CY1112417T1 - Παραγωγα 2-οξο-αλκυλο-1-πιπεραζιν-2-ονης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη - Google Patents

Παραγωγα 2-οξο-αλκυλο-1-πιπεραζιν-2-ονης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

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Publication number
CY1112417T1
CY1112417T1 CY20121100212T CY121100212T CY1112417T1 CY 1112417 T1 CY1112417 T1 CY 1112417T1 CY 20121100212 T CY20121100212 T CY 20121100212T CY 121100212 T CY121100212 T CY 121100212T CY 1112417 T1 CY1112417 T1 CY 1112417T1
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CY
Cyprus
Prior art keywords
oxo
alkyl
piperazin
preparation
application
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Application number
CY20121100212T
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English (en)
Inventor
Marco Baroni
Françoise Bono
Sandrine Delbary-Gossart
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Sanofi
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Application filed by Sanofi filed Critical Sanofi
Publication of CY1112417T1 publication Critical patent/CY1112417T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
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    • A61P17/00—Drugs for dermatological disorders
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
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  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Η παρούσα εφεύρεση έχει ως αντικείμενο τα παράγωγα των παραγώγων της 4-{2-[φαίνυλο-3,6- διυδρο- πυριδιν-1 -υλ]-2- όξο- άλκυλο}-1- πιπεραζιν-2- όνη και 4-{2-[φαίνυλο-2,5- δίυδρο- πυρρολ-1- υλ]-2- όξο- άλκυλο}-1- πιεραζιν-2- όνη του γενικού τύπου (Ι) όπου τα Α, Β, m, R3 και η είναι όπως ορίζονται στην αξίωση 1, την παρασκευή τους και την εφαρμογή τους στη θεραπευτική.
CY20121100212T 2008-06-13 2012-02-29 Παραγωγα 2-οξο-αλκυλο-1-πιπεραζιν-2-ονης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη CY1112417T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0803298A FR2932481B1 (fr) 2008-06-13 2008-06-13 Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.
EP09761938A EP2310383B8 (fr) 2008-06-13 2009-06-12 Derives de 2-oxo-alkyl-1-piperazin-2-one, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
CY1112417T1 true CY1112417T1 (el) 2015-12-09

Family

ID=40305319

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100212T CY1112417T1 (el) 2008-06-13 2012-02-29 Παραγωγα 2-οξο-αλκυλο-1-πιπεραζιν-2-ονης, η παρασκευη τους και η εφαρμογη τους στη θεραπευτικη

Country Status (32)

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US (2) US8247404B2 (el)
EP (1) EP2310383B8 (el)
JP (1) JP5476372B2 (el)
KR (1) KR101601999B1 (el)
CN (1) CN102124001B (el)
AR (1) AR072102A1 (el)
AT (1) ATE535524T1 (el)
AU (1) AU2009259120B2 (el)
BR (1) BRPI0915482B8 (el)
CA (1) CA2726666C (el)
CL (1) CL2010001432A1 (el)
CO (1) CO6300943A2 (el)
CY (1) CY1112417T1 (el)
DK (1) DK2310383T3 (el)
EA (1) EA019924B1 (el)
ES (1) ES2378380T3 (el)
FR (1) FR2932481B1 (el)
HK (1) HK1158632A1 (el)
HR (1) HRP20120187T1 (el)
IL (1) IL209903A (el)
JO (1) JO2773B1 (el)
MX (1) MX2010013694A (el)
MY (1) MY151228A (el)
NZ (1) NZ589842A (el)
PL (1) PL2310383T3 (el)
PT (1) PT2310383E (el)
RS (1) RS52252B (el)
SI (1) SI2310383T1 (el)
TW (1) TWI400238B (el)
UY (1) UY31894A (el)
WO (1) WO2009150387A1 (el)
ZA (1) ZA201008791B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2932482B1 (fr) * 2008-06-13 2010-10-08 Sanofi Aventis Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75
FR2932481B1 (fr) 2008-06-13 2010-10-08 Sanofi Aventis Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.
FR2953836B1 (fr) 2009-12-14 2012-03-16 Sanofi Aventis Nouveaux derives (heterocycle-tetrahydro-pyridine)-(piperazinyl)-1-alcanone et (heterocycle-dihydro-pyrrolidine)-(piperazinyl)-1-alcanone et leur utilisation comme inhibiteurs de p75
FR2953839A1 (fr) 2009-12-14 2011-06-17 Sanofi Aventis Nouveaux derives d'(heterocycle-piperidine condensee)-(piperazinyl)-1alcanone ou d'(heterocycle-pyrrolidine condensee)-(piperazinyl)-1alcanone et leur utilisation comme inhibiteurs de p75
EP2606894A1 (en) 2011-12-20 2013-06-26 Sanofi Novel therapeutic use of p75 receptor antagonists
ES2699410T3 (es) 2014-05-28 2019-02-11 Univ Dresden Tech Ensayo basado en células y métodos de cribado de moduladores de la señalización de p75NTR

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3236243A1 (de) * 1982-09-30 1984-04-05 Merck Patent Gmbh, 6100 Darmstadt Schwefelhaltige indolderivate
FR2744448B1 (fr) * 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
US6613942B1 (en) * 1997-07-01 2003-09-02 Novo Nordisk A/S Glucagon antagonists/inverse agonists
WO1999001423A1 (en) * 1997-07-01 1999-01-14 Novo Nordisk A/S Glucagon antagonists/inverse agonists
CA2369945A1 (en) 1999-04-06 2000-10-12 James L. Kelley Neurotrophic thio substituted pyrimidines
UA77526C2 (en) * 2002-06-07 2006-12-15 Sanofi Aventis Substituted derivatives of 1-piperazineacylpiperidine, a method for the preparation thereof and their use in therapy
FR2862968B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de 4-[(arylmethyl)aminomethyl]piperidine, leur preparation et leur application en therapeutique
FR2862967B1 (fr) * 2003-12-01 2006-08-04 Sanofi Synthelabo Derives de (4-phenylpiperazin-1-yl)acylpiperidine, leur preparation et leur application en therapeutique
FR2932482B1 (fr) * 2008-06-13 2010-10-08 Sanofi Aventis Nouveaux derives de (phenyl-3,6-dihydro-2h-pyridinyl)- (piperazinyl ponte)-1-alcanone et leur utilisation comme inhibiteurs de p75
FR2932481B1 (fr) 2008-06-13 2010-10-08 Sanofi Aventis Derives de 4-{2-°4-phenyl-3,6-dihydro-2h-pyridin-1-yl!-2- oxo-alkyl}-1-piperazin-2-one, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
CN102124001A (zh) 2011-07-13
AR072102A1 (es) 2010-08-04
JO2773B1 (en) 2014-03-15
TWI400238B (zh) 2013-07-01
EA201170015A1 (ru) 2011-06-30
AU2009259120A1 (en) 2009-12-17
NZ589842A (en) 2012-12-21
WO2009150387A1 (fr) 2009-12-17
UY31894A (es) 2010-01-29
EP2310383B8 (fr) 2012-04-11
EP2310383A1 (fr) 2011-04-20
BRPI0915482B1 (pt) 2020-11-24
TW201002686A (en) 2010-01-16
HRP20120187T1 (hr) 2012-03-31
DK2310383T3 (da) 2012-03-26
AU2009259120B2 (en) 2014-01-16
KR20110031317A (ko) 2011-03-25
US8247404B2 (en) 2012-08-21
BRPI0915482A2 (pt) 2015-11-10
JP2011522868A (ja) 2011-08-04
MY151228A (en) 2014-04-30
IL209903A (en) 2014-06-30
FR2932481A1 (fr) 2009-12-18
EP2310383B1 (fr) 2011-11-30
ATE535524T1 (de) 2011-12-15
KR101601999B1 (ko) 2016-03-17
HK1158632A1 (en) 2012-07-20
CO6300943A2 (es) 2011-07-21
CL2010001432A1 (es) 2011-05-13
PT2310383E (pt) 2012-03-06
CA2726666A1 (fr) 2009-12-17
MX2010013694A (es) 2011-02-23
CN102124001B (zh) 2014-01-22
JP5476372B2 (ja) 2014-04-23
US20120289518A1 (en) 2012-11-15
ZA201008791B (en) 2012-02-29
FR2932481B1 (fr) 2010-10-08
ES2378380T3 (es) 2012-04-11
IL209903A0 (en) 2011-02-28
EA019924B1 (ru) 2014-07-30
SI2310383T1 (sl) 2012-03-30
PL2310383T3 (pl) 2012-04-30
CA2726666C (fr) 2016-08-16
RS52252B (en) 2012-10-31
BRPI0915482B8 (pt) 2021-05-25
US20110144122A1 (en) 2011-06-16

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