury Diseases 0.000 claims 1
- 230000036262 stenosis Effects 0.000 claims 1
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- 230000009278 visceral effect Effects 0.000 claims 1
- 125000004429 atom Chemical group 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Oncology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0803298A FR2932481B1 (fr) | 2008-06-13 | 2008-06-13 | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
| PCT/FR2009/051117 WO2009150387A1 (fr) | 2008-06-13 | 2009-06-12 | Derives de 2-oxo-alkyl-1-piperazin-2-one, leur preparation et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120187T1 true HRP20120187T1 (hr) | 2012-03-31 |
Family
ID=40305319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120187T HRP20120187T1 (hr) | 2008-06-13 | 2012-02-27 | Derivati 2-oksoalkil-1-piperazin-2-ona, njihovo dobivanje i njihova upotreba u terapiji |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US8247404B2 (da) |
| EP (1) | EP2310383B8 (da) |
| JP (1) | JP5476372B2 (da) |
| KR (1) | KR101601999B1 (da) |
| CN (1) | CN102124001B (da) |
| AR (1) | AR072102A1 (da) |
| AT (1) | ATE535524T1 (da) |
| AU (1) | AU2009259120B2 (da) |
| BR (1) | BRPI0915482B8 (da) |
| CA (1) | CA2726666C (da) |
| CL (1) | CL2010001432A1 (da) |
| CO (1) | CO6300943A2 (da) |
| CY (1) | CY1112417T1 (da) |
| DK (1) | DK2310383T3 (da) |
| EA (1) | EA019924B1 (da) |
| ES (1) | ES2378380T3 (da) |
| FR (1) | FR2932481B1 (da) |
| HK (1) | HK1158632A1 (da) |
| HR (1) | HRP20120187T1 (da) |
| IL (1) | IL209903A (da) |
| JO (1) | JO2773B1 (da) |
| MX (1) | MX2010013694A (da) |
| MY (1) | MY151228A (da) |
| NZ (1) | NZ589842A (da) |
| PL (1) | PL2310383T3 (da) |
| PT (1) | PT2310383E (da) |
| RS (1) | RS52252B (da) |
| SI (1) | SI2310383T1 (da) |
| TW (1) | TWI400238B (da) |
| UY (1) | UY31894A (da) |
| WO (1) | WO2009150387A1 (da) |
| ZA (1) | ZA201008791B (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2932482B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2932481B1 (fr) | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
| FR2953836B1 (fr) | 2009-12-14 | 2012-03-16 | Sanofi Aventis | Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2953839A1 (fr) | 2009-12-14 | 2011-06-17 | Sanofi Aventis | Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75 |
| EP2606894A1 (en) | 2011-12-20 | 2013-06-26 | Sanofi | Novel therapeutic use of p75 receptor antagonists |
| ES2699410T3 (es) | 2014-05-28 | 2019-02-11 | Univ Dresden Tech | Ensayo basado en células y métodos de cribado de moduladores de la señalización de p75NTR |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3236243A1 (de) * | 1982-09-30 | 1984-04-05 | Merck Patent Gmbh, 6100 Darmstadt | Schwefelhaltige indolderivate |
| FR2744448B1 (fr) * | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
| US6613942B1 (en) * | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| WO1999001423A1 (en) * | 1997-07-01 | 1999-01-14 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
| CA2369945A1 (en) | 1999-04-06 | 2000-10-12 | James L. Kelley | Neurotrophic thio substituted pyrimidines |
| UA77526C2 (en) * | 2002-06-07 | 2006-12-15 | Sanofi Aventis | Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy |
| FR2862968B1 (fr) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique |
| FR2862967B1 (fr) * | 2003-12-01 | 2006-08-04 | Sanofi Synthelabo | Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique |
| FR2932482B1 (fr) * | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75 |
| FR2932481B1 (fr) | 2008-06-13 | 2010-10-08 | Sanofi Aventis | Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique. |
-
2008
- 2008-06-13 FR FR0803298A patent/FR2932481B1/fr not_active Expired - Fee Related
-
2009
- 2009-06-01 JO JO2009197A patent/JO2773B1/en active
- 2009-06-11 TW TW098119565A patent/TWI400238B/zh active
- 2009-06-11 AR ARP090102109A patent/AR072102A1/es active IP Right Grant
- 2009-06-12 DK DK09761938.1T patent/DK2310383T3/da active
- 2009-06-12 KR KR1020117000793A patent/KR101601999B1/ko active IP Right Grant
- 2009-06-12 MY MYPI20105853 patent/MY151228A/en unknown
- 2009-06-12 CN CN200980131553.8A patent/CN102124001B/zh active Active
- 2009-06-12 EA EA201170015A patent/EA019924B1/ru not_active IP Right Cessation
- 2009-06-12 PT PT09761938T patent/PT2310383E/pt unknown
- 2009-06-12 NZ NZ589842A patent/NZ589842A/xx not_active IP Right Cessation
- 2009-06-12 UY UY0001031894A patent/UY31894A/es not_active Application Discontinuation
- 2009-06-12 EP EP09761938A patent/EP2310383B8/fr active Active
- 2009-06-12 AT AT09761938T patent/ATE535524T1/de active
- 2009-06-12 WO PCT/FR2009/051117 patent/WO2009150387A1/fr active Application Filing
- 2009-06-12 ES ES09761938T patent/ES2378380T3/es active Active
- 2009-06-12 CA CA2726666A patent/CA2726666C/fr active Active
- 2009-06-12 SI SI200930179T patent/SI2310383T1/sl unknown
- 2009-06-12 PL PL09761938T patent/PL2310383T3/pl unknown
- 2009-06-12 MX MX2010013694A patent/MX2010013694A/es active IP Right Grant
- 2009-06-12 AU AU2009259120A patent/AU2009259120B2/en active Active
- 2009-06-12 RS RS20120082A patent/RS52252B/en unknown
- 2009-06-12 BR BRPI0915482A patent/BRPI0915482B8/pt active IP Right Grant
- 2009-06-12 JP JP2011513037A patent/JP5476372B2/ja active Active
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2010
- 2010-12-07 ZA ZA2010/08791A patent/ZA201008791B/en unknown
- 2010-12-09 IL IL209903A patent/IL209903A/en active IP Right Grant
- 2010-12-13 US US12/966,408 patent/US8247404B2/en active Active
- 2010-12-13 CO CO10156026A patent/CO6300943A2/es active IP Right Grant
- 2010-12-13 CL CL2010001432A patent/CL2010001432A1/es unknown
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2011
- 2011-11-29 HK HK11112931.4A patent/HK1158632A1/xx not_active IP Right Cessation
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2012
- 2012-02-27 HR HR20120187T patent/HRP20120187T1/hr unknown
- 2012-02-29 CY CY20121100212T patent/CY1112417T1/el unknown
- 2012-07-24 US US13/556,328 patent/US20120289518A1/en not_active Abandoned
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